|
Match
|
Document |
Document Title |
|
|
US20090312286 |
DERIVATIVES OF 4-TRIMETHYLAMMONIUM-3-AMINOBUTYRATE AND 4-TRIMETHYLPHOSPHONIUM-3-AMINOBUTYRATE AS CPT-INHIBITORS
The invention provides a new class of compounds capable of inhibiting carnitine palmitoyl transferase (CPT) having formula (I) The invention also relates to pharmaceutical compositions, which...
|
|
|
US20090312422 |
METHOD OF MODULATING CELLULAR ACTIVITY AND AGENTS USEFUL FOR SAME
Described is a rational design of therapeutic and/or prophylactic methods of treating conditions characterized by aberrant or otherwise unwanted microglial cell functioning and rational design...
|
|
|
US20090306208 |
PROPHYLACTIC OR THERAPEUTIC COMPOSITION FOR HEMOGLOBINURIA OR MYOGLOBINURIA
A prophylactic or therapeutic composition for hemoglobinuria or myoglobinuria which may occur in humans or animals upon loading of exercise or stress or the like is provided. According to the...
|
|
|
US20090306209 |
ENTERIC-COATED FORMULATIONS OF POLYETHYLENE GLYCOL AND ONE OR MORE SOLUBLE AMINO ACIDS FOR ORAL INGESTION AND ENHANCED UPTAKE OF SAME
Oral amino acid formulations comprising polyethylene glycol are enteric coated. Most preferred amino acids are leucine, glutamine, and arginine. The most preferred polyethylene glycols have an...
|
|
|
US20090297468 |
Mixtures Comprising Anthranilic Acid Amides and Cooling Agents as Cosmetic and Pharmaceutical Compositions for Alleviating Itching
The invention relates to a mixture comprising or consisting of:
(a) one or more compounds of Formula 1:
where the symbols in the compound or each compound of Formula 1 are defined as...
|
|
|
US20090291928 |
COMPOSITION FOR AMELIORATION/PREVENTION OF ADVERSE SIDE EFFECT IN STEROID THERAPY
Provided is a composition containing isoleucine, leucine and valine as active ingredients for improving or suppressing side effects associated with a steroid treatment and a composition for...
|
|
|
US20090291978 |
Enzyme Inhibitors
Compounds of formula (I) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers, wherein R 1 is a carboxylic acid group (—COOH), or an ester...
|
|
|
US20090286881 |
SELECTED BETAINES AND THEIR USES
A physiologically acceptable, sterile and pyrogen-free solution of betaine dissolved in a physiologically acceptable solvent, having a pH adjusted to from 5.0 to 8.0 with a betaine concentration of...
|
|
|
US20090281160 |
Angiotensin I-converting enzyme (ace) inhibitors
This invention relates to a process for the synthesis of ketomethylene derivatives of the tripeptide Phe-Gly-Pro (“keto-ACE”, compound 5 a ) and analogues thereof. The synthesis process...
|
|
|
US20090281186 |
Composition and Method for Reducing Stress
The present invention relates to a composition and method for reducing stress, in a mammal, wherein said composition acts by modulating levels and activities of various neurotransmitters and...
|
|
|
US20090274626 |
TARGETING TNF-alpha CONVERTING ENZYME(TACE)- DEPENDENT GROWTH FACTOR SHEDDING IN CANCER THERAPY
The invention provides methods for modulating tumor cell proliferation by contacting cells (e.g. tumor cells) with a TACE inhibitor and a compound that inhibits EGFR tyrosine kinase, whereby the...
|
|
|
US20090270505 |
4-DIMETHYLAMINOBUTYRIC ACID DERIVATIVES
This invention relates to novel 4-dimethylaminobutyric acid derivatives of the formula
wherein A 1 , A 2 , R 1 , m and n are as defined in the description and in the claims, as well as...
|
|
|
US20090264469 |
NOVEL DICARBOXYLIC ACID DERIVATIVES
The present patent application concerns new compounds of formula (I): displaying agonistic activity at sphingosine-1-phosphate (S1P) receptors, their process of preparation and their use as...
|
|
|
US20090264487 |
HEMIASTERLIN ANALOGS
This invention provides analogs of hemiasterlin, methods of synthesis of the analogs and use of the analogs as a cytotoxic anti-mitotic agents.
|
|
|
US20090258946 |
ELECTROSTATICALLY CHARGED NASAL APPLICATION MULTIPURPOSE PRODUCTS AND METHOD
A family of products designed to ameliorate sinusitis and allergic rhinitis, produced by combining certain chemical substances with existing products, thereby producing a synergistic effect and...
|
|
|
US20090253796 |
METHOD FOR TREATING VASCULAR DISEASE
A medicament for prophylactic and/or therapeutic treatment of a vascular disease such as vascular restenosis and/or reocclusion after percutaneous transluminal coronary angioplasty using an...
|
|
|
US20090253795 |
Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibiton of pain and inflammation
A method and solution for perioperatively inhibiting a variety of pain and inflammation processes during arthroscopic procedures. The solution preferably includes a vasoconstrictor that...
|
|
|
US20090252684 |
Determination of tissue-specific profile of amino acid requirements form the relationship between the amounts of tRNAs for individual amino acids and the protein-bound amino acid profile of the tissue
Systems and methods by which optimal profiles of amino acids for specific tissues can be determined. The results of these systems and methods can then be sued to generate medical nutrition products...
|
|
|
US20090253794 |
Fibroblast Activator, Collagen Production Promoter, Collagen Contraction Promoter, Hyaluronic Acid Production Promoter, ATP Production Promoter, Melanin Formation Inhibitor, and Agent for External Application to the Skin
The present invention is a fibroblast activator, collagen production promoter, collagen contraction promoter, hyaluronic acid production promoter, ATP production promoter or melanin formation...
|
|
|
US20090247637 |
Novel Anthranilic Acid Derivatives
The invention is concerned with novel anthranilic acid derivatives of formula (I)
wherein R 1 to R 14 , m and n are as defined in the description and in the claims, as well as physiologically...
|
|
|
US20090239950 |
METHODS FOR SYNTHESIS OF PRODRUGS FROM 1-ACYL-ALKYL DERIVATIVES AND COMPOSITIONS THEREOF
The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require...
|
|
|
US20090234010 |
MANUFACTURE PROCESS OF ORGANIC COMPOUNDS
The present invention relates to a method of preparing N-substituted salicylamides or derivatives thereof and their derivatives, e.g. their salts. In particular, the present invention relates to a...
|
|
|
US20090234011 |
N-ACETYLCYSTEINE AMIDE (NAC AMIDE) FOR THE TREATMENT OF DISEASES AND CONDITIONS ASSOCIATED WITH OXIDATIVE STRESS
Methods and compositions comprising N-acetylcysteine amide (NAC amide) and derivatives thereof are used in treatments and therapies for human and non-human mammalian diseases, disorders, conditions...
|
|
|
US20090226537 |
MIXTURES COMPRISING ANTHRANILIC ACID AMIDES AND ANTIDANDRUFF AGENTS AS COSMETIC AND PHARMACEUTICAL COMPOSITIONS FOR ALLEVIATING ITCHING
The invention relates to a mixture comprising or consisting of:
(a) one or more compounds of Formula 1:
where the symbols in the compound or each compound of Formula 1 are defined as...
|
|
|
US20090227679 |
Novel NIDDM Regimen
The present invention relates to the use of a short-acting oral hypoglycemic agent and to a novel regimen in the treatment of type 2 diabetes in which the endogenous secretion of insulin is...
|
|
|
US20090227592 |
COMPOUNDS EFFECTING GLUCOKINASE
The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R 1 , R 2 , R 3 , n and m are as described in the specification, in the preparation of a...
|
|
|
US20090227625 |
CXCR2 INHIBITORS
The invention relates to compounds of the formula I
in which R1, R2, X, A, B, Z and Y1 to Y4 have the meanings indicated in the claims, and/or a pharmaceutically acceptable salt and/or a prodrug...
|
|
|
US20090221652 |
COMBINATIONS OF METFORMIN AND MEGLITINIDE
Methods of treating glucose related disorders, for example by administering a meglitinide such as mitiglinide, repaglinide, or nateglinide, optionally in combination with a biguanide such as...
|
|
|
US20090215809 |
CRYSTALLINE FORM OF A (3S)-AMINOMETHYL-5-METHYL-HEXANOIC ACID PRODRUG AND METHODS OF USE
A crystalline form of a (3S)-aminomethyl-5-hexanoic acid prodrug and methods of preparing a crystalline form of a (3S)-aminomethyl-5-hexanoic acid prodrug, and methods of using a crystalline form...
|
|
|
US20090215886 |
Anti-Inflammatory Formulation
Compositions comprising apocynin and paeonol. The compositions may be used for the treatment of inflammatory disease.
|
|
|
US20090215900 |
COMPOSITION AND METHOD FOR PROVIDING GLUTAMINE
A process for preparing a glutamine-supplemented food product by contacting water and a nutritive base that pre-dominantly comprises meat and carbohydrate with a peptide source of glutamine to form...
|
|
|
US20090215899 |
N-Phenyloxamide derivatives
A compound represented by the following general formula (I) or a salt thereof, or a hydrate thereof or a solvate thereof having an inhibitory action against plasminogen activator inhibitor-1...
|
|
|
US20090215827 |
INHIBITORS OF CXCR2
The invention relates to compounds of the formula I
in which R1, R2, X, A, B and Y1 to Y4 have the meanings indicated in the claims, and/or a pharmaceutically acceptable salt and/or a prodrug...
|
|
|
US20090209564 |
Glucagon Receptor Antagonist Compounds, Compositions Containing Such Compounds And Methods Of Use
Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also...
|
|
|
US20090209648 |
Phenylacetic Acid Derivatives
Compounds of formula (I) pharmaceutically acceptable salts thereof, and pharmaceutically acceptable esters thereof; which are useful for the treatment of COX-2 dependent disorders.
|
|
|
US20090209525 |
ENABLING METHODS TO IDENTIFY ALLOSTERIC MODULATORS OF RECEPTOR ACTIVITY
A method developed to identify receptor modulators, involving providing a mutant receptor, wherein said mutant receptor has a mutation that alters the activity of said mutant receptor compared to a...
|
|
|
US20090209614 |
GLUTAMINE-CONTAINING COMPOSITIONS AND A METHOD FOR INCREASING BLOOD FLOW USING SAME
The present invention provides a glutamine-containing composition which functions to increase blood flow. Glutamine is present in the composition in an amount of 25 mg/kg body weight to 150 mg/kg...
|
|
|
US20090209503 |
COLONIC DELIVERY THERAPEUTIC AGENTS FOR INFLAMMATORY BOWEL DISEASE
The present invention discloses a therapeutic agent for inflammatory bowel disease, which is in the from of delivering 1 to 5 g of glutamine to the large intestine per one administration; and the...
|
|
|
US20090203626 |
Pediatric Amino Acid Solution for Parenteral Nutrition
The present invention relates to an amino acid solution for the parenteral nutrition of pediatric patients. The amino acid solution provides for an increased concentration of glutamine, tyrosine,...
|
|
|
US20090203706 |
LYSINE-BASED POLYMERIC LINKERS
The present invention provides polymeric linkers containing branching moieties. Methods of making the polymeric linkers and methods of making conjugates using the same are also disclosed.
|
|
|
US20090197957 |
Methods and compositions for the treatment of pain
The present invention relates generally to the area of pain management and more particularly, to a method of analgesia and agents useful for same. More particularly, the present invention relates...
|
|
|
US20090196940 |
COMPOSITIONS AND METHODS FOR SUPPORTING HEAT SHOCK FUNCTION
Compositions and methods for promoting or maintaining protein accretion in cells, particularly in skeletal muscle cells, by supporting heat shock protein function. The compositions comprise...
|
|
|
US20090197958 |
Sustained Release Particulate Oral Dosage Forms of (R) Baclofen and Methods of Treatment
Sustained release particulate oral dosage forms of (R)-baclofen prodrugs and methods of treating a disease comprising orally administering such dosage forms are disclosed.
|
|
|
US20090197959 |
N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS
Described herein are compounds that are antagonists of PGD 2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such...
|
|
|
US20090186034 |
Gene expression markers for inflammatory bowel disease
The present invention relates to methods of gene expression profiling for inflammatory bowel disease pathogenesis, in which the differential expression in a test sample from a mammalian subject of...
|
|
|
US20090176835 |
PHARMACEUTICAL COMPOSITION FOR SUPPRESSION OF THE EXPRESSION OF ATP CITRATE LYASE AND USE THEREOF
The present invention provides a pharmaceutical composition for suppression of the expression of ATP citrate lyase, which contains a compound that suppresses the expression of ATP citrate lyase by...
|
|
|
US20090170908 |
SPIRO COMPOUNDS AND PHARMACEUTICAL USE THEREOF
The Spiro compound represented by the following general formula [Ia], its pharmaceutically acceptable salt or a solvate thereof
|
|
|
US20090163573 |
COMPOSITIONS AND METHODS FOR ENHANCING PROTEIN ACCRETION IN SKELETAL MUSCLE
A nutritional composition comprising at least an effective amount of geranylgeranylacetone or derivative of geranygeranylacetone and an effective amount of glutamine or derivative of glutamine,...
|
|
|
US20090163476 |
N-Phenyl Benzamide Derivatives as Sirtuin Modulators
Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing...
|
|
|
US20090156680 |
Deodorants Containing Aminoacid Derivatives
A deodorant composition comprising an aminoacid compound of formula I or II and a carrier material. I R 1 R 2 N—X—O—CH═CH—CH(NH 2 )CO 2 H II R 1 R 2 N—X—O—CH 2 CH 2 —CH(NH 2 )CO 2...
|