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US20120058153 SYNTHETIC NANOCARRIER VACCINES COMPRISING PROTEINS OBTAINED OR DERIVED FROM HUMAN INFLUENZA A VIRUS HEMAGGLUTININ  
This invention relates to compositions and methods that can be used immunize a subject against influenza. Generally, the compositions and methods include polypeptides obtained or derived from...
US20130071862 FUSION PROTEINS AND THEIR USE IN THE DIAGNOSIS AND TREATMENT OF LEISHMANIASIS  
The present invention relates generally to a fusion protein made from a synthetic gene construct comprising of elements derived from the Leishmania antigens K26, K39, and K9. The fusion protein is...
US20100310461 BINDING OF PATHOLOGICAL FORMS OF PROTEINS USING CONJUGATED POLYELECTROLYTES  
A method for treatment of a disease caused by aggregation of misfolded proteins including subjecting a body fluid of a patient to a separation of an aggregated misfolded protein which includes...
US20130023026 IMMOBILIZATION OF MEMBRANE PROTEINS ONTO SUPPORTS VIA AN AMPHIPHILE  
The invention pertains to the field of membrane protein immobilization onto supports. It relates to a product comprising a support and at least one membrane protein attached to the surface...
US20120129766 METHODS OF TREATING FGF21-ASSOCIATED DISORDERS  
The invention relates to the identification of new polypeptide and protein variants of fibroblast growth factor 21 (FGF21) that have improved pharmaceutical properties. Also disclosed are methods...
US20150192585 METHOD OF EXAMINING MAMMARY GLAND DISEASE  
The object of the present invention is to provide an early mastitis detection method that can detect mastitis easily and quickly when compared to the prior methods and also a biomarker to be used...
US20120063954 ADSORBENTS FOR THE ADSORPTION OF HEPCIDIN  
The invention relates to a device and a method for depletion of hepcidin from blood for treatment of iron deficiency, in particular in anemic patients suffering from chronic renal failure, with...
US20110250215 STRUCTURALLY-RELATED RELAXIN-FUSION PROTEINS WITH EXTENDED IN VIVO HALF-LIVES  
Disclosed are human relaxin-Fc fusion proteins having an increased serum half-life, polynucleotides encoding the same, and intermediates formed during the fusion protein biosynthesis. The fusion...
US20140221569 DECORATED MACROMOLECULAR SCAFFOLDS  
The present invention relates to a method for preparing decorated macromolecular scaffolds. The method of the invention is useful for the generation of bioactive nanoparticles for use in clinical...
US20130045489 NEURAL NANOPROBES  
Neural nanoprobes are described, as well as methods for their use, including for use as a tagging system for neuronal pathway identification. The neural nanoprobes comprise metallic nanoparticles...
US20110212466 Thiol-Modified Surface Immobilization Article And Method  
A method and article to immobilize a protein, including, for example, combining the protein and a mixture comprised of an activated spacer compound having a maleimide group in a buffer solution,...
US20140256879 METHOD FOR SYNTHESIZING PROTEINS  
Method for assembling proteins from peptide fragments. It allows the production of proteins in a manner that is simple, reliable and applicable on an industrial scale. This method allows the...
US20110123592 Biomaterials  
The invention relates to a biomaterial having a latent form of a growth factor immobilised thereon, and to a method of producing the biomaterial, comprising immobilising the latent form of the...
US20110027889 Synthetic Microcarriers for Culturing Cells  
A coated microcarrier for cell culture includes a microcarrier base and a polymeric coating grafted to the base via a polymerization initiator. A method for forming the coated microcarrier...
US20120121537 Methods and Compositions for Inhibiting Hepatitis C Virus Replication  
Compositions and methods for reducing hepatitis C virus (HCV) replication are provided. Also provided are compositions and methods of treating an HCV infection; methods of reducing the incidence...
US20120121531 BIOCOMPOSITE FOR ARTIFICIAL TISSUE DESIGN  
The present invention concerns a biocomposite useful in artificial tissue replacement, methods for its production, and methods of use. The biocomposite can be implanted into humans or animals as...
US20110142756 Method And Composition For The Treatment Of Cancer By The Enzymatic Conversion Of Soluble Radioactive Toxic Precipitates In The Cancer  
The invention features compositions and methods for treating or alleviating a symptom of cancer. The compositions and methods of the invention direct supra-lethal doses of radiation, called...
US20120202263 Bioactive Macromers and Hydrogels and Methods for Producing Same  
The invention concerns macromers, having a molecular weight of at least 2 kDa, comprising at least one unit of the formula P-(protein-P)n, wherein: P is selected from polyethylene glycol (PEG),...
US20150226746 LIGHT HARVESTING MULTICHROMOPHORE COMPOSITIONS AND METHODS OF USING THE SAME  
Light harvesting luminescent multichromophores that are configured upon excitation to transfer energy to, and amplify the emission from, an acceptor signaling chromophore in energy-receiving...
US20120329127 THERAPEUTIC PROTEINS WITH INCREASED HALF-LIFE AND METHODS OF PREPARING SAME  
The present disclosure relates to materials and methods of conjugating a water soluble polymer to a therapeutic protein.
US20110318297 SINGLE PROTEIN NANOCAPSULES FOR PROTEIN DELIVERY WITH LONG-TERM EFFECT  
A protein nanocapsule having a single-protein core and a thin polymer shell anchored covalently to the protein core.
US20140199232 Targeted Therapeutic Nanoparticles  
Disclosure of methods and compositions related to chemical conjugations to nanoparticles of polysaccharides cross-linked to poloxamers as well as nano-sized colloids comprised of polysaccharides...
US20120020911 MATRIX COMPOSED OF A NATURALLY-OCCURRING PROTEIN BACKBONE CROSS LINKED BY A SYNTHETIC POLYMER AND METHODS OF GENERATING AND USING SAME  
The present invention relates to biodegradable scaffolds composed of a naturally-occurring protein backbone cross-linked by a synthetic polymer. Specifically, the present invention provides...
US20110142789 Compositions and Methods for the Diagnosis and Treatment of Amyotrophic Lateral Sclerosis  
Compositions and methods for diagnosis and treatment of ALS are provided.
US20120076749 Modified Blood Factors Comprising a Low Degree of Water Soluble Polymer  
The present invention relates, in general, to materials and methods for the preparation of modified blood factors which have low levels of water soluble polymer molecules conjugated to the blood...
US20140037588 INJECTABLE THERMORESPONSIVE POLYELECTROLYTES  
Provided herein are compositions, devices and systems comprising thermoresponsive, biodegradable elastomeric materials, and methods of use and manufacture thereof.
US20110135707 POLYHYDROXYALKANOATES FOR IN VIVO APPLICATIONS  
Polyhydroxyalkanoates (PHAs) from which pyrogen has been removed are provided for use in numerous biomedical applications. PHAs which have been chemically modified to enhance physical and/or...
US20120276159 TOLEROGENIC SYNTHETIC NANOCARRIERS  
This invention relates, at least in part, to compositions comprising synthetic nanocarriers and immunosuppressants that result in immune suppressive effects. Such compositions can further comprise...
US20140161762 DRUG DELIVERY OF TEMOZOLOMIDE FOR SYSTEMIC BASED TREATMENT OF CANCER  
The present invention relates to methods of drug delivery for the treatment of a condition or disease, such as cancer. In one embodiment, the invention provides a method of preparing a...
US20120328555 DRUG DELIVERY OF TEMOZOLOMIDE FOR SYSTEMIC BASED TREATMENT OF CANCER  
The present invention relates to methods of drug delivery for the treatment of a condition or disease, such as cancer. In one embodiment, the invention provides a method of preparing a...
US20120115962 CYCLODEXTRIN-MODIFIED POLYAMINES FOR DELIVERY OF THERAPEUTIC MOLECULES  
The present invention is directed to drug delivery vehicles comprising one or more cyclodextrin moieties conjugated to a dendritic polyamine for the delivery of small molecule and protein...
US20110038828 MATRIX COMPOSED OF A NATURALLY-OCCURRING PROTEIN BACKBONE CROSS LINKED BY A SYNTHETIC POLYMER AND METHODS OF GENERATING AND USING SAME  
A method of treating a disorder characterized by tissue damage is provided. The method comprising providing to a subject in need-thereof a composition which comprises a synthetic polymer attached...
US20120211423 DRAW SOLUTE FOR FORWARD OSMOSIS, DRAW SOLUTION INCLUDING THE SAME, FORWARD OSMOSIS WATER TREATMENT DEVICE USING THE SAME, AND FORWARD OSMOSIS METHOD FOR WATER TREATMENT USING THE SAME  
A draw solute for forward osmosis may include a copolymer including a first structural unit where a temperature-sensitive side chain is graft polymerized, and a second structural unit including a...
US20150011683 Keratin in Rubber Applications  
A rubber composition includes an elastomer having an elongation at break (Eb) of about 50% or more according to ASTM-D 412 at 25° C., a water-insoluble keratin, and a reinforcing filler. A tire...
US20140039125 POLYMALIC ACID-BASED MULTIFUNCTIONAL DRUG DELIVERY SYSTEM  
A drug delivery system for delivering a drug payload to a specific tissue or cell type is disclosed. The system includes a polymalic acid molecular scaffold which can be used for attaching a...
US20120100185 REGENERATION OF TISSUE WITHOUT CELL TRANSPLANTATION  
The present invention provides methods and compositions for tissue regeneration without cell transplantation.
US20100330143 MODIFIED MACROMOLECULES AND METHODS OF MAKING AND USING THEREOF  
Described herein are composites produced by reacting a first thiolated macromolecule with at least one compound having at least one thiol-reactive electrophilic functional group. The methods...
US20140193342 ENZYME DIRECTED ASSEMBLY OF PARTICLE THERANOSTICS  
Provided herein is a method for enzymatically triggered assembly of polymeric nanostructures for detection of cancer-associated enzymes in vivo. By detecting enzymatic signals associated with...
US20120258049 POLYMALIC ACID BASED NANOCONJUGATES FOR IMAGING  
Nanoconjugates that include a polymalic-based molecular scaffold with one or more imaging moiety and one or more targeting modules attached to the scaffold are provided. Methods of targeting a...
US20130052155 Compositions and Methods for Treating a Disorder or Defect in Soft Tissue  
The present invention encompasses methods and compositions for generating a biomimetic proteoglycan. The invention includes methods of treating a disease, disorder, or condition of soft tissue...
US20140004048 WATER-SOLUBLE NANOPARTICLES  
The invention relates to water-soluble nanoparticles and methods for making such nanoparticles. Specifically, the invention relates to dendrimerization to enhance the solubility of nanoparticles.
US20130072598 Thermoplastics from Distillers Dried Grains and Feathers  
A thermoplastic biobased material-containing composition comprising chemically-modified feathers and/or dried distillers grains and a process for forming the thermoplastic biobased...
US20130017166 Protein-Poly(2-oxazoline) Conjugates for Enhanced Cellular Delivery and Transport Across Biological Barriers  
The present invention provides polymer conjugates and methods of use thereof.
US20130142734 TARGETED DELIVERY SYSTEMS FOR DIAGNOSTIC APPLICATIONS  
Targeting of imaging probes specifically to diseased tissues such as cancer is attractive because it potentially allows the improvement of tumor detection. One of the problems associated with...
US20130158191 Method and Formulation For Reinforcing Elastomers  
A rubber composition has a base rubber, a filler which is a protein, including soy protein, derived from byproducts resulting from the manufacture of biodiesel fuel and a coupling agent.
US20140004076 RECOMBINANT HUMAN G-CSF DIMER AND USE THEREOF FOR THE TREATMENT OF NEUROLOGICAL DISEASES  
This invention relates to a recombinant human G-CSF (rhG-CSF) dimer and its use in the treatment of neurological disorder. In particular, upon ischemic neural injury in animal, this invention can...
US20110293554 RECOMBINANT HUMAN G-CSF DIMER AND USE THEREOF FOR THE TREATMENT OF NEUROLOGICAL DISEASES  
This invention relates to a recombinant human G-CSF (rhG-CSF) dimer and its use in the treatment of neurological disorder. In particular, upon ischemic neural injury in animal, this invention can...
US20130189219 N-TERMINALLY CHEMICALLY MODIFIED PROTEIN COMPOSITIONS AND METHODS  
Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof,...
US20120095166 SELF-ASSEMBLING MONOMERS AND OLIGOMERS AS SURFACE-MODIFYING ENDGROUPS FOR POLYMERS  
Polymers having the formula R(LE)X wherein R is a polymeric core having a number average molecular weight of from 5000 to 7,000,000 daltons and x endgroups, E is an endgroup that is covalently...
US20090189986 BIOMIMETIC MODELLING SYSTEMS FOR REPRODUCING SPREADING PHENOMENA OF COSMETIC AND PHARMACEUTICAL FORMULATIONS ON HUMAN SKIN  
The invention relates to a skin substitute for investigating the behavior of cosmetic and pharmaceutical compositions to be applied topically, where the skin substitute is a three-dimensionally...