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US20090291124 |
Functional Nano-Layered Hemostatic Material/Device
The present invention utilizes a nano-coating of an oxide such as silica, a silicate or another effective oxide on a surface to accelerate blood clotting in mammalian animals. The hemostatic layer...
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US20090291049 |
Targeted delivery to human diseases and disorders
The present invention provides a system presenting site-specific accumulation through a ligand that specifically targets a receptor overexpressed on the surface of specific cells within a target...
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US20090286717 |
Glycopeptide Antibiotic Derivative
The present invention provides a novel glycopeptide antibiotic derivative. These derivatives are represented by the formula (I)
or a pharmaceutically acceptable salt or solvate thereof,
...
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US20090285908 |
METHOD OF TREATING ENDOTHELIAL INJURY
The use of human erythropoietin (EPO) to prevent or treat endothelial injury due to chemotherapy, radiation therapy, mechanical trauma, or to a disease state which damages the endothelium (such as...
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US20090285838 |
USE OF SOLUBLE CD164 IN INFLAMMATION AND AUTOIMMUNE DISORDERS
The present invention relates to novel therapeutic uses of soluble proteins comprising the extracellular region of human CD164, in particular for treating inflammatory and/or autoimmune disorders.
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US20090285800 |
Aberrant expression of CKS1 and CKS2 and uses thereof
The present invention is drawn to providing a therapeutic strategy for prostate cancer. In this regard, the present invention demonstrates that elevated expression of Cks1 contributes to...
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US20090281022 |
Method for Producing Factor VII Glycoforms
The present invention provides preparations of Factor VIIa polypeptides or Factor VIIa-related polypeptides that exhibit predetermined glycoform patterns. The preparations of the invention exhibit...
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US20090280094 |
Treatment of Ischemic Diseases Using Erythropoietin
Disclosed is a method for stimulating revascularization in a subject comprising the steps of:
(a) administering erythropoietin to the subject; (b) collecting peripheral blood mononuclear...
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US20090275497 |
METHOD FOR IDENTIFYING MODULATORS OF THE ACTIVITY OF ION-CHANNELS RECEPTORS
The present invention is directed to a method for selecting or identifying a compound capable of modulating the activity of an ion-channels receptor, such as GABA receptor, by measuring the calcium...
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US20090270310 |
Process for the preparation of a nutrient formulation
The present invention relates to a process for increasing the efficacy and/or bioavailability of a nutrient formulation or composition for the treatment and/or prevention of inflammatory processes...
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US20090269385 |
COMPOSITE IMPLANTS FOR PROMOTING BONE REGENERATION AND AUGMENTATION AND METHODS FOR THEIR PREPARATION AND USE
Collagen based matrices cross-linked by a reducing sugar(s) are used for preparing composite matrices, implants and scaffolds. The composite matrices may have at least two layers including reducing...
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US20090269325 |
Methods for treating bleeding disorders using sulfated polysaccharides
Methods for treating bleeding disorders using non-anticoagulant sulfated polysaccharides (NASPs) as procoagulants are disclosed. NASPs can be administered as single agents, or in combination with...
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US20090264341 |
PURIFIED ARABINOGALACTAN-PROTEIN (AGP) COMPOSITION USEFUL IN THE TREATMENT PSORIASIS AND OTHER DISORDERS
A purified Arabinogalactan-Protein (AGP) composition isolated through a selective method from the leaves and/or stems of Argemone mexicana plant is described. Also described is a purified...
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US20090264340 |
COMPOSITIONS AND METHODS FOR INCREASING THE ORAL ABSORPTION OF ANTIMICROBIALS
The present invention provides compositions and methods for increasing absorption of antibacterial agents, particularly third generation cephalosporin antibacterial agents, in oral dosage solid...
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US20090264339 |
Heterocyclic Compounds
This invention relates to heterocyclic compounds of the formulas shown in the specification. It also relates to methods for treating inflammatory diseases or immune diseases, developmental or...
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US20090263412 |
Non-Splicing Variants of gp350/220
Compositions comprising gp350 variant DNA and amino acid sequences are provided, as are vectors and host cells containing such sequences. Also provided is a process for producing homogeneous gp350...
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US20090263389 |
Use of TGF-Beta Antagonists to Treat or to Prevent Chronic Transplant Rejection
Effective use of a TGF-β antagonist to treat or to prevent loss of transplant function is described herein. Use of a TGF-β antagonist is demonstrated to effectively prevent loss of organ function...
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US20090263353 |
Novel Sulphonylpyrroles as Inhibitors of Hdac S Novel Sulphonylpyrroles
Compounds of a certain formula I,
in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, as well as salts thereof are novel effective HDAC inhibitors.
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US20090258822 |
Diagnosis and Treatment of Age-Related Macular Degeneration
The invention relates to Factor H gene polymorphisms and haplotypes associated with an elevated or a reduced risk of AMD. The invention provides methods and reagents for diagnosis and treatment of...
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US20090258821 |
Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs with an extended therapeutic window
Methods and uses are provided for a pharmaceutical composition with an erythropoietin or a tissue protective cytokine for protecting or restoring function to a responsive cell, tissue, organ or...
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US20090258820 |
ECHINOCANDIN/CARBOHYDRATE COMPLEXES
A complex of an echinocandin compound with a carbohydrate is described having improved thermal stability and water solubility. A process for making the echinocandin/carbohydrate complex is also...
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US20090258004 |
HUMAN BLOOD PROTEINS EXPRESSED IN MONOCOT SEEDS
The invention is directed to blood proteins produced in monocot seeds and isolated therefrom for use in therapeutic compositions, and to methods of making these isolated blood proteins and to...
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US20090257951 |
NGR receptor and methods of identifying tumor homing molecules that home to angiogenic vasculature using same
The present invention provides a method of identifying a tumor homing molecule that homes to angiogenic vasculature by contacting a substantially purified NGR receptor with one or more molecules...
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US20090252722 |
Botulinum Neurotoxin a Protein Receptor and Uses Thereof
The invention relates to a polypeptide comprising an amino acid sequence, at least 70 percent of which are identical to the amino acid sequence of the synaptic vesicle glycoprotein of homo sapiens...
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US20090247451 |
Therapeutic Compositions for Age-Related Macular Degeneration
The invention relates to Factor H gene polymorphisms and haplotypes associated with an elevated or a reduced risk of AMD. The invention provides methods and reagents for diagnosis and treatment of...
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US20090247450 |
G-CSF LIQUID FORMULATION
The invention relates to G-CSF liquid formulations that have a long shelf-life and to methods for producing the same. The invention also relates to liquid formulations containing G-CSF as the...
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US20090246248 |
COATING COMPOSITIONS HAVING IMPROVED PERFORMANCE
The presently disclosed subject matter provides compositions comprising a first substrate-binding domain (a peptide or a polymer) having binding affinity for a tissue or a medical device, a second...
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US20090246133 |
METHODS AND COMPOSITIONS RELATED TO INTERNALIZING RGD PEPTIDES
Disclosed are compositions and methods useful for targeting tissue undergoing angiogenesis or to cells or tissue expressing αv integrins. The compositions and methods are based on peptide...
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US20090239790 |
NOVEL RECOMBINANT PROTEINS WITH N-TERMINAL FREE THIOL
The present invention relates to novel modified proteins having N-terminal free thiols that can be produced by recombinant methods and are ready for further chemical derivatization. In particular,...
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US20090239789 |
METHODS OF TREATMENT WITH DRUG LOADED POLYMERIC MATERIALS
Polymeric microparticles have been developed which encapsulate therapeutic compounds such as drugs, cellular materials or components, and antigens, and can have targeting ligands directly bound to...
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US20090239788 |
RECOMBINANT OR TRANSGENIC FACTOR VII COMPOUND HAVING A MAJORITY OF GLYCAN, BIANTENNARY, BISIALYLATED AND NON-FUCOSYLATED FORMS
The present invention concerns a recombinant or transgenic factor VII compound, each factor VII molecule of the compound having glycan forms linked to N-glycosylation sites, wherein among all the...
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US20090239787 |
SELF-FOAMING CEMENT FOR VOID FILLING AND/OR DELIVERY SYSTEMS
A self-foaming bone cement is described herein. In one variation, the bone cements include a self setting calcium phosphate cement formulation which when cured, forms macroscopic pores of varying...
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US20090238789 |
Modified erythropoietin polypeptides and uses thereof
Modified erythropoietin (EPO) polypeptides and other modified therapeutic polypeptides are provided. The EPO polypeptides and other therapeutic polypeptides are modified to exhibit physical...
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US20090233847 |
Coupling Proteins to a Modified Polysaccharide
The invention relates to a method for coupling proteins to a starch-derived modified polysaccharide. The binding interaction between the modified polysaccharide and the protein is based on a...
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US20090233846 |
HUMAN LUTEINIZING HORMONE SUPERAGONISTS
The invention is directed toward a human glycoprotein hormone having at least one, two, three, four, or five basic amino acids in the α-subunit at positions selected from the group consisting of...
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US20090233845 |
Methods and compositions for non-covalently enhanced receptor binding
The invention features contacting (in vitro or in vivo) a receptor-binding ligand with an organic molecule, which can be a small molecule (i.e., an organic molecule that is not a peptide), or a...
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US20090233844 |
Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs
Methods and compositions are provided for protecting or enhancing an erythropoietin-responsive cell, tissue, organ or body part function or viability in vivo, in situ or ex vivo in mammals,...
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US20090232835 |
Composition for delivery of hematopoietic growth factor
A hematopoietic growth factor delivery composition includes a hematopoietic growth factor, a liquid vehicle, a first biocompatible polymer and a second biocompatible polymer. The composition...
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US20090228994 |
Antibody Composition-Producing Cell
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a...
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US20090227489 |
STAT3 Agonists and Antagonists and Therapeutic Uses Thereof
The present invention relates to methods for modulating, i.e., agonizing or antagonizing, Stat3 (Signal Transducer and Activator of Transcription3) signaling activity for use in gene therapy....
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US20090227488 |
Class of bioactive glycoprotein
The invention relates to a bioactive chemical composition, more specifically to proteins and can be used in medicine, veterinary and cell biology. The invented glycoproteins are extracted with the...
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US20090226460 |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE
The present invention relates to pharmaceutical compositions for the treatment and/or prophylaxis of disease associated with fibrosis in a vertebrate, said composition comprising at least one...
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US20090226397 |
COMPOSITIONS AND METHODS FOR REDUCING THE LIKELIHOOD OF IMPLANTATION FAILURE OR MISCARRIAGE IN RECIPIENTS OF ARTIFICIAL INSEMINATION
Methods and kits for preventing or reducing the likelihood of implantation failure or miscarriage in a recipient of artificial insemination are provided. The methods include administering into a...
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US20090221471 |
PRODRUGS OF VANCOMYCIN WITH HYDROLYSIS RESISTANT POLYMER LINKAGES
Vancomycin-polymer conjugates are disclosed. In preferred aspects, polymer residues which are hydrolysis resistant in vitro, are selectively attached to the sugar amino and/or N-methyl amino groups...
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US20090221470 |
USE OF AN ECHINOCANDIN ANTIFUNGAL AGENT IN COMBINATION WITH A GLYCOPEPTIDE ANTIBACTERIAL AGENT
This invention is directed to methods of administering an echinocandin antifungal agent in combination with a glycopeptide antibacterial agent having a substituent comprising at least about 8...
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US20090220595 |
COMBINATION OF ERYTHROPOIETIN GLYCOISOFORMS
This invention relates to a combination of erythropoietin glycoisoforms, wherein such glycoisoforms may include a quantity of sialic acid ranging from 4 to 10 molecules of sialic acid per molecule...
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US20090220588 |
Simultaneous Delivery of Receptors and/or Co-Receptors for Growth Factor Stability and Activity
The compositions and methods of the present invention relate to the co-delivery of a molecule and a polypeptide to cells to improve the therapeutic efficacy of the molecules. In one embodiment of...
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US20090220518 |
METHODS AND COMPOSITIONS FOR TREATMENT OF GRAFT REJECTION AND PROMOTION OF GRAFT SURVIVAL
Embodiments herein illustrate methods of treating, reducing or preventing transplantation rejection and/or side effects associated with transplantation. Some embodiments relate to compositions and...
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US20090220455 |
PHARMACEUTICAL COMPOSITIONS COMPRISING ELP FUSION PROTEINS
Genetically-encodable, environmentally-responsive fusion proteins comprising ELP peptides. Such fusion proteins exhibit unique physico-chemical and functional properties that can be modulated as a...
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US20090220451 |
CYCLOPROPYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS
Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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