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US20100291027 HYALURONIC ACID (HA) INJECTION VEHICLE  
Disclosed herein are compositions that exhibit viscosities suitable for injectable formulations. The compositions comprise bioactive agent-loaded microparticles and hyaluronic acid or a salt...
US20100272733 ANTIBODIES SPECIFIC TO PRO-ANGIOGENIC ISOFORMS OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF)  
The present invention provides antibodies, as well as molecules having at least the antigen-binding portion of an antibody, against agonist pro-angiogenic, pro-permeability, vasodilatory isoforms...
US20100204114 USE OF A GALANIN PEPTIDE AS A THERAPEUTIC AGENT  
The present invention is directed to the use of the peptide compound Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala- Val-Gly-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-Asn-Gly-Leu-Thr-Ser- OH as...
US20100160241 NOVEL COMPOUND HAVING GPR54 AGONISTIC ACTIVITY  
The present invention provides a compound represented by the following formula (1); wherein R1 is an aryl group etc.;R2 is —CO—NH— etc.;R3 is a methyl group having an aromatic group or a...
US20100029572 Neurotrophic Peptides  
The present invention relates to a neurotrophic peptide having an amino acid sequence selected from the group consisting of VG-DGGLFEKKL (SEQ ID No. 1), EDQQVHFTPTEG (SEQ ID No. 2) and...
US20080090758 CONJUGATES OF DISORAZOLES AND THEIR DERIVATIVES WITH CELL-BINDING MOLECULES, NOVEL DISORAZOLE DERIVATIVES, PROCESSES OF MANUFACTURING AND USES THEREOF  
The present invention provides conjugates of disorazoles and their derivatives with cell-binding molecules, such as peptides, proteins, hormones, blood proteins and antibodies. The present...
US20170100518 Cardiovascular Prostheses  
Cardiovascular prostheses for treating, reconstructing and replacing damaged or diseased cardiovascular tissue that are formed from acellular extracellular matrix (ECM). The cardiovascular...
US20170100506 PROTEASE RESISTANT GROWTH FACTOR FORMULATIONS FOR CHRONIC WOUND HEALING  
A formulation and method of treating chronic wounds is presented. The formulation uses two different fusion peptides, one of which incorporates an elastase resistant peptide, to preserve the...
US20170020961 Methods for Treating Peripheral Nerve Damage  
VEGF-B, as well as a combination of VEGF-B and VEGF-A, mediates peripheral nerve repair. Methods to treat damage to the peripheral nervous system are described.
US20170014547 AMPHIPHILIC DEGRADABLE POLYMERS FOR IMMOBILIZATION AND SUSTAINED DELIVERY OF BIOMOLECULES  
The invention provides a novel approach to controlled delivery of biomolecules (e.g., lipids and proteins) by employing novel amphiphilic polymers that are effective delivery vehicles. These...
US20170007677 PHARMACEUTICAL COMPOSITION FOR CANCER TREATMENT AND PHARMACEUTICAL PREPARATION FOR CANCER TREATMENT CONTAINING SAME COMPOSITION AS ACTIVE INGREDIENT  
The invention provides a novel anticancer therapeutic having a high effect against solid cancers, lacking the side effects of chemotherapeutics, and being unlikely to cause resistance. Provided is...
US20170002056 FUSION PROTEIN INHIBITING ANGIOGENESIS OR GROWTH AND USE THEREOF  
Provided are a fusion protein inhibiting angiogenesis or vascular growth, coding sequence thereof, vector comprising the coding sequence, host cell, pharmaceutical composition and use of the...
US20160367602 Methods for treating hidradenitis suppurativa  
The invention is directed to methods for treating Hidradenitis Suppurativa. Specifically, the invention is directed to treating and reducing inflammation associated Hidradenitis Suppurativa by...
US20160340384 METHOD FOR REFOLDING RECOMBINANTLY PRODUCED POLYPEPTIDES  
Disclosed is a method for refolding recombinantly produced polypeptides comprising the steps of (a)providing inclusion bodies comprising recombinantly produced polypeptides comprising the...
US20160331807 THERAPEUTIC USE OF VEGFR-3 LIGANDS  
The present invention relates to therapeutic methods, uses and compositions for treating glaucoma or ocular hypertension. More specifically, the present invention relates to methods, uses and...
US20160310563 Methods for Treating Diabetic Wounds  
The present invention relates to a method of treating chronic wounds using calreticulin. In particular, the invention relates to the treatment of chronic diabetic wounds using topical application...
US20160297868 Composition and Method for Therapeutic Agent Delivery During Pregnancy  
A composition including an elastin-like polypeptide (ELP) coupled to a therapeutic agent is provided. The ELP comprises at least about 5 repeats of the amino acid sequence VPGXG. Further provided...
US20160289285 RECOMBINANT PROTEINS THAT SIMULTANEOUSLY BIND HGF, VEGF-A AND SERUM ALBUMIN, COMPRISING ANKYRIN REPEAT DOMAINS  
New designed ankyrin repeat domains with binding specificity for serum albumin, recombinant binding proteins comprising at least two designed ankyrin repeat domains with binding specificity for...
US20160271223 USE OF RELAXIN TO RESTORE MATERNAL PHYSIOLOGY IN PREGNANCIES CONCEIVED BY ASSISTED REPRODUCTIVE TECHNOLOGIES  
The subject invention relates to methods for improving a subject's vasculature to normalize maternal hemodynamics, particularly in subjects attempting to conceive via assisted reproductive...
US20160263185 MODIFIED BINDING PROTEINS INHIBITING THE VEGF-A RECEPTOR INTERACTION  
The present invention relates to binding proteins specific for VEGF-A, in particular to recombinant binding proteins comprising a polyethylene glycol moiety and a binding domain, which inhibits...
US20160263184 METHODS OF CONTROLLING VASCULARITY USING RAVER2 AS A MEDIATOR FOR EXPRESSION OF VEGF RECEPTOR SFIT1  
Methods of treating a condition in a subject resulting from abnormally high VEGF signaling through membrane-bound receptors. Such a method can include increasing expression of Raver2 in affected...
US20160256518 PEPTIDES FOR INHIBITING ANGIOGENESIS  
The present invention relates to peptides for inhibiting angiogenesis. The present invention also relates to methods of inhibiting angiogenesis and methods of treating disorders associated with...
US20160244505 VEGF ANTAGONIST FORMULATIONS SUITABLE FOR INTRAVITREAL ADMINISTRATION  
Ophthalmic formulations of a vascular endothelial growth factor (VEGF)-specific fusion protein antagonist are provided suitable for intravitreal administration to the eye. The ophthalmic...
US20160213748 MESENCHYMAL STEM CELL DIFFERENTIATION  
The present invention provides for methods and compositions for treating or preventing arthritis and joint injury.
US20160193298 THERAPEUTIC USE OF VEGF-C AND CCBE1  
The present invention relates to therapeutic methods, uses and compositions comprising CCBE1 and VEGF-C for treating disorders and conditions involving impaired lymphatic system, particularly...
US20160184490 COATINGS COMPRISING BIS-(ALPHA-AMINO-DIOL-DIESTER) CONTAINING POLYESTERAMIDE  
The present invention relates to a coating comprising at least one biodegradable polymer, wherein the polymer comprises at least one or a blend of a poly (ester amide) (PEA) having a chemical...
US20160168240 USE OF VEGF ANTAGONIST IN TREATING CHORIORETINAL NEOVASCULAR AND PERMEABILITY DISORDERS IN PAEDIATRIC PATIENTS  
The present invention relates to the use of a VEGF antagonist in the treatment of chorioretinal neovascular or permeability disorders in children. In particular, the invention provides a VEGF...
US20160159884 System and Method for Collagen Isolation  
System and methods for isolation of collagen and other fibrous tissue from adipose tissue are described herein. The method of the present invention isolates the collagen from adipose tissue by...
US20160158411 PROTEIN BIOMATERIALS AND BIOCOACERVATES AND METHODS OF MAKING AND USING THEREOF  
The present invention relates to protein biocoacervates and biomaterials and the methods of making and using protein biocoacervates and biomaterials. More specifically the present invention...
US20160158410 POLYSACCHARIDE HYDROGELS FOR INJECTION WITH TUNABLE PROPERTIES  
Injectable hydrogels comprising polysaccharides based on disaccharides the backbones of which form an α-helix structure and in which in at least 10% of the disaccharide units the primary hydroxyl...
US20160158320 DEVICE AND METHOD FOR THE DELIVERY OF DRUGS FOR THE TREATMENT OF POSTERIOR SEGMENT DISEASE  
Hydrogel lenses are infused with a drug for the treatment of posterior segment disease. The lenses are placed in contact with the subject's cornea. Drugs can be passively released from the...
US20160151450 Compositions and Methods for Treating Neuropsychiatric Disorders Using an Endothelin-B Receptor Agonist  
The present invention relates to compositions and methods for treating neuropsychiatric disorders in vertebrates and humans. More specifically, the present invention provides for use of IRL-1620,...
US20160144072 Mesh Fiber Members and Methods for Forming and Using Same for Treating Damaged Biological Tissue  
A mesh fiber member having a plurality of biodegradable fibers, the mesh fiber member being configured to induce modulated healing of damaged biological tissue when deployed proximate thereto. The...
US20160136326 COMPOSITIONS AND METHODS FOR MAKING BIODEGRADABLE STRUCTURES  
A composition including PPF or a PPF copolymer that can be used to fabricate biodegradable structures. The composition can be used in 3-D patterning (e.g., 3-D printing and sterolighography)...
US20160120782 FUNCTIONAL COSMETIC COMPOSITION CHARACTERIZED BY CONTAINING GROWTH FACTORS AND AMINO ACIDS  
The present invention relates to a functional cosmetic composition containing growth factors and amino acids, and more particularly to a functional cosmetic composition excellent in skin wrinkle...
US20160115211 COMPOSITIONS AND METHODS FOR REGULATING ANGIOGENESIS AND CHOLESTEROL AND TREATING DYSLIPIDEMIA, ATHEROSCLEROSIS, CANCER AND INFLAMMATORY CONDITIONS  
The invention provides pharmaceutical compounds and formulations comprising nucleic acids and polypeptides for regulating (including upregulating or inhibiting) the expression of ApoA-1 Binding...
US20160114008 Methods for accelerating the healing of connective tissue injuries and disorders  
The invention is directed to methods for accelerating the healing of connective tissue injuries and disorders. In particular, the invention is directed to accelerating the healing of injuries and...
US20160108124 ANTI-DEspR INHIBITORS AS THERAPEUTICS FOR INHIBITION OF PATHOLOGICAL ANGIOGENESIS AND TUMOR CELL INVASIVENESS AND FOR MOLECULAR IMAGING AND TARGETED DELIVERY  
Provided herein are novel compositions comprising anti-DEspR antibodies and fragments thereof, including fully human, composite engineered human, humanized, monoclonal, and polyclonal anto-DEspR...
US20160106878 Wound Dressings and Applications Thereof  
In one aspect, compositions and wound dressings are described herein. In some embodiments, a composition or wound dressing described herein comprises a mesh formed from a plurality of...
US20160082154 Method and System for Treatment of Damaged Biological Tissue  
Biomaterial compositions and articles comprising mesothelial tissue and a growth factor, for treating damaged biological tissue; particularly, damaged cardiovascular tissue. The biomaterial...
US20160074481 Clottable Concentrate Of Platelet Growth Factors And Preparation Method Thereof  
The present disclosure relates to a clottable concentrate of platelet growth factors for therapeutic and/or cosmetic use, preferably comprising the growth factors PDGF, TGT-β, IGF, EGF, CTGF, bFGF...
US20160074337 COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS INCLUDING SUBSTITUTED HEXITOLS SUCH AS DIBROMODULCITOL  
The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal therapeutic performance by either improving...
US20160067283 COMPOSITIONS AND METHODS FOR CARDIAC TISSUE REPAIR  
The invention features compositions comprising agents having cardiac protective activity isolated from epicardial progenitor cells and derivatives thereof, and methods for the use of such...
US20160038632 Adaptive Drug Delivery from an Artificial Polymer Skin with Tunable Properties for Tissue Engineering  
The present invention provides, among other things, a composite device comprised of a porous polymer membrane carrying active growth factors. Composite devices are characterized by an ability to...
US20160038569 PARTICLES CONTAINING A GROWTH FACTOR, AND USES THEREOF  
The present invention concerns particles containing at least one covalently cross-linked polysaccharide and at least one growth factor, a method of preparation, and uses thereof.
US20160033484 SERUM-BASED, DIAGNOSTIC, BIOLOGICAL ASSAY TO PREDICT PREGNANCY DISORDERS  
The invention provides serum-based, diagnostic, biological assays for predicting disorders of pregnancy resulting from poor trophoblast and/or placental ischemia, including preeclampsia. Serum...
US20160030522 COMBINATION THERAPY TO IMPROVE SOFT TISSUE HEALING, FAT GRAFT HEALING, ENDOCHONDRAL BONE HEALING AND OSTEOINTEGRATION  
The present invention is directed to kit, drug combinations and methods for promoting endogenous bone marrow (BM)-derived vasculogenic progenitor cell (PC) mobilization, sensitization of such...
US20160030512 COMBINATION PREPARATION COMPRISING A CYTOKINE ANTAGONIST AND CORTICOSTEROID  
The present invention relates to the treatment of patients with pharmaceutical compositions for a combination therapy with a cytokine antagonist and a corticosteroid. By means of the combination...
US20160022868 Tissue Prostheses for Repairing, Reconstructing and Replacing Damaged or Diseased Biological Structures and Associated Tissue  
Non-antigenic, resilient, bioremodelable, biocompatible tissue prostheses that can be engineered into a variety of shapes and used to repair, augment, reconstruct or replace damaged or diseased...
US20160022775 TREATING LYSOSOMAL STORAGE DISEASE  
Provided herein are compositions, kits and methods related to the treatment of one or more lysosomal storage diseases (LSDs) in a subject and methods of identifying agents that are useful for the...