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US20090311799 |
Nucleic Acid Materials for Nonradiative Energy Transfer and Methods of Production and Use
Nucleic acid materials for FRET-based luminescence and methods of making and using the nucleic acid materials are provided. The nucleic acid materials provide an innovative and synergistic...
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US20090298066 |
Sex-Specific Marker for Shrimps and Prawns
The present invention relates to a sex-specific marker for shrimps and prawns. More specifically, it relates to a sex-specific PCR-based molecular marker, derived from Penaeus monodon , that can...
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US20090291906 |
Oligomeric Compounds And Compositions For Use In Modulation Of Small Non-Coding RNAs
Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding...
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US20090292002 |
NUCLEOTIDE AND AMINO ACID SEQUENCES RELATING TO RESPIRATORY DISEASES AND OBESITY
This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of...
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US20090286285 |
Modified Nucleic Acid Polymers and Methods for their Production
The invention is directed to nucleic acid sequences having decreased thermodynamic stability to complementary sequence as well as a method for producing these sequences.
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US20090281296 |
PROCESS FOR THE PRODUCTION OF CONJUGATES FROM POLYSACCHARIDES AND POLYNUCELOTIDES
The present invention relates to a process for the production of a conjugate from a polynucleotide and a polysaccharide comprising the steps: a) provision of an aldonic acid of the polysaccharide...
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US20090274681 |
NOVEL GENE ENCODING A DNA REPAIR ENZYME AND METHODS OF USE THEREOF
An isolated nucleic acid molecule encoding a human DNA repair enzyme, MED1, is disclosed. Like other mismatch repair genes which are mutated in certain cancers, MED1, encoding nucleic acids,...
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US20090275017 |
Novel Nucleoside or Nucleotide Derivative and Use Thereof
The object of the present invention is to provide a nucleoside or nucleotide having a 5-substituted-2-oxo(1H)pyridin-3-yl group as a base, as well as a method using the same. In one embodiment,...
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US20090269750 |
MARKER AND METHOD FOR CANCER DIAGNOSIS
The present invention relates to a diagnostic cancer marker using variation of a granulocyte colony stimulating factor (G-CSF) gene and a method for preparing the same, and more specifically,...
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US20090269814 |
Method of Analyzing a BRCA2 Gene in a Human Subject
Five novel DNA and protein sequences have been determined for the BRCA2 gene, as have been ten polymorphic sites and their rates of occurrence in the normal alleles of BRCA2. The sequences BRCA2...
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US20090263900 |
Linear donor constructs for targeted integration
Disclosed herein are linear donor molecules comprising homology arms of 50-750 base pairs (e.g., 50-100 base pairs) flanking one or more sequences of interest. The donor molecules and/or...
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US20090263908 |
Liquid crystal condensation of nucleic acid (na) complexes
Upon cooling solutions or melts of nucleic acids or other polymers in which the constituent molecules exhibit a varying tendency to form multi-strand complexes and thus liquid crystal phases, the...
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US20090263413 |
IMMUNOSTIMULATORY OLIGONUCLEOTIDES AND USE THEREOF IN PHARMACEUTICALS
A novel immunostimulatory oligonucleotide by which an IFN-inducing activity is enhanced and an inflammatory cytokine-inducing activity is reduced, and a pharmaceutical containing the same, and an...
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US20090264353 |
Splice Switching Oligomers for TNF Superfamily Receptors and their Use in Treatment of Disease
The present invention relates to compositions and methods for preparing splice variants of TNFalpha receptor (TNFR) in vivo or in vitro, and the resulting TNFR protein variants. Such variants may...
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US20090259030 |
STABILIZED NUCLEIC ACID DARK QUENCHER-FLUOROPHORE PROBES
The present invention provides a new class of solids supports for synthesis of modified oligomers of nucleic acids, and nucleic acid probes that have a format expediently synthesized on the new...
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US20090252828 |
ALPHA-AMYLASE VARIANTS WITH ALTERED PROPERTIES
Disclosed are compositions comprising variants of alpha-amylase that have alpha-amylase activity and which exhibit altered properties relative to a parent AmyS-like alpha-amylase from which they...
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US20090247610 |
INTEGRASE COFACTOR
The present invention provides nucleic acid molecules which include a region specifically interacting with the nucleic acid encoding the LEDGF/P75 protein or the nucleic acid encoding a fragment of...
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US20090246205 |
Inhibition of macrophage-stimulating protein receptor (ron)
The present invention relates to methods for treatment of tumors and other diseases in a mammal comprising administration of antibodies specific for Macrophage-Stimulating Protein Receptor...
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US20090239770 |
DETECTION OLIGOMER AND METHOD FOR CONTROLLING QUALITY OF BIOCHIP USING DETECTION OLIGOMER
A detection oligomer and method for controlling the quality of a biochip using the detection oligomer are provided. The detection oligomer includes a template having a first and second end and...
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US20090239220 |
DLC-1 GENE DELETED IN CANCERS
A cDNA molecule corresponding to a newly discovered human gene is disclosed. The new gene, which is frequently deleted in liver cancer cells and cell lines, is called the DLC-1 gene. Because the...
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US20090226571 |
Fermentative Production of Non-Volatile Microbial Metabolism Products in Solid Form
The present invention relates to a method for the production of at least one nonvolatile microbial metabolite in solid form by sugar-based microbial fermentation, in which process a microorganism...
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US20090226973 |
Reagents and methods for improving reproducibility and reducing mispriming in PCR amplification
An additive for preventing mispriming in polymerase chain reaction (PCR) amplifications and assays comprising a hairpin oligonucleotide having a stem duplex greater than six nucleotides in length...
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US20090229016 |
CAMBIUM/XYLEM-PREFERRED PROMOTERS AND USES THEREOF
The present invention related to nucleic acid molecules corresponding to regulatory portions of genes whose expression is predominant in cambium and/or xylem. The invention also relates to...
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US20090221499 |
Lipidating Sequences and Use thereof for Producing Lipidated Proteins in E. Coli
Production in E. coli of a lipidated fusion protein containing a lipidating sequence derived from Ag473 and a target polypeptide.
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US20090220966 |
THERMOCYCLER AND SAMPLE PORT
The invention relates to continuous flow systems, in particular thermocyclers for the automated and continuous cycling of fluid between a plurality of temperature zones in the amplification of...
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US20090221680 |
Aptamers that bind thrombin with high affinity
The invention provides aptamers capable of binding to thrombin useful as therapeutics for and diagnostics of coagulation related disorders and/or other diseases or disorders in which thrombin has...
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US20090215680 |
Inhibitor peptides
The invention concerns peptides useful as MAP kinase/ERK pathway-specific inhibitors relative to a given substrate in a given subcellular compartment.
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US20090215643 |
Highly Visible Chromosome-Specific Probes and Related Methods
Disclosed are chromosome-specific synthetic oligonucleotides and labeled probe compositions, as well as related methods for preparing and using such compositions. Also disclosed are kits for...
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US20090215635 |
LABELLING STRATEGIES FOR THE SENSITIVE DETECTION OF ANALYTES
The present invention relates to methods and reagents for detecting analytes, e.g. nucleic acids. The new methods and reagents allow a simple and sensitive detection even in complex biological...
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US20090215154 |
Method of preparing micro-and nanometric particles with labile Products
The invention relates to a method of obtaining micro- and nanometric polymeric particles in a controlled, reproducible manner. The aforementioned particles have a spherical shape and a very narrow,...
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US20090209747 |
METHOD TO INHIBIT CELL GROWTH USING OLIGONUCLEOTIDES
Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more...
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US20090209751 |
METHODS AND KITS FOR EXTRACTION OF DNA
Methods and materials are disclosed for use in recovering a biopolymer from a solution. In particular, the invention provides methods for extraction and isolation of nucleic acids from biological...
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US20090202507 |
Intelligent Nanomedicine Integrating Diagnosis And Therapy
A method of controlling the activity of a biologically active compound. The method concerns an oligonucleotide-based compound, comprising a hairpin-forming oligonucleotide, an effector moiety...
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US20090203132 |
PYRROLIDINYL GROUPS FOR ATTACHING CONJUGATES TO OLIGOMERIC COMPOUNDS
The present invention provides pyrrolidinyl compounds that are useful for preparing conjugated oligomeric compounds. The conjugated pyrrolidinyl compounds can be attached to support medium and...
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US20090203572 |
Method for in Vitro Molecular Evolution of Protein Function
The invention provides a method for generating a polynucleotide sequence or population of sequences from parent polynucleotide sequences, the method comprising the steps of (a) providing a first...
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US20090197332 |
Modified Short Interfering RNA
The present invention refers to a double-stranded siRNA molecule comprising a sense Strand and an antisense Strand which is essentially complementary to the sense Strand, each of the sense and the...
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US20090191558 |
DETECTION, IDENTIFICATION AND DIFFERENTIATION OF SERRATIA SPECIES USING THE SPACER REGION
The present invention relates to new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region, between the 16S and 23S rRNA genes, to be used for the specific detection...
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US20090192298 |
Through-bond energy transfer cassettes, systems and methods
The present disclosure relates, according to some embodiments, to compositions, systems, and methods for preparing and using fluorescent through-bond energy transfer cassettes.
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US20090185998 |
NEW ACTIVATED POLY(ETHYLENE GLYCOLS) AND RELATED POLYMERS AND THEIR APPLICATIONS
There are disclosed chemically active poly(ethylene glycols) and other hydrophilic polymers that are suitable for coupling to pharmaceutically or diagnostically active agents such as peptides,...
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US20090181916 |
LNA ANTAGONISTS TARGETING THE ANDROGEN RECEPTOR
The invention relates to oligonucleotide compounds (oligomers), which target androgen receptor mRNA in a cell, leading to reduced expression of the androgen receptor. Reduction of androgen receptor...
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US20090176968 |
Preparation of Triazole Containing Metal Chelating Agents
New chelating agents as well as their tricarbonyl complexes with technetium and rhenium and the use of these compounds in radiodiagnosis and radiotherapy are described. As a peculiarity of this...
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US20090176723 |
Methods and compositions involving miRNA and miRNA inhibitor molecules
The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns...
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US20090163372 |
Nucleolipids and use thereof, and devices for nucleic acid analysis
The invention relates to a method for isolating and/or identifying known or unknown, nucleic acid sequences (target sequences) which are marked, optionally, with reporter groups, by base specific...
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US20090155795 |
BASELESS NUCLEOTIDE ANALOGUES AND USES THEREOF
A method of detecting a target nucleic acid.
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US20090148455 |
Anti-RANTES antibodies and methods of use thereof
The invention relates to fully human monoclonal antibodies, and fragments thereof, that bind to the chemokine Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES, CCL5),...
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US20090143529 |
Peptide purification by means of hard metal ion affinity chromatography
A polymer substrate functionalized with a functionality comprising at least one cyclic, metal ion coordinating ligand group which comprises at least 3 nitrogen donor atoms in the ring of the cyclic...
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US20090142748 |
MICROPOROUS MATERIALS, METHODS OF MAKING, USING, AND ARTICLES THEREOF
Described herein are methods for separating one or more analytes present in a fluid sample. The methods involve passing the fluid through or into a microporous material, wherein the analytes are...
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US20090136932 |
FIBERS WITH ISOLATED BIOMOLECULES AND USES THEREOF
The present invention relates to compositions, methods, and uses for isolated biomolecule-containing fibers. The invention also relates to isolated, elongated biopolymers such as nucleic acids,...
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US20090131648 |
Rigid dendrimeric structures
The present invention provides novel dendrimers having a multimeric structure obtainable by reaction of a core molecule having an adamantoid structure with branching synthons and terminating...
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US20090130752 |
BIODEGRADABLE POLY(DISULFIDE AMINE)S FOR GENE DELIVERY
Poly(disulfide amine)s, methods of making, and methods of use are described. Illustrative embodiments of the poly(disulfide amine)s include poly(CBA-DAE), poly(CBA-DAB), and poly(CBA-DAH). These...
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