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US20060002963 Use of emulsions for intra and periocular injections  
A method for treating eye diseases by injecting intraocularly or periocularly a composition comprising an emulsion and optionally at least a pharmaceutical active ingredient.
US20090054328 Reagents and Methods for Modulating Gene Expression Related to Hypertension  
This invention relates to gene expression and proliferation in eukaryotic, preferably mammalian and most preferably human cells. The invention specifically relates to hypertension associated with...
US20130195991 Composition for Treatment of Damaged Part  
The present invention provides a damaged part treatment composition for repairing a damaged part of a target tissue that includes a stem cell-conditioned medium obtained by culturing stem cells; a...
US20120039980 COMPOSITIONS AND SYSTEMS FOR FORMING CROSSLINKED BIOMATERIALS AND ASSOCIATED METHODS OF PREPARATION AND USE  
Methods of preventing adhesion between issues are provided that utilizes in situ crosslinked biomaterials. The biomaterial contains at least the crosslinked product of two biocompatible,...
US20080200377 POLYMER PARTICLES  
A composition including a solution suitable for introduction into a blood vessel comprising particles comprising a treatment agent and a polymeric product of at least one activated diamine and at...
US20070025957 Vascular targeting of ocular neovascularization  
Methods of treating or preventing eye disease in a subject, involving administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a polypeptide...
US20070207966 Polymeric carrier for delivery of small interfering RNA  
A carrier for delivering small interfering RNA (siRNA) into cells includes a cholesterol residue covalently bonded to oligoarginine. Mixing the siRNA with the carrier produces a complex-containing...
US20070065414 Enhanced delivery of cells  
The present invention provides a method comprising administering cells by infusion through a blood vessel and administering a vasodilator, a vascular enhancer, or both. In accordance with one...
US20100278736 FLT4 (VEGFR-3) as a Target for Tumor Imaging and Anti-Tumor Therapy  
The present invention provide purified Flt4 receptor tyrosine kinase polypeptides and fragments thereof, polynucleotides encoding such polypeptides, antibodies that specifically bind such...
US20100287625 VEGF VARIANTS  
This invention relates to a Vascular Endothelial Growth Factor (VEGF) polypeptide, which polypeptide lacks an amino acid sequence encoded by exon 5 of the VEGF gene. This variant of VEGF is...
US20070190101 Flowable bone grafts  
The present invention is directed to bone graft compositions suitable for administration to the body via a cannula, where the compositions contain mineralized collagen particles and a fluid...
US20060293231 Method for enhancing bone formation  
This invention provides a method for facilitating bone formation in a subject comprising delivering to a bone formation-requiring site a composition of matter comprising platelet-rich plasma,...
US20060089307 Peptides that bind to the heparin binding domian of vegf and vegfr-2  
The present invention relates to new peptides for targeting that bind to the heparin binding domain of vascular endothelial growth factor and its receptor vascular endothelial growth factor...
US20110002880 Material For Wound Healing and Skin Reconstruction  
The invention relates to a material for wound healing and skin reconstruction containing a peptide, wherein the peptide is a self-assembling peptide which is an amphiphilic peptide having 8 to 200...
US20060223104 Methods and compositions for modulating necdin function  
Described herein are methods for identifying and using inhibitors of Necdin function to promote brown adipose tissue (BAT) differentiation, thereby treating obesity.
US20070224178 Multimeric constructs  
Multimeric fusion proteins of an Ig-like domain of Flt-1 are rendered functional by inclusion of a linker moiety. Vectors encoding the fusion proteins and host cells expressing the fusion proteins...
US20070014755 Wound healing polymeric networks  
A composition includes at least one biologically active agent covalently attached to a first polymerizing molecule that is adapted to undergo a free radical polymerization. The first polymerizing...
US20070248675 Composite comprising polysaccharide-functionalized nanoparticle and hydrogel matrix, a drug delivery system and a bone defect replacement matrix for sustained release comprising the same, and the preparation method thereof  
The present invention relates to a nanoparticle-protein-hydrogel composite comprising (1) a polysaccharide-functionalized nanoparticle comprising a core composed of a biodegradable polymer, a...
US20070111944 Purification of vascular endothelial growth factor-B  
The present invention provides a method for purifying recombinant peptides, polypeptides or proteins away from truncated or other full-length forms of these molecules. In particular the invention...
US20050222007 Pharmaceutical composition and method for treatment or prevention of vascular disease or states of tissue hypoperfusion with hypoxic and/or ischemic consequences  
Disclosed is the use of a substance selected from the group consisting of human apo-lactoferrin and/or peptides derivable from human lactoferrin and/or natural metabolites of human lactoferrin...
US20120009123 Albumin binding peptide-mediated disease targeting  
The invention provides compositions and methods for delivering a therapeutic or diagnostic agent to a disease site in a mammal, the method comprising administering to the mammal a therapeutically...
US20090163414 IN-VITRO METHOD FOR SCREENING ACCESSIBLE BIOLOGICAL MARKERS IN PATHOLOGICAL TISSUES  
The present invention refers to an in vitro method for screening specific disease biological markers which are accessible from the extracellular space in pathologic tissues comprising the steps...
US20050181995 Venom-derived vascular endothelial growth factor-like protein having binding activity specific to vascular endothelial growth factor receptor type 2 and use thereof  
An objective of the present invention is to provide a newly isolated vascular endothelial growth factor (VEGF)-like protein having binding activity specific to a vascular endothelial growth factor...
US20150025007 Methods to reduce scarring  
The invention is directed to novel cellular factor-containing solution compositions (referred to herein as “CFS” compositions), including novel sustained-release cellular factor-containing...
US20070141055 Methods and compositions for protein-hydroxy apatite complexes and their application in testing and modulating immunological system including a novel in vitro test for the detection of antibodies against calcium binding protein-hydroxy apatite complexes  
The invention relates to methods and compositions for the manufacture and use of novel hydroxy apatite (HA)-calcium binding protein (CaBP) complexes (CaBP-HA complex) that are useful as antigen...
US20130172252 Methods for promoting hair growth  
The invention is directed to methods for promoting hair growth. Such methods utilize novel compositions, including but not limited to extraembryonic cytokine secreting cells (herein referred to as...
US20080118480 Methods and Compositions for Directing Migration of Neural Progenitor Cells  
Method for modulating the migration of neural progenitor cells in a mammal by exposing the cells to a VEGFR-2 ligand and FGF-2. Methods of treating neurological disorders by exposing the mammal to...
US20140377330 Bioactive Hydrogel  
The invention relates to a bioactive hydrogel as a hybrid material of heparin and star-branched polyethylene glycol with functionalized end groups, wherein the heparin is bound directly by...
US20120058943 Bioactive Hydrogel  
The invention relates to a bioactive hydrogel as a hybrid material of heparin and star-branched polyethylene glycol with functionalized end groups, wherein the heparin is bound directly by...
US20060105950 Morphogen compositions and use thereof to treat wounds  
Disclosed are compositions and methods for promoting or accelerating wound healing and preventing, treating, or reducing symptoms associated with wounds or wounding disorders such as diabetic...
US20090215687 Compounds for Enhancing Hypoxia Inducible Factor Activity and Methods of Use  
The present invention relates to methods for enhancing Hypoxia inducible factor-1 (HIF) activity in a cell by contacting the cell with any one of the following compounds:...
US20070135344 Novel growth factor and a genetic sequence encoding same  
The present invention relates to an isolated molecule having vascular endothelial growth factor-like properties and to a genetic sequence encoding the molecule.
US20070116768 Sustained release preparations composed of biocompatible complex microparticles  
A particle includes a complex between a bioactive agent and a complexing agent, provided that the bioactive agent is other than a polynucleotide and an oligonucleotide, and wherein the particle...
US20120263759 Coating Comprising An Elastin-Based Copolymer  
A copolymer comprising a block of an elastin pentapeptide and method of making and using the copolymer are provided. The copolymer may be used as a coating on a stent. Methods of using a stent...
US20080147065 FLOWABLE CARRIER COMPOSITIONS AND METHODS OF USE  
A composition is provided for faster bone repair and early orthopedic implant fixation. The composition comprises an osteoinductive or osteopromotive biological factor embedded in a carrier...
US20100305034 GROWTH FACTOR ISOFORM  
An isolated VEGF polypeptide having anti-angiogenic activity, said polypeptide including the amino acid sequence of SEQ.ID NO.1, or variants thereof.
US20120321591 ANTI-ANGIOGENIC COMPOUNDS  
The present invention provides various uses of VEGF binding peptides, including methods to treat disorders associated with abnormal angiogenesis. In addition, the invention provides VEGF peptides...
US20060073128 Means and methods for the modulation of arteriogenesis  
The present invention relates generally to the modulation of arteriogenesis and/or the growth of collateral arteries or other arteries from preexisting arteriolar connections. In particular, the...
US20060014204 Methods of inducing formation of functional and organized lymphatic vessels  
Methods of inducing formation of functional and organized lymphatic vessels are described. Specifically, the methods relate to using Tie2 agonists to induce formation of functional and organized...
US20070053870 Polysaccharide-functionalized nanoparticle, drug delivery system for controlled release comprising the same and preparation method thereof  
The present invention provides a polysaccharide-functionalized nanoparticle, a drug delivery system for controlled release comprising the nanoparticle and a preparation method thereof. In...
US20100285000 USE OF VEGFR-2 INHIBITORS FOR TREATING METASTATIC CANCER  
The present application provides compositions and methods for treating metastatic cancer. Patients having or at risk of developing metastases may be treated. Compositions useful for the invention...
US20050233964 Chimeric VEGF peptides  
Compositions for and methods of treating patients with malignancies associated with overexpression of VEGF, particularly ovarian cancer. The compositions include but are not limited to certain...
US20080019918 Medicinal Preparation  
A pharmaceutical preparation has a ligand structure specifically recognizing a target site and an amphiphilic compound having a hydrophobic or amphiphilic group. The pharmaceutical preparation...
US20070212390 Protease-resistant forms of VEGF-D, method of making and method of use  
The present invention provides modified VEGF-D polypeptide variants that are resistant to serine protease processing and methods of making and using the same, as well pharmaceutical compositions...
US20100093624 PEPTIDE THERAPEUTICS THAT BIND VEGF AND METHODS OF USE THEREOF  
The present invention provides peptides and mimetics thereof that bind to VEGF. In preferred embodiments, the peptides of the invention are D type optical isomers which can bind VEGF and which can...
US20080038203 Compositions and Methods for Topical Diagnostic and Therapeutic Transport  
Compositions and therapeutic methods are provided that are useful agent for the delivery, including transdermal delivery, of biologically active agents, such as non-protein non-nucleotide...
US20070269449 Fc Fusion Proteins  
The invention relates to fusion proteins comprising at least a first domain and a second domain selected from a constant Fc immunoglobulin domain.
US20100239654 VESICULAR PHOSPHOLIPID GELS COMPRISING PROTEINACEOUS SUBSTANCES  
The present invention relates to a pharmaceutical composition for sustained release of a pharmaceutically active compound, the composition comprising a vesicular phospholipid gel. More...
US20050032693 Novel polypeptides, their nucleic acids, and methods for their use in angiogenesis and vascularization  
The present invention is directed to novel polypeptides critical for angiogenesis and vascularization, and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors...
US20080045463 Methods For Lowering Hif-1 Mediated Gene Expression  
The present invention relates to the elucidation of specific molecular features of endogenous amino acids and their derivatives for inhibiting hypoxia-inducible gene expression by preventing...