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US20110275534 MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Ovarian Cancer Using a Real-Time PCR Platform  
Methods and compositions for the diagnosis, prognosis and/or treatment of ovarian cancer are disclosed.
US20120225085 DISPLAY OF DISULFIDE LINKED DIMERIC PROTEINS IN FILAMENTOUS PHAGE  
Methods are provided for the display of a complex homodimer protein on the surface of a bacteriophage particle and combinatorial synthetic libraries of such proteins displayed as a fusion...
US20120045467 INFLUENZA VIRUS VACCINE COMPOSITION AND METHODS OF USE  
The present invention is directed to enhancing the immune response of a human in need of protection against IV infection by administering in vivo, into a tissue of the human, at least one...
US20110078828 MULTI EPITOPE VACCINE FOR POULTRY  
Antigenic polypeptides, capable of inducing an immune response against multiple parasites, and methods of designing such polypeptides, are provided. Also provided by the invention are...
US20120180160 ANTIFUNGAL PLANT PROTEINS AND METHODS OF THEIR USE  
DNA constructions that provide for production of potent antifungal proteins in transgenic plants and transformed yeast cells are described. Methods of using the DNA constructs to produce transgenic...
US20140314802 NOVEL COMPOSITIONS AND METHODS  
The present invention is directed to a polypeptide which comprises: (i) an Rv2386c protein sequence; (ii) a variant of an Rv2386c protein sequence; of (iii) an immunogenic fragment of an Rv2386c...
US20110223200 NOVEL COMPOSITIONS AND METHODS  
The present invention is directed to a polypeptide which comprises: (i) an Rv1753c protein sequence; (ii) a variant of an Rv1753c protein sequence; or (iii) an immunogenic fragment of an Rv1753c...
US20110033891 MUSSEL BIOADHESIVE  
The present invention relates to a bioadhesive derived from mussel. In particular, it relates to a novel Mytilus galloprovincialis foot protein type 5 (MGFP-5) and a recombinant protein that is a...
US20120128717 INFLUENZA VIRUS VACCINE COMPOSITION AND METHODS OF USE  
The present invention is directed to compositions and methods for enhancing the immune response of a human in need of protection against influenza virus (IV) infection by administering in vivo,...
US20110129830 DETERMINATION OF KIR HAPLOTYPES ASSOCIATED WITH DISEASE  
Disclosed is a method of determining KIR genotypes for one or more individuals in parallel, the method comprising: for each individual, amplifying the polymorphic exon sequences of the KIR genes,...
US20110177996 REGULATORY PROTEINS IN LUNG REPAIR AND TREATMENT OF LUNG DISEASE  
The DNA-binding protein Sox17 has been found to play an important role in repair of pulmonary tissue after damage, disease, or injury. Nucleic acids encoding proteins involved in pulmonary repair,...
US20110268790 Snake Factor V and Methods of Use Thereof as a Procoagulant  
Compositions and Methods for the treatment of coagulation disorders using Factor V variants are provided. Preferred disorders include hemophilia A and B.
US20130225403 COMPOSITIONS FOR SEED TREATMENT  
Described is a composition for seed treatment comprising a plant seed-binding protein, preferably an antigen-binding plant seed-binding protein. In one embodiment, the seed-binding protein is...
US20130115251 TANDEM FACIAL AMPHIPHILES  
The invention provides tandem facial amphiphiles for biochemical manipulations and characterization of membrane proteins, such as intrinsic membrane proteins. Members of this new family display...
US20130210664 Methods for the Identification of Methyltransferase Interacting Molecules and for the Purification of Methyltransferase Proteins  
The present invention relates to immobilization compounds, immobilization products and preparations thereof as well as methods and uses for the identification of methyltransferase interacting...
US20110003734 PROTEINS AND POLYNUCLEOTIDES OF VIBRIO CHOLERAE  
Therapeutic, diagnostic and environmental monitoring methods employing proteins encoded by the rbmBCDEF gene cluster and by bap1.
US20120156694 PROTEINS USED FOR THE DIAGNOSIS OF LYME BORRELIOSIS  
Chimera proteins including: (i) at least one sequence of a VlsE protein of a Borrelia species selected from B. garinii, B. burgdorferi sensu stricto and B. afzelii, and (ii) at least one sequence...
US20120040926 Process For Obtaining Polysaccharides From Jatoba (Hymenea Courbaril L) Seeds, Cosmetic Composition Comprising Said Polysaccharides And Uses Thereof  
The present invention relates to a process for obtaining polysaccharides from jatoba seeds, comprising the steps of: a) seed processing (dry process); b) aqueous extraction at 1% to 5% of powder...
US20120231028 POLYVALENT VACCINE  
The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to...
US20120121631 POLYVALENT VACCINE  
The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to...
US20110301328 POLYVALENT VACCINE  
The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to...
US20110150915 POLYVALENT VACCINE  
The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to...
US20130259869 REARRANGED TT VIRUS MOLECULES FOR USE IN DIAGNOSIS, PREVENTION AND TREATMENT OF CANCER AND AUTOIMMUNITY  
The present invention relates to rearranged molecules of (a) a specific TT virus sequence and (b) a nucleotide sequence encoding a polypeptide showing homology to mammalian proteins associated with...
US20120040341 Method for the Detection and Diagnosis of Cancer Involving Primers and Probes for the Specific Detection of the MAGE-A3-Marker  
The present invention relates to MAGE-3 specific primers and probes for use new diagnostic kits and methods. The invention further relates to immunotherapeutic treatment of specific populations of...
US20120064169 MULTIPLE ANTIGEN DELIVERY SYSTEM USING HEPATITIS E VIRUS-LIKE PARTICLE  
This invention provides a peptide/nucleic acid composition for oral/mucosal, dual-modal activation of immune protection systems.
US20110239323 ISOLATION AND USE OF FAD2 AND FAE1 FROM CAMELINA  
The present invention provides isolated FAD2 and FAE1 genes and FAD2 and FAE1 protein sequences of Camelina species, e.g., Camelina sativa, mutations in Camelina FAD2 and FAE1 genes, and methods of...
US20110015145 CLADRIBINE FORMULATIONS FOR IMPROVED ORAL AND TRANSMUCOSAL DELIVERY  
Provided are compositions of cladribine and cyclodextrin which are especially suited for the oral and buccal administration of cladribine.
US20120115923 Sirna Compositions Promoting Scar-Free Wound Healing of Skin and Methods for Wound Treatment  
This invention describes compositions and methods using siRNA to target various genes expressed in cells of injured tissue during scar formation to promote scar-free wound healing.
US20130324707 SYNTHETIC AMPHIPHILES FOR MEMBRANE PROTEIN MANIPULATION  
The invention provides amphiphilic compounds and methods for manipulating membrane proteins. Compounds of the invention, for example, the compounds of Formulas I-XIX, can be prepared from readily...
US20100311956 SYNTHETIC AMPHIPHILES FOR MEMBRANE PROTEIN MANIPULATION  
The invention provides amphiphilic compounds and methods for manipulating membrane proteins. Compounds of the invention, for example, the compounds of Formulas I-XIX, can be prepared from readily...
US20110294194 EFFICIENT CELL CULTURE SYSTEM FOR HEPATITIS C VIRUS GENOTYPE 2B  
The present inventors developed hepatitis C virus 2b/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and the complete NS2 were replaced by the corresponding...
US20110014228 IL23 MODIFIED VIRAL VECTOR FOR RECOMBINANT VACCINES AND TUMOR TREATMENT  
The present invention relates to recombinant replicable viral vectors and viruses which are modified with IL23. This IL23 modified virus is highly immunogenic and attenuated for neurotropic...
US20140322192 PROTEOGLYCAN DEGRADING MUTANTS FOR TREATMENT OF CNS  
The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and...
US20110250631 PROTEOGLYCAN DEGRADING MUTANTS FOR TREATMENT OF CNS  
The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and...
US20120270230 MUTANT G-PROTEIN COUPLED RECEPTORS AND METHODS FOR SELECTING THEM  
The invention relates to mutant G-protein coupled receptors with increased conformational stability, and methods of use thereof. In some aspects, polynucleotides encoding the mutant G-protein...
US20140161837 VACCINE ADJUVANT, VACCINE COMPOSITION AND METHOD FOR PREPARING A VACCINE ADJUVANT  
The disclosure provides a vaccine adjuvant, including a polysaccharide derived from Antrodia camphorata (also named Antrodia cinnamomea or Taiwanofungus camphoratus) fruiting body, wherein the...
US20140106985 MICRORNA BIOMARKERS FOR PROGNOSIS OF PATIENTS WITH PANCREATIC CANCER  
The present invention relates to prognostic micro RNA (miRNA) biomarkers based on a specific miRNA expression pattern, which can prove as a valuable prognostic tool to predict the survival of...
US20140271458 DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IL-1 and/or IL-17  
Engineered multivalent and multispecific binding proteins that bind IL-1β and/or IL-17 are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
US20130236458 DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IL-13 AND/OR IL-17  
Engineered multivalent and multispecific binding proteins that bind IL-13 and/or IL-17 are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
US20120321661 Recombinant Measles Virus Useful as a Bivalent Vaccine Against Measles and Malarial Infections  
Provided herein is a vaccine which is safe and effective against malarial infection and a vector which is used in the manufacture of this vaccine and to provide a bivalent vaccine which exhibits an...
US20120164106 ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF  
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The...
US20110306559 METHODS AND COMPOSITIONS FOR TREATING NEUROPATHIC PAIN  
Compositions and methods for the treatment of neuropathic pain are provided. Compositions of the invention may comprise proteins with a zinc-finger domain fused to a regulatory domain that is...
US20110059512 EFFICIENT CELL CULTURE SYSTEM FOR HEPATITIS C VIRUS GENOTYPE 6A  
The present inventors developed hepatitis C virus 6a/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and the complete NS2 were replaced by the corresponding...
US20110059851 SHOC2 Mutations Causing Noonan-Like Syndrome With Loose Anagen Hair  
The present invention is directed to methods of diagnosing Noonan-like syndrome with loose anagen hair comprising detecting a mutation in SHOC2 gene. One specific diagnostic mutation disclosed is...
US20140294875 Leishmania Vaccine Using Sand Fly Salivary Immunogen  
The present invention provides vectors that contain and express in vivo or in vitro sand fly Lu. longipalpis salivary antigens that elicit an immune response in animal or human against Leishmania,...
US20130295084 BINDING PROTEINS HAVING TETHERED LIGHT CHAINS  
The present invention relates to binding proteins having tethered light chains and methods of making and using them.
US20140271699 PREFUSION RSV F PROTEINS AND THEIR USE  
Disclosed are immunogens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the immunogens and methods of producing the...
US20140170182 PRODUCTION OF A CYSTEINE RICH PROTEIN  
The present invention relates to a method for the production of correctly folded Pfs48/45. This is achieved in the lactococcus lactis when Pfs48/45 or fractions thereof are fused genetically to a...
US20100323905 Vhh for the Diagnosis, Prevention and Treatment of Diseases Associated with Protein Aggregates  
The present invention provides heavy chain variable domain antibodies (VHH) for preventing and/or dissolving aggregates. VHH of the invention are preferably used in the treatment of human diseases...
US20120053509 VACCINES FOR HUMAN PAPILLOMA VIRUS AND METHODS FOR USING THE SAME  
Improved anti-HPV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HPV 6, HPV 11, HPV 33 and HPV58 E6 and E7. Pharmaceutical...