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US20090215792 |
METHOD OF TREATING CHRONIC MYELOGENOUS LEUKEMIA CELLS
Here, the inventors disclose the treatment of imatinib mesylate resistant chronic myelogenous leukemia cells with a cotreatment of vorinostat (SAHA, suberoylanilide hydroxamic acid) and dasatinib,...
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US20090186809 |
USE OF VALPROIC ACID FOR THE TOPICAL TREATMENT OF MILD TO MODERATE ACNE VULGARIS
The present invention provides a surprising therapeutic beneficial use for the topical application of valproic acid as a single agent therapy for patients suffering from mild to moderate acne...
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US20090137679 |
ZN2+Chelating Motif-Tethered Short-Chain Fatty Acids as a Novel Class of Histone Deacetylase Inhibitors
Zn 2+ -chelating motif-tethered fatty acids as histone deacetylase (HDAC) inhibitors. Compounds performed well in in vitro and in vivo tests.
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US20090118205 |
Antisense Oligonucleotides Directed to Ribonucleotide Reductase R2 and uses Thereof in the Treatment of Cancer
The present invention provides antisense oligonucleotides directed to a mammalian ribonucleotide reductase R2 gene and combinations of the antisense oligonucleotides with one or more...
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US20090054720 |
Use of histone deacetylase inhibitors in combination with radiation for the treatment of cancer
The present invention relates to a method for the treatment of cancer in a patient in need thereof. The method comprises administering to a patient in need thereof a first amount of a histone...
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US20090010941 |
Methods for treating HIV
The invention relates to methods of treating HIV by administering a TRAIL receptor activator. The invention also relates to methods for inducing apoptosis in an HIV reservoir cell by contacting the...
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US20080312199 |
Treatments of therapy resistant diseases and drug combinations for treating the same
The present invention provides novel methods and kits for diagnosing the presence of cancer within a patient, and for determining whether a subject who has cancer is susceptible to different types...
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US20080274120 |
Histone Deacetylase (Hdac) Inhibitors (Pxd101) for the Treatment of Cancer Alone or in Combination With Chemotherapeutic Agent
The present invention relates generally to methods for treating cancer. In one respect, the present invention relates to a method of treating a hematological cancer (e.g., multiple myeloma,...
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US20080234265 |
Histone Deacetylase Inhibitors Sensitize Cancer Cells to Epidermal Growth Factor Inhibitors
Disclosed is the use of a combination of histone deacetylase inhibitors and epidermal growth factor receptor (EGFR) inhibitors to treat cancer.
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US20080176916 |
A-AMINO-N-HYDROXY-ACETAMIDE DERIVATIVES
The invention relates to α-amino-N-hydroxy-acetamide derivatives of formula I,
wherein R is di-lower alkyl amino, 1,2,3-triazol-1-yl, 1,2,3-triazol-2-yl or 1,2,4-triazol-4-yl, m represents an...
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US20080161411 |
METHODS AND COMPOSITIONS FOR TREATING PULMONARY DISORDERS USING OPTICALLY PURE (R,R)-FORMOTEROL
A method and composition are disclosed utilizing the pure (R,R) isomer of formoterol, which is a potent bronchodilator with reduced adverse effects, a low incidence of the development of tolerance...
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US20080161401 |
CARBAMIC ACID COMPOUNDS COMPRISING A SULFONAMIDE LINKAGE AS HDAC INHIBITORS
This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula: (I) A is an aryl group; Q 1 is a covalent bond or an aryl leader...
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US20080139547 |
ACETYLENE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE
The present invention is directed to certain hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone...
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US20080132575 |
Formulations Of Suberoylanilide Hydroxamic Acid And Methods For Producing Same
The present invention provides a pharmaceutical composition or crystalline composition with a specific dissolution profile, which comprises suberoylanilide hydroxamic acid or a pharmaceutically...
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US20080118518 |
Cancer stem cell-targeted cancer therapy
The present invention provides methods for stabilizing, reducing or eliminating cancer cells. In particular, the present invention provides prophylactically and/or therapeutically effective...
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US20080114069 |
Methods of inducing terminal differentiation
The present invention provides methods of selectively inducing terminal differentiation, cell growth arrest and/or apoptosis of neoplastic cells, and/or inhibiting histone deacetylase (HDAC) by...
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US20080108559 |
COMPOSITIONS AND METHODS FOR TREATING DISEASES THROUGH INHIBITION OF DNA METHYLATION AND HISTONE DEACETYLASE
Compositions and methods are provided for treating diseases associated with aberrant silencing of gene expression such as cancer and hematological disorders by reestablishing the gene expression...
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US20080096889 |
Histone Deacetylases Inhibitors
New inhibitors of histone deacetylases having antitumor activity, and the process of preparation thereof are herein described. These compounds belong to the structural formula (I)
where R 1 ...
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US20080070954 |
Acylurea Connected And Sulfonylurea Connected Hydroxamates
The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to acylurea/sulfonylurea containing compounds...
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US20080039528 |
Zinc finger ejectors and methods of use thereof
Techniques for the chelation or ejection of Zn2+ from zinc finger peptides are disclosed, which can be useful in the treatment or control of viruses and viral diseases and malaria. The invention...
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US20080033024 |
ARYL AMINO ACID DERIVATIVES AS INHIBITORS FOR TREATING INFLAMMATION
The present invention relates to a chemical genus of 3-(triaryl)-2-aminopropanol derivative inhibitors of LTA4H (leukotriene A4 hydrolase) useful for the treatment and prevention of inflammatory...
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US20080015190 |
Inhibitors of Histone Deacetylase
The present invention relates to hydroxamic acid derivatives that are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are useful for treating cellular proliferative...
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