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US20120094956 Treatment of Cancer with Specific RXR Agonists  
A method of treating cancer is disclosed comprising administering to a patient in need of such treatment a RXR agonist at a level below the RAR activating threshold and at or above the RXR...
US20130184323 TREATMENT OF ENDOPLASMIC RETICULUM STRESS-RELATED DISEASES AND CONDITIONS  
A method of treating a disease or condition associated with at least one of a cellular accumulation of unfolded and/or misfolded proteins, an abnormal unfolded protein response (UPR), an...
US20110301105 COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS  
We have discovered that p63 inhibition results in increased cellular proliferation. We have also performed a screen for agents capable of increasing cellular proliferation, (e.g., of stem cells...
US20130196950 RETINOID REPLACEMENTS AND OPSIN AGONISTS AND METHODS FOR THE USE THEREOF  
Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided.
US20110034448 CARBONIC ANHYDRASE INHIBITOR SUSTAINED RELEASE INTRAOCULAR DRUG DELIVERY SYSTEMS  
Biocompatible intraocular drug delivery systems include a carbonic anhydrase inhibitor therapeutic agent and a polymeric component in the form of an implant, a microparticle, a plurality of...
US20130035338 EYELID TREATMENT  
The current application is directed topical treatments that improve facial appearance by causing eyelids to naturally open more widely, or be more fully raised, as well as to treatment of ptosis...
US20110028477 STABLE OPHTHALMIC FORMULATIONS  
Disclosed herein are stable formulations suitable for the treatment of glaucoma and ocular hypertension.
US20130310438 BICYCLIC COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES  
Provided is a compound which has strong intraocular pressure lowering action and has no side effect on eyes such as ocular stimulating property, humor protein rise etc. Since a compound represented...
US20130053385 METHOD OF COMBATING AND CONTROLLING PESTS  
The use of a compound of formula I wherein the substituents are as defined in claim 1, or compositions containing them in controlling insects, acarines, nematodes or molluscs.
US20110245172 BIOCOMPATIBLE OLIGOMER-POLYMER COMPOSITIONS  
The present invention relates to biocompatible oligomer-polymer compositions for the in situ formation of implants, wherein the implants release a bioactive agent, a metabolite, or a prodrug...
US20130040935 CYCLIC KETO-ENOLS FOR THERAPY  
The invention relates to 5′-biphenyl-substituted cyclic ketoenols for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and t...
US20110136802 SHIP1 MODULATORS AND METHODS RELATED THERETO  
Compounds of structure (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Such compounds have activity as...
US20110190307 Assay  
The present invention provides zebrafish based methods for the identification of compounds potentially useful in the treatment of motor neuron degenerative diseases (MNDDs), compounds identified by...
US20130096106 COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS  
Compounds represented by formula: Wherein X, Y and Z are as defined herein, pharmaceutically acceptable salts thereof, and related compounds, are suitable for use in treating or preventing a...
US20100323033 CANCER SENSITIZER COMPRISING CHLOROGENIC ACID  
The present invention relates to a cancer sensitizer comprising chlorogenic acid or a derivative thereof. In particular, the present invention relates to a cancer sensitizer comprising chlorogenic...
US20090176862 Methods for treating chemotherapy and radiation therapy side effects  
A method for treating chemo therapy or radiation therapy side effects in a mammal undergoing chemotherapy and/or radiation therapy, the method comprising a step of administering to the mammal a...
US20120172751 Assessment and Modulation of Cerebrospinal Fluid for Head Pain  
The disclosure relates to the discovery that certain cerebrovascular disorders in humans who exhibit seemingly normal intracranial pressure (ICP) and do not exhibit hydrocephalus can be alleviated...
US20120276108 MONOSACCHARIDE-BASED COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE AND INFLAMMATORY DERMATOLOGICAL DISEASES  
The present invention relates to compounds and methods which may be useful as inhibitors of glycolysis, inhibitors of protein glycosylation, anti-virals, and down-regulators of insulin receptor and...
US20130165495 NEURONAL CIRCUIT-DEPENDENT NEUROPROTECTION BY INTERACTION BETWEEN NICOTINIC RECEPTORS  
A method of inhibiting excitotoxicity by indirectly activating α4β2 nicotinic acetylcholine receptors (nAChRs) which indirectly activate synaptic AMPA and NMDA receptors is disclosed Inhibitors o...
US20110196014 METHIONINE ANALOGS AND METHODS OF USING SAME  
Provided are methionine analogs which may be useful for inhibiting protein synthesis, inhibiting microbial growth and/or treating infectious diseases. In some instances, the analogs exhibit...
US20110281883 4-Phenyl-pyrane-3,5-diones, 4-Phenyl-thiopyrane-3,5-diones and Cyclohexanetriones and Their Use as Insecticides, Acaricides and/or Fungicides  
The present invention relates to the use of compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7, r, Y and G have the meanings given above as insecticides and/or acaricides and/or fungicides.
US20060252818 Monoamine re-uptake inhibitors and methods relating thereto  
Monoamine re-uptake inhibitors and more specifically serotonin and noradrenaline re-uptake inhibitors are disclosed that have utility in the treatment of disorders of the central or peripheral...
US20120115778 Methods of Suppressing Appetite by the Administration of Antagonists of the Serotonin HTR1a or HTR2b Receptors or Inhibitors of TPH2  
Methods for treating eating disorders associated with excessive weight gain, suppressing appetite, reducing body weight, or treating obesity in an animal by administering one or more antagonists of...
US20100292270 TREATMENT OF CACHEXIA  
The present invention provides a means for prevention and treatment of cachexia and other chronic illnesses including but not limited to the promotion of weight gain, reduction or prevention of...
US20130303473 LIQUID PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF A POSTERIOR EYE DISEASE  
The invention provides pharmaceutical compositions based on liquid vehicles whose density is substantially higher than that of aqueous physiological fluids. The compositions are useful as medicines...
US20060269907 Decontamination of biological fluids using diphenylpyrilium compounds  
The present invention affords means for decontaminating biological fluids such as blood and blood components. The method involves contacting a biological fluid with a diphenylpyrilium compound, and...
US20120093917 METNASE AND INTNASE INHIBITORS AND THEIR USE IN TREATING CANCER  
This invention relates to novel cancer treatment compositions and associated therapeutic methods. More particularly, this invention relates in part to small chemical inhibitors of DNA repair...
US20050038103 Uses of dorzolamide  
A method of improving visual acuity and visual field in individuals in need of such treatment comprising administering to the eyes of an individual an effective amount of dorzolamide as well as a...
US20130142858 DRUG DELIVERY DEVICES FOR DELIVERY OF OCULAR THERAPEUTIC AGENTS  
Drug delivery devices comprising a non-bioabsorbable polymer structure configured to support a composition comprising an active agent. The devices include a plurality of portions fused together and...
US20110053904 CARBOCYCLIC GLYT1 RECEPTOR ANTAGONISTS  
The present invention relates to the use of a compound of formula I wherein R1, R2, R3, R4, X and n are as defined herein or to a pharmaceutically acceptable acid addition salt, to a racemic...
US20050009820 Thiochromenones used to combat painful conditions and neurodegenerative diseases  
The invention relates to novel thiochromenones and processes for their preparation, to their use for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of...
US20120041016 11-Aza, 11-Thia and 11-Oxa Sterol Compounds and Compositions  
The invention provides compositions comprising formula 1 steroids, e.g., 16α-bromo-3β-hydroxy-5α-androstan-17-one hemihydrate and one or more excipients, including compositions that comprise a li...
US20140080891 FUSED CYCLIC COMPOUNDS  
The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof. The compound or a salt thereof or a prodrug...
US20120046338 FUSED CYCLIC COMPOUNDS  
The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof. The compound or a salt thereof or a prodrug...
US20110015225 Heterocyclic compound  
The present invention provides to a compound having melanin-concentrating hormone receptor antagonistic action and low toxicity, and useful as a agent for the prophylaxis or treatment of obesity...
US20130109718 1-CYCLOALKYL- OR 1-HETEROCYCLYL-HYDROXYIMINO-3-PHENYL-PROPANES  
This invention relates to novel 1-cycloalkyl- or 1-heterocyclyl-hydroxyimino-3-phenyl-propanes of the formula wherein R1 to R7 are as defined in the description and in the claims, as well as...
US20070185055 Method for treating cachexia with retinoid ligands  
The present invention relates to a method of treatment of cachexia in a subject in need of treatment. More specifically, the present invention relates to the use of retinoid compounds that act on...
US20090076076 INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF  
The present invention relates to semicarbazone or thiosemicarbazone inhibitors of cysteine proteases and methods of using such compounds to prevent and treat protozoan infections such as...
US20110281930 Use of 2-Aryl-5-heterocyclyl-cyclohexane-1,3-dione Compounds as Insecticides, Acaricides, and/ or Fungicides  
The present invention relates to the use of compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, X and G have the meanings given above as insecticides and/or acaricides and/or fungicides.
US20050148627 Benzopyran compounds for use in the treatment and prevention of inflammation related conditions  
The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are...
US20100004312 FUSED CYCLIC COMPOUNDS  
The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof. The compound or a salt thereof or a prodrug...
US20070232649 Heteroaryl Sulfones and Sulfonamides and Therapeutic Uses Thereof  
Compounds of Formula I: wherein R1, R2, M, Q and n are as defined herein, are useful as antiproliferative agents including, for example, as anticancer agents.
US20050113409 Method for the prevention or treatment of pain, inflammation and inflammation-related disorders with a Cox-2 selective inhibitor in combination with a nitric oxide-donating agent and compositions therewith  
A method is described for the prevention or treatment of pain, inflammation, and inflammation-related disorders in a subject in need of such prevention or treatment, the method comprising...
US20110224196 TREATMENT OF OBSTRUCTIVE SLEEP APNEA SYNDROME WITH A COMBINATION OF A CARBONIC ANHYDRASE INHIBITOR AND AN ADDITIONAL ACTIVE AGENT  
This invention relates generally to methods and pharmaceutical formulations useful in treating patients suffering from obstructive sleep apnea syndrome (OSAS). Treatment of OSAS is effected by...
US20100130495 COMPOUNDS 563  
The present invention relates to novel compounds of formula I and therapeutically acceptable salts thereof, their pharmaceutical compositions, processes for making them and their use as therapeutic...
US20090215827 INHIBITORS OF CXCR2  
The invention relates to compounds of the formula I in which R1, R2, X, A, B and Y1 to Y4 have the meanings indicated in the claims, and/or a pharmaceutically acceptable salt and/or a prodrug...
US20090099207 Cyclic sulfones useful as BACE inhibitors  
The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free base form or in acid addition salt form, to their...
US20110142771 Photostabilization of Retinoids with Alkoxycrylene Compounds  
The photostabilizing electronic excited state energy—particularly singlet state energy from retinoid compounds—has been found to be readily transferred to (accepted by) α-cyanodiphenylacrylate comp...
US20130252937 NEW INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS  
The present invention relates to compounds of general formula I, wherein the groups R1, R2 and m are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the...
US20100099688 NOVEL PHOSPHODIESTERASE INHIBITORS  
The present invention relates to a compound according to formula I, wherein X, A, G, E, R1, R2, R3 are as shown herein; and pharmaceutically acceptable salts, hydrates, N-oxides or solvates hereof....
Matches 1 - 50 out of 119 1 2 3 >