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US20120184731 Method for synthesizing beta lactam compounds by decomposition of an alpha-diazo-beta-ketoamide using a fluorescent light source  
Novel methods for the production of enantiomerically pure (EP) β-lactams by decomposition of α-diazo-β-ketoamides using fluorescent light.
US20130331578 NOVEL IMINOSUGARS AND THEIR APPLICATIONS  
Iminosugar compounds are described that have inbuilt delivery features by virtue of covalent incorporation of a tocopherol moiety, or alternative moieties that are analogues of tocopherol or...
US20150148533 New Synthetic Route For The Preparation Of Beta-aminobutyryl Substituted 5,6,7,8-tetrahydro[1,4]diazolo[4,3-alpha]Pyrazin-7-yl Compounds  
The present invention relates to a process for preparing □-aminobutyryl substituted 5,6,7,8-tetrahydro[1,4]diazolo[4,3-α]pyrazin-7-yl compounds.
US20110229918 Method of Quantifying Transient Interactions Between Proteins  
The invention relates to a precursor for producing sintered metallic components, a method for producing the precursor and the production of the components. The object of the invention is to...
US20080318920 DEUTERIUM-ENRICHED EZETIMIBE  
The present application describes deuterium-enriched ezetimibe, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
US20110312903 FLUORINATION OF ORGANIC COMPOUNDS  
Methods for fluorinating organic compounds are described herein.
US20130053325 Secondary Structure Stabilized NMDA Receptor Modulators and Uses Thereof  
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of diseases and disorders such as learning,...
US20080033165 [Beta]-Lactamyl Vasopressin V1a Antagonists and Methods of Use  
Novel 2-(azetidin-2-on-1-yl) alkanedioic acid derivativies and 2-(azetidin-2-on-1-yl) alkoxyalkanoic acid derivativies are described for use in the treatment of disease states responsive to...
US20120208994 AZETIDINONE COMPOUNDS AND MEDICAL USE THEREOF  
Preparation of azetidinone compounds and medical use thereof are provided by the present invention. More particularly, azetidionne compounds, shown as formula (I), wherein R1, R2, R3, R4, R5 and...
US20070265202 Compounds That Modulate Trh Actions  
The invention relates to compounds that inhibit thyrotropin-releasing hormone (TRH) degrading ectoenzyme and/or enhance, and/or mimic the biological actions of TRH. The compounds find therapeutic...
US20090186866 THERAPEUTIC BETA-LACTAMS  
Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof,are disclosed, wherein Y, A, R, D, and n are as described. Methods, compositions, and medicaments related thereto...
US20110152233 PYRROLIDINE COMPOUNDS  
The present application relates to compounds of formula wherein R1, R2, R3, R4, and n are defined herein or to a pharmaceutically active salt thereof. The present compounds are high potential NK-3...
US20130289013 IMIDAZO[1,2-a]PYRIDINE COMPOUNDS  
Imidazo[1,2-a]pyridines are disclosed. Compounds of the invention are useful therapeutic agents and their inclusion in pharmaceutical formulations and use in methods of treatment are disclosed.
US20080274947 Hydroxy-Substituted Diphenylazetidinones for the Treatment of Hyperlipidemia  
The present invention comprises compounds and compositions for the treatment of metabolic disorders and more particularly, those insulin-related metabolic disorders of the blood such as...
US20070161577 Tethered dimers and trimers of 1,4-diphenylazetidin-2-ones  
Derivatives of 1,4-diphenylazetidin-2-ones useful for the treatment of hypercholesterolemia are disclosed. The compounds are of the general formula
US20070249816 Methods for carbon istope labeling synthesis by rhodium-promoted carbonylation via isocyanate using azides and carbon-isotope monoxide  
Methods and reagents for rhodium-promoted carbonylation via isocyanate using carbon-isotope labeled carbon monoxide are provided. The resultant carbon isotope labeled compounds are useful as...
US20070049748 PREPARATION OF EZETIMIBE  
A process for preparing ezetimibe.
US20060160785 Ezetimibe polymorphs  
Provided are processes for preparing crystalline forms of ezetimibe, such as ezetimibe Form A or Form B, for example, by precipitating ezetimibe from selected solvents. Alternatively, some forms...
US20120022248 B-LACTAM COMPOUNDS  
Novel methods for the production of enantiomerically pure (EP) β-lactams by decomposition of α-diazo-β-ketoamides.
US20070135357 Anti-hypercholesterolemic compounds  
The instant invention provides novel cholesterol absorption inhibitors of Formula I and the pharmaceutically acceptable salts and esters thereof. The compounds are useful for lowering plasma...
US20060223993 Colorant compounds, intermediates, and compositions  
Colorants are disclosed that exhibit high color strength, bright shades, and high thermal stability. Such compounds have found application as colorants for polyethylene terephthalate (“PET”)....
US20110230457 Substituted Isoquinolinones and Quinazolinones  
The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I) wherein Z is CH2 or N—R4 and X, R1, R2, R4, R6, R7 and n are as defined in the description. Such...
US20080227974 Novel Substituted Azetidinones  
Novel azetidinones and pharmaceutical compositions are described, as are the methods of using such compounds and compositions to treat subjects, including humans, suffering from hyperlipidemia,...
US20050171080 Polymorphs of ezetimibe and process for preparation thereof  
The present invention relates to novel crystalline forms and amorphous form of Ezetimibe and the processes for the preparation thereof.
US20120196740 Process for Producing Optically Pure beta-Lactones from Aldehydes and Compositions Produced Thereby  
Bi-functional cobalt-containing catalysts useful for making stereo specific compounds and compositions, along with methods of making, and uses thereof in the syntheses of optically pure β-lactones...
US20130231322 THERAPEUTIC SUBSTITUTED BETA-LACTAMS  
A compound having a structure is disclosed herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
US20130184249 PYRROLIDINE DERIVATIVES  
The present invention relates to compounds of formula wherein R1, R2, R3, R4, Z, and n are as defined herein or to a pharmaceutically active salt thereof. Compounds of the invention are high...
US20090203578 CERTAIN CRYSTALLINE DIPHENYLAZETIDINONE HYDRATES, PHARMACEUTICAL COMPOSITIONS THEREOF AND METHODS FOR THEIR USE  
Provided are certain crystalline hydrates of the formula I in which n has a value of from 0.5 to 1.8. The compound may be suitable, for example, as a hypolipidemic.
US20120309734 COMBRETASTATIN DERIVATIVES AND USES THEREFOR  
Cancer is one of the major causes of death worldwide. Although many advances have been made in the treatment and management of the disease, the existence of chemotherapy-resistance means there is...
US20070032646 Novel taxanes and methods related to use and preparation thereof  
Disclosed are taxanes having utility as intermediates in the preparation of paclitaxel, taxotere and analogs thereof, and methods related to the preparation of the same.
US20150218091 CRYSTAL FORMS OF AZETIDINONE COMPOUNDS AND PREPARING METHODS THEREOF  
The present invention provides crystal forms of the compound of (3R,4S)-4-(4-hydroxyphenyl)-3-[3-(4-fluorophenyl)-4-hydroxyb ut-2(Z)-enyl]-1-(4-fluorophenyl)-2-azetidinone (formula A). The crystal...
US20070037971 PROCESS FOR DESILYLATION OF CARBAPENEM INTERMEDIATES  
Provided are processes for desilylating carbapenem intermediates. In particular, such desilylation reactions are done in the presence of one or more desilylating agents selected from acetyl...
US20060281728 3-Substituted beta-lactamyl vasopressin v1a antagonists  
Novel 2-(azetidin-2-on-1-yl)alkanedioic acids and derivatives thereof are described. Methods for using 2-(azetidin-2-on-1-yl)alkanedioic acids and derivatives thereof in the treatment of disease...
US20080200669 Processes For Production of Phenolic 4-Biphenylylazetidin-2-Ones  
The present invention relates to processes for the production of phenolic 4-biphenylylazetidin-2-one derivatives of formula
US20090047716 REDUCTION PROCESSES FOR THE PREPARATION OF EZETIMIBE  
Processes for preparing ezetimibe-related compounds with a ketoreductase and for purifying ezetimibe are disclosed.
US20090227786 PROCESSES FOR PREPARING INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF EZETIMIBE  
The invention relates, in general, to an improved process for the preparation of the compounds (3R,4S)-4-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-3-[3-(4-f luorophenyl)-3-oxopropyl]azetidin-2-one...
US20060234996 Novel crystalline form of ezetimibe and processes for the preparation thereof  
A novel crystalline form of Ezetimibe and processes for the preparation thereof are disclosed.
US20100069347 HETEROCYCLYL-SUBSTITUTED ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS  
This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts thereof, wherein R12 is a hydroxylated alkyl group and R9 contains a heterocyclic...
US20110059939 THERAPEUTIC COMPOUNDS  
Compounds comprising formula (I) or a pharmaceutically acceptable salt thereof, a dashed line represent the presence or absence of a double bond, are disclosed, wherein J1, J2, U1, B, Y, and A are...
US20060217537 Methods for carbon isotope labeling synthesis by transition metal-promoted carbonylation via ketene using diazo compounds and carbon-isotope monoxide  
Methods and reagents for transition metal-promoted carbonylation via diazo compounds using carbon-isotope labeled carbon monoxide are provided. The resultant carbon-isotope labeled compounds are...
US20110087010 ANTI-ANGIOGENIC COMPOUNDS  
The present invention provides AA targeting compounds which comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody. Various uses of the compounds are...
US20090318404 SUBSTITUTED BETA-LACTAMS  
Disclosed herein is a compound comprising or a pharmaceutically acceptable salt or a prodrug or a metabolite thereof;wherein Y is an organic acid functional group, or an amide or ester thereof...
US20100144698 SUBSTITUTED AZETIDINONES  
Compounds are provided which have the structure Wherein A, B, C, D, m, Y, Ra, Rc, Rd, and Rd′ are as described herein, and which are useful as inhibitors of tryptase, thrombin, trypsin, Factor Xa,...
US20070203080 New Drug Delivery System for Crossing the Blood Brain Barrier  
New ubiquinol analogs are disclosed, as well as methods of using these compounds to deliver drug moieties to the body.
US20070287692 ASPARTYL PROTEASE INHIBITORS  
Disclosed are compounds of formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, U, W, X, R1, R2, R6, R7, R30 and R31 are as described above in the...
US20090093627 Process for preparing intermediates of ezetimibe by microbial reduction  
Processes of preparing an ezetimibe intermediate by microbial reduction and further converting the intermediate to ezetimibe are provided. Also provided is an ezetimibe intermediate with high...
US20090099355 Processes for Production of 4-(Biphenylyl)Azetidin-2-One Phosphonic Acids  
The present invention relates to processes for the production of 4-(biphenylyl)azetidin-2-one phosphonic acid derivatives of formula
US20050096466 Process for the preparation of tetrazol-derived compounds as growth hormone secretagogues  
A process for the preparation of tetrazole-derived compounds useful as growth hormone secretagogues is described.
US20110144326 Method for manufacturing stereoselective preparation of 4-BMA using a chiral auxiliary and chiral auxiliary  
The present invention relates to a process for preparing (3R,4S)-3-[[[R]-1′-t-butyldimethylsilyloxy]ethyl]-4-[(R)-1″- carboxyethyl]-2-azetidinone (beta-methylazetidin-2-one; 4-BMA), a key...
US20090216009 PROCESS FOR THE PRODUCTION OF EZETIMIBE AND INTERMEDIATES USED IN THIS PROCESS  
An industrially easily realizable and economical process comprising only few steps, and built on new intermediates for the production of...

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