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US20130216479 SITE-SPECIFIC CHEMICAL MODIFICATION OF PROTEINS AT THEIR N-TERMINI, ENABLING THE FORMATION OF HOMOGENEOUS ADDUCTS  
Site-specific modifications of proteins at their N-termini are provided. In particular, a chemical modification of proteins at their N-termini via a transamination reaction to form homogeneous...
US20110098219 System for Curing Hepatic Cancer with Leptin  
The present invention cures hepatic cancer by MPA with the help of leptin. A therapeutic drug of MPA combined with leptin is applied to a liver cancer patient. Or, MPA can be directly applied to a...
US20140121157 METHODS FOR TREATING PROGRESSIVE COGNITIVE DISORDERS RELATED TO NEUROFIBRILLARY TANGLES  
The described invention provides methods for treating or preventing progression of a progressive cognitive disease, disorder or condition, and methods for improving resilience of cognitive...
US20120010132 METHODS FOR TREATING PROGRESSIVE COGNITIVE DISORDERS RELATED TO NEUROFIBRILLARY TANGLES  
The described invention provides methods for treating or preventing progression of a progressive cognitive disease, disorder or condition, and methods for improving resilience of cognitive...
US20140336111 Therapeutic Use of Activators of Zinc Finger Protein GL13  
The present invention relates to the therapeutic use of activators of the zinc finger protein GLI3 in diseases that are associated with reduced Hedgehog signaling in hepatocytes, in particular...
US20120058940 AZINONE-SUBSTITUTED AZAPOLYCYCLE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF  
Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and...
US20110003738 AZINONE-SUBSTITUTED AZAPOLYCYCLE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF  
Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and...
US20150038409 Leptin Compositions and Methods for Treating Progressive Cognitive Function Disorders Resulting from Accumulation of Neurofibrillary Tangles and Amyloid Beta  
The present disclosure provides compositions containing a leptin product and methods of clinical therapy and diagnostic methods for progressive cognitive disorders. According to one aspect, the...
US20140088000 Leptin Rescues Neurons from Alzheimer's Disease Related Pathways Triggered by Lipid Burden  
The described invention relates to compositions and methods for rescuing neurons from Alzheimer's Disease related pathways triggered by lipid burden or metabolic insult.
US20110212889 USE OF LEPTIN FOR THE TREATMENT OF FATTY LIVER DISEASES AND CONDITIONS  
The invention generally relates to the use of leptin in the treatment of a leptin-responsive disease or condition in a non-lipodystrophic subject. More particularly, the invention is directed to...
US20120058939 AZABICYCLOALKANE-INDOLE AND AZABICYCLOALKANE-PYRROLO-PYRIDINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF  
Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and...
US20120035102 AZINONE-SUBSTITUTED AZABICYCLOALKANE-INDOLE AND AZABICYCLOALKANE-PYRROLO-PYRIDINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF  
Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and...
US20110003739 AZINONE-SUBSTITUTED AZABICYCLOALKANE-INDOLE AND AZABICYCLOALKANE-PYRROLO-PYRIDINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF  
Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and...
US20110003737 AZABICYCLOALKANE-INDOLE AND AZABICYCLOALKANE-PYRROLO-PYRIDINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF  
Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and...
US20130023470 EXENDIN AND EXENDIN AGONISTS FOR EATING DISORDERS  
Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist,...
US20110034377 Exendin and Exendin Agonists for Eating Disorders  
Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist,...
US20110092417 LEPTIN FUSION PROTEINS  
The disclosure relates to leptin fusion polypeptides; nucleic acid molecules encoding said polypeptides and methods of treatment that use said polypeptides.
US20150203568 ALBUMIN FUSION PROTEINS  
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors...
US20130190230 COMPOSITIONS AND METHODS FOR TREATING COGNITIVE DEFICITS  
A method of treating or preventing cognitive impairment deficits in subjects with age-associated cognitive decline or a dementing illness includes administering to the subject a therapeutically...
US20120244156 LEPTIN AS AN ANTI- AMYLOIDOGENIC BIOLOGIC AND METHODS FOR DELAYING THE ONSET AND REDUCING ALZHEIMER'S DISEASE-LIKE PATHOLOGY  
The present invention relates to methods for treating, preventing, or diagnosing the pathology of progressive cognitive disorders resulting from accumulation of an amyloid peptide, in particular,...
US20110104265 COMPOSITIONS AND METHODS OF TARGETED NANOFORMULATIONS IN THE MANAGEMENT OF OSTEOPOROSIS  
A composition and method for treating a bone condition of an animal. The compostion includes nanoparticles; a targeted moiety covalently bonded to an outer surface of each nanoparticle; and...
US20110256123 Methods and uses of leptin in immune modulation and hepatocellular carcinoma  
The present invention relates to methods for the modulation of immune responses. More particularly, the invention relates to methods and uses of leptin for immune-modulation of the balance between...
US20140256621 ENGINEERED POYPEPTIDES HAVING ENHANCED DURATION OF ACTION AND REDUCED IMMUNOGENICITY  
Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including once weekly administration. The compounds are engineered polypeptides...
US20130023469 LEPTIN FOR USE IN INCREASING LIVER REGENERATION  
Activators of the AKT/mTOR pathway, in particular leptin, are useful in methods and compositions for increasing regeneration of liver, increasing liver mass or improving liver function, or a...
US20130274182 ENGINEERED POLYPEPTIDES HAVING ENHANCED DURATION OF ACTION  
Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including once weekly administration. The compounds are engineered polypeptides...
US20130203661 HIGHLY SOLUBLE LEPTINS  
The disclosure provides chimeric polypeptides and nucleic acid molecules encoding chimeric polypeptides. Also provided are pharmaceutical compositions and methods of treatment for diseases and...
US20050065078 Use of leptin for infant with low birth weight for prevention of obesity  
The invention discloses the therapeutic and prophylactic administration of leptin to (i) an infant of low birth weight for age; (ii) a nursing mother of an infant, the infant having low birth...
US20120108503 METHODS FOR TREATING TYPE I DIABETES WITH LEPTIN AND LEPTIN AGONISTS  
The present invention provides for methods of treating type I diabetes by inducing hyperleptinemia in subjects afflicted with type I diabetes. These methods can achieve normoglycemia and suppress...
US20130183309 Fragments, Mutants and Chimeric Fusion Proteins of Leptin For Treating Alzheimer's Disease  
The described invention relates to methods for treating, preventing, or diagnosing the pathology of progressive cognitive disorders resulting from accumulation of an amyloid peptide, in...
US20150132287 METHODS OF DECREASING LEPTIN LEVELS OR ACTIVITY FOR TREATING INFLAMMATION  
The present invention is directed to methods for modulating the Th/Th2 cell balance toward anti-inflammatory cytokine producing cells in a subject comprising decreasing the amount, the expression,...
US20120149636 Modified Leptin Polypeptides and Their Uses  
Modified human leptin polypeptides and uses thereof are provided.
US20060199761 Insulin resistance improving agent  
The invention provides an insulin resistance improving agent which contains, as an active component, a C-terminal globular domain of adiponectin, adiponectin, or a gene for the domain or...
US20140094407 DEVICES AND METHODS FOR TREATING AND/OR PREVENTING DISEASES  
The invention relates to a therapeutic device for the delivery of therapeutic agents, e.g. a peptide such as leuprolide, via the vagina to a female mammal. In some embodiments, the invention also...
US20130065825 Compositions and Methods for Delaying Senescence or Cell Death in Neurons  
The described invention provides methods and compositions for enhancing the enzymatic activity of Sirtuin family members by using Leptin, Leptin analogs, Leptin derivatives, or Leptin agonists....
US20110212138 SUSTAINED RELEASE FORMULATIONS USING NON-AQUEOUS CARRIERS  
The disclosure provides one-component, injectable, sustained release formulations which comprise microspheres containing active pharmaceutical ingredients (e.g., exenatide), wherein the...
US20060040861 Method of treating, preventing, and diagnosing prostate cancer  
A method of treating prostate cancer in a prostate cancer patient is disclosed. In one embodiment of the present invention, the method comprises the step of decreasing or blocking the patient's...
US20150190466 METHODS OF TREATING METABOLIC DISEASE  
The invention provides methods for treating metabolic disease in a subject and methods for increasing the expression of ILDR2 in a subject. The invention further provides a method for identifying...
US20130133089 HIGH AFFINITY LEPTINS AND LEPTIN ANTAGONISTS  
Leptin muteins, in particular leptin antagonists, with increased binding affinity to leptin receptor are provided. These compounds as well as pharmaceutical composition comprising them are useful...
US20130344027 MULTI-FUNCTIONAL POLYMERIC MATERIALS AND THEIR USES  
Multifunctional polymers are disclosed having a smart segment and a biodegradable segment. Advantageously, the biodegradable segment includes a hydrophilic segment and a hydrophobic segment....
US20080152696 Use of Leptin for the Prevention of Excess Body Weight and Composition Containing Leptin  
The invention relates to the use of leptin in the preparation of an ingestible composition for children from nursing infants to adolescents, comprising leptin at a concentration greater than 50...
US20050065080 Use of leptin in fertility  
The present invention relates to the use of leptin in treating infertility and particularly to the use of leptin in triggering ovulation.
US20130190225 Use of Leptin for Treating Human Lipoatrophy and Method of Determining Predisposition to Said Treatment  
Leptin, leptin analogs, and leptin derivatives are used to treat patients with lipoatrophy. Leptin is effective against conditions of lipoatrophy for both genetic and acquired forms of the...
US20110306540 Use of Leptin for Treating Human Lipoatrophy and Method of Determining Predisposition to Said Treatment  
Leptin, leptin analogs, and leptin derivatives are used to treat patients with lipoatrophy. Leptin is effective against conditions of lipoatrophy for both genetic and acquired forms of the...
US20090215694 Lyophilized Formulations of Exendins and Exendin Agonist Analogs  
Novel formulations containing exendins, exendin agonists and/or exendin analogs are provided.
US20110081426 AMINOTHIAZOLE MODULATORS OF BETA-3-ADRENORECEPTOR  
The present invention relates to new aminothiazole modulators of beta-3-adrenoreceptor activity, pharmaceutical compositions thereof, and methods of use thereof.
US20050112149 Single-dose taste inhibitor units  
A package of single-dose taste inhibitor units available in multiple forms, such as lozenges, dissolvable strips, gum, chewable tablets, hard candies, and candies or chewing gums with liquid or...
US20140221281 DUAL GLP1/GIP OR TRIGONAL GLP1/GIP/GLUCAGON AGONISTS  
The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as...
US20070275874 Use of Leptin in Wound Healing  
As described herein, leptin treatment significantly increased wound contraction and epithelial regeneration while reducing granulation tissue and wound area, consistent with a healing augmentation...
US20070161548 Use of adam 12 for diagnosis and therapy of preeclampsia  
The present invention relates to the significant role of ADAM 12, ADAM 12-L, and ADAM 12-S in preeclampsia and related disorders. The invention further relates to the use of said genes and gene...
US20070292412 Novel genes and markers in type 2 diabetes and obesity  
Genes, SNP markers and haplotypes of susceptibility or predisposition to T2D and subdiagnosis of T2D and related medical conditions are disclosed. Methods for diagnosis, prediction of clinical...
Matches 1 - 50 out of 104 1 2 3 >