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US20090286880 |
NOVEL PROCESS
The present invention relates to a novel process for the preparation of γ-amino acids, such as (±)-3-(aminomethyl)-5-methyl-hexanoic acid 1, which is a key intermediate in the preparation of the...
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US20090280061 |
ESTERS OF 5-AMINOLEVULINIC ACID AS PHOTOSENSITIZING AGENTS IN PHOTOCHEMOTHERAPY
The present invention relates to compounds being esters of 5 -aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2-CH2CO—OR1...
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US20090274626 |
TARGETING TNF-alpha CONVERTING ENZYME(TACE)- DEPENDENT GROWTH FACTOR SHEDDING IN CANCER THERAPY
The invention provides methods for modulating tumor cell proliferation by contacting cells (e.g. tumor cells) with a TACE inhibitor and a compound that inhibits EGFR tyrosine kinase, whereby the...
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US20090270493 |
CYCLIC 1-(ACYLOXY)-ALKYL PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF
The present invention provides cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, methods of making cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl...
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US20090259167 |
METHODS AND COMPOSITIONS FOR DOSE-DEPENDENT PHOTODYNAMIC THERAPY OF DISORDERS
The invention provides methods and compositions for treating a tissue disorder in a subject by parenterally administering a solution of aminolevulinic acid (ALA) or a derivative thereof that is not...
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US20090258015 |
Modulators of Candida Hyphal Morphogenesis and Uses Thereof
The invention relates to modulation of fungal morphology between yeast-to-hyphal growth transition by controlling muramyl-L-alanine concentration and uses thereof.
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US20090253792 |
ACTIVE AGENT DELIVERY SYSTEMS AND METHODS FOR PROTECTING AND ADMINISTERING ACTIVE AGENTS
The present invention relates to active agent delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to active...
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US20090247636 |
AGENT FOR SUPPRESSION OF GASTRIC EMPTYING COMPRISING 4-HYDROXYISOLEUCINE
The present invention aims to provide a more effective gastric emptying suppressant and food intake suppressant, wherein the solving means are a gastric emptying suppressant containing...
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US20090247635 |
METHOD FOR TREATING ANAL PRURITIS AND OTHER PERIANAL DISORDERS
The invention relates to methods and compositions for the treatment of pruritis ani and other perianal disorders. There are currently few treatments for these conditions, many of which have...
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US20090239949 |
Polar Hydrophilic Prodrugs of Amphetamine and Other Stimulants and Processes for Making and Using the Same
Disclosed are polar, hydrophilic stimulant prodrug compositions comprising at least one stimulant chemically attached to a polar hydrophilic ligand, a salt thereof, a derivative thereof, or a...
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US20090234009 |
Kallikrein Inhibitors and Anti-Thrombolytic Agents and Uses Thereof
Methods, kits and compositions are described that include a non-naturally occurring kallikrein inhibitor and an anti-thrombolytic agent, e.g., an anti-fibrinolytic agent, for preventing or reducing...
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US20090220575 |
COMPOSITIONS AND METHODS FOR THE SUSTAINED RELEASE OF BETA-ALANINE
Methods and compositions are provided for increasing the anaerobic working capacity of muscle and other tissues. Also provided are compositions formulated for the sustained release of free...
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US20090215898 |
TRANEXAMIC ACID FORMULATIONS
Disclosed are immediate release oral tranexamic acid formulations and methods of treatment therewith.
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US20090215842 |
Method of Treating Schizophrenia Prodrome
The present invention relates to a method of treating schizophrenia prodrome in human subjects using a NMDA glycine site agonist, a glycine transporter-1 inhibitor or mixtures thereof, optionally...
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US20090215751 |
Use of Selective Chloride Channel Modulators to Treat Alcohol and/or Stimulant Substance Abuse
The invention relates to methods of and treatments for using pharmaceutical compositions from a class of compounds that directly or indirectly selectively modulates GABA A chloride channel...
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US20090214504 |
Methods and Compositions for Topical Treatment of Medical Conditions Including Wounds and Inflammation
A method for treating a patient suffering from a wound, ulcer, or inflammation includes providing a topical formulation comprising a carrier and a combination of active ingredients that includes at...
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US20090214452 |
Arginine Heteromers for Topical Administration
The invention is directed to a strategy for providing therapeutic or cosmetic benefit to skin by topically applying arginine chemically bound to a second (non-oligo arginine) compound in order to...
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US20090209646 |
TRANEXAMIC ACID FORMULATIONS
Disclosed are modified release oral tranexamic acid formulations and methods of treatment therewith.
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US20090209645 |
METHODS FOR TREATING VASOMOTOR SYMPTOMS USING GABA ANALOGS IN A GASTRIC RETENTIVE DOSAGE FORM
Methods for treating vasomotor symptoms associated with menopause are described.
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US20090203792 |
METHODS OF TREATING NON-PAINFUL BLADDER DISORDERS USING ALPHA2DELTA SUBUNIT CALCIUM CHANNEL MODULATORS
A method is provided for treatment of non-painful bladder disorders, particularly non-painful overactive bladder without loss of urine. The method comprises administration of an α 2 δ subunit...
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US20090203791 |
NATEGLINIDE-CONTAINING PREPARATION
The present invention discloses, as a immediate-release preparation useful as an antidiabetic, a nateglinide-containing preparation comprising nateglinide as an active ingredient wherein the...
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US20090203790 |
GAMMA-L-PGA PRODUCING MICROORGANISM, METHOD OF PRODUCING GAMMA-L-PGA USING THE MICROORGANISM, CROSSLINKED SUBSTANCE PRODUCED USING THE MICROORGANISM, AND EXTERNAL DERMAL AGENT PRODUCED USING THE MICROORGANISM
There are provided a microorganism characterized by producing poly-γ-L-glutamate with a molecular weight of 1,300,000 or greater and uniform optical purity under liquid culture conditions, a...
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US20090203789 |
Fast Dissolution Amino Acid Composition
The present invention relates to oral dosage formulations for the rapid release of amino acids. A rapid release is achieved through the process of milling whereby the milled amino acids are more...
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US20090203669 |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF ADDICTION AND OTHER NEUROPSYCHIATRIC DISORDERS
The present invention is based, in part, on our discovery that certain types of therapeutic agents can be used in combination to treat a variety of neuropsychiatric and related disorders, including...
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US20090203634 |
Compositions and Uses of Amooranin Compounds
Amooranin (AMR) has been found to cause tumor cell death through G 2 /M cell cycle arrest, caspase activation, and apoptosis. Furthermore, it has been demonstrated that AMR is a substrate for...
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US20090197956 |
TREATMENT OF ACUTE OTITIS MEDIA WITH XYLITOL AND N-ACETYLCYSTEINE
The present invention relates to the discovery that the treatment of Acute Otis Media (AOM) can be accomplished by a synergistic combination of xylitol and N-acetylcysteine. The treatment with this...
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US20090192071 |
USE OF PHOTODYNAMIC THERAPY TO ENHANCE TREATMENT WITH IMMUNO-MODULATING AGENTS
Methods of enhancing the efficacy and safety of treatment with immuno-modulating agents are provided. The inventive methods combine treatment with immuno-modulating agents with photodynamic therapy...
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US20090191282 |
CONTROLLED RELEASE COMPOSITION CONTAINING A STRONTIUM SALT
A controlled release pharmaceutical composition comprising a strontium salt. The invention also relates to the use of a strontium salt for treating a male suffering from diseases and conditions...
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US20090176882 |
GASTRIC RETENTIVE GABAPENTIN DOSAGE FORMS AND METHODS FOR USING SAME
Provided is a method of treating a patient suffering from a pain state by administering to the patient a gastric retentive dosage form of gabapentin that is capable of administration in once-daily...
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US20090176881 |
Unsaturated Alkyl Esters of 5-Aminolevulinic Acid, their Preparation and their Use
Disclosed are unsaturated alkyl esters of 5-aminovulinic acid of the following chemical formula 1, or pharmaceutically acceptable salts thereof, a method for preparing the same, and uses thereof....
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US20090176743 |
Methods for treating or preventing reactivation of a latent herpesvirus infection
The invention is directed to methods and compositions for treating or preventing reactivation of a latent herpesvirus infection and the associated complications and outcomes. The methods involve...
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US20090170946 |
Composition for Mold Remediation
An anti-fungal composition is disclosed and has enhanced microbiocidal activities for killing or inhibiting growth of live mold cells and spores. Further, the composition stops the production of...
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US20090170945 |
PREGABALIN SALTS
Pregabalin besylate and pregabalin tosylate are pharmaceutically acceptable acid addition salts of pregabalin that are isolatable in solid state, particularly crystalline state, sufficiently...
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US20090169595 |
Controlled Release Polymeric Compositions of Bone Growth Promoting Compounds
The present invention is directed to an improved system for controlled release of a bone growth promoting compound and to a flowable composition for its formation. The flowable composition is...
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US20090156679 |
LEVODOPA PRODRUG MESYLATE, COMPOSITIONS THEREOF, AND USES THEREOF
(2R)-2-Phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate and crystalline form thereof, methods of making the same, pharmaceutical compositions thereof, and methods of...
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US20090156678 |
PROCESS FOR THE PRODUCTION OF 2-[4-(3- AND 2-FLUOROBENZYLOXY) BENZYLAMINO] PROPANAMIDES
A process for obtaining therapeutically active 2-[4-(3- and 2-(fluorobenzyloxy)benzylamino]propanamides and their salts with pharmaceutically acceptable acids with high purity degree, in...
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US20090156677 |
Gabapentin-containing Solid Compositions and Process for Preparing the Same
The present invention provides a stabilized solid composition containing a 4-amino 3-substituted-butanoic acid derivative which can be obtained by incorporating a humectant as a stabilizer.
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US20090156676 |
Organic salts of beta-alanine
The present invention relates to stable salts of β-alanine and an organic acid endowed with enhanced nutritional and/or therapeutical efficacy in respect to their individual effects and to solid...
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US20090156402 |
4-ALKOXY-CYCLOHEXANE-1-AMINO-CARBOXYLIC ESTERS AND PROCESSES FOR THEIR PREPARATION
The invention relates to novel 4-alkoxy-cyclohexane-1-amino-carboxylic esters of the formula (IV)
in which R 1 and R 2 are as defined in the description,
to intermediates and processes for...
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US20090155393 |
METHOD FOR PROLONGING THE LIFE OF ANIMALS
A method for increasing the longevity of an old animal comprising administering to the animal a composition comprising one or more antioxidants in a total antioxidant amount sufficient to increase...
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US20090136438 |
PHOTO-PROTECTIVE DERMATOLOGICAL FORMULATIONS AND METHODS OF USING THE SAME
It is described a dermatological formulation comprising: one or more amino acid-based antioxidants in an amount effective to reduce or repair photodamage to skin exposed to UV radiation; and a...
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US20090131524 |
SIALIC ACID ABC TRANSPORTERS IN PROKARYOTES THERAPEUTIC TARGETS
This invention provides a novel bacterial sialic acid transporter that is a member of the family of ABC transporters. The transporter is a useful target for pharmaceuticals.
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US20090131384 |
COMPOUNDS AND METHODS FOR TREATMENT OF DISORDERS ASSOCIATED WITH ER STRESS
The invention provides novel compounds, methods for treating or preventing a condition related to ER-stress, e.g. hypercholesterolemia, atherosclerosis and related conditions, and pharmaceutical...
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US20090123400 |
COMPOSITIONS AND METHODS FOR REDUCING PHOTOSENSITIVITY ASSOCIATED WITH PHOTODYNAMIC THERAPY
The present invention provides compositions and methods for decreasing photosensitivity induced by photodynamic therapy (PDT). The compositions and methods of the present method employ porphyrin...
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US20090118341 |
Method for treatment of chronic neuropathic pain
Chronic pain is treated in an individual suffering from chronic pain by administering to the individual an amount of a therapeutic containing a glycine receptor agonist such as D-cycloserine or a...
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US20090117053 |
LOCAL DELIVERY OF 5-AMINOLEVULINIC-ACID BASED COMPOUNDS TO TISSUES AND ORGANS FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES
In accordance with an aspect of the present invention, a 5-aminolevulinic-acid-based compound (ALA-based compound) is delivered locally to a tissue or organ within a subject's body. In another...
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US20090111778 |
2-Keto-Oxazoles as Modulators of Fatty Acid Amide Hydrolase
Certain 2-keto-oxazole compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states,...
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US20090111733 |
PAR-4 RELATED METHODS AND COMPOSITIONS
Provided herein are methods and compositions for treating or preventing mood disorders and certain other mental disorders. Methods may comprise increasing PAR-4 levels or activity and/or the...
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US20090105222 |
PREVENTION AND TREATMENT OF FUNCTIONAL SOMATIC DISORDERS, INCLUDING STRESS-RELATED DISORDERS
Methods for the prevention or treatment of stress-related disorders by administering a therapeutically effective amount of a dual serotonin/norepinephrine reuptake inhibitor to an individual under...
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US20090092642 |
Skin and/or Hair Products, Containing Compounds With an Isoprenoid Structure
A composition of matter that is suitable for use on skin or hair. The composition comprises one or more compounds of formula
wherein Rx, Ry, R 3 and R 5 are as defined in the specification,...
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