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US20090209473 |
Componds and methods for pormoting angiogenesis
Angiogenesis may be initiated or increased through the use of gamma-secretase inhibitors. The gamma-secretase inhibitor can be a dipeptide class, sulfonamide class, transition state mimic class,...
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US20090149510 |
Compositions and methods for modulating a kinase cascade
The invention relates to compounds and methods for modulating one or more components of a kinase cascade.
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US20090131441 |
Metabolites Of 2-Arylpropionic Acid Derivatives And Pharmaceutical Compositions Containing Them
Metabolites of 2-(R)-4-isobutylarylpropionamides and pharmaceutical compositions containing such compounds are useful in inhibiting the chemotactic activation of neutrophils (PMN leukocytes)...
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US20090124498 |
2-CYANOBENZENESULFONAMIDE COMPOUNDS FOR SEED TREATMENT
The present invention provides a method for the for the protection of seeds from soil insects and of the resulting plant's roots and shoots from soil and foliar insects comprising contacting the...
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US20090105319 |
NAPHTHALENE-BASED INHIBITORS OF ANTI-APOPTOTIC PROTEINS
Methods of using apogossypol and its derivatives for treating inflammation is disclosed. Also, there is described a group of compounds having structure A, or a pharmaceutically acceptable salt,...
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US20090093485 |
Novel Sulphonamide Derivatives as Glucocorticoid Receptor Modulators for the Treatment of Inflammatory Diseases
Compounds of formula (I) or a pharmaceutically acceptable salt thereof; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating the...
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US20090069420 |
Small molecule inhibitors of STAT3 with anti-tumor activity
The present invention concerns compounds, compositions containing these compounds, and methods of using these compounds and compositions as inhibitors of Stat3 signaling, Stat3 dimerization,...
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US20090047278 |
Novel Combinational Use of Sulfonamide Compound
The present invention relates to a pharmaceutical composition, a kit and a method for treating cancer, comprising a sulfonamide compound in combination with a substance having an EGF inhibitory...
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US20090042929 |
11-Beta-Hydroxysteroid Dehydrogenase Inhibitors
There is provided a compound having Formula (I) R 1 -Z-R 2 wherein R 1 is a group selected from optionally substituted fused polycyclic groups, substituted alkyl groups, branched alkyl groups,...
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US20090030055 |
PKC activation as a means for enhancing sAPPALPHA secretion and improving cognition using bryostatin type compounds
The present invention relates to compositions and methods to modulate α-secretase and/or to improve cognitive ability. The invention further relates the improved/enhanced cognitive ability in...
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US20090030038 |
Novel 8-Sulfonylamino-3 Aminosubstituted Chroman or Tetrahydronaphtalene Derivatives Modulating the 5Ht6 Receptor
The present invention relates to new compounds of formula I. (I) wherein R 1 to R 12 , X, Q and n are as defined as in formula I, or salts, solvates or solvated salts thereof, processes for their...
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US20090023735 |
Sulphonamide Derivatives
The invention relates to sulphonamide derivatives of formula (I), where R C is selected from a group consisting of dialkylamino, NO 2 , CN, aminocarbonyl, monoalkylaminocarbonyl,...
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US20090012053 |
Use of LXR agonists for the treatment of osteoarthritis
Disclosed herein are methods of preventing and treating osteoarthritis through the use of LXR agonists.
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US20080311074 |
Inhibitors against activation of NF-kappaB
A method of inhibiting NF-κB activation in a mammal including a human, which comprises the step of administering an effective dose of a substance selected from the group consisting of a compound...
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US20080255240 |
Sulfonamide Derivatives
Novel sulfon amide derivatives are chemical uncouplers useful e.g. for the treatment of obesity.
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US20080255169 |
Sulphonamide Derivatives
The invention relates to sulphonamide derivatives of formula (I),
where
R C is optionally substituted 4-6-membered heterocyclic ring containing one or more N atoms, or R C forms together with...
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US20080221169 |
AQUAPORIN MODULATORS AND METHODS OF USING THEM FOR THE TREATMENT OF EDEMA AND FLUID IMBALANCE
Compounds, including 3-carboxy aryl sulfonamide compounds, which agonize or antagonize aquaporin channels and methods of using them to treat disorders or diseases mediated by aquaporins.
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US20080167317 |
Combination Therapy
This invention relates to combination therapy for the treatment of lower urinary tract symptoms (LUTS) associated with or without benign prostatic hyperplasia (BPH). The combination therapy...
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US20080119555 |
Aryl Alkyl Sulfonamides As Therapeutic Agents For The Treatment Of Bone Conditions
The present invention pertains to certain aryl alkyl sulfonamides and derivatives thereof which, inter alia, inhibit osteoclast survival, formation, and/or activity; and/or inhibit bone resorption,...
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US20080113030 |
Sustained release tamsulosin formulations
A sustained release tamsulosin formulation contains tamsulosin, a hydrophobic polymer, a microsphere forming agent and a diluent. The hydrophobic polymers include pH-dependent and pH-independent...
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US20080069851 |
SUBSTITUTED N-AMINOMETHYLENE SULFONAMIDES, PRODUCTION AND USE THEREOF AS MEDICAMENTS
Disclosed are compounds of the general formula (I), with the definitions of the substituents R 1 to R 5 , A and X being detailed in the text, and to their physiologically tolerated salts, to...
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US20080051330 |
Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses
Novel compositions and methods of treating and preventing a viral infection are provided. A method of blocking a viral infection facilitated by a serine proteolytic (SP) activity is disclosed,...
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US20080027073 |
Substituted indanyl sulfonamide compounds, their preparation and use as medicaments
The present invention refers to new indanyl sulphonamide compounds with general formula (I), as well as to their preparation procedure, their application as medicine and the pharmaceuticals...
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