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US20090298925 |
SUBSTITUTED BENZOPYRANS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS
The present invention relates to substituted benzopyran derivatives, stereoisomers, and pharmaceutical acceptable salts thereof useful as Estrogen Receptor beta agonists for treating Estrogen...
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US20090298924 |
HYDROXAMIC ACID DERIVATIVES AS INHIBITORS OF HDAC ENZYMATIC ACTIVITY
Compounds of formula (I) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers:
wherein Y 1 is a bond, —(C═O)—, —S(O 2 )—,...
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US20090298842 |
Novel therapeutic targets for the treatment of mycobacterial infections and compounds useful therefor
Described herein is the discovery that certain mycobacterial serine/threonine protein kinases, particularly protein kinase G (PknG), are effective therapeutic targets for the treatment of...
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US20090291978 |
Enzyme Inhibitors
Compounds of formula (I) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers, wherein R 1 is a carboxylic acid group (—COOH), or an ester...
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US20090286863 |
SULFAMATOBENZOTHIOPHENE DERIVATIVES
The invention relates to novel compound of the general formula (I), in which R has the meanings indicated in Claim 1 , to the preparation thereof and to the use thereof as medicaments. The...
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US20090286862 |
Therapeutic agent for psychoneurotic disease
The present invention relates to a preventive and/or therapeutic agent for psychoneurotic diseases, comprising an EP 3 antagonist represented by the general formula (I):
(wherein the meanings...
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US20090264474 |
SULFONAMIDES AS TRPM8 MODULATORS
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:
...
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US20090264470 |
CB1 Antagonists and Inverse Agonists
The present invention relates to methods of treating obesity, anorexia nervosa, or bulimia nervosa comprising administering a compound of the invention. The present invention further relates to the...
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US20090264411 |
FUSED THIOPHENE DERIVATIVES AS MEK INHIBITORS
A series of 4,5,6,7-tetrahydrothieno[2,3-c]azepin-8-one derivatives, and analogues thereof, which are substituted in the 2-position by a substituted anilino moiety, being selective inhibitors of...
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US20090258936 |
CXCR2 INHIBITORS
The invention relates to compounds of the formula I
in which R1, R2, A, B, X and Y have the meanings indicated in the claims, and/or a pharmaceutically acceptable salt and/or a prodrug thereof....
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US20090258906 |
CXCR2 ANTAGONISTS
The invention relates to compounds of the formula I
in which R1, R2, A, B, X and Y have the meanings indicated in the claims, and/or a pharmaceutically acceptable salt and/or a prodrug thereof....
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US20090253656 |
BCRP/ABCG2 INHIBITOR
The present invention is directed to a breast cancer resistance protein (BCRP/ABCG2) inhibitor. The BCRP inhibitor contains, as an active ingredient, an acrylonitrile derivative represented by...
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US20090247567 |
BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE
Benzopyran and benzoxepin compounds of Formulas I and II, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful...
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US20090247536 |
Bissulfonamide Compounds As Agonists Of GalR1, Compositions, And Methods Of Use
Embodiments of the present invention provide bissulfonamide compounds that are agonists of GalR1. The present invention further provides compositions comprising bissulfonamide compounds that are...
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US20090233963 |
METHODS TO DETERMINE SUCEPTIBILITY TO TREATMENT WITH LEUKOTRIENE MODIFIERS
The present invention provides a method of determining the susceptibility of a subject to treatment with a leukotriene modifier by determining the subject's cysteinyl leukotriene (CysLT) level and...
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US20090227667 |
FLUORO- AND TRIFLUOROALKYL-CONTAINING HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION AND DERIVATIVES THEREOF
Compounds of Formula (I),
are provided where T is CHO, COR 8 , or C(OH)R 1 R 2 ; R 1 and R 2 are hydrogen, optionally substituted lower alkyl, CF 3 , optionally substituted alkenyl, or...
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US20090227625 |
CXCR2 INHIBITORS
The invention relates to compounds of the formula I
in which R1, R2, X, A, B, Z and Y1 to Y4 have the meanings indicated in the claims, and/or a pharmaceutically acceptable salt and/or a prodrug...
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US20090226422 |
Chemical Inhibitors of Inhibitors of Differentiation
The present invention provides identification of inhibitors of inhibitors of differentiation (Id) for use in the treatment and prevention of diseases in mammals. The inhibitors of Id are effective...
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US20090221687 |
Tetracyclic Monoamine Reuptake Inhibitors for Treatment of Cns Diseases and Disorders
Novel tetracyclic dibenzo(e,h)azulene compounds of formula I; their pharmacologically acceptable derivatives; process and intermediates for their preparation; pharmaceutical compositions containing...
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US20090221654 |
PROSTAGLANDIN E1 AND E2 ANALOGS FOR THE TREATMENT OF VARIOUS MEDICAL CONDITIONS
A prostaglandin analog with selectivity to EP receptors and demonstrating EP agonist activity that may be used to expand hematopoietic stem cell populations or to treat or prevent influenza, bone...
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US20090221572 |
4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE DERIVATIVES AND THEIR USE AS SIGMA RECEPTOR LIGANDS
The present invention relates to compounds having pharmacological activity towards the sigma (σ) receptor, and more particularly to some 4, 5, 6, 7 tetrahydrobenzo[b]thiophene derivatives, wherein...
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US20090221564 |
Heterocyclic Compounds and Their Use in the Treatment of Cardiovascular Disease
Heterocyclic compounds of the formula (I) are provided: wherein ring A, ring B, R 1 , R 2 , R 3 , R 4 , Y, m, n and q are as identified herein. R 1 is in particular amidino. The invention further...
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US20090220583 |
Method and composition for treating inflammatory disorders
There is provided homogeneous pharmaceutical compositions for the treatment of inflammatory disorders comprising an antiinflammatory and/or antihistaminic active ingredient, a polar lipid liposome...
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US20090209532 |
PHARMACEUTICAL COMPOUNDS
Compounds of formula (I) exhibit COMT enzyme inhibiting activity and are thus useful as COMT inhibitors.
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US20090191283 |
TREATMENT OF HEADACHES, NECK PAIN, JOINT PAIN AND INFLAMMATORY-TYPE PAIN
The formulation provides a method of treating headaches, neck, joint and inflammatory-type pain in a mammalian subject by administering to the subject a therapeutically effective amount of a...
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US20090186916 |
AMINOINDANE DERIVATIVE OR SALT THEREOF
Provided is a compound that is an NMDA receptor antagonist having a broader safety margin, and is useful as an agent for treating or preventing Alzheimer's disease, cerebrovascular dementia,...
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US20090176865 |
SULFAMIDE DERIVATIVE USEFUL FOR THE TREATMENT OF EPILEPSY
The present invention is directed to novel sulfamide derivatives, pharmaceutical compositions comprising said compounds and methods for the treatment of epilepsy and related disorders comprising...
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US20090163547 |
INDENE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS
The present invention makes reference to new indene derivatives with general formula (I), as well as to their preparation procedures, their application as medicament and the pharmaceutical...
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US20090143411 |
Thiophens and Their Use as Anti-Tumor Agents
The present invention provides novel compounds and pharmaceutical compositions thereof, as well as methods for using the compounds and pharmaceutical compositions for treating tumors. Examples of...
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US20090137659 |
COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM
Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of...
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US20090131510 |
COMPOUNDS WITH ACTIVITY AT ESTROGEN RECEPTORS
Disclosed herein are compounds of Formula I
as disclosed herein, methods of modulating the activity of an estrogen receptor and methods of treating a disorder associated with estrogen receptors.
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US20090131468 |
Bis-(Sulfonylamino) Derivatives in Therapy 065
The invention provides compounds of formula
wherein R 1 , R 2 , R 3 , A and m are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically...
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US20090105308 |
Benzoheterocylethylcarboxamide derivatives
The present invention relates to novel benzoheterocyclylethylcarboxamide derivatives of formula (I) in which the substituents are in the description, their process of preparation, their use as...
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US20090105259 |
Acyclic 1,4-Diamines and Uses Thereof
This invention relates to novel compounds useful in the treatment of diseases associated with TRPV4 channel receptor. More specifically, this invention relates to certain acyclic diamines, which...
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US20090099147 |
NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS
The present invention relates to non-steroidal progesterone receptor modulators of the general formula I
the use of the progesterone receptor modulators for producing medicaments, and...
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US20090082308 |
Benzothiophene derivatives
The present invention relates to a novel class of benzothiophene amide derivatives. The hydroxamic acid compounds can be used to treat cancer. The benzothiophene amide compounds can also inhibit...
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US20090069408 |
TRICYCLIC COMPOUNDS USEFUL IN TREATING IRON DISORDERS
This invention is directed to, for example, compounds of formula (I):
wherein n, m, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are as defined herein, as a stereoisomer, enantiomer,...
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US20090069391 |
Benzothiophene hydroxamic acid derivatives
The present invention relates to a novel class of hydroxamic acid derivatives. The hydroxamic acid compounds can be used to treat cancer. The hydroxamic acid compounds can also inhibit histone...
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US20090062297 |
Hydroxyalkylarylamide Derivatives
The present invention relates to a novel class of hydroxyalkylarylamide derivatives. The instant compounds can be used to treat cancer. The fluorinated arylamide derivatives can also inhibit...
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US20090062284 |
Thio-Substituted Biarylmethanesulfinyl Derivatives
The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that...
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US20090054235 |
Benzoheterocyclylethylbenzamide derivatives
The present invention relates to novel benzoheterocyclylethylbenzamide derivatives of formula (I) in which the substituents are in the description, their process of preparation, their use as...
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US20090041839 |
PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF PAIN
The present invention provides pharmaceutical compositions comprising an allosteric adenosine A 1 receptor enhancer, such as T-62, in an oral dosage form and processes for the manufacture of such...
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US20090030038 |
Novel 8-Sulfonylamino-3 Aminosubstituted Chroman or Tetrahydronaphtalene Derivatives Modulating the 5Ht6 Receptor
The present invention relates to new compounds of formula I. (I) wherein R 1 to R 12 , X, Q and n are as defined as in formula I, or salts, solvates or solvated salts thereof, processes for their...
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US20090030006 |
SPIROKETAL DERIVATIVES AND USE THEREOF AS DIABETIC MEDICINE
The present invention provides a compound of Formula (I):
wherein R 1 , R 2 , R 3 and R 4 are each independently selected from a hydrogen atom, an optionally substituted C 1 -C 6 alkyl...
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US20090023799 |
CRYSTALS OF (2-AMINO-4,5,6,7-TETRAHYDROBENZO[b]THIEN-3-YL)(4-CHLOROPHENYL)METHANONE
The present invention provides crystal forms of (2-amino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)(4-chloroph
enyl)methanone of the formula
processes for the production of such crystal forms;...
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US20090023751 |
COMPOUNDS THAT PROTECT AGAINST SENSORY HAIR CELL DEATH
The present invention provides methods of identifying compounds that protect against ototoxicity induced by one or more noxious stimuli, and methods of treating an individual with compounds...
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US20090023721 |
Novel Substituted Tetracyclic Tetrahydrofuran, Pyrrolidine and Tetrahydrothiophene Derivatives and Their Use as a Medicament
This invention concerns novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives with binding affinities towards serotonin receptors, in particular 5-HT 2A ...
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US20090018149 |
4,5,6,7-tetrahydrobenzo[b]thiophene derivatives and methods for medical intervention against mycobacterial infections
Described are 4,5,6,7-tetrahydrobenzo[b]thiophene derivatives and pharmaceutically acceptable salts thereof, the use of these derivatives for the prophylaxis and/or treatment of...
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US20090012107 |
Antiviral Compounds and Methods of Using Thereof
Disclosed herein are compounds which exhibit antiviral activity against a plurality of viruses belonging to different families such as Bornaviridae, Filoviridae, Paramyxoviridae, Rhabdoviridae,...
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US20090012075 |
Fluorinated Arylamide Derivatives
The present invention relates to a novel class of fluorinated arylamide derivatives. The instant compounds can be used to treat cancer. The fluorinated arylamide derivatives can also inhibit...
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