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US20090281059 |
COATING FOR A MEDICAL DEVICE HAVING AN ANTI-THROMBOTIC CONJUGATE
A conjugate between an anti-thrombotic agent and bioabsorbable polymer is provided. Also, a method is provided for applying a coating comprising an anti-thrombotic agent and bioabsorbable polymer...
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US20090274741 |
POLYMERS CONTAINING POLY(ESTER AMIDES) AND AGENTS FOR USE WITH MEDICAL ARTICLES AND METHODS OF FABRICATING THE SAME
Polymers containing poly(ester amides) and agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate...
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US20090270332 |
GENETIC POLYMORPHISMS ASSOCIATED WITH VENOUS THROMBOSIS, METHODS OF DETECTION AND USES THEREOF
The present invention is based on the discovery of genetic polymorphisms that are associated with venous thrombosis. In particular, the present invention relates to nucleic acid molecules...
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US20090269385 |
COMPOSITE IMPLANTS FOR PROMOTING BONE REGENERATION AND AUGMENTATION AND METHODS FOR THEIR PREPARATION AND USE
Collagen based matrices cross-linked by a reducing sugar(s) are used for preparing composite matrices, implants and scaffolds. The composite matrices may have at least two layers including reducing...
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US20090258055 |
Heparin Prodrugs and Drug Delivery Stents Formed Therefrom
A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a...
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US20090258054 |
Heparin Prodrugs and Drug Delivery Stents Formed Therefrom
A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a...
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US20090238852 |
METHODS FOR CONTROLLING INTRACELLULAR CALCIUM LEVELS ASSOCIATED WITH AN ISCHEMIC EVENT
Described herein are methods for controlling the intracellular calcium concentration in a subject prior to experiencing an ischemic event, while experiencing an ischemic event, or while suffering...
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US20090220606 |
TREATMENT AND PREVENTION OF ABNORMAL CELLULAR PROLIFERATION
This invention provides a method for inhibiting or preventing the abnormal growth of cells, including transformed cells, by administering an effective amount of O-acylated heparin derivative....
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US20090216317 |
Delivery of Highly Lipophilic Agents Via Medical Devices
An apparatus and system for delivering a lipophilic agent associated with a medical device including: a medical device, a first lipophilic agent capable of penetrating a body lumen, wherein the...
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US20090214623 |
ANISOTROPIC HYDROGELS
The invention relates to an anisotropic hydrogel and a method of producing the anisotropic hydrogel. The hydrogel exhibiting anisotropic properties is poly(vinyl alcohol) produced by preparing a...
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US20090214563 |
TREATMENT FOR ANTIPHOSPHOLIPID-SYNDROME-RELATED PREGNANCY COMPLICATIONS
The present application provides compositions and methods for treating antiphospholipid-syndrome-related pregnancy complications with tissue factor antagonists.
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US20090202607 |
HEPARIN-LIKE COMPOUNDS, THEIR PREPARATION AND USE TO PREVENT ARTERIAL THROMBOSIS ASSOCIATED WITH VASCULAR INJURY AND INTERVENTIONS
Heparin-like compounds inhibit collagen-induced platelet aggregation in flowing whole blood. The compounds share properties displayed by native mast-cell derived heparin proteoglycans (HEP-PG)...
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US20090202628 |
Nanoparticles for protein drug delivery
The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced...
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US20090196928 |
Biocompatible hydrogel compositions
Compositions, instruments, systems, and methods are providing for creating families of materials having diverse therapeutic indications and possessing enhanced biocompatibility. One genus platform...
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US20090191183 |
SUBSTITUTED INDOLES
Disclosed herein are substituted indole cysteinyl leukotriene receptor modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
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US20090191177 |
Enantiomerically Pure (-) 2-[1-(7-methyl-2-(morpholin-4-yl)-4-oxo-4H-pyrido[1,2-A]pyrimidin-9-yl)ethylamino]benzoic Acid, Its Use In Medical Therapy, And A Pharmaceutical Composition Comprising It - 026
The present invention relates to enantiomerically pure (−) 2-[1-(7-methyl-2-(morpholin-4-yl)-4-oxo-4H-pyrido[1,2-a]pyri
midin-9-yl)ethylamino]benzoic acid or pharmaceutically acceptable salts...
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US20090181927 |
BONDING TISSUES AND CROSS-LINKING PROTEINS WITH NAPHTHALIMIDE COMPOUNDS
Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide...
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US20090181067 |
IMMOBILIZED BIOLOGICALLY ACTIVE ENTITIES HAVING HIGH BIOLOGICAL ACTIVITY FOLLOWING MECHANICAL MANIPULATION
The present invention is directed to immobilized biologically active entities that retain significant biological activity following mechanical manipulation of a substrate material to which the...
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US20090181889 |
COMPOSITIONS AND METHODS FOR DETECTION AND TREATMENT OF HUMAN HERPESVIRUS (HHV)-6
Disclosed herein are compositions and methods for detection and treatment of human herpesvirus (HHV)-6.
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US20090175928 |
Lip Plaster
The invention relates to a self-adhesive lip plaster which comprises at least one single-layered matrix and which contains at least one antiviral active medical substance for using in the event of...
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US20090162438 |
COMPOSITIONS AND METHODS FOR JOINING NON-CONJOINED LUMENS
Disclosed are compositions, methods, and kits for joining together non-conjoined lumens in a patient's body including vascular lumens. More particularly, in various aspects, this invention provides...
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US20090149424 |
HEPARIN CONJUGATES AND METHODS
Heparin conjugates and methods of making and use thereof are disclosed. An illustrative heparin conjugate includes a composition wherein a bile acid is bonded to heparin through the 3-carbon of the...
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US20090149423 |
USE FOR A VERY LOW MOLECULAR WEIGHT HEPARINS
The present invention relates to the use of heparin oligosaccharides having a molecular weight≦5050 Da and an anti-factor Xa activity≦80 IU/mg, or their sodium salts, for preparing a medicament...
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US20090143330 |
Crystalline Polymorphic Forms Of Monosodium N-[-8-(2-Hydroxybenzoyl)Amino]Caprylate
The present invention relates to crystalline polymorphic forms of monosodium N-[8-(2-hydroxybenzoyl)amino] caprylate (“SNAC”), including two hydrates, a methanol solvate, and an ethanol...
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US20090142413 |
Targeted short-lived drug delivery
An aspect of the disclosure includes a system for delivering therapeutic agents. In an embodiment, the system includes an implantable medical device comprising at least one reservoir that holds at...
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US20090143331 |
POLYSACCHARIDE GEL FORMULATION HAVING INCREASED LONGEVITY
Described herein are polysaccharide gel formulations including at least one inhibitor of polysaccharide degradation and methods of making the same. The methods described herein involve the steps of...
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US20090124540 |
Anti-adhesion composites and methods of use thereof
Described herein are composites that inhibit or reduce adhesion between two or more tissues. Also described herein are methods of using the composites.
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US20090124574 |
Carotenoid analogs and derivatives for the prevention of platelet aggregation
The presently described embodiments are directed to compositions that include one or more carotenoid analogs or derivatives for use in the treatment of a disorder associated with platelet...
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US20090117078 |
CROSSLINKED COMPOUNDS AND METHODS OF MAKING AND USING THEREOF
Described herein are crosslinked compounds useful in numerous treatments. Described herein are methods of making crosslinked compounds via (1) die oxidative coupling of two or more thiol compounds...
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US20090118225 |
1-Methyl Nicotinamide and Derivatives for Treatment of Gastric Injury
The present invention is directed to nicotinamide derivatives, and their use in treating gastrointestinal disorders.
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US20090105194 |
PROCESS FOR THE PRODUCTION OF A LOW MOLECULAR WEIGHT HEPARIN
The invention provides a process for the production of a very low molecular weight heparin (VLMWH) composition having a VLMWH content, relative to total heparin content, of at least 10% wt, said...
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US20090105195 |
COMPOSITION COMPRISING MICROBICIDAL ACTIVE INGREDIENTS
An antimicrobial composition having a broad-spectrum activity against microorganisms is provided. The antimicrobial composition includes about 0.1 to about 10 percent by weight of a polyurethane...
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US20090098119 |
ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME
The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially...
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US20090098174 |
HEPARIN COATING OF BIOLOGICAL TISSUE
The present invention discloses an in vitro method to provide biological tissue with a heparin coating comprising the following steps; linking a biotin reagent to biological tissue, linking an...
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US20090092580 |
DIALKYL ETHER DELIVERY AGENTS
The present invention provides dialkyl ether compounds and pharmaceutically acceptable salts thereof, compositions containing the same and one or more active agents, and methods of administering...
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US20090087484 |
Formulation and dosage form for increasing oral bioavailability of hydrophilic macromolecules
A formulation and dosage form for enhancing the bioavailability of orally administered hydrophilic macromolecules includes a permeation enhancer, a hydrophilic macromolecule, and a carrier such as...
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US20090082249 |
NUTRITIONAL SUPPLEMENT FOR A CATEGORY OF HIV PATIENTS
The present invention relates to a nutritional product for HIV patients that are not on Highly Active Antiretroviral Therapy. More specifically the invention relates to a nutritional composition...
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US20090060970 |
Compositions and methods of administering paclitaxel with other drugs using medical devices
Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs...
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US20090054374 |
METHODS OF TREATING ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
The present invention provides methods for treating and preventing acute exacerbations of Chronic Obstructive Pulmonary Disease. The methods particularly comprise administering to a patient have...
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US20090054256 |
METHOD EVOLVED FOR RECOGNITION OF THROMBOPHILIA (MERT)
Methods for predicting an individual's genetic risk for developing venous thrombosis in diverse ethnic populations is disclosed, as are arrays and kits which can be used to practice the method. The...
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US20090048173 |
Use Of Dipyridamole For Treatment Of Resistance To Platelet Inhibitors
The invention relates to a method of treatment of resistance to platelet inhibitors, i.e. a method to overcome resistance of treatment with platelet inhibitors, said method comprising administering...
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US20090042834 |
Stabilized Glycosaminoglycan Preparations and Related Methods
Compositions comprising a glycosaminoglycan (e.g., a hyaluronan, hyaluronic acid, hyaluronate, sodium hyaluronate, dermatan sulfate, karatan sulfate, chondroitin 6-sulfate, heparin, etc.) in...
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US20090036405 |
METHOD FOR BLOCKING LIGATION OF THE RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS (RAGE)
A method and medicament is provided for treating and inhibiting interaction of the receptor for advanced glycation end-products (RAGE) and its ligands using a natural or synthetic sulfated...
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US20090028824 |
SYSTEMS AND METHODS FOR DELIVERING DRUGS
A patch pump device generally includes at least one fluid source, a fluid communicator, and an electrochemical actuator. The fluid communicator is in fluid communication with the fluid source. The...
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US20090012494 |
INTRADERMAL DELIVERY OF BIOLOGICAL AGENTS
The present invention relates to methods for intradermally delivering one or more biologically active agents such as vaccines and therapeutic agents into the dermis layer of the skin of a subject...
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US20090004118 |
Multifunctional Nanoparticle Conjugates And Their Use
Disclosed herein are conjugates comprising a nanocarrier, a therapeutic agent or imaging agent and a targeting agent. Also disclosed herein are compositions comprising such conjugates and methods...
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US20090004253 |
Composite device for the repair or regeneration of tissue
The present invention is directed to composite devices comprising a tissue-engineering scaffold and an anionic polysaccharide/structural protein coating. The composite devices are useful for the...
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US20080286279 |
Treatment of Severe Community-Acquired Pneumonia by Administration of Tissue Factor Pathway Inhibitor (Tfpi)
Methods for prophylactically or therapeutically treating severe pneumonia involve administration of tissue factor pathway inhibitor (TFPI) or a TFPI analog to patients suffering from or at risk of...
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US20080286327 |
THOMBOLYSIS AND CHRONIC ANTICOAGULATION THERAPY
Method and systems of treating a patient with at least one of a myocardial infarction, a stroke, and a pulmonary embolism include providing a stimulator coupled to at least one electrode and a...
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US20080279845 |
COMBINATION THERAPY WITH A COMPOUND ACTING AS A PLATELET ADP RECEPTOR INHIBITOR
The present invention is directed to pharmaceutical compositions and methods of using combination therapies containing...
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