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US20090292108 |
Insulinotropic peptide synthesis using solid and solution phase combination techniques
The present invention relates to the preparation of insulinotropic peptides that are synthesized using a solid and solution phase (“hybrid”) approach. Generally, the approach includes...
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US20090292003 |
CELL PENETRATING PEPTIDES FOR INTRACELLULAR DELIVERY OF MOLECULES
The present invention concerns cell-penetrating peptides which comprise an amino acid sequence consisting of GLX 9 RALX 9 RX 1 LX 2 RSLX 9 X 3 X 4 X 5 X 6 X 7 X 8 (SEQ ID No: 1), wherein X 1 is...
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US20090291898 |
Novel anti-microbial peptidomimetic compounds and methods to calculate anti-microbial activity
This invention encompasses synthetic antimicrobial peptide analogs having certain un-natural amino acids, including the un-natural amino acids hydrophobic tetrahydroisoquinolinecarboxylic acid...
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US20090291896 |
GENES ENCODING NOVEL PROTEINS WITH PESTICIDAL ACTIVITY AGAINST COLEOPTERANS
The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding δ-endotoxins having pesticidal activity against pests of the...
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US20090291441 |
POLYPEPTIDE, NUCLEIC ACID MOLECULE ENCODING IT AND THEIR USES
A polypeptide containing epitope of the amino acid sequence shown in SEQ ID NO:3 is provided, which is selected from the amino acid sequence of SEQ ID NO:3 and amino acids at 16-32 positions, amino...
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US20090286747 |
MNTF PEPTIDE COMPOSITIONS AND METHODS OF USE
The present invention relates to novel Motoneuronotrophic Factors (MNTF) peptides and analogs thereof, including compositions capable of promoting the growth and viability of neurons. MNTF peptides...
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US20090286742 |
Peptides Effective in the Treatment of Tumors and Other Conditions Requiring the Removal or Destruction of Cells
The invention is directed to methods of treating conditions requiring removal or destruction of harmful or unwanted cells in a patient, such as benign and malignant tumors, using compounds...
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US20090286740 |
PEPTIDES AND DERIVATIVES THEREOF, THE MANUFACTURING THEREOF AS WELL AS THEIR USE FOR PREPARING A THERAPEUTICALLY AND/OR PREVENTIVELY ACTIVE PHARMACEUTICAL COMPOSITION
Peptides and derivatives thereof of the following general formula I:
(SEQ ID NO: 1) (I) H 2 N-GHRPX 1 X 2 PX 3 X 4 X 5 PX 6 PPPX 7 X 8 X 9 X 10 B(1)B(2)B(3)- X 11 ,
wherein:
B(1) denotes...
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US20090286739 |
PEPTIDES, PEPTIDOMIMETICS AND DERIVATIVES THEREOF, THE MANUFACTURING THEREOF AS WELL AS THEIR USE FOR PREPARING A THERAPEUTICALLY AND/OR PREVENTIVELY ACTIVE PHARMACEUTICAL COMPOSITION
Peptides, peptidomimetics and derivatives thereof of the following general formula I:
(SEQ ID NO: 1) (I) H 2 N-GHRPX 1 X 2 X 3 - β -X 4 X 5 X 6 X 7 X 8 X 9 X 10 -X 11 ,
in which
X 1 -X 10 ...
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US20090286737 |
ERBB INTERFACE PEPTIDOMIMETICS AND METHODS OF USE THEREOF
Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in...
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US20090286722 |
Analogs of Gastric Inhibitory Polypeptide as a Treatment for Age Related Decreased Pancreatic Beta Cell Function
Peptide analogues and methods are provided for treating age-related symptoms of decreased pancreatic beta-cell function, including glucose intolerance, type 2 diabetes, beta-cell glucose...
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US20090286719 |
MODIFICATION OF CUPREDOXIN DERIVED PEPTIDES AND METHODS OF USE THEREOF
The present invention provides modified cupredoxin derived peptides with pharmacologic activity that have improved pharmacokinetic properties, and methods to use them to treat mammals suffering...
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US20090286293 |
ETHANOL PRODUCTION IN NON-RECOMBINANT HOSTS
Non-recombinant bacteria that produce ethanol as the primary fermentation product, associated nucleic acids and polypeptides, methods for producing ethanol using the bacteria, and kits are disclosed.
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US20090286224 |
Method for producing human antibodies with properties of agonist, antagonist, or inverse agonist
A method for obtaining agonist, antagonist and inverse agonist, to a given physiological receptor is disclosed. For the method, use is made of in silico design synthetic immunogens, which are...
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US20090285820 |
Methods of Treating Degenerative Disorders With Rac 1B Inhibitor
The invention relates to compositions and methods for treating degenerative disorders. More particularly, the invention relates to methods of treating amyloïd beta peptide-related disorders,...
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US20090285753 |
Novel haptotactic peptides
Novel cell attachment peptides having sequences homologous to specific portions of the carboxy terminal sequence of fibrinogen chains are disclosed. The novel peptides, derived from proteins...
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US20090281277 |
PEPTIDES CAPABLE OF BINDING TO SERUM PROTEINS AND COMPOUNDS, CONSTRUCTS AND POLYPEPTIDES COMPRISING THE SAME
The present invention relates to amino acid sequences that are capable of binding to serum proteins; to compounds, proteins, polypeptides, fusion proteins or constructs comprising or essentially...
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US20090281041 |
ANTIVIRAL CELL-PENETRATING PEPTIDES
Disclosed herein are cell penetrating peptides useful as treatment for Human Immunodeficiency Virus.
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US20090280190 |
ANTI-ANGIOGENIC PEPTIDES FROM THE N-TERMINUS OF ENDOSTATIN
Provided herein are anti-angiogenic comprising the N-terminal end of endostatin, nucleic acids encoding the same, pharmaceutical preparations comprising an effective amount of the peptide and...
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US20090280165 |
COMPOUNDS THAT BIND ALPHA5BETA1 INTEGRIN AND METHODS OF USE
The present invention provides biologically active compounds that bind an αsβi integrin. Also included in the present invention are methods for using such biologically active compounds.
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US20090280125 |
Prion epitopes and methods of use thereof
Prion peptides comprising prion epitopes and fusions thereof, that display enhanced immunogenicity are described. Also described are methods of treating and diagnosing prion disease.
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US20090275506 |
LONG LASTING NATRIURETIC PEPTIDE DERIVATIVES
This invention relates to long lasting natriuretic peptide (NP) derivatives. The NP derivative has a NP peptide and a reactive entity coupled to the NP peptide. The reactive entity is able to...
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US20090275504 |
PCSK9 PROTEINS, FRAGMENTS THEREOF AND METHODS OF MODULATING PCSK9 PHOSPHORYLATION AND LOW DENSITY LIPOPROTEIN (LDLR) DEGRADATION
The present invention provide PCSK9 polypeptides, fragments thereof and methods of modulating PCSK9 phosphorylation and low density lipoprotein degradation.
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US20090275503 |
DIASTEREOMERIC PEPTIDES FOR MODULATING T CELL IMMUNITY
The present invention provides diastereomeric peptides derived from the T Cell Receptor alpha Transmembrane Domain, and lipophilic conjugates thereof, which peptides and conjugates are effective in...
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US20090275101 |
Pancreatic Cancer Genes
The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or...
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US20090275083 |
ISOLATED PEPTIDES HAVING PHOSPHOLIPASE INHIBITORY ACTIVITY
The invention provides for isolated peptides having phospholipase inhibitory activity, polypeptides comprising phospholipase inhibitory activity and lipases capable of being inhibited by the...
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US20090275020 |
Traceability of Cellular Cycle Anomalies Targeting Oncology and Neurodegeneration
The present invention relates to the field of medicine and biology. It concerns a novel test for screening and for therapeutic follow-up in oncology. More particularly, it relates to diagnostic...
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US20090274714 |
TUMOUR-ASSOCIATED PEPTIDES BINDING TO HUMAN LEUKOCYTE ANTIGEN (HLA) CLASS I OR II MOLECULES AND RELATED ANTI-CANCER VACCINE
The present invention relates to immunotherapeutic methods, and molecules and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of...
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US20090274658 |
Tight Junction Modulating Peptides for Enhanced Mucosal Delivery of Therapeutic Compounds
Compositions and methods are provided that include a biologically active agent and a permeabilizing agent effective to enhance mucosal delivery of the biologically active agent in a mammalian...
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US20090274625 |
Compositions and Methods for The Treatment of Cancer
The instant invention provides methods and compositions for the treatment and diagnosis of cancer, e.g., cancers characterized by the expression of prostate specific membrane antigen (PSMA).
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US20090274619 |
TUMOR VASCULATURE MARKERS AND METHODS OF USE THEROF
This invention provides methods of detecting and localizing tumor vasculature cells (TVC) and solid tumors; and treating, impeding vascularization of, and determining the stage of solid tumors in a...
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US20090270334 |
NEURONAL DIFFERENTIATION INHIBITOR PEPTIDE AND USE THEREOF
Disclosed is a neuronal differentiation inhibitor which comprises at least one peptide capable of inhibiting or controlling the neuronal differentiation of at least one cell capable of being...
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US20090270333 |
Methods of using motilin homologs
The present invention is directed to polynucleotides, polypeptides and peptide fragments thereof, and uses thereof for a novel cDNA sequence which has homology to motilin. Tissue distribution of...
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US20090269847 |
SELF-ASSEMBLING PEPTIDE AMPHIPHILES AND RELATED METHODS FOR GROWTH FACTOR DELIVERY
Amphiphilic peptide compounds comprising one or more epitope sequences for binding interaction with one or more corresponding growth factors, micellar assemblies of such compounds and related...
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US20090269370 |
VACCINES COMPRISING MULTIMERIC HSP60 PEPTIDE CARRIERS
The present invention provides improved vaccine compositions having enhanced immunogenicity and methods of using same. The compositions and methods include immunogenic conjugates containing peptide...
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US20090269285 |
Diagnostic And Therapeutic Epitope, And Transgenic Plant
A peptide analogue which is not more than 50 amino acids in length, and which is capable of being recognized by a T cell receptor that recognizes an epitope comprising sequence 62 PQPELPY 68 (SEQ...
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US20090264365 |
CONFORMATIONALLY CONSTRAINED PARATHYROID HORMONE (PTH) ANALOGS
The present invention relates to conformationally constrained parathyroid hormone (PTH) analogs, and methods of preparing and using the PTH analogs. The invention provides novel PTH polypeptide...
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US20090264344 |
RETROCYCLINS: ANTIVIRAL AND ANTIMICROBIAL PEPTIDES
Retrocyclin peptides are small antimicrobial agents with potent activity against bacteria and viruses. The peptides are nonhemolytic, and exhibit minimal in vitro cytotoxicity. A pharmaceutical...
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US20090263847 |
LSR RECEPTOR, ITS ACTIVITY, ITS CLONING AND ITS APPLICATIONS TO THE DIAGNOSIS, PREVENTION AND/OR TREATMENT OF OBESITY AND RELATED RISKS OR COMPLICATIONS
The present invention relates to a new complex receptor polypeptide LSR (Lipolysis Stimulated Receptor), characterized by its functional activities, the cloning of the cDNAs complementary to the...
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US20090263783 |
NUCLEIC SEQUENCE AND DEDUCED PROTEIN SEQUENCE FAMILY WITH HUMAN ENDOGENOUS RETROVIRAL MOTIFS, AND THEIR USES
The present invention provides a translational product encoded by the nucleotide sequence of SEQ ID NO: 2, which corresponds to the gag gene of an endogenous human retrovirus named HERV-7q. The...
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US20090258079 |
Biocompatible Block Copolymer, Use Thereof and Manufacturing Method Thereof
A biocompatible block copolymer having a hydrophobic segment composed of amino acid and hydroxycarboxylic acid and a hydrophilic segment composed of polyalkylene oxide, wherein the terminal not...
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US20090253895 |
Printable Materials
The present invention provides compounds of the general formula I, and uses thereof for printing electronic components such as wires, resistors and LEDs.
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US20090253635 |
PEPTIDES AND PEPTIDOMIMETICS HAVING ANTI-PROLIFERATIVE ACTIVITY AND/OR THAT AUGMENT NUCLEIC ACID DAMAGING AGENTS OR TREATMENTS
This invention provides compounds including peptides and peptidomimetics that can be used to treat cell proliferative disorders, such as those associated with benign and malignant tumor cells....
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US20090253632 |
Therapeutic peptides and method
A polypeptide comprising one or more sequences derived from CDR2 or CDR3 of a TREM- 1 protein, characterised by the ability to treat, ameliorate, or lessen the symptoms of conditions including...
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US20090253631 |
Anti-Inflammatory Peptides
The present invention relates, inter alia, to a method of ameliorating an inflammatory skin condition. Thus, the present invention provides a peptide that includes the amino acid sequence KMIKP...
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US20090253629 |
USE OF DEFENSINS AGAINST MENINGITIS
The present invention relates to methods for treating meningitis, such as bacterial meningitis, with defensin polypeptides.
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US20090253619 |
Novel peptide involved in energy homeostasis
The expression of a mRNA encoding a putative 76 amino acid, secreted protein (“Enho1”) was found to negatively correlate with fasting triglyceride and cholesterol levels. A recombinant...
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US20090253206 |
NUCLEAR TRANSPORT AGENT AND METHOD FOR PRODUCING SAID AGENT
The present invention relates to a transport agent for transporting nucleic acids into eukaryotic cells and a method for producing said agent. The invention further concerns methods for...
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US20090247608 |
Targeting Lipids
The present invention provides targeting lipids of structure
L 100— linker—L 101 (CI),
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US20090247464 |
Compositions and Methods for Topical Application and Transdermal Delivery of an Oligopeptide
The invention relates to the transdermal application of oligopeptides for reducing synaptic transmission in tissues of an animal. In one aspect, this invention relates to compositions comprising an...
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