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US20130102759 Synthetic Oligosaccharides for Moraxella Vaccine  
The present invention provides synthetic Moraxella catarrhalis lipooligosaccharide (LOS)-based oligosaccharides and conjugates containing various M. catarrhalis serotype-specific oligosaccharide...
US20130324701 COMPOSITIONS AND METHODS OF TREATING DISEASE WITH FGFR FUSION PROTEINS  
The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion...
US20120301921 COMPOSITIONS AND METHODS OF TREATING DISEASE WITH FGFR FUSION PROTEINS  
The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion...
US20120129766 METHODS OF TREATING FGF21-ASSOCIATED DISORDERS  
The invention relates to the identification of new polypeptide and protein variants of fibroblast growth factor 21 (FGF21) that have improved pharmaceutical properties. Also disclosed are methods...
US20150094267 SUCCINIMIDE-ACTIVATED NITROXYL COMPOUNDS AND METHODS FOR THE USE THEREOF FOR NITROXYLATION OF PROTEINS  
The present invention relates to succinimide-activated nitroxyl compounds and methods for the synthesis of such compounds. The present invention also relates to the use of succinimide-activated...
US20130178603 MULTI-MODE CANCER TARGETED NANOPARTICULATE SYSTEM AND A METHOD OF SYNTHESIZING THE SAME  
The various embodiments herein provide a method of synthesizing a multi-mode cancer targeted nanoparticles. The method comprises the steps of preparing a plurality of nanoparticles and covalently...
US20120244577 MULTIVALENT HETEROMULTIMER SCAFFOLD DESIGN AND CONSTRUCTS  
Provided herein are multifunctional heteromer proteins. In specific embodiments is a heteromultimer that comprises: at least two monomeric proteins, wherein each monomeric protein comprises at...
US20130095551 METHOD FOR CHANGING CONFORMATION OF GLOBULAR PROTEINS  
A method for changing conformation of globular proteins is provided. The method controls the concentration of the globular proteins and the adsorption time of the globular proteins from the...
US20110150901 BINDING PROTEINS THAT BIND TO HUMAN FGFR1C, HUMAN BETA-KLOTHO AND BOTH HUMAN FGFR1C AND HUMAN BETA-KLOTHO  
Binding proteins that specifically bind to β-Klotho or portions thereof, FGFR1c or portions thereof, or both FGFR1c and β-Klotho, and optionally other proteins as well are provided. Coding...
US20140235532 IMMUNOGENIC ESCHERICHIA COLI HEAT STABLE ENTEROTOXIN  
The present invention relates to methods and compositions for the treatment and prevention of diarrhea and diarrheal related diseases and disorders in both animals and humans. In some embodiments,...
US20130172532 METHOD FOR MAKING RHENIUM-186/188 LABELED HUMAN SERUM ALBUMIN MICROSPHERES AND KIT FOR MAKING THE SAME AND METHOD FOR USING THE KIT  
The present invention relates to a method for preparing 186/188Re-labeled human serum albumin (HSA) microspheres by 186/188Re(I)-tricarbonyl ion. This radioactive particle can be subjected to...
US20130216570 MULTICOMPONENT VACCINE FOR MALARIA PROVIDING LONG-LASTING IMMUNE RESPONSES AGAINST PLASMODIA  
Disclosed are immunogenic conjugates which elicit an immune response to Plasmodium proteins. In particular examples, the Plasmodium proteins include sexual stage surface proteins, circumsporozoite...
US20110142756 Method And Composition For The Treatment Of Cancer By The Enzymatic Conversion Of Soluble Radioactive Toxic Precipitates In The Cancer  
The invention features compositions and methods for treating or alleviating a symptom of cancer. The compositions and methods of the invention direct supra-lethal doses of radiation, called...
US20140213511 COMPOSITIONS AND METHODS OF USE FOR TREATING METABOLIC DISORDERS  
Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
US20120329127 THERAPEUTIC PROTEINS WITH INCREASED HALF-LIFE AND METHODS OF PREPARING SAME  
The present disclosure relates to materials and methods of conjugating a water soluble polymer to a therapeutic protein.
US20130184212 FIBRONECTIN BASED SCAFFOLD PROTEINS HAVING IMPROVED STABILITY  
The present application provides fibronectin based scaffold proteins associated with improved stability. The application also relates to stable formulations of fibronectin based scaffold proteins...
US20120171747 SIGNAL AMPLIFICATION MICROSPHERES, THEIR USE IN ONE-STEP AND MULTI-STEP ANALYTICAL AMPLIFICATION PROCEDURES AND METHODS FOR THEIR PRODUCTION  
The present invention relates to microspheres comprising protein signal precursor molecules, or a carrier protein bonded to signal precursor molecules, wherein said signal precursor molecules are...
US20140242666 VACCINE FOR SHIGELLA  
Disclosed are immunogenic conjugates and therapeutic compositions that include such immunogenic conjugates. Also disclosed are methods of treating and/or inhibiting an Shigella sonnei infection....
US20110212125 VACCINE FOR SHIGELLA  
Disclosed are immunogenic conjugates and therapeutic compositions that include such immunogenic conjugates. Also disclosed are methods of treating and/or inhibiting an Shigella sonnei infection....
US20130177919 PROTEIN PRODUCTION  
The invention concerns the field of protein production and cell culture technology. CERT is identified as a novel in vivo PKD substrate. Phosphorylation on serine 132 by PKD decreases the affinity...
US20120083455 HYMAN SERUM ALBUMIN-siRNA NANO-SIZED CARRIER SYSTEM  
Disclosed are a human serum albumin-siRNA carrier system having siRNA bound to human serum albumin and a user thereof, and especially, human serum albumin-siRNA carrier system, which has a...
US20140255401 Kv1.3 Antagonists and Methods of Use  
The present invention relates to Kv1.3 antagonists, and polynucleotides encoding them, and methods of making and using the foregoing.
US20110236931 CHEMICAL AND BIOCHEMICAL ADDUCTS AS BIOMARKERS FOR ORGANOPHOSPHATE EXPOSURE  
Provided is a method to identify OP-adducted biomarkers of OP exposure as well as compounds containing OPs that can provide OP adducts.
US20110288269 Design of Spacers To Increase The Expression of Recombinant Fusion Proteins  
The present invention relates to fusion proteins. The invention specifically relates to compositions and methods of Tf-based fusion proteins that demonstrate a high-level expression of transferrin...
US20130310317 TARGETED THERAPEUTICS BASED ON ENGINEERED PROTEINS FOR TYROSINE KINASES RECEPTORS, INCLUDING IGF-IR  
The present invention provides innovative proteins that bind to insulin-like growth factor-I receptor (IGF-IR), as well as other important proteins. The invention also provides innovative proteins...
US20110015130 Polypeptides Selective for alphavbeta3 Integrin Conjugated With a Variant Of Human Serum Albumin (HSA) And Pharmaceutical Uses Thereof  
The invention generally relates to fusion proteins comprising a rhodostomin variant having an RGD motif variant 48ARLDDL53, wherein the rhodostomin variant is conjugated with a variant of Human...
US20130310537 Method and Kit for Preparing a Radiopharmaceutical  
The invention relates to a method and a kit for preparing a radiopharmaceutical, the method comprising the steps: elution of a 68Ge/68Ga-Generator using hydrochloric acid as an eluent for...
US20120094909 FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND TO PCSK9  
The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat...
US20120046231 COMPOSITION AND PROCESS FOR SYNTHESIZING POLYMERIZED HUMAN SERUM ALBUMIN FOR APPLICATIONS IN TRANSFUSION MEDICINE  
Described herein is a composition and process for synthesizing a human serum albumin (HSA) based plasma replacement composition that includes a polymerized HSA (PolyHSA) that is chemically...
US20150072919 FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND TO MYOSTATIN  
The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat...
US20140309163 FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND TO MYOSTATIN  
The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat...
US20140107020 FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND TO MYOSTATIN  
The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat...
US20120041178 Coenzyme Q10 Nanoparticles, Preparation Method Thereof and Composition Containing Said Nanoparticles  
Provided are a coenzyme Q10 nanoparticle, a method of preparing the same and a composition having the nanoparticle. According to the present invention, Coenzyme Q10 may be dissolved in only a...
US20110286976 BI-SPECIFIC FUSION PROTEINS  
Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair damaged...
US20140038893 TARGETED THERAPEUTICS BASED ON ENGINEERED PROTEINS THAT BIND EGFR  
The present invention relates to single domain proteins that bind to epidermal growth factor receptor (EGFR). The invention also relates to single domain proteins for use in diagnostic, research...
US20110053842 TARGETED THERAPEUTICS BASED ON ENGINEERED PROTEINS THAT BIND EGFR  
The present invention relates to single domain proteins that bind to epidermal growth factor receptor (EGFR). The invention also relates to single domain proteins for use in diagnostic, research...
US20140315816 ALBUMIN VARIANTS  
The invention relates to variants of a parent albumin having altered plasma half-life compared with the parent albumin. The invention also relates to fusion polypeptides and conjugates comprising...
US20120322739 Albumin Variants  
The invention relates to variants of a parent albumin having altered plasma half-life compared with the parent albumin. The invention also relates to fusion polypeptides and conjugates comprising...
US20130224285 ESTROGEN RECEPTOR ALPHA POLYPEPTIDE SEQUENCE, DIAGNOSTIC AND THERAPEUTIC APPLICATIONS THEREOF  
The present invention presents new insights in the mechanism of action of the estrogen receptor alpha in breast cancer cells and provides means and tools for modulating said mechanisms of action,...
US20120329176 INDIRECTLY LABELLED ASSAY CONJUGATES AND METHODS OF PREPARING AND USING SAME  
Indirectly labelled assay conjugates prepared by a method that includes the step of submitting the binding member comprised by the conjugate to denaturing conditions prior to labelling the binding...
US20110027912 PURIFIED SERUM ALBUMIN, AND IMMUNOLOGICAL MEASUREMENT METHOD  
An object of the present invention is to provide: a purified serum albumin having less lot-to-lot variation; and an immunoassay method utilizing the purified serum albumin, in which high...
US20140179596 ALBUMIN FUSION PROTEINS  
Provided herein are albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins and vectors containing these nucleic acids, host cells transformed with these nucleic acids...
US20140316111 Chemical Reagents for the Activation of Polysaccharides in the Preparation of Conjugate Vaccines  
This invention provides novel reagents for cyanating polysaccharides in aqueous or part aqueous solutions so that they may be covalently linked to proteins either directly or through a spacer....
US20140323688 Chemical Reagents for the Activation of Polysaccharides in the Preparation of Conjugate Vaccines  
This invention provides novel reagents for cyanating polysaccharides in aqueous or part aqueous solutions so that they may be covalently linked to proteins either directly or through a spacer....
US20140316110 Chemical Reagents for the Activation of Polysaccharides in the Preparation of Conjugate Vaccines  
This invention provides novel reagents for cyanating polysaccharides in aqueous or part aqueous solutions so that they may be covalently linked to proteins either directly or through a spacer....
US20130344104 OLIGOSACCHARIDES AND OLIGOSACCHARIDE-PROTEIN CONJUGATES DERIVED FROM CLOSTRIDIUM DIFFICILE POLYSACCHARIDE PS-II, METHODS OF SYNTHESIS AND USES THEREOF, IN PARTICULAR AS A VACCINE  
The present invention provides an oligosaccharide-protein conjugate comprising an oligosaccharide, in particular synthetic oligosaccharide, derived from the repeating unit of the Clostridium...
US20140010850 ALBUMIN FIBERS AND FABRICS AND METHODS OF GENERATING AND USING SAME  
Provided are method of generating a fiber from a globular protein such as albumin. Also provided are albumin fibers and fabrics and methods of using same for bonding a damaged tissue or for ex...
US20140205839 PURE ALBUMIN AND ITS METHOD OF PREPARATION AND DETECTION  
The subject of the present invention is a pure monomeric bovine serum albumin, a method of producing it characterised by the use column chromatography in resin and a method of identifying it using...
US20140056906 SECRETED PROTEINS  
The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and...
US20130171652 Blocking Reagent and Methods for the Use Thereof  
The present invention relates to the use of a conjugate of a non-analyte-specific binding protein coupled to a nucleic acid as a blocking reagent in a probe-based detection assay, which uses a...

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