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US20090291988 |
Reversible Inhibitors of Monoamine Oxidase A and B
The instant invention relates to compounds of formula I, diagrammed below, wherein R3, E, D and Y are defined in the application, which are useful as reversible inhibitors of monoamine oxidase-B...
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US20090291945 |
CYSTEINE PROTEASE INHIBITORS
To provide a compound having an excellent cysteine protease inhibitory effect, and to provide a drug for treatment or prevention of the disease selected from the group consisting of osteoporosis,...
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US20090281103 |
Renin Inhibitors
The present invention relates to novel renin inhibitors of the general Formula (I), and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also...
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US20090281085 |
3-(4-FLUOROPHENYL)-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS HAVING ANALGESIC ACTIVITY
Compounds according to the formula below are disclosed herein:
Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
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US20090264479 |
Papain Family Cysteine Protease Inhibitors for the Treatment of Parasitic Diseases
Several parasites responsible for mammalian diseases are dependent on cysteine protease for various life-cycle functions. Inhibition of these proteases can be useful in the treatment of these...
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US20090253703 |
ORGANIC COMPOUNDS
Disclosed are δ-amino-γ-hydroxy-ω-aryl-alkanoic acid amide compounds of formula (I)
and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions...
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US20090253701 |
ORGANIC COMPOUNDS
Disclosed are δ-amino-γ-hydroxy-ω-aryl-alkanoic acid amide compounds of formula (I)
and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions...
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US20090247540 |
PEPTIDE AND SMALL MOLECULE AGONISTS OF EPHA AND THEIR USES
Methods and compositions for activating an EphA receptor can be used for identifying therapeutic agents for cancer.
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US20090238756 |
IMAGE-GUIDED THERAPY OF MYOCARDIAL DISEASE: COMPOSITION, MANUFACTURING AND APPLICATIONS
Compositions and methods for imaging and for chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns agents comprising a targeting moeity comprising a beta-adrenergic...
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US20090215852 |
COMPOSITIONS AND METHODS FOR AMELIORATING CACHEXIA
The invention provides preparations, formulations, kits and other products of manufacture (e.g., blister packs) comprising combinations of beneficial ingredients that are serviceable as therapies...
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US20090203669 |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF ADDICTION AND OTHER NEUROPSYCHIATRIC DISORDERS
The present invention is based, in part, on our discovery that certain types of therapeutic agents can be used in combination to treat a variety of neuropsychiatric and related disorders, including...
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US20090182019 |
Histone deacetylase inhibitors
The present invention provides novel HDAC inhibitors and methods of treating diseases using the same.
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US20090156678 |
PROCESS FOR THE PRODUCTION OF 2-[4-(3- AND 2-FLUOROBENZYLOXY) BENZYLAMINO] PROPANAMIDES
A process for obtaining therapeutically active 2-[4-(3- and 2-(fluorobenzyloxy)benzylamino]propanamides and their salts with pharmaceutically acceptable acids with high purity degree, in...
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US20090149544 |
Alpha-aminoamide derivatives
This invention relates to novel alpha-aminoamide derivatives, their pharmaceutically acceptable salts, solvates, and hydrates thereof. This invention also provides compositions comprising a...
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US20090137681 |
Sirtuin Inhibiting Compounds
Provided herein are compositions and methods for treating or preventing cancer and autoimmune diseases. Compositions comprise a sirtuin inhibitory compound that decreases the activity of a sirtuin,...
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US20090131473 |
2-(ARYLOXY) ACETAMIDE FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS
The present invention relates generally to novel 2-(aryloxy)acetamides of Formula (I):
or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the...
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US20090131441 |
Metabolites Of 2-Arylpropionic Acid Derivatives And Pharmaceutical Compositions Containing Them
Metabolites of 2-(R)-4-isobutylarylpropionamides and pharmaceutical compositions containing such compounds are useful in inhibiting the chemotactic activation of neutrophils (PMN leukocytes)...
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US20090117197 |
COMPOSITIONS AND METHODS FOR AMELIORATING CACHEXIA
The invention provides preparations, formulations, kits and other products of manufacture (e.g., blister packs) comprising combinations of beneficial ingredients that are serviceable as therapies...
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US20090105222 |
PREVENTION AND TREATMENT OF FUNCTIONAL SOMATIC DISORDERS, INCLUDING STRESS-RELATED DISORDERS
Methods for the prevention or treatment of stress-related disorders by administering a therapeutically effective amount of a dual serotonin/norepinephrine reuptake inhibitor to an individual under...
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US20090088480 |
SOLID FORMS OF SELECTIVE ANDROGEN RECEPTOR MODULATORS
The present invention relates to solid forms of (S)—N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenox
y)-2-hydroxy-2-methylpropanamide and process for producing the same.
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US20090088408 |
PHARMACEUTICAL COMPOSITIONS ON ANTICHOLINERGICS, CORTICOSTEROIDS AND BETAMIMETICS
The present invention relates to novel pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics, processes for preparing them and their use in the treatment of...
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US20090082378 |
DERIVATIVES OF 4-(2-AMINO-1-HYDROXIETHYL)PHENOL AS AGONISTS OF THE B2 ADRENERGIC RECEPTOR
This present disclosure relates to compounds of formula (I):
The present disclosure also relates to pharmaceutical compositions comprising the compounds of formula (I) and to their methods of...
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US20090069431 |
DEUTERIUM-ENRICHED MILNACIPRAN
The present application describes deuterium-enriched milnacipran, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
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US20090068252 |
Transdermal Absorption Preparation
A transdermal absorption preparation having a support and a pressure-sensitive adhesive layer consisting of multiple layers, wherein the pressure-sensitive adhesive layer comprises a drug-retaining...
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US20090060917 |
Carbamate Stereoisomer
The compound of formula (I)
is a water-stable, long acting β 2 -selective adrenoceptor agonist useful as a bronchodilator in the treatment of bronchoconstriction associated with reversible...
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US20090049935 |
Stabilized milnacipran formulation
It is intended to provide a milnacipran formulation which is more stable than a conventionally known milnacipran formulation, and a method of stabilizing a milnacipran formulation. The object could...
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US20090005361 |
Combination of Organic Compounds
The present invention relates to a combination, such as a combined preparation or pharmaceutical composition, respectively, comprising a therapeutic agent acting on the renin-angiotensin system...
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US20080319083 |
MEDICINE FOR TRANSNASAL ADMINISTRATION
The object is to provide an SNRI-containing preparation which has a higher absorbability compared to a conventional SNRI preparation, produces its effect rapidly, and is readily administered to a...
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US20080319057 |
2-Phenylethylamino Derivatives as Calcium and/or Sodium Channel Modulators
2-Phenylethylamino substituted carboxamide derivatives of formula (I); wherein J, W, R 0 , R 1 , R 2 , R 3 , and R 4 have the meanings as defined in the specification and pharmaceutically...
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US20080312330 |
Methods for Reducing Mortality and Morbidity by Postoperative Administration of a Pharmacologic Cardiovascular Agent
The present invention relates to methods for reducing mortality and cardiovascular morbidity following surgery. In particular, the invention relates to the intensive postoperative administration of...
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US20080311099 |
Pyridoxal-5-Phosphate and Related Compounds in Combination With Therapeutic Cardiovascular Compounds for Treating Angina
Methods for treating angina are described. A method for treating angina includes concurrently administering a compound with a therapeutic cardiovascular compound. A combination therapy employs...
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US20080293820 |
METHODS FOR IMPROVING PHYSICAL FUNCTION IN FIBROMYALGIA
Methods for improving physical function in fibromyalgia syndrome by administering an NSRI such as milnacipran as disclosed.
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US20080293819 |
DI-FLUORO CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS
The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S, and are therefore useful in treating diseases mediated by...
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US20080255205 |
Multi-cyclic compounds and methods of use
The present invention relates to compounds of Formulas I and II,
wherein B 1 , B 2 , B 3 , B 4 , C 1 , C 2 , ring D, L 1 , L 2 and R 1-4 are defined herein, synthetic intermediates, and...
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US20080255072 |
Composition for Inhibition of Cathepsin K
The present invention relates to the a method of inhibiting bone resorption in a mammal in need thereof with an oral pharmaceutical composition comprising a cathepsin K inhibitor, or a...
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US20080255062 |
AXON REGENERATION FROM ADULT SENSORY NEURONS
A method for rapidly screening small molecules to identify small molecules that stimulate axon regeneration and outgrowth from adult sensory neurons. The method generally comprises preparing a...
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US20080253960 |
Lipoprotein-Based Nanoplatforms
The present invention provides a non-naturally occurring lipoprotein nanoplatform (“LBNP”) comprising at least one cell surface receptor ligand; at least one lipoprotein; and at least one...
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US20080249130 |
Gut microsomal triglyceride transport protein inhibitors
Compounds represented by formula (I):
are inhibitors of gut microsomal triglyceride transfer protein. Such compounds are useful in treating diseases or conditions such as diabetes and obesity,...
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US20080234254 |
Inhibitors of Histone Deacetylase
The present invention relates to a benzamide derivative comprising a head, spacer and cap group wherein the spacer includes a benzene ring substituted with an additional spacer and wherein the...
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US20080221217 |
Phenyl Compounds and Their Use in the Treatment of Type II Diabetes
The present invention is directed to compounds of formula (I) or a pharmaceutically acceptable salt thereof; wherein A is (xx); X is selected from CH, CF and N, R5 is selected from H, C 1 -C 6 ...
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US20080221166 |
AMINOAMIDES AS OREXIN ANTAGONISTS
The present invention relates to compounds of formula I
wherein Ar 1 , Ar 2 , Ar 3 , n, and
R 1 to R 8 are as defined herein and to pharmaceutically suitable acid addition salts, optically...
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US20080188529 |
Cathepsin cysteine protease inhibitors
This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for...
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US20080176947 |
Heterocyclic-Substituted Alkanamides Useful as Renin Inhibitors
Compounds of the general formula (I) in which the meanings of the substituents R 1 and R 2 are as stated in claim 1 , have renin-inhibiting properties and can be used as medicines.
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US20080167381 |
5-Amino-4-Hydroxy-2-Isopropyl-7-[4-Methoxy-3-(3-Methoxypropoxy)Benzyl]-8-Methylnonamides
Compounds of the general formula (I) in which R is heterocyclyl which is bonded via a carbon atom and is mono- or polysubstituted by C 1-6 -alkyl, trifluoromethyl, nitro, amino, C 1-6 -alkylamino,...
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US20080167371 |
Diaryl, Dipyridinyl and Aryl-Pyridinyl Derivatives and Uses Thereof
Compounds of Formula (I) that act as antagonists at the mu, kappa and/or delta opioid receptors and therefore useful in the treatment of diseases, conditions and/or disorders that benefit from such...
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US20080161255 |
Use of Parp Inhibitors for Prevention and Treatment of Diabetic and Insulin Resistance Complications
The present invention provides methods of inhibiting the development or progression of atherosclerotic, microvascular, or neurologic disease due to diabetes or insulin resistance in a mammal, or...
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US20080153919 |
METHODS OF TREATING FIBROMYALGIA SYNDROME, CHRONIC FATIGUE SYNDROME AND PAIN
The present invention provides a method of treating fibromyalgia syndrome (FMS), chronic fatigue syndrome (CFS), and pain in an animal subject. The method generally involves administering a...
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US20080153902 |
Phenyloctanamides
Compounds of the general formula (I) in which the substituents R, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are each as defined in claim 1 have renin-inhibiting properties and can be used as medicaments.
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US20080153824 |
Method for Controlling Fungal Diseases in Leguminous Plants
Method for controlling rust infections in leguminous plants by using orysastrobin, mixtures of orysastrobin and a fungicidally active compound II from the group of the azoles, acylalanines, amine...
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US20080153808 |
ALPHA-2 RECEPTOR PAN AGONIST AND SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITOR COMPOSITIONS FOR TREATING CHRONIC PAIN
Disclosed herein is a pharmaceutical composition comprising a serotonin-norepinephrine reuptake inhibitor and a pan-alpha-2 receptor agonist. The composition is effective for treating chronic pain,...
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