Sign up


Match Document Document Title
US20110251073 Compositions And Methods Comprising Variant Microbial Proteases  
The present invention provides methods for protein engineering. Specifically, the invention provides methods utilizing site evaluation libraries to design libraries that optimize two or more...
US20140315804 FUSION PROTEINS COMPRISING PDGF AND VEGF BINDING PORTIONS AND METHODS OF USING THEREOF  
The present provides fusion proteins comprising PDGF and VEGF binding portions, and recombinant viral particles encoding the fusion proteins. Compositions comprising the fusion proteins and viral...
US20110300113 Death Receptor CD95 Controls Neurogenesis of Adult Neural Stem Cells in Vivo and in Vitro  
The present invention relates to the activation of the CD95L/CD95 system for inducing neuronal differentiation in vitro and in vivo and the use of CD95L compositions to effect differentiation.
US20130333061 ISOLATED NOVEL NUCLEIC ACID AND PROTEIN MOLECULES FROM SOY AND METHODS OF USING THOSE MOLECULES TO GENERATE TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS  
This disclosure provides purified nucleic acids and polypeptides. Also provided are transgenic plants, seeds, and plant cells containing DNA for expression of the proteins that are useful for...
US20120246748 ISOLATED NOVEL ACID AND PROTEIN MOLECULES FROM SOY AND METHODS OF USING THOSE MOLECULES TO GENERATE TRANSGENE PLANTS WITH ENHANCED AGRONOMIC TRAITS  
This disclosure provides purified nucleic acids and polypeptides. Also provided are transgenic plants, seeds, and plant cells containing DNA for expression of the proteins that are useful for...
US20120040884 Methods and Reagents for Treatment and Diagnosis of Vascular Disorders and Age-Related Macular Degeneration  
Disclosed are screening methods for determining a human subject's propensity to develop a vascular disorder and/or age-related macular degeneration (AMD), therapeutic or prophylactic compounds for...
US20130130927 DETECTION AND QUANTIFICATION OF MICRORNAS IN THE CIRCULATION AND THE USE OF CIRCULATING MICRORNAS AS BIOMARKERS FOR CANCER  
The present invention relates to the identification of circulating miRNAs as biomarkers suitable for use in the diagnosis and prognosis of a number of cancers, in particular breast cancer. In...
US20150044181 IDENTIFICATION OF CHANNELRHODOPSIN-2 (CHR2) MUTATIONS AND METHODS OF USE  
The invention provides compositions and kits including at least one nucleic acid or polypeptide molecule encoding for a mutant ChR2 protein. Methods of the invention include administering a...
US20120100165 DRUG TRANSPORTER, AND ADJUVANT AND VACCINE EACH UTILIZING SAME  
An objective of the invention is to provide a drug delivery vehicle capable of allowing a vaccine or adjuvant to reach a target cell or tissue efficiently while being capable of improving the...
US20150056240 COMPOSITIONS AND METHODS RELATED TO PROTEIN A (SPA) VARIANTS  
The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and...
US20130011834 MEAN DNA COPY NUMBER OF CHROMOSOMAL REGIONS IS OF PROGNOSTIC SIGNIFICANCE IN CANCER  
Methods for predicting a disease free time interval (DFI) for a cancer patient under consideration for initial or further chemotherapy treatment are disclosed. The methods include obtaining a...
US20110162105 Nucleic Acids Encoding Desaturases and Modified Plant Oil  
The present invention relates to nucleic acids derived from Drechslera tritici-repentis, Cylindorcarpon herteronema, Diploida natalensis, Stagonospora nodorum, Microdochium nivalae and Periplaneta...
US20140249047 GENETIC MARKER FOR THE DIAGNOSIS OF DEMENTIA WITH LEWY BODIES  
Specific polymorphisms in BChE gene have been found which allow determining whether a patient suffers from dementia with Lewy bodies (DLB), and allow distinguishing it from Alzheimer's disease. The...
US20140170151 Synthetic Oligosaccharides for Staphylococcus Vaccine  
The present invention synthetic oligo-β-(1→6)-glucosamine structures and a methodology which essentially allows for the synthesis of any oligo-β-(1→6)-glucosamine species having a definite numbe...
US20130116423 Synthetic Oligosaccharides for Staphylococcus Vaccine  
The present invention synthetic oligo-β-(1→6)-glucosamine structures and a methodology which essentially allows for the synthesis of any oligo-β-(1→6)-glucosamine species having a definite numbe...
US20120040353 Detection and quantification of microRNAs in the circulation and the use of circulating microRNAs as biomarkers in cancer  
The present invention relates to the identification of biomarkers suitable for use in the diagnosis and prognosis of a number of cancers. In addition, the invention relates to improved methods for...
US20120121637 CHIMERIC FACTOR H BINDING PROTEINS (FHBP) AND METHODS OF USE  
Chimeric fHbps that can elicit antibodies that are bactericidal for different fHbp variant strains of N. meningitidis, and methods of use, are provided.
US20120107873 Method of Producing a Sweet Protein  
The present invention relates to a method of producing a recombinant sweet protein in a filamentous fungus. The invention also relates to isolated polynucleotides encoding the sweet protein and to...
US20120201852 Vaccines Against Japanese Encephalitis Virus and West Nile Virus  
The invention provides attenuated Flavivirus vaccines, such as vaccines against Japanese encephalitis virus and West Nile virus, as well as methods of making and using these vaccines.
US20100298238 NONTOXIC SHIGA-LIKE TOXIN MUTANT COMPOSITIONS AND METHODS  
Disclosed are nontoxic mutants of Shiga-like toxin (Stx1 or Stx2), nucleic acids encoding them, compositions containing the mutants and methods of using the mutants in connection with hemolytic...
US20120270797 ENGINEERED PROTEINS INCLUDING MUTANT FIBRONECTIN DOMAINS  
The present invention features engineered proteins that can include a genetically modified Fn domain; two or more such domains joined to one another; or at least one genetically modified Fn domain...
US20140343132 GENE EXPRESSION AND PAIN  
The present invention relates to double-stranded oligonucleotides, pharmaceutical compositions thereof, and use of such double-stranded oligonucleotides and pharmaceutical compositions to modulate...
US20120232131 GENE EXPRESSION AND PAIN  
The present invention relates to double-stranded oligonucleotides, pharmaceutical compositions thereof, and use of such double-stranded oligonucleotides and pharmaceutical compositions to modulate...
US20110166212 GENE EXPRESSION AND PAIN  
The present invention relates to double-stranded oligonucleotides, pharmaceutical compositions thereof, and use of such double-stranded oligonucleotides and pharmaceutical compositions to modulate...
US20140011694 METHODS, SYSTEMS, DATABASES, KITS AND ARRAYS FOR SCREENING FOR AND PREDICTING THE RISK OF AN IDENTIFYING THE PRESENCE OF TUMORS AND CANCERS  
The invention relates to predicting or determining risk of a tumor or cancer, or the presence or absence of a tumor or cancer, in a subject. The invention also relates to methods of correlating...
US20110236969 METHODS OF GENERATING VARIANT PROTEINS WITH INCREASED HOST STRING CONTENT AND COMPOSITIONS THEREOF  
The present invention relates to novel methods for generating variant proteins with increased host string content, and proteins that are engineered using these methods.
US20110052626 LEPORIPOXVIRUS-DERIVED VACCINE VECTORS  
The invention relates to modified leporipoxyinises expressing a chimeric envelope protein resulting from the fusion of an envelope protein of mature intracellular virions or of an envelope protein...
US20110275534 MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Ovarian Cancer Using a Real-Time PCR Platform  
Methods and compositions for the diagnosis, prognosis and/or treatment of ovarian cancer are disclosed.
US20120225085 DISPLAY OF DISULFIDE LINKED DIMERIC PROTEINS IN FILAMENTOUS PHAGE  
Methods are provided for the display of a complex homodimer protein on the surface of a bacteriophage particle and combinatorial synthetic libraries of such proteins displayed as a fusion...
US20120045467 INFLUENZA VIRUS VACCINE COMPOSITION AND METHODS OF USE  
The present invention is directed to enhancing the immune response of a human in need of protection against IV infection by administering in vivo, into a tissue of the human, at least one...
US20110078828 MULTI EPITOPE VACCINE FOR POULTRY  
Antigenic polypeptides, capable of inducing an immune response against multiple parasites, and methods of designing such polypeptides, are provided. Also provided by the invention are...
US20120180160 ANTIFUNGAL PLANT PROTEINS AND METHODS OF THEIR USE  
DNA constructions that provide for production of potent antifungal proteins in transgenic plants and transformed yeast cells are described. Methods of using the DNA constructs to produce transgenic...
US20140314802 NOVEL COMPOSITIONS AND METHODS  
The present invention is directed to a polypeptide which comprises: (i) an Rv2386c protein sequence; (ii) a variant of an Rv2386c protein sequence; of (iii) an immunogenic fragment of an Rv2386c...
US20110223200 NOVEL COMPOSITIONS AND METHODS  
The present invention is directed to a polypeptide which comprises: (i) an Rv1753c protein sequence; (ii) a variant of an Rv1753c protein sequence; or (iii) an immunogenic fragment of an Rv1753c...
US20110033891 MUSSEL BIOADHESIVE  
The present invention relates to a bioadhesive derived from mussel. In particular, it relates to a novel Mytilus galloprovincialis foot protein type 5 (MGFP-5) and a recombinant protein that is a...
US20120128717 INFLUENZA VIRUS VACCINE COMPOSITION AND METHODS OF USE  
The present invention is directed to compositions and methods for enhancing the immune response of a human in need of protection against influenza virus (IV) infection by administering in vivo,...
US20110129830 DETERMINATION OF KIR HAPLOTYPES ASSOCIATED WITH DISEASE  
Disclosed is a method of determining KIR genotypes for one or more individuals in parallel, the method comprising: for each individual, amplifying the polymorphic exon sequences of the KIR genes,...
US20110177996 REGULATORY PROTEINS IN LUNG REPAIR AND TREATMENT OF LUNG DISEASE  
The DNA-binding protein Sox17 has been found to play an important role in repair of pulmonary tissue after damage, disease, or injury. Nucleic acids encoding proteins involved in pulmonary repair,...
US20110268790 Snake Factor V and Methods of Use Thereof as a Procoagulant  
Compositions and Methods for the treatment of coagulation disorders using Factor V variants are provided. Preferred disorders include hemophilia A and B.
US20150079630 CYCLIC RNA AND PROTEIN PRODUCTION METHOD  
The present invention provides a cyclic RNA preferable for carrying out rotary protein translation in which translation domains other than that of the target protein are sufficiently short and...
US20130225403 COMPOSITIONS FOR SEED TREATMENT  
Described is a composition for seed treatment comprising a plant seed-binding protein, preferably an antigen-binding plant seed-binding protein. In one embodiment, the seed-binding protein is...
US20150011739 TANDEM FACIAL AMPHIPHILES  
The invention provides tandem facial amphiphiles for biochemical manipulations and characterization of membrane proteins, such as intrinsic membrane proteins. Members of this new family display...
US20130115251 TANDEM FACIAL AMPHIPHILES  
The invention provides tandem facial amphiphiles for biochemical manipulations and characterization of membrane proteins, such as intrinsic membrane proteins. Members of this new family display...
US20130210664 Methods for the Identification of Methyltransferase Interacting Molecules and for the Purification of Methyltransferase Proteins  
The present invention relates to immobilization compounds, immobilization products and preparations thereof as well as methods and uses for the identification of methyltransferase interacting...
US20110003734 PROTEINS AND POLYNUCLEOTIDES OF VIBRIO CHOLERAE  
Therapeutic, diagnostic and environmental monitoring methods employing proteins encoded by the rbmBCDEF gene cluster and by bap1.
US20120156694 PROTEINS USED FOR THE DIAGNOSIS OF LYME BORRELIOSIS  
Chimera proteins including: (i) at least one sequence of a VlsE protein of a Borrelia species selected from B. garinii, B. burgdorferi sensu stricto and B. afzelii, and (ii) at least one sequence...
US20120040926 Process For Obtaining Polysaccharides From Jatoba (Hymenea Courbaril L) Seeds, Cosmetic Composition Comprising Said Polysaccharides And Uses Thereof  
The present invention relates to a process for obtaining polysaccharides from jatoba seeds, comprising the steps of: a) seed processing (dry process); b) aqueous extraction at 1% to 5% of powder...
US20150065378 SYNTHETIC OLIGONUCLEOTIDES FOR DETECTION OF NUCLEIC ACID BINDING PROTEINS  
Synthetic oligonucleotides that comprise a nucleic acid binding protein binding site, PCR primer sequences, and tag sequences that do not bind to nucleic acid binding proteins, with a total length...
US20120231028 POLYVALENT VACCINE  
The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to...
US20120121631 POLYVALENT VACCINE  
The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to...