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US20090191133 |
MODULATION OF STAT 6 EXPRESSION FOR THE TREATMENT OF AIRWAY HYPERRESPONSIVENESS
Disclosed herein are compounds, compositions and methods for modulating the expression of STAT 6 in a cell, tissue, or animal. Also provided are uses of disclosed compounds and compositions in the...
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US20090118205 |
Antisense Oligonucleotides Directed to Ribonucleotide Reductase R2 and uses Thereof in the Treatment of Cancer
The present invention provides antisense oligonucleotides directed to a mammalian ribonucleotide reductase R2 gene and combinations of the antisense oligonucleotides with one or more...
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US20090093620 |
Annotated Plant Genes
The present invention is in the field of plant biochemistry. More specifically the invention relates to nucleic acid sequences from plant cells, in particular, nucleic acid sequences from maize,...
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US20090053138 |
Stabilized Aptamers to Platelet Derived Growth Factor and their Use as Oncology Therapeutics
Materials and methods are provided for producing and using aptamers as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and/or VEGF receptor or any combination...
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US20080182237 |
Lung cancer-related nucleic acids
Described are polynucleotides associated with lung cancer. The polynucleotides are miRNAs, miRNA precursors, and associated nucleic acids. Methods and compositions are described that can be used...
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US20080115237 |
NOVEL ECDYSONE RECEPTOR-BASED INDUCIBLE GENE EXPRESSION SYSTEM
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a...
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US20080113931 |
RNAi MODULATION OF AHA AND THERAPEUTIC USES THEREOF
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of an Aha gene (Aha1 gene), comprising an antisense strand having a nucleotide sequence which is...
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US20080113378 |
siRNA targeting interleukin-1 receptor-associated kinase 4 (IRAK4)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
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US20080113377 |
siRNA Targeting proto-oncogene MET
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
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US20080113376 |
siRNA targeting myeloid differentiation primary response gene (88) (MYD88)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
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US20080113375 |
siRNA targeting superoxide dismutase 1 (SOD1)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
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US20080113374 |
siRNA targeting fructose-1,6-bisphosphatase 1 (FBP1)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
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US20080113373 |
siRNA targeting amyloid beta (A4) precursor protein (APP)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
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US20080113372 |
siRNA targeting glucagon receptor (GCGR)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
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US20080113371 |
siRNA targeting beta secretase (BACE)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
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US20080113370 |
siRNA targeting apolipoprotein B (APOB)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
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US20080113369 |
siRNA targeting diacylglycerol O-acyltransferase homolog 2 (DGAT2)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
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US20080108712 |
NUCLEOTIDE SEQUENCE ASSOCIATED WITH ACUTE CORONARY SYNDROME AND MORTALITY
The present invention provides methods for diagnosing and/or treating subjects that either have or are at risk for developing acute coronary syndrome. In addition, the invention provides isolated...
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US20080108584 |
COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF IKK-B GENE
The invention relates to a doable-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the IKK-B gene, comprising an antisense strand having a nucleotide sequence which is less that...
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US20080108139 |
COMPOSITION OF MATTER COMPRISING PRIMARY NUCLEIC ACID COMPONENT
The present invention provides an array of compositions useful for effecting and/or exhibiting changes in biological functioning and processing within cells and in biological systems containing...
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US20080108123 |
MAGNETIC SUBSTANCE-BIOSUBSTANCE COMPLEX STRUCTURE, PEPTIDE FRAGMENT CAPABLE OF LINKING TO MAGNETIC SUBSTANCE AND GENE THEREFOR, AND PROCESS FOR PRODUCING THE COMPLEX STRUCTURE
A magnetic substance-biosubstance complex structure comprises a magnetic substance-containing carrier and a biosubstance immobilized on the carrier, the biosubstance being immobilized through a...
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US20080108072 |
MAIZE EVENT DP-098140-6 AND COMPOSITIONS AND METHODS FOR THE IDENTIFICATION AND/OR DETECTION THEREOF
Compositions and methods related to transgenic glyphosate/ALS inhibitor-tolerant maize plants are provided. Specifically, the present invention provides maize plants having a DP-098140-6 event...
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US20080108055 |
METHOD FOR DETECTING WEST NILE VIRUS NUCLEIC ACIDS IN THE 3' NON-CODING REGION
Compositions, methods and kits for detecting flavivirus nucleic acids. Particularly described are methods for detecting West Nile virus nucleic acids in the 3′ non-coding region.
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US20080107667 |
PROMISCUOUS HER-2/NEU CD4 T CELL EPITOPES
The present invention relates to the discovery of novel T cell epitopes of the human HER-2/Neu protein that is promiscuous for at least 25 different HLA-DR alleles. The invention also relates to...
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US20080107656 |
IMMUNOGENIC COMPOSITIONS AND METHODS OF USE THEREOF
The present invention relates generally to a method of eliciting or otherwise inducing an immune response to a Plasmodium microorganism and compositions for use therein. More particularly, the...
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US20080104734 |
RECOMBINANT ANTIBODIES TO SCLEROTINIA ANTIGENS
The invention is directed to recombinant antibodies which bind to Sclerotinia sclerotiorum antigens and comprise a single chain variable fragment (scFv). The antigen may be selected from SSPG1d...
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US20080103291 |
DNA MOLECULES ENCODING LIGAND GATED ION CHANNELS FROM DERMACENTOR VARIABILIS
The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Dermacentor variabilis ligand gated ion channel proteins. The present invention also...
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US20080103090 |
Human Secreted Proteins
The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating cancer and other hyperproliferative...
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US20080102504 |
Methods and apparatus for characterizing polynucleotides
Systems and methods for analysis of polymers, e.g., polynucleotides, are provided. The systems are capable of analyzing a polymer at a specified rate. One such analysis system includes a structure...
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US20080102489 |
DNA MOLECULES ENCODING LIGAND GATED ION CHANNELS FROM DERMACENTOR VARIABILIS
The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Dermacentor variabilis ligand gated ion channel proteins. The present invention also...
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US20080097082 |
NOVEL POLYPEPTIDE HORMONE PHOSPHATONIN
The present invention relates to a novel human protein called phosphatonin, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant...
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US20080096836 |
Screening method
The invention relates to methods for the identification of novel receptors and/or novel ligands. The invention is based on the concept that parasites have developed a number of biologically active...
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US20080096835 |
Inhibitory oligonucleotides targeted to BCL-2
Inhibitory oligonucleotides are disclosed which are targeted to three specific target regions and subsequences of the target regions found on nucleic acids encoding Bcl-2. These inhibitory...
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US20080096819 |
Amino acid substituted molecules
The invention provides compositions and methods of identifying, modifying and producing modified target molecules, including therapeutic molecules by modification with non-natural amino acids....
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US20080096256 |
Method for gene expression
The invention relates to a method for gene expression in a cell-free translation system, wherein the reaction solution comprises an RNA matrix with a gene sequence, which codes for an expression...
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US20080096251 |
Invertebrate-Derived Gonadotropic Hormone and its Synthesis
The structure of gonadotropic hormone of an invertebrate ( Asterina pectinifera ) was elucidated. The gonadotropic hormone is a peptide with molecular weight 4500 to 4900 composed of two subunits,...
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US20080096213 |
Method for confirming conversion treatment and nucleic acid molecule used therefor
There is provided a method for confirming conversion treatment of non-methylated cytosine, including a step of mixing a DNA taken from a living body, with a nucleic acid for accuracy control having...
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US20080096210 |
Cancer suppressing agent
An object of the present invention is to provide a cancer suppressing agent containing a cancer suppressing gene that is discovered through the use of a novel method rather than through existing...
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US20080096208 |
BIOMARKERS FOR ASSESSING RESPONSE TO C-MET TREATMENT
Biomarkers that correlate to treatment with drugs that inhibit c-met are disclosed. These biomarkers have been shown to have utility in assessing response to the compounds. The expression level of...
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US20080096205 |
Diagnostic methods and kits for colorectal cancer
The present application discloses a diagnostic method and a kit for prognosis assessment of colorectal cancer (CRC) and a novel tumor suppressor gene to be used for diagnosis of colorectal cancer...
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US20080096201 |
Assay for identifying biological targets of polynucleotide-binding compounds
The present invention provides methods and systems for the identification of a biological target of a chemical compound, such as saframycin A, known to bind a polynucleotide. The invention also...
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US20080091000 |
Stress-inducible plant promoters
The present invention discloses and claims stress-inducible plant promoters, DNA constructs with such promoters, transgenic plants containing such promoters and DNA constructs, isolated DNAs...
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US20080090999 |
Nucleotide and amino acid sequences from xenorhabdus and uses thereof
The invention provides isolated nucleotide sequences from Xenorhabdus nematophila species Xs86068, and, in particular, nucleotide sequences that encode insect inhibitory proteins, the...
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US20080090998 |
Genes and uses for plant improvement
Transgenic seed for crops with improved traits are provided by trait-improving recombinant DNA where plants grown from such transgenic seed exhibit one or more improved traits as compared to a...
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US20080090997 |
siRNA targeting complement component 3 (C3)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
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US20080090291 |
Synthetic nucleic acid molecule compositions and methods of preparation
A method to prepare synthetic nucleic acid molecules having reduced inappropriate or unintended transcriptional characteristics when expressed in a particular host cell.
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US20080090260 |
Substrates and Assays for Beta Secretase Activity
The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a β-secretase cleavage...
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US20080090257 |
COMPOSITIONS AND METHODS FOR INHIBITING OR INDUCING ADIPOGENESIS
This invention relates generally to compositions and methods which utilization nuclear receptors for regulating adipogenesis in cells. Specifically, the invention is directed to compositions which...
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US20080089882 |
Novel Polypeptide Useful for Cancer Diagnosis and Treatment
The present invention provides a method capable of effectively detecting cancer by finding a novel cancer marker. The present invention also provides a pharmaceutical composition for preventing or...
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US20080089862 |
PROTEASE INHIBITORS AND METHOD OF SCREENING THEREOF
The present invention provides novel recombinant protein and peptide inhibitors of NS3 serine protease of the hepatitis C virus (HCV). The invention discloses analogs, fragments and derivatives of...
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