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US20090191213 |
Compositions and methods for regulating NK cell activity
The present invention relates to novel compositions and methods for regulating an immune response in a subject. More particularly, the invention relates to specific antibodies that regulate the...
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US20080280322 |
Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
The present invention relates to the field of glycosylation engineering of proteins. More particularly, the present invention relates to glycosylation engineering to generate proteins with improved...
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US20080187540 |
Antibodies to OCIF-binding molecules
A novel protein which binds to Osteoclastogenesis Inhibitory Factor (OCIF-binding molecule; OBM), a process for preparing the same, DNA encoding said protein, a protein having an amino acid...
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US20080182236 |
Asthma Susceptibility Locus
The present invention describes a susceptibility locus which is functionally related to asthma. The locus maps within human chromosome 7p15-p14. The invention also describes a novel human gene,...
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US20080138796 |
NRIF3, a novel co-activator for nuclear hormone receptors
Nucleic acids encoding NRIF3 are described. Polypeptides having amino acid sequences of NRIF3 proteins are also provided. A method is also provided for isolating and cloning NRIF3 cDNA. NRIF3 is...
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US20080107657 |
ANTIBODIES THAT BIND TO AN EPITOPE ON THE HUNTINGTON'S DISEASE PROTEIN
The present invention relates generally to the generation and characterization of anti-huntingtin antibodies binding an epitope on the Huntington's disease protein. The invention further relates to...
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US20080107643 |
MAMMALIAN CHEMOKINES; RECEPTORS; REAGENTS; USES
Novel chemokines and 7 transmembrane receptors from mammals, reagents related thereto, including purified proteins, specific antibodies, and nucleic acids encoding the chemokines and receptors are...
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US20080102072 |
MONOCLONAL ANTIBODIES TO TYPE I INTERFERON RECEPTOR
Anti-IFNAR1 monoclonal antibodies with neutralizing activities against the anti-viral cytopathic effects of various type I interferons are provided.
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US20080089887 |
Members of the FC Receptor Homolog Gene Family (FcRH1-3,6) Related Reagents and Uses Thereof
The invention relates to members of the Fc receptor homolog (FcRH) subfamily, as well as fragments and variants thereof. Each FcRH is a Type I transmembrane receptor, preferably, comprises an...
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US20080089837 |
TARGETED BINDING AGENTS DIRECTED TO PDGFR-ALPHA AND USES THEREOF
Targeted binding agents directed to the antigen PDGFR-alpha and uses of such agents are disclosed herein. More specifically the invention relates to fully human monoclonal antibodies directed to...
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US20080064858 |
Binding partners for the thyrotropin receptor and uses thereof
A binding partner for the TSH receptor, which binding partner comprises, or is derived from, a human monoclonal or recombinant antibody, or one or more fragments thereof, reactive with the TSH...
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US20080064764 |
Calcium-sensing receptor 2 (CAR2) and methods for using
The current disclosure provide a novel human calcium sensing receptor named CaR2 and the nucleotide sequence that encodes the receptor. The disclosure further provides antibodies specific for CaR2....
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US20080044415 |
Hepatocyte growth factor receptor antagonists and uses thereof
Hepatocyte growth factor (HGF) receptor antagonists are provided. The HGF receptor antagonists include HGF receptor antibodies and fragments thereof. The HGF receptor antagonists can be employed to...
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US20080038824 |
Composition and Method for Elevating Gene Transfer Efficiency
It is intended to provide a method whereby transfer efficiency can be improved under any conditions in the case of transferring (in particular, transfecting) a target substance that cannot easily...
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US20080038272 |
Monoclonal antibody against frizzled receptors
The present invention relates to a monoclonal antibody or fragment thereof, which binds specifically and/or selectively to human receptors of the Frizzled (FZD) family. It further relates to a...
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US20080038265 |
Antibodies to Erythropoietin Receptor and Uses Thereof
The present invention relates to antibodies and antigen-binding portions thereof that bind to and activate an erythropoietin receptor. The invention also relates to nucleic acid sequences encoding...
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US20080008713 |
Single domain antibodies against tnfr1 and methods of use therefor
Provided are concentrated preparations comprising single immunoglobulin variable domain polypeptides that bind target antigen with high affinity and are soluble at high concentration, without...
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