Matches 1 - 50 out of 199 1 2 3 4 >

AcclaimIP-ad

Match Document Document Title
US20130164367 TREATMENT OF NEURODEGENERATIVE DISEASE WITH CREB-BINDING PROTEIN  
The present invention relates to improving cognition and treating of neurodegenerative disease using CREB-binding protein. The protein may be delivered to the brain by an expression vector, in...
US20140243264 METHODS OF TREATMENT FOR RETINAL DISEASES  
The present invention provides methods of treating a retinal disorder comprising administering an effective amount of a neurotrophic factor to a subject having the retinal disorder. The...
US20120316112 RESCUE OF PHOTORECEPTORS BY INTRAVITREAL ADMINISTRATION OF AN EXPRESSION VECTOR ENCODING A THERAPEUTIC PROTEIN  
The invention provides methods for treating ocular diseases using a recombinant vehicle to express a protein useful in the treatment of ocular disease, with particular preference for use of...
US20150231208 Treatment of Allodynia, Hyperalgsia, Spontaneous Pain, and Phantom Pain  
The present invention relates to use of Cometin in a method of treatment of allodynia, hyperalgesia, spontaneous pain and/or phantom pain. In a preferred embodiment the disorder to be treated is...
US20140274897 METHOD FOR PREVENTING AND TREATING DIABETES USING NEURTURIN  
The present invention relates generally to methods for preventing and/or treating pancreatic disorders, particularly those related to diabetes, by administering a neurturin protein product.
US20140349930 TREATMENT USING NEUBLASTIN POLYPEPTIDES  
The invention relates to treatments of neuropathic pain, including tactile allodynia, and to treatments for reducing loss of pain sensitivity associated with neuropathy. The present treatments...
US20150202262 TREATMENT OF ALLODYNIA, HYPERALGESIA, SPONTANEOUS PAIN AND PHANTOM PAIN  
The present invention relates to the use of Meteorin for the treatment of allodynia, hyperalgesia, spontaneous pain and phantom pain. In a preferred embodiment the disorder to be treated is...
US20110071078 METHODS FOR TREATING NEUROLOGICAL DEFICITS  
The present invention features methods and compositions for treating a patient who has a neurological deficit. The method can be carried out, for example, by contacting (in vivo or in culture) a...
US20120064030 METHODS OF TREATING NERVOUS SYSTEM CONDITIONS  
Methods of treating nervous system conditions. In at least one embodiment of a method of treating a mammalian patient having a neuronal injury or insult of the present disclosure, the method...
US20140315805 LOCALLY RELEASED GROWTH FACTORS TO MEDIATE MOTOR RECOVERY AFTER STROKE  
Methods of improving recovery of a mammal after an ischemic event (e.g., stroke) are provided. In various embodiments the methods involve administering a neural growth factor (e.g., BDNF) into the...
US20110274718 System for Modulating Expression of Hypothalmic Brain-Derived Neurotrophic Factor (BDNF)  
Methods for treating tumor associated diseases by administering a nucleic acid sequence encoding brain derived neurotrophic factor (BDNF) where the expression reduces the symptoms of the disease...
US20130309304 COMPOUNDS AND METHODS  
The present invention relates to pharmaceutical formulations suitable for targeting particular tissue and/or organ(s) with a formulated active ingredient, for example when administered upstream of...
US20120195939 PARENTERAL COMPOSITION COMPRISING MICROSPHERES WITH A DIAMETER BETWEEN 10 AND 20 MICRONS  
The present invention relates to pharmaceutical formulations suitable for targeting particular tissue and/or organ(s) with a formulated active ingredient, for example when administered upstream of...
US20120064029 COMPOSITIONS FOR TREATING NERVOUS SYSTEM CONDITIONS  
Compositions for treating nervous system conditions. In at least one embodiment of a stem cell conditioned medium of the present disclosure, the stem cell comprises a cell culture supernatant...
US20050163764 Treatment with agonists of toll-like receptors  
Mammals are treated with agonists of bacterially-activated TLRs. The agonist are administered orally or mucosally. In one embodiment, the mammal treated is subject to a gastro-intestinal injury....
US20140031284 NEUREGULIN VARIANTS AND METHODS OF SCREENING AND USING THEREOF  
The present invention provides polypeptide variants of neuregulin-1β (NRG-1β) that have enhanced or decreased binding affinity to ErbB3 and/or ErbB4. The invention also provides methods of...
US20110217264 METHODS AND COMPOSITIONS FOR DELIVERY OF EXOGENOUS FACTORS TO NERVIOUS SYSTEM SITES  
The present invention relates to treatment methods and methods for sustained delivery of one or more exogenous factors to desired nervous system sites. In certain embodiments, the invention...
US20120009245 Administration of Growth Factors for the Treatment of CNS Disorders  
A method and system that is directed to the local delivery of growth factors to the mammalian CNS to treat CNS disorders associated with neuronal death and/or dysfunction is described.
US20100330050 USE OF HUMAN STEM CELLS AND/OR FACTORS THEY PRODUCE TO PROMOTE ADULT MAMMALIAN CARDIAC REPAIR THROUGH CARDIOMYOCYTE CELL DIVISION  
The present invention relates to methods and compositions for stimulating the proliferation of cardiomyocytes for enhancement of cardiac repair. The invention is based on the discovery that upon...
US20110293578 Use of Stem Cells to Prevent Neuronal Dieback  
The invention is generally directed to treatment of neuronal injury. In particular, the invention is directed to reducing axonal retraction (“dieback”) that occurs as a result of the interaction...
US20150164989 COMPOSITIONS COMPRISING PEDF AND USES OF SAME IN THE TREATMENT AND PREVENTION OF OVARY-RELATED SYNDROMES  
A method of treating or preventing an ovary-related syndrome associated with infertility in a subject in need thereof is provided. The method comprising administering to the subject a...
US20150024025 ALIGNED NANOFIBROUS STRUCTURES FOR AXONAL REGENERATION AFTER SPINAL CORD INJURY OR SURGERY  
Embodiments of the present disclosure provide for aligned nanofibrous polymer matrix structure, structures incorporating aligned nanofibrous polymer matrix structures, methods of using aligned...
US20110217280 METHODS FOR TREATING NEUROPSYCHIATRIC CONDITIONS  
Provided herein are methods for treating a subject suffering from a neuropsychiatric condition (e.g., schizophrenia). The methods include systemic administration of a pharmacological composition...
US20130267464 THERAPEUTIC USE OF A GROWTH FACTOR, METRNL  
The present invention relates to the field of therapeutic use of proteins, genes and cells, in particular to the therapy based on the biological function of a secreted therapeutic protein, METRNL,...
US20130078220 DOPAMINERGIC NEURONAL SURVIVAL-PROMOTING FACTORS AND USES THEREOF  
In general, the invention features substantially purified MANF and substantially purified nucleic acids encoding the same. The invention also features a pharmaceutical composition that includes...
US20130259875 ACTH FOR TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS  
Provided herein are methods of treatment of Amyotrophic Lateral Sclerosis comprising administration of adrenocorticotropic hormone (ACTH), or fragment, analog, complex or aggregate thereof, or any...
US20110129462 INTRANASAL ADMINISTRATION OF ACTIVE AGENTS TO THE CENTRAL NERVOUS SYSTEM  
Pharmaceutical compositions and methods for delivering a polypeptide to the central nervous system of a mammal via intranasal administration are provided. The polypeptide can be a catalytically...
US20070299010 CPG15 and CPG15-2 compounds and inhibitors as insulin receptor and insulin-like growth factor receptor agonists and antagonists  
Disclosed herein are CPG15 and CPG15-2 compounds and inhibitors that act as agonists and antagonists of the insulin receptor and insulin-like growth factor receptors, and the use of such...
US20150020222 NEUROTROPHIC FACTOR MANF AND USES THEREOF  
The present invention generally relates to the field of treatment of neuronal disorders and more particularly to neurotrophic factor MANF and uses thereof. The present invention provides a...
US20070293428 Methods of treating joint pain in a subject by using an anti-angiogenic agent  
A method for treating a joint pain in a subject comprising providing an effective amount of an anti-angiogenic agent to a synovial capsule adjacent to the joint.
US20140296142 GENE THERAPY FOR DIABETIC NEUROPATHY USING AN HGF ISOFORM  
The present invention relates to a pharmaceutical composition for the prevention or treatment of diabetic neuropathy, wherein the pharmaceutical composition comprises, as active ingredients,...
US20140377360 COMPOSITION FOR CONTROLLED RELEASE OF PHYSIOLOGICALLY ACTIVE SUBSTANCE  
A composition for controlled release of a physiologically active substance can release a physiologically active substance in vivo at the desired timing. The composition includes an inner layer...
US20100291065 Compositions for Protein Delivery and Methods of Use Thereof  
Compositions and methods for the delivery of a protein of interest are provided.
US20150094263 Use of Neuregulin to Treat Peripheral Nerve Injury  
The disclosure provides compositions and methods for preventing, ameliorating a sign or symptom of, or treating peripheral nerve injury.
US20080260644 CHLORIDE TRANSPORT UPREGULATION FOR THE TREATMENT OF TRAUMATIC BRAIN INJURY  
Compositions and methods are provided for the alleviation of pathology induced by traumatic brain injury.
US20110136738 Alternatively Transcribed Genes Associated with Schizophrenia  
Methods of identifying gene targets associated with schizophrenia or the symptoms thereof, as well as to specific nucleic acid molecules that have been discovered to be associated with...
US20120214737 METHODS FOR PROTECTING DOPAMINERGIC NEURONS FROM STRESS AND PROMOTING PROLIFERATION AND DIFFERENTIATION OF OLIGODENDROCYTE PROGENITORS BY NRG-2  
The invention features methods of treatment and diagnosis using NRG-2 polypeptides, nucleic acid molecules, and antibodies. The invention also provides novel NRG-2 polypeptides and nucleic acid...
US20150025008 Compositions and Methods of Detecting and Treating Neural Tube Defects  
The present invention generally relates to compositions, reagents and methods for detecting and treating a neural tube defect in a fetus. One aspect of the invention provides a method including...
US20080020975 Galanin Receptors and Brain Injury  
There is provided the use of a GALR2-specific agonist in the preparation of a medicament for the prevention or treatment of brain injury, damage or disease, wherein the brain injury or damage is...
US20070027079 GHRP 2 strips  
The products that exist on the market today that produce the same results are with injection. This new product, HGH Strips, is taken orally through strips that are placed on the back of the...
US20110052531 CYCLIC GLYCYL-2-ALLYL PROLINE AND ITS USE IN TREATMENT OF PERIPHERAL NEUROPATHY  
Embodiments of this invention provide methods for therapeutic use of cyclic G-2-allylProline (cG-2-allylP) to treat peripheral neuropathies, including toxin-induced peripheral neuropathy and...
US20050143299 Use of relaxin as adjuvant in the differentiation of stem cells for the reconstruction of tissues  
On the basis of the experimental results it has emerged that relaxin has a pro-differentiating effect on stem cells. It is therefore suggested the use of this hormone as principal component of a...
US20090111748 FIBROBLAST GROWTH FACTOR-2 PROMOTES NEUROGENESIS AND NEUROPROTECTION AND PROLONGS SURVIVAL IN HUNTINGTON'S DISEASE  
This invention pertains to the discovery that fibroblast growth factor 2 (FGF2) stimulates neurogenesis, induces migration of newborn cells into the striatum and cortex, is neuroprotective, and...
US20120269815 NEUROTROPHINS AND USES THEREOF  
A neurotrophin polypeptide, and a biologically active fragment thereof, are described. Also, methods are disclosed that include providing a composition comprising the neurotrophin polypeptide to a...
US20060234922 Remedy for corneal failure  
The present invention provides a new type of pharmaceutical agent that recovers corneal sensitivity after corneal surgery or improves the condition of dry eye. Application of a somatostatin...
US20080113908 Use of CRF receptor agonists for the treatment or Prophylaxis of diseases, for example Neurodegenerative diseases  
CRF receptor agonists, especially CRF receptor-1 agonists such as CRF, urocortin, sauvagine or urotensin 1, can be used for the prevention or inhibition of neuronal cell death in a mammal...
US20130171139 NCAM-VASE AND NEURODEGENERATION  
Inhibitors of NCAM-VASE, compositions comprising said inhibitors, and methods of using said inhibitors for stimulation of neuroplasticity and/or neuroregeneration in the central nervous system,...
US20060105958 Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis  
The present invention provides a method of increasing neural stem cell numbers or neurogenesis by using a pheromone, a luteinizing hormone (LH) and/or a human chorionic gonadotrophin (hCG). The...
US20130237477 COMPOSITIONS AND METHODS FOR INCREASING VASCULARIZATION  
Disclosed are methods of increasing vascularization in a tissue by administering a neublastin polypeptide to a mammal exhibiting impaired or inadequate blood flow in the tissue. The methods can be...
US20110104165 METHOD OF UPREGULATING SORLA FOR THE TREATMENT OF ALZHEIMER'S DISEASE  
The present invention is directed to use of an agent capable of upregulating the Vps10p-domain receptor SorLA. In particular, the present invention relates to use of CTGF and/or BDNF and/or...
Matches 1 - 50 out of 199 1 2 3 4 >