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US20090286776 |
HEXENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC APPLICATIONS THEREOF
Compounds of the formula (I): in which R, R 1 , R 2 and R 3 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical...
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US20090285888 |
DERIVATIVES OF DIHYDROXYPHENYLALANINE
The invention relates to derivatives of dihydroxyphenylalanine, to their synthesis and to pharmaceutical compositions containing said derivatives of dihydroxyphenylalanine. Furthermore, the...
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US20090270385 |
SUBSTITUTED ARYLCYCLOPENTENES AS THERAPEUTIC AGENTS
Compounds comprising
or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein G, B, Y, and A are as described. Methods, compositions, and medicaments related thereto...
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US20090264524 |
AGENT FOR RECOVERY FROM CEREBRAL FATIGUE
The present invention relates to a recuperative agent for cerebral fatigue and a recuperative food for cerebral fatigue, each including as active ingredients one or more members selected from the...
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US20090264487 |
HEMIASTERLIN ANALOGS
This invention provides analogs of hemiasterlin, methods of synthesis of the analogs and use of the analogs as a cytotoxic anti-mitotic agents.
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US20090264477 |
BETA ADRENERGIC RECEPTOR AGONISTS FOR TREATMENT OF PAIN AND/OR INFLAMMATION
Effective treatments of pain and/or inflammation are provided. Through the administration of an effective amount of at least one beta adrenergic agonist at or near a target site, one can reduce,...
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US20090239941 |
AMINO ACID DERIVATIVES
Compounds of formula (I) are active as dopaminergic compounds or as compounds which or as compounds which diminish the symptoms of dopamine deficiency: wherein: R 1 and R 2 are independently...
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US20090233996 |
AVERMECTIN/BENZOYL PEROXIDE COMPOSITIONS FOR TREATING AFFLICTIONS OF THE SKIN, E.G., ROSACEA
Pharmaceutical/dermatological compositions containing at least one avermectin compound, e.g., ivermectin and benzoyl peroxide, are useful for treating afflictions of the skin, especially rosacea.
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US20090226380 |
Topical Skin Treating Compositions
A topical composition and methods of using same for treating various skin disorders or conditions. In a particular aspect, these compositions comprise a storage-stable benzoyl peroxide-containing...
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US20090221527 |
TUMOR NECROSIS FACTOR INHIBITORS
The present invention is directed to compounds that are allosteric inhibitors of tumor necrosis factor receptor I, compositions comprising such compounds, and methods of using such compounds and...
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US20090221517 |
Biologically Active Compounds
Compounds having useful biological activity, particularly antioxidant and anti-inflammatory activity, derived from Centipeda cunninghamii , and biologically active derivatives thereof,...
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US20090220591 |
Pharmaceutical Compositions Comprising Non-Steroidal Antiinflammatory Drug, Antipyretic-Analgesic Drug and Proton Pump Inhibotor
The present invention relates to pharmaceutical compositions in the form of fixed combination comprising non-steroidal anti-inflammatory drug or its single enantiomers or salts thereof,...
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US20090215881 |
Polyphenolic Bioprecursors
Cosmetic and therapeutic, in particular dermatological bioprecursors have the formula [A] n —PP—[B] m wherein PP is a polyphenol radical in which each hydroxyl function is protected by a group...
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US20090203777 |
ORGANIC COMPOUNDS
The invention describes novel pharmaceutically acceptable salt forms of camostat, processes for lyophilisation, taste-masked formulations, nebulised formulations and the use of each of the...
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US20090203681 |
NOVEL N-(2-AMINO-PHENYL)-AMIDE DERIVATIVES
The present invention provides novel compounds of the general formula (I)
and pharmaceutically acceptable salts thereof, processes for the manufacture of these novel compounds and medicaments...
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US20090202464 |
Fragrance Compounds
A method of providing a fragrant odour to an application, comprising the addition thereto of at least one compound of the formula (I) wherein X and Y are independently selected from the group...
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US20090197924 |
2-AMINO-2-PHENYL-ALKANOL DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
2-amino-2-phenyl-alkanol ester derivatives of general formula (I) in which: R 1 is H, straight or branched 1 to 4C alkyl, straight or branched 2 to 4C alkyl substituted by OH, alkoxy, alkylthio,...
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US20090192222 |
MESOPHASIC FORMS OF (3S)-AMINOMETHYL-5-METHYL-HEXANOIC ACID PRODRUGS AND METHODS OF USE
Mesophasic forms of (3S)-aminomethyl-5-hexanoic acid prodrugs and methods of preparing and methods of using mesophasic forms of (3S)-aminomethyl-5-hexanoic acid prodrugs are provided.
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US20090192221 |
CARBAMATE ANTIBIOTICS
The invention relates to the field of antibiotic compositions, both inside and outside the medical field. Presented is a new class of antibiotic compounds around the lead compound...
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US20090170937 |
Amino Acid Derivatives
Compounds of formula (I) have activity in alleviating the effects of impaired dopaminergic signaling, for example in the treatment of Parkinsons Disease:
wherein: R 1 is a carboxyl, carboxyl...
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US20090156670 |
NONAQUEOUS LIQUID PARENTERAL ACECLOFENAC FORMULATION
A nonaqueous liquid parenterally deliverable pharmaceutical formulation, and more particularly a nonaqueous liquid parenteral Aceclofenac formulation comprising the selective NSAID Aceclofenac, is...
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US20090156653 |
Amino alcohol derivatives, salts thereof and immunosuppresive agents
An amino alcohol derivative represented by the following general formula (1) (for example, (±)-2-amino-5-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-2-
methylpentane- 1 -ol) exhibits strong...
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US20090156585 |
ORGANIC COMPOUNDS
A specific combination, linked pro-drug or a compound of an angiotensin receptor antagonist and a NEPi are used in the treatment of hypertension.
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US20090137668 |
C-NITROSO-DERIVED NITROXYL DONORS
Active compounds of Formula (I) are described: wherein: R 1 and R 2 are each independently C1-C4 alkyl; or R 1 and R 2 together form a C2-C7 alkylene chain; and Z is a non-steroidal...
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US20090124689 |
CETP Inhibitors
Compounds having a biphenyl group substituted with a phenyl or heteroaromatic group, as shown in Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and...
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US20090098180 |
FUNCTIONALIZED AMINO ACIDS AND ABSORBABLE POLYMERS THEREFROM
The present invention relates to compounds of formula I and II, which are functionalized amino acids, and polymers formed from the same.
Polymers formed from the functionalized amino acids are...
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US20090093510 |
Use of Nitrooxyderivatives of Drug for the Treatment of Muscular Dystrophies
The present invention relates to the use of nitric oxide releasing compounds for retarding or reversing muscular dystrophies such as Duchenne and Becker dystrophies.
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US20090076143 |
COMPOSITIONS AND METHODS FOR TREATING INFLAMMATION AND INFLAMMATION-RELATED DISORDERS BY PLECTRANTHUS AMBOINICUS EXTRACTS
The crude extract of Plectranthus Amboinicus (PA) has anti-inflammatory effects and can inhibit AP-1 binding in vitro. The incubation with PA crude extract resulted in significant inhibition of...
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US20090076131 |
Anti-Cancer and Anti-Inflammatory Effects of Annurca Apple Extracts and Compositions Purified Therefrom
The present invention includes compositions and methods for modulating cell proliferation using a pharmaceutical effective amount of an isolated and purified polyphenolic composition having one or...
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US20090042980 |
Neuroprotective compositions and methods
Neurite outgrowth-promoting prostaglandins (NEPPs) and other electrophilic compounds bind to Keap1, a negative regulator of the transcription factor Nrf2, and prevent Keap1-mediated inactivation of...
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US20090042955 |
BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS
Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
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US20090041666 |
Ophthalmic formulations of Amyloid-beta contrast agent and methods of use thereof
The invention provides ophthalmic formulations of Amyloid-β contrast agents. Also provided are methods of using such formulations in the diagnosis of Alzheimer's Disease or a predisposition...
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US20090036525 |
Non-Natural Amino Acid Derivatives
Compounds of formula (I) have activity in alleviating the effects of impaired dopaminergic signaling, for example in the treatment of Parkinsons Disease:
wherein: R 1 is a carboxyl, carboxyl...
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US20090036523 |
PRODRUGS OF CANNABIDIOL, COMPOSITIONS COMPRISING PRODRUGS OF CANNABIDIOL AND METHODS OF USING THE SAME
Described herein are cannabidiol prodrugs, methods of making cannabidiol prodrugs, formulations comprising cannabidiol prodrugs and methods of using cannabidiols. One embodiment described herein...
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US20090036516 |
COMPOUNDS FOR TREATING METABOLIC SYNDROME
Compounds of general formula:
wherein R′, R, x and z have the meaning reported in the specification, are useful for treating inflammatory diseases including metabolic syndrome, diabetes,...
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US20090035315 |
Method of Improving Treatments in Rheumatic and Arthritic Diseases
Improved treatments of joint diseases, such as, e.g. osteoarthritis and rheumatoid arthritis, and pain, wherein a strontium-containing compound is administered alone or in combination with one or...
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US20090022821 |
COMPOSITIONS FROM WAX MYRTLE FOR THE TREATMENT OF CANCER, CARDIOVASCULAR AND INFLAMMATORY DISEASES
The present invention relates to the use of certain novel compositions from wax myrtle ( Morella cerifera ) which are inhibitors of nuclear factor kappa B (NF-kB), oxidative stress (activation of...
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US20090012160 |
Carnitine Conjugates As Dual Prodrugs, Methods Of Production And Uses Thereof
The present invention discloses novel dual prodrug compounds of formula (1), methods for their preparation and intermediates in their syntheses, formula (1): wherein A is a single bond, —O—, or...
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US20090011059 |
Ginger Extract For Inhibiting Human Drug Transporters
The present invention relates to the use of a ginger extract on its own or in combination with pharmaceutical compositions for inhibiting human drug transporters for positively influencing the oral...
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US20090005446 |
Prophylactic Antistress Agent
The present invention relates to a prophylactic antistress agent and a central fatigue improver, which contain chlorogenic acids or pharmaceutically acceptable salts thereof as active ingredients....
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US20080312322 |
Organic Compounds
A compound of formula (I); in free or pharmaceutically acceptable salt form, where R 1 , R 2 , R 3 , R 4 , R 5 , m, n, w, X, Y and Q have the meanings as indicated in the specification, are useful...
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US20080305135 |
Wasp repellents
A method of repelling wasps, which method comprises using a preparation comprising (a) one or more of ethyl 3-(N-n-butyl-N-acetylamino)propionate, dihydronepetalactone, and extract of catmint, and...
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US20080293781 |
Salicylic Acid Derivatives
The present invention refers to O-acyl salicylic acid derivatives (I) bearing a NO donor moiety, a process for their preparation and pharmaceutical compositions containing them. (I) wherein: D is...
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US20080255149 |
Carboxyamine Compounds and Methods of Use Thereof
The invention relates to the use of carboxyamine compounds and salts thereof in the treatment of HDAC dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of...
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US20080214663 |
Levodopa dimethyl-substituted diester prodrugs compositions, and methods of use
Levodopa dimethyl-substituted diester prodrugs pharmaceutical, compositions comprising levodopa dimethyl-substituted diester prodrugs, and methods of using such prodrugs and pharmaceutical...
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US20080214656 |
Compounds With Diphenoyl-Structure For the Treatment of Immune Diseases
A composition comprising compounds with a diphenoyl (DP 5 structure for preventing or treating an immune disease and a prophylactic or therapeutic method for the immune disease based on the...
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US20080199542 |
Use of Winter Savory (Satureja Montana) or the Extracts Thereof For the Preparation of Medicaments For the Treatment of the Premature Ejaculation
The use of Winter savory or its purified extracts rich in rosmarinic acid, the use of rosmarinic acid and the extracts containing it for the preparation of medicaments for the treatment of...
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US20080194646 |
Methods For Avoiding Edema in the Treatment of Metabolic, Inflammatory, and Cardiovascular Disorders
Compounds, compositions, and methods of treating or preventing PPARγ-mediated diseases, including cancer, using phenoxy acetic acid derivatives and prodrugs are provided.
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US20080171789 |
Catechol protected levodopa diester prodrugs, compositions, and methods of use
Catechol protected levodopa diester prodrugs pharmaceutical, compositions comprising catechol protected levodopa diester prodrugs, and methods of using such prodrugs and pharmaceutical compositions...
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US20080132488 |
Prodrugs of (2R)-2-Propyloctanoic Acid For the Treatment of Stroke
Disclosed are prodrugs of (2R)—2-propyloctanoic acid, and pharmaceutical compositions comprising them, which may be effective in modulating multiple events in the biochemical cascade of stroke....
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