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US20090311252 |
Anti-activin antibodies and uses for promoting bone growth
In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density.
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US20090311248 |
Hepatitis C Virus Neutralizing Antibodies
The invention relates to anti-HCV antibodies and more specifically to neutralizing anti-HCV antibodies and their variable and complementarity determining regions (CDR). In particular, the...
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US20090312190 |
Methods and Proteins for the Prophylactic and/or Therapeutic Treatment of Four Serotypes of Dengue Virus and Other Flaviviruses
The present invention is related to the field of the pharmaceutical industry, and describes a conserved area on the surface of the E protein that can be used for the development of wide-spectrum...
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US20090311245 |
METALLOPROTEINASE 9 BINDING PROTEINS
Proteins that bind to matrix metalloproteinase 9 and methods of using such proteins are described.
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US20090311253 |
Dual Variable Domain Immunoglobulins and Uses Thereof
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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US20090311271 |
Methods and Compositions for Selective Inhibition of Ligand Binding to the Lectin-Like Receptor for Oxidized Low Density Lipoprotein (LOX-1)
The present invention provides methods of selectively inhibiting the binding of one ligand for LOX-1, but not one other ligand for LOX-1. Moreover, the invention relates to the identification of...
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US20090311251 |
SCFV ANTIBODIES WHICH PASS EPITHELIAL AND/OR ENDOTHELIAL LAYERS
scFv antibodies which specifically bind selected antigens and are obtainable by a method comprising (i) selecting from a pool of soluble and stable antibody frameworks a soluble and stable...
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US20090304713 |
BINDING AGENTS
Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
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US20090304675 |
METHOD OF MODULATION OF MULLERIAN INHIBITORY SUBSTANCE (MIS) RECEPTOR FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
This invention relates to methods for modulating neuronal cell death or impairment, and methods for the treatment, prevention, and/or amelioration of symptoms of one or more conditions or diseases...
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US20090304715 |
MODIFIED ANTIBODIES WITH ENHANCED BIOLOGICAL ACTIVITIES
The present inventors generated modified antibodies in which several Fc domains are linked in tandem to the C terminus of the heavy chain, and modified antibodies in which Fc domains are linked in...
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US20090304716 |
TREATMENT OF METASTATIC BREAST CANCER
The present invention relates to the use of an anti-EpCAM antibody for the manufacture of a medicament for the treatment of metastatic breast cancer. The present invention further relates to a...
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US20090304693 |
Dual Variable Domain Immunoglobulins and Uses Thereof
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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US20090307806 |
GENETIC MARKERS FOR HIGH OLEIC ACID CONTENT IN PLANTS
The present invention relates to a mutated nucleic acid sequence of a delta-12 oleate desaturase enzyme (FAD2)—encoding nucleic acid from a Cruciferae plant, wherein said mutated nucleic acid...
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US20090304577 |
Peptides for Treatment and Diagnosis of Autoimmune Disease
There are provided peptides derived from antibodies with reactivity against a GPI linkage epitope and functionally equivalent ligands. These peptides can be used in the therapy and diagnosis of a...
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US20090305434 |
METHOD OF DIAGNOSING NEUROPHSYCHIATRIC DISEASES, EATING DISORDERS OR METABOLIC DISEASES
The application relates to a method of diagnosing neuropsychiatric diseases, eating disorders and/or metabolic diseases, which comprises: (i) measuring the affinity and/or the avidity of...
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US20090306342 |
BINDING OF MOLECULES
A method of binding a target molecule from an analyte containing the target molecule in admixture with at least one non-target molecule, which method comprises exposing the analyte to a substrate...
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US20090304575 |
IN VITRO METHOD FOR IDENTIFYING COMPOUNDS FOR CANCER THERAPY
The present invention relates to an in vitro method for identifying and evaluating compounds useful in the treatment of different types of cancer, especially lung, breast, colorectal and bladder...
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US20090304781 |
MASTER GENE OF ARTERIOGENESIS
The present invention relates to a pharmaceutical composition comprising (a) a polynucleotide comprising or consisting of a nucleotide sequence encoding a polypeptide with the amino acid sequence...
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US20090306347 |
ANTIBODY PRODUCED USING OSTRICH AND METHOD FOR PRODUCTION THEREOF
Disclosed is an antibody produced using an ostrich. Also disclosed is a method for producing the antibody. By using an ostrich, it becomes possible to produce antibodies (particularly antibodies...
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US20090297507 |
ADAM10 in Cancer Diagnosis, Detection and Treatment
This invention is in the field of cancer-related genes. Specifically it relates to methods for detecting cancer or the likelihood of developing cancer based on the presence or absence of the ADAM10...
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US20090297440 |
Gene Differentially Expressed in Breast and Bladder Cancer and Encoded Polypeptides
The present invention relates to a novel human gene that is differentially expressed in human carcinoma. More specifically, the present invention relates to a polynucleotide encoding a novel human...
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US20090299190 |
Ultrasound Molecular Sensors and Uses Thereof
The present invention relates to the use of polymers as contrast agents for ultrasounds. The idea is to have a molecular imprint in the polymer that is specific for a given molecule or analyte....
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US20090298195 |
SYNTHETIC IMMUNOGLOBULIN DOMAINS WITH BINDING PROPERTIES ENGINEERED IN REGIONS OF THE MOLECULE DIFFERENT FROM THE COMPLEMENTARITY DETERMINING REGIONS
Method for engineering an immunoglobulin comprising at least one modification in a structural loop region of said immunoglobulin and determining the binding of said immunoglobulin to an epitope of...
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US20090299033 |
Methods and Compositions for F-18 Labeling of Proteins, Peptides and Other Molecules
The present application discloses compositions and methods of synthesis and use of F-18 labeled molecules of use, for example, in PET imaging techniques. In particular embodiments, the labeled...
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US20090297505 |
ABETA BINDING MOLECULES
The present invention encompasses isolated antibodies, or fragments thereof, that are humanized variants of murine antibody 266 which employ complementarily determining regions derived from murine...
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US20090298919 |
Tumor homing molecules, conjugates derived therefrom, and methods of using same
The present invention provides tumor homing molecules, which selectively home to a tumor. The invention also provides methods of using a tumor homing molecule to target an agent such as a drug to a...
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US20090297494 |
Diagnostic and treatment of a mental disorder
The present invention generally relates to the field of neurological, physiological and psychotic dysfunctions associated with a mental disorder such as schizophrenia, or a predisposition therefor....
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US20090298762 |
CONJUGATES OF BIOLOGICALLY ACTIVE PROTEINS HAVING A MODIFIED IN VIVO HALF-LIFE
Disclosed are biologically active protein conjugates that comprise a biologically active polypeptide coupled via a peptide bond to a polypeptide comprising from 2 to about 500 units of a repeating...
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US20090291462 |
Detection or Quantification of Aggrecan and its Fragments
An immunoassay for aggrecan and/or aggrecan derived fragments comprises contacting a sample with an immunological binding partner which has specific binding affinity for the G2 domain of aggrecan...
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US20090292109 |
Method of Isolating Biomacromolecules Using Polyalkylene Glycol and Transition Metals
The present invention is related to a method of isolating a biological macromolecule in a composition. Specifically, the present invention is related to a method of isolating a biomacromolecule in...
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US20090291094 |
ANTIBODIES AND PROCESSES FOR PREPARING THE SAME
Provided herein are various processes for the improved production of antibody producing organisms, antibody producing tissues, antibody producing cells and antibodies. In certain embodiments,...
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US20090291090 |
ANTI-CD33 ANTIBODIES AND METHOD FOR TREATMENT OF ACUTE MYELOID LEUKEMIA USING THE SAME
The present invention relates to antibodies that bind CD33. More particularly, the invention relates to anti-CD33 antibodies, fragments and homologues of these antibodies, humanized and resurfaced...
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US20090288176 |
Novel Gene Disruptions, Compositions and Methods Relating Thereto
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic...
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US20090285837 |
HER2 ANTIBODY COMPOSITION
A composition comprising a main species HER2 antibody that binds to domain II of HER2, and an amino acid sequence variant thereof comprising an amino-terminal leader extension is disclosed....
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US20090286256 |
ISOLATED HUMAN AUTOANTIBODIES TO NATRIURETIC PEPTIDES AND METHODS AND KITS FOR DETECTING HUMAN AUTOANTIBODIES TO NATRIURETIC PEPTIDES
The present disclosure relates to isolated human autoantibodies and assays and kits for detecting human autoantibodies reactive with at least one natriuretic peptide or natriuretic peptide fragment...
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US20090286312 |
Methods and Compositions for Treating Allergic Diseases
Disclosed in the present invention are antibodies that specifically recognize and antagonize human TSLP receptor, and methods of employing these antibodies to treat or ameliorate diseases or...
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US20090285812 |
ANTI-PSGL-1 ANTIBODIES AND METHODS OF IDENTIFICATION AND USE
The present invention is directed to antibodies and binding fragments thereof, which bind with high affinity and specificity to human P-selectin glycoprotein ligand 1 (PSGL-1) and which block both...
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US20090285831 |
IMMUNOINTERACTIVE MOLECULES
The present invention relates generally to immunointeractive molecules and more particularly antibodies which bind to vascular endothielial growth factor-B (VEGF-B) or its functional or structural...
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US20090285805 |
Binding molecules
The present invention relates to the manufacture of a diverse repertoire of functional heavy chain-only antibodies that undergo affinity maturation, and uses thereof. The invention also relates to...
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US20090286283 |
METHOD AND AFFINITY COLUMN FOR PURIFYING PROTEINS
Disclosed herein is a method of purifying target proteins from a sample using the specific affinity between a peptide tag and a protease inhibitor. Also disclosed herein is an affinity...
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US20090285799 |
Antibody Antagonists of Interleukin-13 Receptor Alpha1
Antibody antagonists of human interleukin-13 receptor alpha 1 are disclosed. The antibody molecules are useful in the inhibition of IL-13Rα1-mediated activities and, accordingly, present desirable...
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US20090285830 |
ANTIBODIES TO LYMPHOTOXIN-ALPHA
The invention provides various antibodies that bind to lymphotoxin-α, methods for making such antibodies, compositions and articles incorporating such antibodies, and their uses in treating, for...
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US20090280502 |
ANTI-2-O-DESULFATED ACHARAN SULFATE ANTIBODY AND ITS APPLICATION
An antibody that reacts with 2-O-desulfated acharan sulfate, a hybridoma that produces the antibody, a detection method and a detection kit to which the antibody is applied are disclosed. The...
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US20090280499 |
METHOD AND KIT FOR DETECTING, OR DETERMINING 3,4- METHYLENEDIOXYMETHAMPHETAMINE
The invention provides a hapten, an immunogen comprising the hapten coupled to an antigenicity-conferring carrier material, a conjugate comprising the hapten coupled to a labelling agent, as well...
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US20090281284 |
GOLD-BINDING PROTEIN AND USE THEREOF
A protein utilizing an anti-gold antibody and a gold-binding side which is a part of the anti-gold antibody is constructed. This protein is capable of specifically binding to gold. This protein or...
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US20090280118 |
METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING DISEASE ASSOCIATED WITH alphaVbeta5 INTEGRIN
The present invention provides compositions and methods for treating and preventing disease associated with αvβ5 integrin by blocking binding to αvβ5 integrin.
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US20090281285 |
BINDING MEMBER WHICH BINDS TO BOTH LEWIS-Y AND LEWIS-B HAPTENS, AND ITS USE FOR TREATING CANCER
The invention relates to the use of a binding member which binds to Lewis y and Lewis b haptens in the treatment of tumours and leukaemia. The binding member may be an antibody which binds to...
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US20090280510 |
Antibodies Specific to Heterodimers of Bcl-2 Family and Uses Thereof
Isolated antibodies specifically binding to heterodimers of the Bcl-2 family and uses thereof for detecting presence of Bcl-2 heterodimers in a patient.
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US20090281277 |
PEPTIDES CAPABLE OF BINDING TO SERUM PROTEINS AND COMPOUNDS, CONSTRUCTS AND POLYPEPTIDES COMPRISING THE SAME
The present invention relates to amino acid sequences that are capable of binding to serum proteins; to compounds, proteins, polypeptides, fusion proteins or constructs comprising or essentially...
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US20090280110 |
Cell Model for Alzheimer's Disease Pathology
The present invention encompasses compositions and methods for studying in cell culture the pathologic changes associated with Alzheimer's disease. The present invention further relates to methods...
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