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US20120311741 SOPHOROLIPID TRANSPORTER PROTEIN  
The invention relates to a transporter protein involved in the transport of sophorolipids. More specifically, it relates to a Candida bombicola sophorolipid transporter protein, and the use of...
US20120141456 Use of DR6 and p75 Antagonists to Promote Survival of Cells of the Nervous System  
The present invention relates to Death Receptor-6 (DR6) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to be important for regulating...
US20100330580 METHOD FOR THE IN VITRO DIAGNOSIS OR PROGNOSIS OF TESTICULAR CANCER  
A method for in vitro diagnosis or prognosis of testicular cancer in a biological sample from a patient suspected of suffering from testicular cancer, having a step of detecting the presence or...
US20120065106 Methods and Compositions for Enhanced Protein Expression and Purification  
Methods for enhancing expression levels, secretion, and purification of heterologous fusion proteins in a host cell are disclosed.
US20130254935 AP2 DOMAIN TRANSCRIPTION FACTOR ODP2 (OVULE DEVELOPMENT PROTEIN 2) AND METHODS OF USE  
Methods and compositions for modulating plant development are provided. Nucleotide sequences and amino acid sequences encoding Ovule Development Protein 2 (ODP2) proteins are provided. The...
US20110010795 AP2 DOMAIN TRANSCRIPTION FACTOR ODP2 (OVULE DEVELOPMENT PROTEIN 2) AND METHODS OF USE  
Methods and compositions for modulating plant development are provided. Nucleotide sequences and amino acid sequences encoding Ovule Development Protein 2 (ODP2) proteins are provided. The...
US20140044739 CDIM Binding Proteins And Uses Thereof  
The present disclosure relates to Cell Death Inducing Molecule (“CDIM”) binding proteins and pharmaceutical compositions thereof. Particularly, the disclosure provides CDIM binding proteins that...
US20140357565 METHOD OF PRODUCING FACTOR VIII PROTEINS BY RECOMBINANT METHODS  
Provided herein are methods and compositions for producing Factor VIII proteins. Such methods include introducing into a cell a nucleic acid molecule encoding a Factor VIII protein operably linked...
US20120028900 METHOD OF PRODUCING FACTOR VIII PROTEINS BY RECOMBINANT METHODS  
Provided herein are methods and compositions for producing Factor VIII proteins. Such methods include introducing into a cell a nucleic acid molecule encoding a Factor VIII protein operably linked...
US20150166612 Vaccines And Methods For Using The Same  
Improved anti-HCV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HCV genotype 1a, including for example, NS4B, NS5A and...
US20120093863 HCV VACCINES AND METHODS FOR USING THE SAME  
Improved anti-HCV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HCV genotype 1a, including for example, NS4B, NS5A and...
US20150141321 COMPOUND AND METHOD FOR TREATING MYOTONIC DYSTROPHY  
Provided are 9-base morpholino antisense compounds targeted to polyCUG repeats in the 3′UTR region of dystrophia myotonica protein kinase (DMPK) mRNA, and related methods for treating myotonic...
US20140107013 COMPOUND AND METHOD FOR TREATING MYOTONIC DYSTROPHY  
Provided are 9-base morpholino antisense compounds targeted to polyCUG repeats in the 3′UTR region of dystrophia myotonica protein kinase (DMPK) mRNA, and related methods for treating myotonic...
US20110269665 COMPOUND AND METHOD FOR TREATING MYOTONIC DYSTROPHY  
Provided are 9-base morpholino antisense compounds targeted to polyCUG repeats in the 3′UTR region of dystrophia myotonica protein kinase (DMPK) mRNA, and related methods for treating myotonic...
US20110159607 BIOMARKER FOR OSTEOARTHRITIS AND/OR OTHER AGEING-RELATED DISEASES, AND USE THEREOF  
The invention relates to the identification of a biomarker whose abundance in biological samples is changed in subjects with osteoarthritis and/or other ageing-related diseases. The biomarker has...
US20110159514 BIOMARKER FOR OSTEOARTHRITIS AND/OR OTHER AGEING-RELATED DISEASES, AND USE THEREOF  
The invention relates to the identification of a biomarker whose abundance in biological sample is changed in subjects with osteoarthritis and/or other ageing-related diseases. The biomarker has...
US20130225664 METHODS AND COMPOSITIONS FOR DECREASING CHRONIC PAIN  
The present invention provides compositions and methods for the selective silencing of neurons in pain pathway by using a combination of inhibitory light-sensitive protein gene transfer and...
US20140294771 Adeno-Associated Virus Virions with Variant Capsid and Methods of Use Thereof  
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via...
US20110251073 Compositions And Methods Comprising Variant Microbial Proteases  
The present invention provides methods for protein engineering. Specifically, the invention provides methods utilizing site evaluation libraries to design libraries that optimize two or more...
US20140315804 FUSION PROTEINS COMPRISING PDGF AND VEGF BINDING PORTIONS AND METHODS OF USING THEREOF  
The present provides fusion proteins comprising PDGF and VEGF binding portions, and recombinant viral particles encoding the fusion proteins. Compositions comprising the fusion proteins and viral...
US20110300113 Death Receptor CD95 Controls Neurogenesis of Adult Neural Stem Cells in Vivo and in Vitro  
The present invention relates to the activation of the CD95L/CD95 system for inducing neuronal differentiation in vitro and in vivo and the use of CD95L compositions to effect differentiation.
US20130333061 ISOLATED NOVEL NUCLEIC ACID AND PROTEIN MOLECULES FROM SOY AND METHODS OF USING THOSE MOLECULES TO GENERATE TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS  
This disclosure provides purified nucleic acids and polypeptides. Also provided are transgenic plants, seeds, and plant cells containing DNA for expression of the proteins that are useful for...
US20120246748 ISOLATED NOVEL ACID AND PROTEIN MOLECULES FROM SOY AND METHODS OF USING THOSE MOLECULES TO GENERATE TRANSGENE PLANTS WITH ENHANCED AGRONOMIC TRAITS  
This disclosure provides purified nucleic acids and polypeptides. Also provided are transgenic plants, seeds, and plant cells containing DNA for expression of the proteins that are useful for...
US20120040884 Methods and Reagents for Treatment and Diagnosis of Vascular Disorders and Age-Related Macular Degeneration  
Disclosed are screening methods for determining a human subject's propensity to develop a vascular disorder and/or age-related macular degeneration (AMD), therapeutic or prophylactic compounds for...
US20130130927 DETECTION AND QUANTIFICATION OF MICRORNAS IN THE CIRCULATION AND THE USE OF CIRCULATING MICRORNAS AS BIOMARKERS FOR CANCER  
The present invention relates to the identification of circulating miRNAs as biomarkers suitable for use in the diagnosis and prognosis of a number of cancers, in particular breast cancer. In...
US20150044181 IDENTIFICATION OF CHANNELRHODOPSIN-2 (CHR2) MUTATIONS AND METHODS OF USE  
The invention provides compositions and kits including at least one nucleic acid or polypeptide molecule encoding for a mutant ChR2 protein. Methods of the invention include administering a...
US20120100165 DRUG TRANSPORTER, AND ADJUVANT AND VACCINE EACH UTILIZING SAME  
An objective of the invention is to provide a drug delivery vehicle capable of allowing a vaccine or adjuvant to reach a target cell or tissue efficiently while being capable of improving the...
US20150056240 COMPOSITIONS AND METHODS RELATED TO PROTEIN A (SPA) VARIANTS  
The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and...
US20130011834 MEAN DNA COPY NUMBER OF CHROMOSOMAL REGIONS IS OF PROGNOSTIC SIGNIFICANCE IN CANCER  
Methods for predicting a disease free time interval (DFI) for a cancer patient under consideration for initial or further chemotherapy treatment are disclosed. The methods include obtaining a...
US20110162105 Nucleic Acids Encoding Desaturases and Modified Plant Oil  
The present invention relates to nucleic acids derived from Drechslera tritici-repentis, Cylindorcarpon herteronema, Diploida natalensis, Stagonospora nodorum, Microdochium nivalae and Periplaneta...
US20140249047 GENETIC MARKER FOR THE DIAGNOSIS OF DEMENTIA WITH LEWY BODIES  
Specific polymorphisms in BChE gene have been found which allow determining whether a patient suffers from dementia with Lewy bodies (DLB), and allow distinguishing it from Alzheimer's disease....
US20140170151 Synthetic Oligosaccharides for Staphylococcus Vaccine  
The present invention synthetic oligo-β-(1→6)-glucosamine structures and a methodology which essentially allows for the synthesis of any oligo-β-(1→6)-glucosamine species having a definite number...
US20130116423 Synthetic Oligosaccharides for Staphylococcus Vaccine  
The present invention synthetic oligo-β-(1→6)-glucosamine structures and a methodology which essentially allows for the synthesis of any oligo-β-(1→6)-glucosamine species having a definite number...
US20120040353 Detection and quantification of microRNAs in the circulation and the use of circulating microRNAs as biomarkers in cancer  
The present invention relates to the identification of biomarkers suitable for use in the diagnosis and prognosis of a number of cancers. In addition, the invention relates to improved methods for...
US20120121637 CHIMERIC FACTOR H BINDING PROTEINS (FHBP) AND METHODS OF USE  
Chimeric fHbps that can elicit antibodies that are bactericidal for different fHbp variant strains of N. meningitidis, and methods of use, are provided.
US20120107873 Method of Producing a Sweet Protein  
The present invention relates to a method of producing a recombinant sweet protein in a filamentous fungus. The invention also relates to isolated polynucleotides encoding the sweet protein and to...
US20120201852 Vaccines Against Japanese Encephalitis Virus and West Nile Virus  
The invention provides attenuated Flavivirus vaccines, such as vaccines against Japanese encephalitis virus and West Nile virus, as well as methods of making and using these vaccines.
US20100298238 NONTOXIC SHIGA-LIKE TOXIN MUTANT COMPOSITIONS AND METHODS  
Disclosed are nontoxic mutants of Shiga-like toxin (Stx1 or Stx2), nucleic acids encoding them, compositions containing the mutants and methods of using the mutants in connection with hemolytic...
US20120270797 ENGINEERED PROTEINS INCLUDING MUTANT FIBRONECTIN DOMAINS  
The present invention features engineered proteins that can include a genetically modified Fn domain; two or more such domains joined to one another; or at least one genetically modified Fn domain...
US20140343132 GENE EXPRESSION AND PAIN  
The present invention relates to double-stranded oligonucleotides, pharmaceutical compositions thereof, and use of such double-stranded oligonucleotides and pharmaceutical compositions to modulate...
US20120232131 GENE EXPRESSION AND PAIN  
The present invention relates to double-stranded oligonucleotides, pharmaceutical compositions thereof, and use of such double-stranded oligonucleotides and pharmaceutical compositions to modulate...
US20110166212 GENE EXPRESSION AND PAIN  
The present invention relates to double-stranded oligonucleotides, pharmaceutical compositions thereof, and use of such double-stranded oligonucleotides and pharmaceutical compositions to modulate...
US20140011694 METHODS, SYSTEMS, DATABASES, KITS AND ARRAYS FOR SCREENING FOR AND PREDICTING THE RISK OF AN IDENTIFYING THE PRESENCE OF TUMORS AND CANCERS  
The invention relates to predicting or determining risk of a tumor or cancer, or the presence or absence of a tumor or cancer, in a subject. The invention also relates to methods of correlating...
US20110236969 METHODS OF GENERATING VARIANT PROTEINS WITH INCREASED HOST STRING CONTENT AND COMPOSITIONS THEREOF  
The present invention relates to novel methods for generating variant proteins with increased host string content, and proteins that are engineered using these methods.
US20110052626 LEPORIPOXVIRUS-DERIVED VACCINE VECTORS  
The invention relates to modified leporipoxyinises expressing a chimeric envelope protein resulting from the fusion of an envelope protein of mature intracellular virions or of an envelope protein...
US20110275534 MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Ovarian Cancer Using a Real-Time PCR Platform  
Methods and compositions for the diagnosis, prognosis and/or treatment of ovarian cancer are disclosed.
US20120225085 DISPLAY OF DISULFIDE LINKED DIMERIC PROTEINS IN FILAMENTOUS PHAGE  
Methods are provided for the display of a complex homodimer protein on the surface of a bacteriophage particle and combinatorial synthetic libraries of such proteins displayed as a fusion...
US20120045467 INFLUENZA VIRUS VACCINE COMPOSITION AND METHODS OF USE  
The present invention is directed to enhancing the immune response of a human in need of protection against IV infection by administering in vivo, into a tissue of the human, at least one...
US20110078828 MULTI EPITOPE VACCINE FOR POULTRY  
Antigenic polypeptides, capable of inducing an immune response against multiple parasites, and methods of designing such polypeptides, are provided. Also provided by the invention are...
US20120180160 ANTIFUNGAL PLANT PROTEINS AND METHODS OF THEIR USE  
DNA constructions that provide for production of potent antifungal proteins in transgenic plants and transformed yeast cells are described. Methods of using the DNA constructs to produce...