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US20090300802 |
Plant defense signal peptides
A 23 amino acid peptide, AtPep1, plays an important role as a signaling component of the innate immune system of Arabidopsis . The peptide precursor gene is transcribed in response to elicitors...
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US20090298919 |
Tumor homing molecules, conjugates derived therefrom, and methods of using same
The present invention provides tumor homing molecules, which selectively home to a tumor. The invention also provides methods of using a tumor homing molecule to target an agent such as a drug to a...
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US20090298762 |
CONJUGATES OF BIOLOGICALLY ACTIVE PROTEINS HAVING A MODIFIED IN VIVO HALF-LIFE
Disclosed are biologically active protein conjugates that comprise a biologically active polypeptide coupled via a peptide bond to a polypeptide comprising from 2 to about 500 units of a repeating...
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US20090298707 |
SPARSE MATRIX SYSTEM AND METHOD FOR IDENTIFICATION OF SPECIFIC LIGANDS OR TARGETS
In certain embodiments, this invention pertains to the creation of “Sparse Matrix” libraries of compounds. The sparse matrix libraries of this invention typically span an n-dimensional...
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US20090297689 |
PEPTIDYLARGININE DEIMINASE AND USES THEREOF IN THE PRODUCTION OF CITRULLINATED PROTEINS AND PEPTIDES
The present invention relates to a protein, peptide or protein hydrolysate wherein the molar ratio of citrulline and arginine residues, being part of protein or peptide, is at least 0.15,...
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US20090297545 |
IMMUNOMODULATORY DAIRY PEPTIDES AND USES THEREOF
The present invention provide a new method for modulating the immune system of a subject in need thereof by administering a dairy-derived peptide to the subject, particularly a...
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US20090292108 |
Insulinotropic peptide synthesis using solid and solution phase combination techniques
The present invention relates to the preparation of insulinotropic peptides that are synthesized using a solid and solution phase (“hybrid”) approach. Generally, the approach includes...
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US20090291899 |
Selective Modulation of Receptor Signalling
The present invention relates to a method of selectively modulating a signalling pathway of interest controlled by a cell receptor involved in signalling through multiple signalling pathways The...
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US20090291048 |
LEUKOCYTE-BINDING POLYPEPTIDES AND USES THEREOF
The present invention provides molecules capable of specifically binding the activated form of the beta-integrin Mac-1. The molecules may be provided in the form of peptides, polypeptides and...
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US20090286745 |
INHIBITION OF ALPHA-SYNUCLEIN AGGREGATION
This invention relates to the inhibition of alpha-synuclein aggregation using peptidyl compounds which are retroenantiomers of the alpha-synuclein sequence, in particular retroenantiomers of...
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US20090285843 |
EPITOPE SEQUENCES
Disclosed herein are polypeptides, including epitopes, clusters, and antigens. Also disclosed are compositions that include said polypeptides and methods for their use.
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US20090285753 |
Novel haptotactic peptides
Novel cell attachment peptides having sequences homologous to specific portions of the carboxy terminal sequence of fibrinogen chains are disclosed. The novel peptides, derived from proteins...
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US20090281278 |
MODIFIED MOLECULES WHICH PROMOTE HEMATOPOIESIS
The present disclosure relates to modified EPO mimetic peptides having specific properties.
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US20090281042 |
COMPOSITIONS AND METHODS USING SAME FOR THE DETECTION OF VIRUSES
An isolated peptide is provided. The isolated peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17,...
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US20090281032 |
Modified CCK peptides
The invention concerns a peptide based on biologically active CCK-8. The peptide has improved characteristics for the treatment of at least one of obesity and type 2 diabetes and has the structure:...
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US20090280190 |
ANTI-ANGIOGENIC PEPTIDES FROM THE N-TERMINUS OF ENDOSTATIN
Provided herein are anti-angiogenic comprising the N-terminal end of endostatin, nucleic acids encoding the same, pharmaceutical preparations comprising an effective amount of the peptide and...
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US20090280138 |
PEPTIDE
The present invention relates to peptide epitopes of 5T4 antigen and their use in immunotherapy. In particular, the present invention relates to any one of the peptide epitopes as described herein...
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US20090280137 |
Methods, Compositions, and Sequences of ZP-Binding Peptides for Immunocontraception of Dogs and Other Animals
Disclosed are methods, compositions, and zona pellucida binding peptides and polypeptides for use in immunocontraception of canines and other animals. The disclosed compositions may include...
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US20090275522 |
Novel Compounds
The present invention relates to novel compounds, pharmaceutical compositions comprising the same, use of said compounds for the manufacture of a medicament for treatment of inter alia shock...
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US20090275503 |
DIASTEREOMERIC PEPTIDES FOR MODULATING T CELL IMMUNITY
The present invention provides diastereomeric peptides derived from the T Cell Receptor alpha Transmembrane Domain, and lipophilic conjugates thereof, which peptides and conjugates are effective in...
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US20090275500 |
PEPTIDE-CONTAINING FOOD INTAKE REGULATOR
A safe and widely-applicable food intake regulator can be provided by using at least one peptide selected from the group consisting of a fish or mammalian melanin-concentrating hormone (MCH) and...
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US20090275101 |
Pancreatic Cancer Genes
The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or...
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US20090274714 |
TUMOUR-ASSOCIATED PEPTIDES BINDING TO HUMAN LEUKOCYTE ANTIGEN (HLA) CLASS I OR II MOLECULES AND RELATED ANTI-CANCER VACCINE
The present invention relates to immunotherapeutic methods, and molecules and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of...
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US20090270312 |
HIV-I GP41 FUSION PEPTIDES FOR IMMUNOMODULALTION
The present invention provides pharmaceutical compositions and methods for prevention or treatment of autoimmune diseases and other T cell mediated inflammatory diseases and conditions, which...
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US20090269847 |
SELF-ASSEMBLING PEPTIDE AMPHIPHILES AND RELATED METHODS FOR GROWTH FACTOR DELIVERY
Amphiphilic peptide compounds comprising one or more epitope sequences for binding interaction with one or more corresponding growth factors, micellar assemblies of such compounds and related...
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US20090269366 |
T CELL EPITOPE PEPTIDES OF 6B11 OVARIAN CANCER ANTI-IDIOTYPIC ANTIBODY
The present invention provides two T-cell epitode peptides of anti-idiotype antibody 6B11 of ovarian cancer, the sequences of which are shown in SEQ ID NO:3 or 6. The present invention also...
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US20090263847 |
LSR RECEPTOR, ITS ACTIVITY, ITS CLONING AND ITS APPLICATIONS TO THE DIAGNOSIS, PREVENTION AND/OR TREATMENT OF OBESITY AND RELATED RISKS OR COMPLICATIONS
The present invention relates to a new complex receptor polypeptide LSR (Lipolysis Stimulated Receptor), characterized by its functional activities, the cloning of the cDNAs complementary to the...
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US20090259020 |
HIGHLY FLUORINATED BETA-AMINO ACIDS AND METHODS OF MAKING AND USING SAME
Disclosed are compounds having the structure:
wherein R 1a and R 1b are independently H, alkyl, F, or fluoroalkyl; wherein R 2a , R 2b , R 2a′ , and R 2b′ are independently H, alkyl, F,...
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US20090258079 |
Biocompatible Block Copolymer, Use Thereof and Manufacturing Method Thereof
A biocompatible block copolymer having a hydrophobic segment composed of amino acid and hydroxycarboxylic acid and a hydrophilic segment composed of polyalkylene oxide, wherein the terminal not...
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US20090253896 |
SELECTIVE SUBSTRATES FOR MATRIX METALLOPROTEINASES
The invention provides isolated MMP-2, MMP-9 and MT1-MMP selective substrate polypeptides or functional peptidomimetics. The selective substrate polypeptides contain the following sequences: MMP-2...
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US20090253895 |
Printable Materials
The present invention provides compounds of the general formula I, and uses thereof for printing electronic components such as wires, resistors and LEDs.
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US20090253638 |
Somatostatin Antagonists
The invention features somatostatin antagonists having a D-amino acid at the second residue.
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US20090253636 |
Novel Antifungal Agent
It is intended to provide a novel peptide which can exert higher antifungal effect also on a patient whose organ function is impaired with no side effect problems. The peptide comprises the...
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US20090253635 |
PEPTIDES AND PEPTIDOMIMETICS HAVING ANTI-PROLIFERATIVE ACTIVITY AND/OR THAT AUGMENT NUCLEIC ACID DAMAGING AGENTS OR TREATMENTS
This invention provides compounds including peptides and peptidomimetics that can be used to treat cell proliferative disorders, such as those associated with benign and malignant tumor cells....
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US20090252752 |
KDR PEPTIDES AND VACCINES COMPRISING THE SAME
The present invention provides nonapeptides selected from peptides comprising the amino acid sequence of SEQ ID NO:2, 3, 5, 8, 11, or 12; nonapeptides or decapeptides selected from peptides...
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US20090247608 |
Targeting Lipids
The present invention provides targeting lipids of structure
L 100— linker—L 101 (CI),
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US20090247467 |
PEPTIDE EPITOPES OF VEGFR-2/KDR THAT INHIBIT ANGIOGENESIS
The disclosure provides antigenic peptides of Vascular Endothelial Growth Factor Receptor 2(VEGFR-2)/KDR. Pharmaceutical compositions including the peptides and/or antigen presenting cells that...
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US20090247464 |
Compositions and Methods for Topical Application and Transdermal Delivery of an Oligopeptide
The invention relates to the transdermal application of oligopeptides for reducing synaptic transmission in tissues of an animal. In one aspect, this invention relates to compositions comprising an...
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US20090247455 |
Isolation of Inhibitors of IRES-Mediated Translation
The present invention relates to a method for identifying or determining a compound that inhibits or reduces internal ribosome entry site (IRES) mediated translation. For example, the present...
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US20090246133 |
METHODS AND COMPOSITIONS RELATED TO INTERNALIZING RGD PEPTIDES
Disclosed are compositions and methods useful for targeting tissue undergoing angiogenesis or to cells or tissue expressing αv integrins. The compositions and methods are based on peptide...
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US20090239806 |
GLYPICAN-3 (GPC3)-DERIVED TUMOR REJECTION ANTIGENIC PEPTIDES USEFUL FOR HLA-A2-POSITIVE PATIENTS AND PHARMACEUTICAL COMPRISING THE SAME
It is an object of the present invention to identify a glypican-3-derived peptide which can bind to HLA-A2 and activate human killer T cells, so as to provide a means for carrying out an...
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US20090239246 |
Biomarkers
The invention provides methods for predicting, diagnosing or monitoring acute cardiac disorders, cardiac transplant rejection, or distinguishing acute cardiac disorders from pulmonary disorders, by...
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US20090238817 |
ANTI-CELL PROLIFERATIVE COMPOUNDS AND METHODS OF USE
The invention provides compounds such as proteins, peptides, peptidomimetics and small molecules, methods for treating cell proliferative disorders such as neoplasia, tumor, or cancer, and...
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US20090234096 |
Influenza inhibiting compositions and methods
The present invention provides compositions useful for treating or preventing influenza infections. The composition comprises an isolated polypeptide including a sequence of at least 8 contiguous...
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US20090233986 |
Methods and compositions for using sax2
The present invention is generally directed to factors involved in energy metabolism. More specifically, a new gene is identified and shown to be a homeobox Sax2 gene that is involved with an...
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US20090233870 |
Antimicrobial Peptides
The present invention relates to peptides with antimicrobial or endotoxin-neutralizing activity having the general formula (Xaa 1 ) M -(Xaa 2 ) 0 -Xaa 3 -(Xaa 4 ) P -(Xaa 5 ) Q -(Xaa 6 ) M -(Xaa 7...
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US20090233868 |
Small antiviral peptides against hepatitis C virus
Disclosed herein is a small 7 amino-acid peptide, corresponding to the C terminus of RRM2 of the human La protein that binds to the IRES element of hepatitis C virus RNA and its derivatives. This...
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US20090233859 |
Competitive Regulation of Hepcidin mRNA by Soluble and Cell-Associated Hemojuvelin
Disclosed herein are hemojuvelin-specific siRNAs that vary hemojuvelin mRNA concentration. Also disclosed herein, GPI-hemojuvelin positively regulated hepcidin mRNA expression, independently of the...
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US20090233854 |
NOVEL APPLICATION OF APELIN
The present invention provides a preventive/therapeutic agent for mood disorders or drug dependence, and so on. A pharmaceutical composition of the present invention comprising a substance...
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US20090233366 |
COMPOSITION FOR INTRODUCTION OF NUCLEIC ACID
Composition with weak cytotoxicity for introducing a nucleic acid, such as a short oligonucleotide or a gene, into a cell for expression of the gene in the cell. The composition includes a lipid...
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