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US20080176257 |
Assay for Antibodies
The presence and quantity of an antibody of interest in a patient's bloodstream or other biological sample can serve as an important clinical or other analytical or diagnostic tool. ELISA methods,...
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US20080124331 |
COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR
The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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US20080109917 |
CARD-DOMAIN CONTAINING POLYPEPTIDES, ENCODING NUCLEIC ACIDS, AND METHODS OF USE
The invention provides caspase recruitment domain (CARD)-containing polypeptides and functional fragments thereof, encoding nucleic acid molecules, and specific antibodies. Also provided are...
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US20080108796 |
Human IL-1 epsilon DNA and polypeptides
The invention is directed to purified and isolated novel human IL-1 epsilon polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such...
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US20080107656 |
IMMUNOGENIC COMPOSITIONS AND METHODS OF USE THEREOF
The present invention relates generally to a method of eliciting or otherwise inducing an immune response to a Plasmodium microorganism and compositions for use therein. More particularly, the...
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US20080107642 |
ANTIBODIES AGAINST GPR64 AND USES THEREOF
GPR64 antibody compositions are provided. These antibodies may be used for diagnosis or treatment of cancer, especially ovarian cancer, Ewing's sarcoma, uterine cancer, and other GPR64 expressing...
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US20080107597 |
ISOLATION OF ANTIBODIES THAT CROSS-REACT AND NEUTRALIZE RANKL ORIGINATING FROM MULTIPLE SPECIES
The invention provides specific binding members (e.g., antibodies or antigen-binding fragments thereof) which bind to RANKL originating from multiple species. An epitope recognized by the specific...
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US20080102484 |
Dendritic cell transmembrane serine protease
Isolated Dendritic Cell Transmembrane Serine Proteases (DCTSPs), DNAs encoding such DCTSPs, and pharmaceutical and/or diagnostic compositions made therefrom, are disclosed. The isolated DCTSPs can...
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US20080102479 |
METHOD OF DIAGNOSING LAWSONIA INTRACELLULARIS
The present invention relates to the field of animal health and in particular to Lawsonia intracellularis . In particular, the invention relates to a method of diagnosing Lawsonia intracellularis...
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US20080090993 |
PURIFIED MAMMALIAN CYTOKINES; RELATED REAGENTS AND METHODS
CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and...
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US20080089891 |
Cancerous disease modifying antibodies
The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer...
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US20080085557 |
Human Cancer Stem Cell Culture Compositions Comprising Erbb2 Variants and Methods of use Thereof
The present invention provides compositions and methods for the culture and maintenance of cancer stem cells. More particularly, the present invention provides the identification of cancer stem...
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US20080085531 |
Antagonistic anti-human CD40 monoclonal antibody
The present invention provides novel antagonistic anti-human CD40 monoclonal antibodies, methods for generating them and uses thereof.
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US20080085262 |
PURIFIED MAMMALIAN CYTOKINES; RELATED REAGENTS AND METHODS
CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and...
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US20080081043 |
NK cell activation inducing ligand (NAIL) DNA and polypeptides, and use thereof
The invention is directed to purified and isolated novel NAIL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides,...
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US20080076141 |
Novel murine and human kinases
The invention is directed to purified and isolated novel murine and human kinase polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such...
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US20080075726 |
Anti-IL-6 monoclonal antibodies and uses thereof
The present invention provides novel monoclonal antibodies that bind specifically to IL-6. The antibodies of the invention comprise a variable heavy chain (VH) region selected from any of the VH...
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US20080070278 |
Novel agent for controlling cell activity
This invention describes a novel agent for the targeted control of a mammalian cell activity, in particular the agent is used to control the interaction of particular cell types with their external...
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US20080069828 |
Methods, kits, and antibodies for detecting parathyroid hormone
The present invention relates to novel methods and compositions useful for detecting whole parathyroid hormone at a physiological level and parathyroid fragments in a mammalian sample. Such...
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US20080069820 |
Multispecific antibodies
The invention provides multispecific antibodies and methods of making and using such antibodies.
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US20080064096 |
Isolated nucleic acid molecules which encode a soluble IL-TIF receptor or binding protein which binds to IL-TIF/IL-22, and uses thereof
The invention relates to soluble proteins which bind to the molecule known as IL-TIF/IL-22. The proteins can antagonize the effect of IL-TIF/IL-22 on target cells. The nucleic acid molecules...
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US20080064094 |
Polynucleotides encoding two novel human G-protein coupled receptors, HGPRBMY28 and HGPRBMY29, and splice variants thereof
The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding...
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US20080058248 |
Toxin Complex Proteins and Genes from Xenorhabdus bovienii
The subject invention relates to novel Xenorhabdus toxin complex (TC) proteins and genes that encode these proteins. More specifically, the subject invention relates to TC genes and proteins...
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US20080057520 |
IMMUNOASSAYS FOR SPECIFIC DETERMINATION OF SCCA ISOFORMS
The present invention relates to monoclonal antibodies capable of distinguishing squamous cell cancer antigens, SCCA, in either free or complex bound forms, preferably antigens SCCA1 and SCCA2, as...
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US20080057065 |
Phep, an Amino Acid Permease of Staphylococcus Aureus
The present invention relates to antigenic polypeptides expressed by pathogenic microbes, including antigenic polypeptides encoded by the nucleic acid sequence of FIG. 1, vaccines comprising the...
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US20080050383 |
IMMUNOTHERAPY FOR CLEARING PATHOLOGICAL TAU CONFORMERS
The present invention relates to methods of treating and preventing Alzheimer's Disease or other tauopathies in a subject by administering a tau protein, its immunogenic epitopes, or antibodies...
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US20080050381 |
Antihuman Baff Antibody
An antibody against a peptide having an amino acid sequence AVQGPEETVT QDC (expressed in single letter amino acid code) corresponding to the 134- to 146-positions in human BAFF (B cell activating...
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US20080045454 |
Polynucleotide encoding a TRIM-cyp polypeptide, compositions thereof, and methods of using same
The invention provides an isolated nucleic acid encoding a TRIM—cyclophilin A fusion sequence encoding a TRIMcyp fusion protein which is active as an anti-viral agent, and in particular an...
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US20080044408 |
Cytotoxicity mediation of cells evidencing surface expression of CD63
This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of tumor cells; and most particularly to the use of cancerous disease...
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US20080039413 |
Novel compositions and methods in cancer
The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide...
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US20080038270 |
Antibody Specific For A Chondroitin Sulphate Epitope
An antibody specific for a chondroitin sulphate epitope is described, as is a hybridoma cell line which produces such an antibody. The antibody is useful in the diagnosis and treatment of...
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US20080038268 |
Streptococcus Pyogenes Antigens
The present invention relates to antigens, more particularly an antigen of Streptococcus pyogenes (also called group A Streptococcus (GAS)) bacterial pathogen which is useful as vaccine...
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US20080038260 |
ILT3 binding molecules and uses therefor
The present invention provides binding molecules that specifically bind to ILT3, e.g., human ILT3 (hILT3), on antigen presenting cells, such as for example, monocytes, macrophages and dendritic...
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US20080038257 |
HEPATOCYTE GROWTH FACTOR (HGF) BINDING PROTEINS
The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as...
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US20080033150 |
Assays, antibodies, and standards for detection of oxidized and MDA-modified low density lipoproteins
Immunoassays for malondialdehyde-modified low density lipoprotein (MDA-modified LDL) and oxidized low density lipoprotein (OxLDL), monoclonal antibodies (and the cell lines for them) for use in the...
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US20080033148 |
ANTI-IL-TIF ANTIBODIES AND METHODS OF USING IN INFLAMMATION
The present invention relates to blocking the activity of IL-TIF polypeptide molecules. IL-TIF is a cytokine involved in inflammatory processes and human disease. The present invention includes...
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US20080032402 |
Method for the Discrimination and Isolation of Mammary Epithelial Stem and Colony-Forming Cells
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US20080020406 |
Antibodies to a human Kchannel and therapeutic applications thereof
The present invention relates to a novel human K + ion channel, to nucleic acid molecules encoding the same and to vectors comprising said nucleic acid molecules. The invention additionally...
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US20080020404 |
Search for cancer markers by a novel screening method
The present invention relates to a method of concentrating low molecular weight peptides in the supernatant of serum-free cultured cells, said method comprising allowing the peptides to bind to a...
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US20080014194 |
Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease
The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including Lewy bodies of alpha-synuclein in the brain of a patient. Such...
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US20080008707 |
Denatured collagen peptides and uses thereof
The invention provides peptide antagonists, such as synthetic collagen peptides. The invention provides antibody antagonists, or functional fragments thereof, that preferentially bind to denatured...
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US20080004432 |
HEMCM42 antibodies
The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells,...
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US20080003693 |
METHODS AND MATERIALS FOR DETECTING FRAMESHIFT MUTATIONS
The invention relates to methods and materials for detecting in a biological sample the presence or absence of a target protein having a frameshift mutation that results in missense amino acid...
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