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US20090075871 |
Modified Thioredoxin
The present invention relates to a human modified thioredoxin composed of any of the following polypeptides: (a) a polypeptide modified by alteration or chemical modification of a cysteine residue...
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US20090053213 |
Anti-Gm-Csf Antibodies and Uses Therefor
The present invention provides recombinant antigen-binding regions, antibodies and functional fragments thereof that are specific for GM-CSF, which plays an integral role in various disorders or...
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US20090010847 |
Connective Tissue Growth Factor-4
The present invention relates to a novel human protein called Connective Tissue Growth Factor-4, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells,...
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US20080305520 |
Mechanosensitive ion channels and methods of use
The present invention provides methods for identifying agents that decrease the activity of a mechanosenitive ion channels, preferably, a mechanosensitive Ca 2+ -permeable channel (MscCa) channel....
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US20080292632 |
Irta2 Antibodies and Methods of Use
Antibodies that specifically bind the extracellular domain of IRTA2 are disclosed herein. In one embodiment, these antibodies do not specifically bind IRTA1, IRTA3, IRTA4, or IRTA5. In one example,...
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US20080268499 |
WHITEFLY ECDYSONE RECEPTOR NUCLEIC ACIDS, POLYPEPTIDES, AND USES THEREOF
The present invention relates to a novel isolated whitefly ecdysone receptor polypeptide. The invention also relates to an isolated nucleic acid encoding the whitefly ecdysone receptor polypeptide,...
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US20080227734 |
Mutant Lrp5/6 Wnt-Signaling Receptors in Cancer Diagnosis, Prognosis, and Treatment
A novel mutant form of lrp5 and lrp6 genes, the mutant LRP5 and LRP6 receptor proteins expressed therefrom, and a cell line which expresses the mutant LRP5 and/or LRP6 receptor proteins. Methods of...
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US20080226586 |
Chemokine Beta-15
The present invention concerns a member of the human chemokine CC protein family. In particular, isolated nucleic acid molecules are provided encoding the chemokine β-15 protein. Chemokine β-15...
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US20080187540 |
Antibodies to OCIF-binding molecules
A novel protein which binds to Osteoclastogenesis Inhibitory Factor (OCIF-binding molecule; OBM), a process for preparing the same, DNA encoding said protein, a protein having an amino acid...
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US20080182236 |
Asthma Susceptibility Locus
The present invention describes a susceptibility locus which is functionally related to asthma. The locus maps within human chromosome 7p15-p14. The invention also describes a novel human gene,...
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US20080181906 |
Polyvalent Immunogen
The present invention relates, generally, to a polyvalent immunogen and, more particularly, to a method of inducing neutralizing antibodies against HIV and to a polyvalent immunogen suitable for...
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US20080181885 |
NUCLEIC ACIDS AND CORRESPONDING PROTEINS ENTITLED 202P5A5 USEFUL IN TREATMENT AND DETECTION OF CANCER
A novel gene 202P5A5 and its encoded protein, and variants thereof, are described wherein 202P5A5 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the...
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US20080166755 |
Intracellular delivery of osteoinductive proteins and peptides
The invention provides fusion polypeptides comprising protein transduction domains and osteoinductive polypeptides, as well as methods of using such polypeptides to induce osteogenesis and to...
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US20080138796 |
NRIF3, a novel co-activator for nuclear hormone receptors
Nucleic acids encoding NRIF3 are described. Polypeptides having amino acid sequences of NRIF3 proteins are also provided. A method is also provided for isolating and cloning NRIF3 cDNA. NRIF3 is...
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US20080115237 |
NOVEL ECDYSONE RECEPTOR-BASED INDUCIBLE GENE EXPRESSION SYSTEM
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a...
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US20080113449 |
Novel receptors
The invention provides isolated nucleic acid and amino acid sequences of novel receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of...
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US20080109917 |
CARD-DOMAIN CONTAINING POLYPEPTIDES, ENCODING NUCLEIC ACIDS, AND METHODS OF USE
The invention provides caspase recruitment domain (CARD)-containing polypeptides and functional fragments thereof, encoding nucleic acid molecules, and specific antibodies. Also provided are...
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US20080108511 |
GENES AND GENE PRODUCTS DIFFERENTIALLY EXPRESSED DURING HEART FAILURE
Certain examples disclosed herein are directed to genes and gene products that are differentially expressed during heart failure. In particular, certain examples are directed to genes which are...
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US20080107668 |
CYTOTOXIC T-LYMPHOCYTE-INDUCING IMMUNOGENS FOR PREVENTION, TREATMENT, AND DIAGNOSIS OF CANCER
The present invention relates to compositions and methods for the prevention, treatment, and diagnosis of cancer, especially carcinomas, such as breast carcinoma. The invention discloses peptides,...
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US20080103099 |
Apoptin-associating protein
The invention relates to the field of apoptosis. The invention provides novel therapies, for example, novel combinatorial therapies or novel therapeutic compounds that can work alone, sequentially...
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US20080102475 |
Alternatively spliced isoform of phosphodiesterase 4B (PDE4B)
The present invention features nucleic acids and polypeptides encoding novel splice variant isoform of phosphodiesterase 4B (PDE4B). The polynucleotide sequence of PDE4Bsv1 is provided by SEQ ID...
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US20080102115 |
Modified coagulation factor IX polypeptides and use thereof for treatment
Provided are modified factor IX (FIX) polypeptides and methods of generating modified FIX polypeptides. Also provided are pharmaceutical compositions, including compositions formulation for oral...
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US20080096981 |
Antibodies against inducible TH2 cell factors
A novel TH2 associated gene that is induced by IL-9 has been identified and isolated, thereby providing a therapeutic target for IL-9 mediated diseases such as atopic allergy and asthma-related...
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US20080096820 |
Prodomain modulators of ADAM 10
The presently disclosed subject matter discloses isolated ADAM 10 modulating peptides and related compounds useful for studying the biological functions of ADAM 10 and for the treatment of diseases...
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US20080096796 |
Peptides That Stimulate Cell Survival and Axon Regeneration
Peptides which consist of or comprise the tetrameric peptide structural unit: Xaa-Xaa-Xaa-Xaa (SEQ.ID.NO.: 1) in which Xaa at position 1 represents Glu or Asp, Xaa at position 2 represents any...
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US20080096250 |
Toll/Interleukin-1 receptor adapter protein (TIRAP)
TIRAP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing TIRAP polypeptides and...
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US20080096228 |
Compositions And Methods Relating To Mammalian Internal Ribosome Entry Sites
Contemplated compositions and methods are directed to IRES sequences and their use, especially in the context of CML. Among other contemplated aspects IRES sequences described herein are highly...
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US20080096224 |
Emission ratiometric indicators of phosphoinositides
Emission ratiometric indicators of phosphoinositides comprise a fusion protein comprising a pleckstrin homology (PH) domain of Akt (also known as protein kinase B) and a “pseudoligand”...
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US20080096213 |
Method for confirming conversion treatment and nucleic acid molecule used therefor
There is provided a method for confirming conversion treatment of non-methylated cytosine, including a step of mixing a DNA taken from a living body, with a nucleic acid for accuracy control having...
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US20080090776 |
EML4-ALK FUSION GENE
The present inventors found that a fusion gene present in some cancer patients is an oncogene. The present invention relates to a polypeptide as a novel fusion protein, a polynucleotide encoding...
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US20080090762 |
Epithelum-derived T-cell factor
Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for...
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US20080090291 |
Synthetic nucleic acid molecule compositions and methods of preparation
A method to prepare synthetic nucleic acid molecules having reduced inappropriate or unintended transcriptional characteristics when expressed in a particular host cell.
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US20080090270 |
Nogo receptor homologues and their use
This invention relates to gene polypeptides and polynucleotides that encode proteins of the Nogo-66 receptor (NgR) family and are therefore called NgR homologue 1 (NgRH1). The invention further...
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US20080090249 |
Ube2g2 Binding Domain in The Ubiquitin Ligase Gp78 And Methods Of Use Thereof
The present invention features isolated nucleic acid molecules, designated G2BD nucleic acid molecules, which encode the binding site from the gp78 ubiquitin ligase that binds to the Ube2G2...
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US20080085323 |
Product and Methods for Diagnosis and Therapy for Cardiac and Skeletal Muscle Disorders
Disclosed are products and methods to promote myoblast activation and cardiac and skeletal muscle growth or regeneration, and to treat heart and skeletal muscle diseases, based on the...
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US20080081903 |
METHOD FOR SCREENING TRANSCRIPTIONAL COREGULATORY PROTEINS OF TRANSCRIPTION FACTORS, AND ANDROGEN RECEPTOR TRANSCRIPTIONAL COREGULATORY PROTEINS AS TARGETS FOR ANDROGEN RECEPTOR-DEPENDENT DISEASES
The present invention also provides a method for screening and isolating transcriptional coregulatory proteins of transcription factors. Using this method, a new class of proteins, androgen...
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US20080075724 |
Molecules designated B7L-1
The invention is directed to B7L-1 as a purified and isolated protein, the DNA encoding the B7L-1, host cells transfected with cDNAs encoding B7L-1 and processes for preparing B7L-1 polypeptides.
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US20080075672 |
Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in...
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US20080070840 |
Thrombopoietic compounds
The invention relates to the field of compounds, especially peptides or polypeptides, that have thrombopoietic activity. The peptides and polypeptides of the invention may be used to increase...
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US20080070831 |
VASCULAR ENDOTHELIAL GROWTH FACTOR D(VEGF-D) ANTIBODIES AND VECTORS, AND METHODS OF USES
VEGF-D, a new member of the PDGF family of growth factors, which among other things stimulates endothelial cell proliferation and angiogenesis and increases vascular permeability, as well as...
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US20080070252 |
CHR and POMC effects on animal growth
The present invention provides for selection of bovine animals that will display phenotypes associated with increased rates of growth. These phenotypes include hot carcass weight, average daily...
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US20080070251 |
Method of Producing Factor VIII Proteins by Recombinant Methods
Provided herein are methods and compositions for producing Factor VIII proteins. Such methods include introducing into a cell a nucleic acid molecule encoding a Factor VIII protein operably linked...
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US20080070249 |
Novel Activating Agent of Glucose Uptake and a Screening Method Therefor
An activating agent of glucose uptake comprising as an active ingredient a substance having a PGC-1β function; and a method of screening for an activating agent of glucose uptake, comprising the...
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US20080066200 |
COMPOSITIONS AND METHODS FOR HUMANIZATION AND OPTIMIZATION OF N-GLYCANS IN PLANTS
Methods for altering the N-glycosylation pattern of proteins in higher plants are provided. The methods comprise introducing into the plant a recombinant construct that provides for the inhibition...
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US20080064764 |
Calcium-sensing receptor 2 (CAR2) and methods for using
The current disclosure provide a novel human calcium sensing receptor named CaR2 and the nucleotide sequence that encodes the receptor. The disclosure further provides antibodies specific for CaR2....
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US20080064652 |
Methods and compositions for treating hypercholesterolemia
The present invention provides methods and compositions for treating hypercholesterolemia using therapeutic apoE proteins. A therapeutic apoE protein is a naturally-occurring apoE protein (e.g.,...
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US20080064631 |
T-CELL RECEPTORS FOR USE IN DIAGNOSIS AND THERAPY OF CANCERS AND AUTOIMMUNE DISEASE
The specification describes the sequences for two T-cell receptors—one having a high affinity and one having low affinity for the HLA-A2-restricted peptide PR1. Use of the T-cell receptors and...
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US20080064084 |
Method For Producing Recombinant Trypsin
The present invention concerns a method for producing recombinant trypsin from porcine pancreas in Pichia pastoris which is soluble and secreted into the culture medium, whereby expression at pH...
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US20080063636 |
Variant Amyloid Protein
It is intended to provide a novel amyloid protein (human variant amyloid protein) useful as an antigen molecule or the like for improving a vaccine therapy. This human variant amyloid protein is a...
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US20080060092 |
COMPOSITIONS AND METHODS FOR HUMANIZATION AND OPTIMIZATION OF N-GLYCANS IN PLANTS
Methods for altering the N-glycosylation pattern of proteins in higher plants are provided. The methods comprise introducing into the plant a recombinant construct that provides for the inhibition...
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