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US20090292025 Novel crystalline forms of armodafinil and preparation thereof  
The invention encompasses crystalline forms of armodafinil, processes for preparing the crystalline forms, and pharmaceutical formulation.
US20090282496 Androgen Receptor Related Methods for Treating Bladder Cancer  
Disclosed are compositions and methods for treating bladder cancer.
US20090281193 Process for the Preparation of and Crystalline Forms of Optical Enantiomers of Modafinil  
The invention relates to a polymorphic form of (−)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 9.45,...
US20090281192 Process for the Preparation of and Crystalline Forms of Optical Enantiomers of Modafinil  
The invention relates to a polymorphic form of (−)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 12.38,...
US20090270512 Pan-Antagonists For The Androgen Receptor And Androgen Receptor Mutants Associated With Anti-Androgen Withdrawal  
Disclosed herein are novel antagonists of the androgen receptor and androgen receptor mutations associated with clinical failure of currently prescribed anti-androgens and use of said antagonists...
US20090270511 PRODRUGS OF INHIBITORS OF CATHEPSIN S  
The present invention provides compounds of formula (I) which are prodrugs of inhibitors of cathepsin S and as such are useful in the prevention and treatment of cathepsin S dependent diseases and...
US20090270510 GLYCINE TRANSPORT INHIBITORS  
The present invention relates to compounds of formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in...
US20090239829 THIOARYL SUBSTITUTED INHIBITORS OF ZINC PROTEASES AND THEIR USE  
There are described compounds having the general formula (I) below and their pharmaceutically acceptable salts thereof, wherein E, X, m, q, R 1 , R 2 , n and ZBG have the meanings reported in the...
US20090233962 Amide derivative and insecticide containing the same  
The present invention is to provide a compound represented by the general formula (1) exhibiting a high insecticidal effect and an insecticide comprising the compound as an active ingredient. The...
US20090175939 PHARMACEUTICAL COMPOSITIONS  
Methods and compositions are provided which comprise effective amounts of analgesic to treat a subject, including reducing or eliminating an adverse effect associated with the analgesic.
US20090156683 FAST RELEASE SOLID FORMULATION, PREPARATION AND USE THEREOF  
The present invention relates to a chemically stable formulation of florfenicol, (and structurally related compounds) in compositions such as soluble blended powders, granules, fast-dissolving...
US20090149397 TREATMENT OF CANCER WITH COMBINATIONS OF TOPOISOMERASE INHIBITORS AND PARP INHIBITORS  
In one aspect, the present invention provides a composition and a kit comprising a combination of topoisomerase inhibitor and PARP inhibitor for treatment of cancer. In another aspect, the...
US20090143445 HDAC Inhibitors  
This invention provides the compound having the structure wherein n is 1-10; X is C—R 11 or N, wherein R 11 is H, OH, SH, F, Cl, SO 2 R 7 , NO 2 , trifluoromethyl, methoxy, or CO—R 7...
US20090137594 Pentafluorosulphanyl-Substituted Compound And Its Use For Producing Medicaments  
The present invention relates to pentafluorosulphanyl-substituted compounds, methods for their production, medicaments containing such compounds and the use of such compounds for producing...
US20090123545 Rapid Onset and Short Term Modafinil Compositions and Methods of Use Thereof  
Compositions are described that comprise a modafÊnil component that is a combination of the d- and l-enantiomers of modafinil and wherein the modafÊnil component is greater than 50% by weight...
US20090118215 Bioresorbable Controlled-Release Composition  
A novel method for the preparation of a highly densified and at least partly, preferably fully or almost fully hydrated ceramic for use in the preparation of a pharmaceutical composition notably...
US20090105346 Novel crystalline forms of armodafinil and preparation thereof  
The invention encompasses crystalline forms of armodafinil, processes for preparing the crystalline forms of armodafinil, pharmaceutical formulation thereof, and method of treating excessive...
US20090105309 Medicinal Compounds  
Compounds of formula (I): and salts, solvates, and physiologically functional derivatives thereof, useful for the prophylaxis or treatment of a clinical condition for which a selective β 2...
US20090099264 Fluoroalkylamine Derivatives as Cathepsin Inhibtors  
The present invention provides compounds of formula I which are inhibitors of cathepsin S and as such are useful in the prevention and treatment of cathepsin S dependent diseases and conditions...
US20090082462 DEUTERIUM-ENRICHED ARMODAFINIL  
The present application describes deuterium-enriched amodafinil, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
US20090082461 DEUTERIUM-ENRICHED MODAFINIL  
The present application describes deuterium-enriched modafinil, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
US20090076158 DEUTERIUM-ENRICHED BICALUTAMIDE  
The present application describes deuterium-enriched bicalutamide, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
US20090054444 SUBSTITUTED PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS  
Compounds of Formula (I) wherein R 1 is a cycloalkylsulphonyl group, or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and...
US20090036462 Formulations for parenteral administration of (e)-2, 6-dialkoxystyryl 4-substituted benzylsulfones  
Formulations are provided for parenteral administration of (amino substituted (e)-2,6-dialkoxystyryl 4-substituted benzylsulfones and the sodium and potassium salts thereof for the prevention...
US20090036420 BENZAMIDE DERIVATIVES AND THEIR USE FOR TREATING CNS DISORDERS  
The present invention relates to methods of treating CNS disorders with a compound of formula I wherein X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 are as defined in the...
US20090023781 Haloalkyl Containing Compounds as Cysteine Protease Inhibitors  
The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these...
US20080318930 Sulfonyl Compound as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase-1  
Sulfonyl derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as...
US20080317843 NANOPARTICULATE FORMULATIONS OF MODAFINIL  
The present invention is directed to compositions comprising a nanoparticulate modafinil compositions, or a salt(s), or an enantiomer(s), or a prodrug(s), or a polymorph(s) or derivative thereof,...
US20080312329 Nonpeptide Inhibitors of Matrix Metalloproteinases  
Disclosed are selective inhibitors of matrix metalloproteinases represented by the following formula (I). wherein X is (CH 2 ) n O, (CH 2 ) n S, (CH 2 ) n NR 1 , (CH 2 ) n (CH 2 ), or CH═CH,...
US20080287446 Sulfonyl Containing Compounds as Cysteine Protease Inhibitors  
The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these...
US20080286205 Method for Treating Prostate Diseases Based on Local Delivery of Active Substances  
A method for treating prostate related diseases in a subject, the method comprising i) optionally administering to subject an initial boost dose of one or more active substances and/or prodrugs,...
US20080269282 Compounds for Inhibiting Copper-Containing Amine Oxidases and Uses Thereof  
This invention is directed to inhibitors of copper-containing amine oxidases (E.C.1.4.3.6) including semicarbazide-sensitive amine oxidase (SSAO; also known as vascular adhesion protein-1, VAP-I),...
US20080234233 MEDICAMENT FOR TREATMENT OF NEURODEGENERATIVE DISEASES  
A medicament for preventive and/or therapeutic treatment of neurodegenerative diseases such as Alzheimer's disease or the like which comprises as an active ingredient a substance selected from the...
US20080221216 Use of modafinil to treat spasticity  
The invention provides a method of reducing spasticity in a mammal involving administering modafinil or related compounds. The spasticity can be secondary to multiple sclerosis, spinal cord injury,...
US20080207761 Pharmaceutical formulations of modafinil  
Compositions of modafinil and methods of treating neurologically related conditions with the administration of modafinil. Also compositions that include modafinil and one or more excipients such as...
US20080194694 ANTIPARASITIC AGENTS  
The present invention relates to compounds of the formula (I) or a tautomer or prodrug thereof, or a pharmaceutically acceptable salt of said compound, tautomer or prodrug, wherein: R 1 , R 2 ,...
US20080194693 Aminoacetonitrile Derivatives and Their Use for Controlling Parasites on Warm-Blooded Animals  
The invention relates to compounds of the general formula (I) wherein Ar, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , W, a, b, m, n, o and p are as defined in claim 1 , and to any...
US20080187508 Treatment of Golmerular Basement Membrane Disease Involving Matrix Metalloproteinase-12  
Methods for treating glomerular basement membrane disease such as Alport syndrome involving matrix metalloproteinase-12 are disclosed. Treatment may be affected, for example, by administering...
US20080181966 Modafinil pharmaceutical compositions  
Pharmaceutical compositions comprising modafinil in the form of particles of defined size and methods for preparing same. The particle size of modafinil can have a significant effect on the potency...
US20080171767 Acetamide Compounds as Fungicides  
Compounds of the general formula (I); wherein the substituents are as defined in claim 1 , are useful as fungicides.
US20080171750 Modulation Of Neurogenesis With Use of Modafinil  
The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes...
US20080161404 Bicalutamide for Delivering Increasing Steady State Plasma Levels  
The present invention relates to a method of treating a metastatic prostate cancer patient by administering to said patient an effective amount of a bicalutamide ( 4′...
US20080153918 Modafinil Polymorphic Forms  
Polymorphic forms of modafinil racemate, methods of preparation thereof, pharmaceutical compositions and methods of therapeutic treatment involving modafinil polymorphic forms.
US20080139636 Adamantane derivatives  
The invention provides adamantane derivatives of formula (I), a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions,...
US20080138315 Method for treating a disease, disorder or adverse effect caused by an elevated serum concentration of an ugtiai substrate  
The present invention is directed to a method for inducing UGT1A1 isoform expression for treatment of a disease, disorder or adverse effect caused by an elevated serum concentration of an UGT1A1...
US20080108559 COMPOSITIONS AND METHODS FOR TREATING DISEASES THROUGH INHIBITION OF DNA METHYLATION AND HISTONE DEACETYLASE  
Compositions and methods are provided for treating diseases associated with aberrant silencing of gene expression such as cancer and hematological disorders by reestablishing the gene expression...
US20080103104 TREATMENT OF CANCER  
The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides compositions and methods for treating cancer...
US20080097385 Therapeutic Adjuncts to Enhance the Organ Protective Effects of Postconditioning  
Provided herein is a method of postconditioning reperfusion of an organ or tissue injured by ischemia in combination with the administration of one or more tissue protective agents that enhance the...
US20080090912 Compositions containing prodrugs of florfenicol and methods of use  
The present invention provides compositions and methods for administering florfenicol to mammals. The compositions contain a prodrug of florfenicol in a pharmaceutically acceptable carrier. In one...
US20080076800 Benzene, Pyridine, and Pyridazine Derivatives  
Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein A, Q 1 , Q 2 , Q 3 , R 3 , R 4 , R 5 , R O , m, and p are as defined herein. Compounds of Formula I are...
Matches 1 - 50 out of 64 1 2 >