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US20090304783 |
COMPOSITIONS AND METHODS FOR TREATING BACTERIA
The present invention relates to the field of bacteriology. In particular, the present invention provides compositions (e.g., comprising a lantibiotic and mupirocin or gentamicin) and methods of...
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US20090305955 |
Cyclopeptide with Anti-Cancer Activity Derived from Collagen Type IV
The present invention relates to a cyclopeptide characterized in that it comprises the YSNS amino acid sequence, and more particularly a cyclopentapeptide which forms a β-bend structure at the...
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US20090305956 |
Treatment of Ras-Expressing Tumors
The present invention provides compositions and methods for the treatment of /?αs-expressing tumors using at least one DAC inhibitor (e.g., romidepsin).
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US20090305958 |
STABILIZING ALKYLGLYCOSIDE COMPOSITIONS AND METHODS THEREOF
The present invention relates to alkylglycoside-containing compositions and methods for increasing the stability, reducing the aggregation and immunogenicity, increasing the biological activity,...
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US20090305954 |
HISTIDINE-CONTAINING DIASTEREOMERIC PEPTIDES AND USES THEREOF
Diastereomeric peptides with a net positive charge greater than +1, and cyclic derivatives thereof, are provided, having at least 13 amino acid residues, comprising histidine and one or more...
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US20090305957 |
PREPARATION OF BIODEGRADABLE POLYESTERS WITH LOW-BURST PROPERTIES BY SUPERCRITICAL FLUID EXTRACTION
The invention provides methods of extracting a biodegradable polyester with a supercritical fluid effective to obtain a purified biodegradable polyester, such as a purified biodegradable...
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US20090291880 |
METHODS COMPRISING DESMOPRESSIN
The present disclosure is directed to gender, age, and dose effects of desmopressin on reducing nocturnal voids, increasing an initial period of undisturbed sleep, and/or reducing nocturnal urine...
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US20090291881 |
COATINGS FOR DRUG DELIVERY DEVICES
A polymer coating for medical devices based on a polyolefin derivative. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The...
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US20090291879 |
Modulation of cartilage homeostasis by active domains of cell binding extracelular matrix molecules
A linear or cyclic peptide and the use of said peptide in medicine and especially in the manufacture of a medicament for the treatment and/or prophylaxis of a disease associated with inflammatory...
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US20090285895 |
Pharmaceutical Formulation for Regulating the Timed Release of Biologically Active Compounds Based on a Polymer Matrix
A formulation containing a biologically active compound having a structure with hydrogen bonding sites is blended with a polymer having a structure with complementary hydrogen bonding sites, the...
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US20090280083 |
Compounds for the Treatment of Hepatitis C
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating...
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US20090275498 |
NOVEL PEPTIDES
The invention relates to an isolated, synthetic or recombinant χ-conotoxin peptide having the ability to inhibit a neuronal amine transporter, nucleic acid molecules encoding all or part of such...
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US20090275499 |
NONSTRUCTURAL PROTEIN NS1 AS A NOVEL THERAPEUTIC TARGET AGAINST FLAVIVIRUSES
The secretion or biological activity of Flaviviruses, as well as the biological activity of NS1 protein from Flavivirus-infected cells, can be inhibited by contacting the cells or the protein with...
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US20090274730 |
COMPOSITIONS AND METHODS FOR TREATING INFLAMMATION
Provided are electrokinetically-generated fluids (e.g., gas-enriched electrokinetic fluids or solutions), and therapeutic compositions and methods for use in treating inflammation or at least one...
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US20090269394 |
METHODS AND COMPOSITIONS FOR TREATING ONCHOMYCOSIS
The present invention relates to methods for treating and completely curing fungal, yeast and/or mold infections in human subjects comprising topically administering to a human subject in need...
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US20090264342 |
COMPOSITIONS AND METHODS FOR ANTIBIOTIC POTENTIATION AND DRUG DISCOVERY
The present invention provides methods for identifying target genes whose partial or complete functional inactivation potentiates the activity of an antibiotic agent, e.g., a quinolone antibiotic....
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US20090263334 |
Cyclic Glycyl-2-Allyl Proline Improves Cognitive Performance in Impaired Animals
Embodiments of this invention provide methods for therapeutic use of cyclic G-2-Allyl Proline to treat cognitive disorders as well as manufacture of medicaments including tablets, capsules,...
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US20090258070 |
Topical LFA-1 antagonists for use in localized treatment of immune related disorders
This invention provides specifically formulated LFA-1 antagonists or pharmaceutically acceptable salts thereof that are suitable for topical delivery. In particular, the LFA-1 antagonists are...
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US20090247452 |
PHARMACEUTICAL FORMULATIONS FOR REDUCING PAIN
The present invention is direct to a method of producing analgesia in a mammalian subject. The method includes administering to the subject an omega conopeptide, preferably ziconotide, in...
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US20090238867 |
Nanoparticulate Anidulafungin Compositions and Methods for Making the Same
Nanoparticulate compositions comprising anidulafungin are described, as well as methods of making such compositions. Also described are methods for treatment of fungal infections.
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US20090238858 |
Compositions and Methods for Treating Ophthalmic Diseases
Degradable polymeric compositions containing water-insoluble drugs blended with copolymers of biocompatible diphenol compound monomer units with pendant carboxylic acid groups polymerized with...
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US20090221472 |
Method for treating transplant rejection
Compositions and methods for treating transplant rejection in a mammalian transplant recipient are provided. The method involves administering a therapeutically effective amount of Serp- 1 , its...
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US20090215675 |
Means for the inhibition of anti-beta1-adrenergic receptor antibodies
The present invention is related to a peptide selected from the group comprising a) a cyclic peptide of formula (I): Cyclo(AIa-x-x-x-x-x-x-x-x-x-Cys-x-x-x-Pro-x-Cys-Cys-xk-GIn),
(I) whereby k is...
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US20090215676 |
Method of treatment
Disclosed is a method for attenuating the effects of growth hormone (GH) in a subject. The method comprises the administration of both a GH antagonist and a somatostatin agonist to said subject,...
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US20090215677 |
POLYMYXIN DERIVATIVES AND USES THEREOF
The present invention relates to a polymyxin derivative wherein R1, R2 and R3 are optional and R1, R2, R3, R5, R8 and R9 are cationic or neutral amino acid residues selected so that the total...
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US20090208552 |
CROSS-LINKED FATTY ACID-BASED BIOMATERIALS
Fatty acid-based, pre-cure-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be...
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US20090209456 |
COMPOSITIONS AND METHODS FOR IMPROVING FACIAL AND BODY AESTHETICS
Compositions and methods of treating facial and body tissue aesthetics and reconstruction are disclosed using immunosuppressive agents either by themselves or in conjunction with other soft tissue...
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US20090203582 |
LYSOBACTIN AMIDES
The invention relates to lysobactin amides and methods for their preparation, as well as their use for manufacturing medicaments for the treatment and/or prophylaxis of diseases, in particular...
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US20090203583 |
Use of Type-B Lantibiotic-Based Compounds having Antimicrobial Activity
The present invention provides methods for the treatment or prophylaxis of a microbial infection of the lower intestine or colon in a subject, the method comprising administering to the subject a...
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US20090203581 |
Novel Peptides for Use in the Treatment of Obesity
The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment...
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US20090197799 |
METHODS FOR PREPARING PURIFIED LIPOTIDES
The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria,...
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US20090197798 |
COMPOSITION FOR TREATING CANCER AND USE THEREOF
The present invention provides a cyclic peptide containing RRXR motif. The present invention also provides a composition comprising the said cyclic peptide and a pharmaceutical acceptable carrier....
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US20090191216 |
Antibody or a fragment thereof, having neutralizing activity against HIV
The invention relates to a monoclonal antibody or a fragment thereof, recognizing a peptide of sequence set forth as SEQ ID NO 7 or an analogue thereof, wherein the complementarity determining...
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US20090186809 |
USE OF VALPROIC ACID FOR THE TOPICAL TREATMENT OF MILD TO MODERATE ACNE VULGARIS
The present invention provides a surprising therapeutic beneficial use for the topical application of valproic acid as a single agent therapy for patients suffering from mild to moderate acne...
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US20090175822 |
C5-SUBSTITUTED, PROLINE-DERIVED, MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS
The present invention relates to compounds of Formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof:
which inhibit serine protease activity, particularly the activity of...
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US20090175846 |
Oligodendrocyte-Myelin Glycoprotein Compositions and Methods of Use Thereof
The present invention is based on the discovery that oligodendrocyte-myelin glycoprotein (OMgp), which is ex-pressed by oligodendrocytes and CNS myelin, negatively regulates oligodendrocyte and...
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US20090169510 |
NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION
The embodiments provide compounds of the general Formulae I through general Formula VIII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The...
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US20090170753 |
CAPSOFUNGIN FORMULATIONS
The present invention relates to pharmaceutical compositions comprising a pharmaceutically acceptable salt of caspofungin as active ingredient being useful for the prevention and/or treatment of...
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US20090162454 |
Compositions and Methods for Effecting NAD+ Levels Using A Nicotinamide Phosphoribosyl Tranferase Inhibitor
The present invention relates to methods for decreasing cellular DNA repair in a target patient; decreasing cellular NAD + biosynthesis in a target patient; increasing efficiency of radiation...
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US20090156471 |
Use of anti-amyloid agents for treating and typing pathogen infections
A method of preventing or treating a pathogen infection in a subject is provided. The method comprising administering to a subject in need thereof a therapeutically effective amount of an anti...
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US20090137462 |
PHARMACEUTICAL COMPOSITION COMPRISING CYCLIC SOMATOSTATIN ANALOGUES
The present invention describes parenteral pharmaceutical compositions comprising a somatostatin analogue and novel somatostatin analogues.
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US20090124537 |
Screening method for bone morphogenetic mimetics
Disclosed are methods for identifying agents which modulate the activity of bone morphogenetic protein-7. These methods for identifying agents utilize bone morphogenetic protein receptors,...
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US20090123370 |
ALPHAVBETA6 PEPTIDE LIGANDS AND THEIR USES
AVβ6 peptide ligands, functional variants thereof and their nucleic acids encoding them are disclosed with their uses in the treatment and imaging of AVβ6 mediated diseases.
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US20090118167 |
Selective Vpac2 Receptor Peptide Agonists
The invention provides VPAC2R peptide agonists coupled to at least one polyethylene glycol molecule or derivative thereof, resulting in a biologically active peptide with an extended half-life and...
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US20090118168 |
TOPICAL ADMINSTRATION OF ACYCLOVIR
The present invention provides a topical composition comprising (a) at least one delivery agent compound and (b) a acyclovir compound. Methods of treatment, and methods of preparing the topical...
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US20090111741 |
METHOD FOR TREATING AND/OR PREVENTING DRUG SEEKING BEHAVIOR
A dynorphin-A analog can be used for treatment, inhibition, and/or prevention of cocaine seeking behavior, and or the drug seeking behavior for a cocaine derivative or other structurally related...
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US20090105128 |
CANNABINOID RECEPTOR TARGETED AGENT
Compounds of the following formula:
wherein X is H or substituted with
with at least one X being substituted; and halo is fluorine, chlorine, bromine, iodine; and stereoisomers and conjugable...
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US20090082258 |
Means and Methods for Treating Advanced Stage Neuroblastoma
The present invention relates to uses of compounds having a structure as shown by formula (I) for the manufacture of a pharmaceutical composition for the treatment of neuroblastoma. Moreover, the...
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US20090082259 |
DEUTERIUM-ENRICHED OCTREOTIDE
The present application describes deuterium-enriched octreotide, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
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US20090074871 |
Composition for filling bone defects
The invention is directed toward an improved formable bone composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing...
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