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US20090318546 |
Chromen-2-One Derivatives
A compound of formula (I)
wherein R 1 , R 2 , R 3 , R 4 , R 5 , and ring A are as defined in the specification, processes for their production, their uses, in particular in...
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US20090285797 |
USE OF INHIBITORS OF CYP2A6 FOR REGULATING NICOTINE METABOLISM
The invention relates to methods and compositions for regulating nicotine metabolism. Also provided are methods for screening and assessing substances for regulating nicotine metabolism. Methods...
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US20090275650 |
3-Acyl coumarins, thiochromones and quinolones and therapeutic uses thereof
Compounds of Formula I:
wherein R 1 , R 2 , M, Q and n are as defined herein, are useful as antiproliferative agents including, for example, as anticancer agents.
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US20090274737 |
IMPLANT COMPRISING A SURFACE OF REDUCED THROMBOGENICITY
An implant for a human or animal body, comprising a surface having reduced thrombogenic properties, whose surface has a wetting angle of Θ, where Θ≦80°. Also disclosed is a method for...
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US20090270332 |
GENETIC POLYMORPHISMS ASSOCIATED WITH VENOUS THROMBOSIS, METHODS OF DETECTION AND USES THEREOF
The present invention is based on the discovery of genetic polymorphisms that are associated with venous thrombosis. In particular, the present invention relates to nucleic acid molecules...
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US20090197945 |
Method for Generating Reference Controls for Pharmacogenomic Testing
Reference controls for use with pharmacogenomic testing, and methods for their identification, preparation, and use, are disclosed. The reference controls can confirm that pharmacogenomic testing...
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US20090170930 |
METHODS FOR DIRECTING DIFFERENTIATION OF CLONOGENIC NEURAL STEM CELLS WITH COUMARINS
A method for promoting differentiation of clonogenic neural stem cells (NSCs), comprising administering to a patient in the need of such promoting a coumarin compound represented by formula I or by...
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US20090149417 |
Methods and compositions for the treatment of cancer using benzopyrone-type PARP inhibitors
The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides compositions and methods for treating cancer...
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US20090149397 |
TREATMENT OF CANCER WITH COMBINATIONS OF TOPOISOMERASE INHIBITORS AND PARP INHIBITORS
In one aspect, the present invention provides a composition and a kit comprising a combination of topoisomerase inhibitor and PARP inhibitor for treatment of cancer. In another aspect, the...
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US20090130083 |
Therapeutic Agents Targeting the NCCA-ATP Channel and Methods of Use Thereof
The present invention is directed to therapeutic compositions targeting the NC Ca-ATP channel of an astrocyte, neuron or capillary endothelial cell and methods of using same. More specifically,...
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US20090124683 |
MERCAPTAN AND SELENO-MERCAPTAN COMPOUNDS AND METHODS OF USING THEM
Novel mercaptan compounds, particularly those including a photolabile protecting group, are described as well as methods of using the compounds for the prevention and treatment of ocular damage and...
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US20090118361 |
SUPPRESSOR OF EXPRESSION OF MCP-1, AND AMELIORATING AGENT FOR INFLAMMATORY DISEASE, PHARMACEUTICAL, SUPPLEMENT, FOOD, BEVERAGE OR FOOD ADDITIVE USING THE SUPPRESSOR
A suppressor of the expression of MCP-1 is provided that is excellent in safety and is widely applicable to, for example, foods. The suppressor of the expression of MCP-1 according to the present...
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US20090076122 |
PARP Modulators and Treatment of Cancer
The invention relates to a method of modulating poly(ADP-ribose)polymerase-1 (PARP-1) activity in a mammal comprising administering to a mammal an effective amount of an organic aromatic compound...
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US20090005436 |
Substituted Aminoalkyl- and Amidoalkyl-Benzopyran Derivatives
This invention is related to novel aminoalkyl- and amidoalkyl-benzopyran derivatives of the following general formula (I)
wherein: the group
is a substituent in position 6...
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US20080306041 |
Cardiovascular Compounds Comprising Heterocyclic Nitric Oxide Donor Groups, Compositions and Methods of Use
The invention describes compositions and kits comprising at least one cardiovascular compound comprising at least one heterocyclic nitric oxide donor group, and, optionally, at least one nitric...
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US20080293684 |
Heterocyclic Acetophenone Potentiators of Metabotropic Glutamate Receptors
The present invention is directed to compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of...
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US20080286327 |
THOMBOLYSIS AND CHRONIC ANTICOAGULATION THERAPY
Method and systems of treating a patient with at least one of a myocardial infarction, a stroke, and a pulmonary embolism include providing a stimulator coupled to at least one electrode and a...
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US20080267908 |
Il-32 Modulators
The present invention relates to methods of screening for modulators of interleukin 32 (IL-32), to modulators of IL-32 and to their use. Proteinase 3 has been identified as an IL-32 binding protein...
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US20080262081 |
Novel Use of Nutraceutical Compositions Comprising Resveratrol
The use of resveratrol, a derivative, metabolite or analogue thereof, in combination with at least one additional component selected from EGCG, coenzyme Q-IO, genistein, lycopene, hydroxytyrosol...
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US20080233189 |
Pharmaceutical Tablets Comprising Two or More Unitary Segments
Accurate means of dosing with a compressed, segmented pharmaceutical tablet, and tablettes formed from said tablets, is disclosed.
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US20080226758 |
Lipoxygenase and Cyclooxygenase Inhibition
The present invention relates to methods, compositions and their constituents for inhibiting 5-Lipoxygenase (5-LO), 15-Lipoxygenase (15-LO), cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2),...
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US20080221159 |
Inhibitors of human immunodeficiency virus replication
Compounds of formula I:
wherein a, b, c, X, R 2 , R 3 , R 4 , R 6 and R 7 are defined herein, are useful as inhibitors of HIV replication.
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US20080221029 |
METHODS FOR TREATMENT OF THIOL-CONTAINING COMPOUND DEFICIENT CONDITIONS
Certain embodiments in the present invention provide for methods for therapy of lung diseases and other conditions such as infection are provided. In certain embodiments, the methods comprise one...
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US20080221204 |
Materials and Methods for Treating Coagulation Disorders
This invention is drawn to compounds which are more easily metabolized by the metabolic drug detoxification systems. Particularly, warfarin analogs which have been designed to include esters within...
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US20080194522 |
Development of Fluorogenic Substrates For Monoamine Oxidases (Mao-A and Mao-B)
The present invention relates to compounds useful for detecting the activity of monoamine oxidases, compounds useful for competitively inhibiting monoamine oxidases, for determining inhibitors of...
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US20080176830 |
Compounds, Compositions, and Methods
Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
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US20080153872 |
Bis-(Coumarin) Compounds With Anti-Inflammatory Activity
Certain bis-(coumarin) compounds as well as the products of their intramolecular cyclization including pharmaceutically acceptable salts, hydrates, solvates, clathrates, prodrugs, tautomers and...
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US20080119421 |
Process for treating a biological organism
A process for treating a biological organism, comprising the steps in which a cell cycle arresting drug is administered to the organism to produce synchronized cells, the microtubules within the...
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US20080113924 |
Neuramindase Inhibitor
There are provided a novel compound having irreversible inhibitory activity against neuraminidase, a therapeutic agent and a detection agent for a disease involving neuraminidase. A compound...
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US20080096958 |
Antibacterial Composition
The object of the present invention is to provide an antibacterial composition which has an improved antibacterial effect and a wider antibacterial spectrum than conventional antibacterial agents...
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US20080076778 |
METHODS FOR DESIGNING PARP INHIBITORS AND USES THEREOF
The present invention relates to a computer-assisted method of a designing of a PARP inhibitor comprising: a) determining an interaction between a candidate PARP protein and a known PARP inhibitor...
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US20080075692 |
METHODS FOR TREATING BLOOD DISORDERS
Methods of treating blood disorders are described.
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US20080032982 |
Butanoic Acid Derivatives, Processes For The Preparation Thereof, Pharmaceutical Compositions Comprising Them, And Therapeutic Applications Thereof
Compounds of the formula (I): in which R, R 1 and R 2 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical...
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US20080026018 |
Administration of coumarin, butylated hydroxyanisole and ethoxyquine for the treatment of canities
At least one compound selected from among coumarin and/or derivative thereof, butylated hydroxyanisole, ethoxyquine and mixtures thereof, and admixtures thereof with other active agents selected...
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US20080027112 |
BICYCLIC HETEROARYL INHIBITORS OF PDE4
The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases...
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US20080027111 |
Treatment and prevention of cardiovascular disease using mast cell stabilizers
The present invention is directed to methods of treating or preventing the development of cardiovascular disease by administering compounds that stabilize mast cells. In addition, it includes...
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US20080021097 |
Arginase levels/activity
This invention relates to compositions, and methods of use thereof, for treating conditions associated with elevated arginase levels and/or activity comprising administering to a subject in need...
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US20080020068 |
Use Of Trisubstituted Benzopyranones
The present invention relates to the use of trisubstituted benzopyranones for the treatment or propylaxis of pathological conditions associated with oxidative stress and/or inflammatory reactions...
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US20080009544 |
Pharmaceutical Composition Useful as Acetylcholinesterase Inhibitors
A pharmaceutical composition useful as acetylcholinesterase inhibitors. The present invention relates to pharmaceutical composition comprising the naturally occurring compounds selected from (±)...
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