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US20090232879 |
Thyromimetics for the Treatment of Fatty Liver Diseases
The present invention is directed toward the use of thyromimetic compounds that are thyroid receptor ligands, pharmaceutically acceptable salts thereof, and to prodrugs of these compounds for...
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US20090227603 |
LEUKOTRIENE B4 INHIBITORS
Provided herein are compounds of the formula (I):
as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and...
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US20090221709 |
METHODS OF MODIFYING TASTE SENSATION IN AN ANIMAL USING COMPOUNDS THAT MODULATE T1R1/T1R3 Or T1R2/T1R3 RECEPTORS
Methods of modifying taste sensation in an animal are provided. These methods comprise administrating compounds that modulate T1R1/T1R3 or T1R2/T1R3 receptors.
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US20090221708 |
Medicinal preparation
Medicine, in particular broad spectrum medicinal preparations. This invention is based on the use of 4-chlorine-2-methyl-phenoxy-acetic acid of formula I, the pharmacologically acceptable...
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US20090214466 |
Methods of Alleviating Disorders and Their Associated Pain
The invention relates generally to the field of treatment of headache, post-laminectomy syndrome, and other disorders associated with localized pain. The compositions and methods described herein...
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US20090209588 |
Novel compounds, their preparation and use
Novel compounds of the general formula (I), in which the variables are as defined in claim 1 , the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the...
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US20090181893 |
USE OF AGENTS THAT PREVENT GENERATION OF AMYLOID AND AMYLOID-LIKE LIPOPROTEINS, AND/OR USE OF AGENTS THAT PROMOTE SEQUESTRATION AND/OR DEGRADATION OF, AND/OR PREVENT NEUROTOXICITY OF SUCH PROTEINS IN THE TREATMENT OF HEARING LOSS AND IMPROVING BODY BALANCE
The present invention provides compositions and methods for treating otic disorders. More specifically, the present invention describes the use of agents that down-regulate expression of Tanis...
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US20090182053 |
FENOFIBRIC ACID AMORPHOUS DISPERSION; METHOD OF MAKING; AND METHOD OF USE THEREOF
Disclosed are fenofibric acid amorphous dispersions containing amorphous fenofibric acid and an amorphous dispersion excipient. The amorphous dispersions can be prepared by e.g., spray drying...
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US20090170939 |
Use of Fenofibrate or a Derivative Thereof for Preventing Diabetic Retinopathy
This invention relates to the use of fenofibrate or a derivative thereof for the manufacture of a medicament for the prevention and/or treatment of retinopathy.
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US20090088435 |
METHODS AND COMPOUNDS FOR TREATING RETINOL-RELATED DISEASES
Compounds that reduce serum retinol levels are used to treat ophthalmic conditions associated with the overproduction of waste products that accumulate during the course of the visual cycle. We...
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US20090074845 |
TRANSDERMAL ACTIVE PRINCIPLE DELIVERY MEANS
A transdermal active principle delivery means comprises a skin adherent or otherwise skin-tolerant substrate applicable to a skin area affected by DNA virus, which substrate includes a composition...
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US20090042781 |
Methods for Treating Diabetes
Methods for treating diabetes by increasing the insulin secretion by administration of a GLP-1 receptor agonist and/or a DPP-IV inhibitor in combination with a proton pump inhibitor and optionally...
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US20090029947 |
Sphingosine-1-phosphate receptor agonist and antagonist compounds
The present invention is directed to novel, potent, and selective agents, which are agonists or antagonists of the one or more of the individual receptors of the S1P receptor family. The compounds...
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US20080319078 |
Triphenylethylene Compounds Useful as Selective Estrogen Receptor Modulators
Triphenylethylene compounds of formula (I) are provided. The compounds are particularly useful for selective estrogen receptor modulation.
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US20080312241 |
Cicletanine and PKC inhibitors in the treatment of pulmonary and cardiac disorders
Embodiments of the present invention are related to novel therapeutic drugs, drug combinations, and associated methods for treating or preventing pulmonary disease, including pulmonary...
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US20080287441 |
ALPHA-(TRIFLUOROMETHYL-SUBSTITUTED ARYLOXY, ARYLAMINO, ARYLTHIO OR ARYLMETHYL)-TRIFLUOROMETHYL-SUBSTITUTED PHENYLACETIC ACIDS AND DERIVATIVES AS ANTIDIABETIC AGENTS
Compounds having a formula:
or a pharmaceutically acceptable salt or prodrug thereof, are provided, and are useful for the treatment of metabolic disorders.
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US20080279808 |
2,3,4,5-Tetrahydroxy-6-Sulfooxy Hexanoic Acid, Pharmaceutically Acceptable Salts and Equilibrium Forms Thereof, Processes for Their Preparation, Pharmaceutical Compositions Comprising Such Compounds and Their Medical Use
The invention relates to novel compounds of general formula I wherein M represents hydrogen, or a metallic cation, preferably an alkaline metal, or alkaline-earth metal, and n is equal to 1, 2 or...
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US20080280986 |
TREPROSTINIL TREATMENT FOR INTERSTITIAL LUNG DISEASE AND ASTHMA
The present invention describes methods for using Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of interstitial lung disease or...
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US20080280815 |
Lowering Serum Lipids
The present invention relates to a method for lowering serum lipids, eg. triglycerides and/or cholesterol in a subject comprising administering a GLP-1 agonist to said subject.
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US20080269189 |
Method for Avoiding Edema in the Treatment or Prevention of Ppary-Responsive Diseases, Including Cancer
Compounds, compositions, and methods of avoiding edema while treating or preventing PPARĪ³-mediated diseases, including cancer, using derivatives and prodrugs are provided.
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US20080269335 |
Crth2 Receptor Antagonists
There are provided according to the invention compounds of formula (I) in free or salt form, wherein R<1>, R<2>, R<3>, X, Y, Z, m, and n are as described in the specification,...
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US20080262087 |
T1R HETERO-OLIGOMERIC TASTE RECEPTORS AND CELL LINES THAT EXPRESS SAID RECEPTORS AND USE THEREOF FOR IDENTIFICATION OF TASTE COMPOUNDS
The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results...
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US20080253985 |
Compositions for Lowering Serum Cholesterol and/or Triglycerides
The invention provides methods and compositions for treating hyperlipidemia and disorders associated with hyperlipidemia in a mammal. Compositions useful in the practice of the invention include a...
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US20080220066 |
Anti-Viral Topical Gel Formulations Containing a Diuretic Such as Furosemide and/or a Cardiac Glycoside Such as Digoxin
An anti-viral topical gel formulation comprising at least one loop diuretic and/or cardiac glycoside in a gel carrier medium, said formulation capable of transdermal delivery of the said diuretic...
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US20080200502 |
METHODS OF LOWERING LIPID LEVELS IN A MAMMAL
This invention relates to methods for lowering lipid levels in mammals using compounds that inhibit advanced glycation endproducts (AGEs), LR-9, LR-74 and LR-90. These compounds, which inhibit...
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US20080194646 |
Methods For Avoiding Edema in the Treatment of Metabolic, Inflammatory, and Cardiovascular Disorders
Compounds, compositions, and methods of treating or preventing PPARĪ³-mediated diseases, including cancer, using phenoxy acetic acid derivatives and prodrugs are provided.
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US20080194564 |
Hexenoic Acid Derivatives, Processes for the Preparation Thereof, Pharmaceutical Compositions Comprising Them, and Therapeutic Applications Thereof
Compounds of the formula (I): in which R, R 1 , R 2 and R 3 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical...
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US20080132480 |
Biphenyloxyacetic Acid Derivatives for the Treatment of Respiratory Disease
The invention relates to substituted phenoxyacetic acids of formula (I), where the variables are as defined in claim 1 , as useful pharmaceutical compounds for treating respiratory disorders,...
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US20080124280 |
Thyroid Hormone Analogs and Methods of Use
Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric form of thyroid hormone, or an antagonist thereof, to...
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US20080119561 |
METHODS FOR PREVENTING OR DELAYING CATHETER- BASED RESVASCULARIZATION
Aggressively lowering cholesterol in patients suffering from coronary artery disease prevents or delays the need for catheter-based revascularization.
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US20080113902 |
Use of ramoplanin to treat diseases associated with the use of antibiotics
The invention features a method of treating or preventing a disease associated with the use of antibiotics in a patient in need thereof by administering to the patient ramoplanin in an amount and...
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US20080103165 |
PPAR MEDIATED MODULATION OF NEUROGENESIS
The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system including by stimulating or increasing neurogenesis, neuroproliferation,...
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US20080095711 |
Modulators of Pulmonary Hypertension
Compounds, compositions, and methods for inhibiting pulmonary hypertension are disclosed. The invention is particularly directed to the use of agents that specifically inhibit the activity of...
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US20080096962 |
Process for the Preparation of Substituted Tetralin and Substituted Indane Derivatives
The present invention relates to novel processes for the preparation of substituted tetralin and substituted indane derivatives. The present invention is further directed to novel processes for the...
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US20080058414 |
Substituted Cyclopentanes Or Cyclopentanones As Therapeutic Agents
Novel compounds, and therapeutic methods, compositions and medicament related thereto are disclosed herein.
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US20080051411 |
Salts of Fenofibric Acid and Pharmaceutical Formulations Thereof
In one aspect, the present invention relates to a formulation in the form of molecular dispersion comprising i) fenofibric acid, a physiologically acceptable salt or derivative thereof and...
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US20080032982 |
Butanoic Acid Derivatives, Processes For The Preparation Thereof, Pharmaceutical Compositions Comprising Them, And Therapeutic Applications Thereof
Compounds of the formula (I): in which R, R 1 and R 2 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical...
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US20080014290 |
Composition and Method of Treating a Sore Throat
A composition comprising an antacid, and a local, topical anesthetic. The composition is used to relieve pain or discomfort associated with a sore throat, and therefore, the invention is also...
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