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US20090292024 |
SUBSTITUTED PROPANAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
It is an object of the present invention to provide a substituted propanamide derivative or a pharmacologically acceptable salt thereof that is useful as a prophylactic or therapeutic agent for a...
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US20090292018 |
Dicarbonic Acid Derivatives, Metastasis Inhibitors and Agents Increasing Chemotherapeutic Activity of Anti-Tumor Preparations, Method for Enhancing the Cytostatic Efficiency and Metastasis Process Inhibiting Method
The invention relates to dicarbonic acid derivatives and concerns dicarbonic acid monooxydamines and dioxydamides, which are physiologically active substances and can be used as low-toxic and...
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US20090292001 |
TRICYCLIC DERIVATIVES AS POTENT AND SELECTIVE HISTONE DEACETYLASE INHIBITORS
The present invention relates to certain tricyclic derivatives which are capable of inhibiting histone deacetylases. The compounds of this invention are therefore useful in treating diseases...
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US20090280172 |
GALENIC FORMULATIONS OF ORGANIC COMPOUNDS
The present invention relates to a dosage form for transmucosal administration comprising a therapeutically effective amount of aliskiren or a pharmaceutically acceptable salt thereof, and an...
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US20090275660 |
STABLE PARENTERAL FORMULATIONS OF TIGECYCLINE
The present invention relates to stable parenteral formulations of tigecycline and process of preparation thereof, wherein the formulation comprises of an edetate, a pH modifying agent or an...
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US20090264533 |
Methods and Compositions for Modulating RHO-Mediated Gene Transcription
The present invention is directed to methods and compositions methods and compositions for determining and inhibiting gene transcription in mammalian cells. The invention relates to novel...
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US20090253709 |
SYNTHESIS, TELOMERASE INHIBITION AND CYTOTOXIC STUDIES ON 2,7-DISUBSTITUTED ANTHRAQUINONE DERIVATIVES
An series of 2,7-disubstituted anthraquinone derivatives including a formula I are provided.
R is a first substituted group selected from a group consisting of a hydrogen, an amino group, a...
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US20090253672 |
Cathepsin Cysteine Protease Inhibitors
This invention relates to a novel class of compounds, represented by the formula (I) below, wherein the meanings of R1, R2, R3, R4, R5, R6, R7, X and Y are indicated therein, which are cysteine...
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US20090247506 |
Antibacterial agents
Antibacterial compounds of formula I are provided:
As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such...
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US20090239946 |
Pharmaceutical compositions of HDAC inhibitors and chelatable metal compounds, and metal-HDAC inhibitors chelate complexes
The present invention provides pharmaceutical compositions of an HDAC inhibitor and a chelatable metal compound. In one embodiment, the invention provides a method of treating cancer and...
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US20090239866 |
PEPTIDE DEFORMYLASE INHIBITORS
Novel PDF inhibitors and novel methods for their use are provided.
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US20090239811 |
POLYCATIONIC COMPOUNDS AND USES THEREOF
Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a...
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US20090233949 |
ISOSERINE DERIVATIVES FOR USE AS COAGULATION FACTOR IXA INHIBITORS
The invention relates to the compounds of formula (I)
having antithrombotic activity which especially inhibit blood clotting factor IXa, to methods for producing the same and to the use thereof...
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US20090227617 |
Esters Of Glucuronide Prodrugs Of Anthracyclines And Method Of Preparation And Use In Tumor-Selective Chemotherapy
The invention relates to novel esters and in particular to some novel esters of glucuronide prodrugs of anthracyclines having tunable water-solubility, their synthesis and use in tumor-selective...
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US20090227571 |
Androgen Receptor Modulator Compounds and Methods
Provided herein are compounds that bind to androgen receptors and modulate the activity and/or the amount of androgen receptors and to methods for making and using such compounds. Also provided are...
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US20090221713 |
APOE MIMETIC AGENTS
The invention provides low molecular weight apoE mimetic agents suitable for preparing a medicament to treat autoimmune, inflammatory or neurodegenerative disease, (X) a -L-(X) b (Formula (I))...
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US20090215813 |
HISTONE DEACETYLASE INHIBITORS AS IMMUNOSUPPRESSANTS
A method of preventing or suppressing an immune response or immune mediated response comprising administering an effective amount of an histone deacetylase inhibitor compound alone or in...
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US20090215623 |
Insecticidal 3-acylaminobenzanilides
Novel 3-acylaminobenzanilides of the formula (I)
wherein R 1 represents phenyl which may be substituted or a 5-member or 6-member heterocyclic ring group, which may be substituted,...
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US20090197823 |
ALISKIREN MODULATION OF NEUROGENESIS
The disclosure provides compositions and methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis by use of a renin...
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US20090191252 |
Pesticide compositions
This invention is related to the field of compositions useful in the control of pests that eat cellulose, such as, termites, where said composition is compacted and where said composition comprises...
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US20090181917 |
MEN1 GENE FOR DIAGNOSIS AND TREATMENT OF DIABETES
This invention relates to the inhibition of expression or function of Men1 gene or its encoded proteins for the purpose of treating diabetes and screening and researching agents capable of...
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US20090170842 |
BRCA1-BASED BREAST OR OVARIAN CANCER PREVENTION AGENTS AND METHODS OF USE
A pharmaceutical composition for use in treating, inhibiting, and/or preventing breast and/or ovarian cancer can include: a molecule having a structure of one of Compounds 1-38, pharmaceutically...
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US20090163595 |
Method of Modulating Membrane Potential of a Cell
Provided herein are methods of modulating membrane potential of a cell membrane using self-assembling compounds. Also provided herein are methods of regulating a natural voltage-dependent ion...
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US20090163543 |
Histone Deacetylase Inhibitors and Methods of Use Thereof
One aspect of the invention relates to HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided. The invention also provides methods for...
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US20090149496 |
INHIBITORS OF THE TASK-1 AND TASK-3 ION CHANNEL
The invention relates to the use of Kv1.5 inhibitors for the therapy or prophylaxis of respiratory disorders, sleep-related respiratory disorders, central and obstructive sleep apneas, upper airway...
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US20090149465 |
AMINOTETRALIN COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS
The invention provides aminotetralin compounds of formula (I):
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , n, and m are defined in the specification, or a pharmaceutically-acceptable salt...
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US20090143472 |
INTERMEDIATE COMPOUNDS AND THEIR USE IN PREPARATION OF LACOSAMIDE
The present invention is concerned with novel compounds and their use for the preparation of lacosamide. The present invention also contemplates processes for the preparation of lacosamide...
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US20090143471 |
Process for the Atomization of Ioxilan
The invention relates to a process for the preparation of ioxilan of formula 5-[N-(2,3-dihydroxypropyl)acetamido]-2,4,6-triiodo-N-(2,3-di
hydroxypropyl)-N′-(2-hydroxyethyl)isophthalamide by...
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US20090143374 |
Use of Compounds and Compositions for the Treatment of Amyloid Diseases
Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, pharmaceutical compositions containing them, and their use in the treatment of amyloid...
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US20090137451 |
Methods for Assessing Suitability of Cancer Patients for Treatment with Histone Deacetylase Inhibitors
This invention is in the field of cancer therapy and provides the use of E2F1 activity for assessing suitability of a cancer patient for treatment with histone deacetylase inhibitors (HDACIs).
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US20090131528 |
SALT
The invention relates to a new salt of aliskiren, the respective production and usage, and pharmaceutical preparations containing such a salt.
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US20090118375 |
Optically active phthalamides
Novel optically active phthalamides of the formula (I) in which A, q, R 1 , R 2 , E 1 , E 2 , X, m, Y, n and Z are as defined in the description, processes for preparing these compounds and their...
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US20090118269 |
Methods for Treating Spinal Muscular Atrophy Using Tetracycline Compounds
Methods for using tetracycline compounds for the treatment of spinal muscular atrophy are described.
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US20090118199 |
SUBSTITUTED ACRYLAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
A pharmaceutical composition comprising a compound having Formula (I) or a pharmacologically acceptable salt thereof as an active ingredient:
[wherein,
R 1 is, for example, a C 6 -C 10 ...
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US20090105343 |
Cancer Therapy And Medicaments Therefor
The present invention relates to a novel cancer therapy, particularly, but not exclusively, to a prostate, bladder and breast cancer therapy and to Compositions and medicaments for use in said...
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US20090105319 |
NAPHTHALENE-BASED INHIBITORS OF ANTI-APOPTOTIC PROTEINS
Methods of using apogossypol and its derivatives for treating inflammation is disclosed. Also, there is described a group of compounds having structure A, or a pharmaceutically acceptable salt,...
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US20090105237 |
Cooling compounds
A method of conferring a cooling effect on the skin or mucous membranes by applying thereto at least one compound of the Formula I:
(a) wherein B is selected from H, CH 3 , C 2 H 5 , OCH 3...
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US20090099204 |
Amide derivative, insecticide containing the same and method for application thereof as insecticide
The present invention is to provide a compound represented by the general formula (1) exhibiting a high insecticidal effect and an insecticide comprising the compound as an active ingredient. The...
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US20090093544 |
INSECTICIDAL COMPOSITIONS HAVING IMPROVED EFFECT
The present invention relates to the increase of the action of crop protection agents containing certain phthalic acid diamides by the addition of ammonium salts and/or phosphonium salts or by the...
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US20090088479 |
SALT OF ALISKIREN WITH SULFURIC ACID
The invention relates to a new salt of aliskiren, the respective production and usage, and pharmaceutical preparations containing such a salt.
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US20090082458 |
DEUTERIUM-ENRICHED ALISKIREN
The present application describes deuterium-enriched aliskiren, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
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US20090076154 |
DEUTERIUM-ENRICHED VORINOSTAT
The present application describes deuterium-enriched vorinostat, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
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US20090076153 |
DEUTERIUM-ENRICHED TIGECYCLINE
The present application describes deuterium-enriched tigecycline, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
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US20090076115 |
Photosensitizers for Targeted Photodynamic Therapy
The present invention relates to photosensitizer compounds based on functionalized fullerenes useful in targeted photodynamic therapy (PDT), and methods of use thereof.
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US20090076092 |
METHOD FOR DISRUPTING REPRODUCTIVE PERFORMANCE OF ARTHROPODS
Disclosed is a method for disrupting reproductive performance of an adult arthropod pest comprising contacting the adult arthropod pest or its environment with a sub-lethal, reproduction-disruptive...
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US20090076021 |
THERAPEUTIC COMBINATIONS AND METHODS FOR CARDIOVASCULAR IMPROVEMENT AND TREATING CARDIOVASCULAR DISEASE
A therapeutic combination, useful in a co-therapy method for improving cardiovascular performance and/or treating cardiovascular diseases, is provided comprising a first agent and a second agent,...
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US20090069430 |
DIBENZENE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS
The invention is directed to a compound of formula (I)
Having VDCC blocking activity. These compounds are useful for the treatment of a series of human diseases and conditions, especially...
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US20090062395 |
RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION
The present invention relates to methods for the prevention of, delay progression to or treatment of hypertension, comprising administering to a warm-blooded animal a therapeutically effective...
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US20090041747 |
Compounds for Stabilizing Factor VII Polypeptide Formulations
The invention relates to novel compounds with formula (I) and their use in stabilization of Factor VIIa or other Factor VII polypeptides, particularly in aqueous liquid compositions thereof.
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US20090036537 |
AROMATIC TRIAMIDE-LANTHANIDE COMPLEXES
The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also...
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