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US20090281162 |
Crystalline forms of atorvastatin
The present invention is directed to new crystalline forms of Atorvastatin calcium (2:1), referred to hereinafter as polymorphic Forms X, A, B1, B2, C, D and E. Furthermore, the present invention...
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US20090281085 |
3-(4-FLUOROPHENYL)-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS HAVING ANALGESIC ACTIVITY
Compounds according to the formula below are disclosed herein:
Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
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US20090275581 |
RENIN INHIBITORS
Disclosed are compounds according to Formula I:
wherein the variables are defined herein. Such compounds are can bind aspartic proteases to inhibit their activity. They are useful in the...
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US20090264497 |
STABLE PHARMACEUTICAL FORMULATION COMPRISING A HMG-COA REDUCTASE INHIBITOR
Lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin, and derivatives and analogs thereof are known as HMG-CoA reductase inhibitors and are used as antihypercholesterolemic agents. The...
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US20090264377 |
Anti-neoplastic compositions comprising extracts of black cohosh
A method is provided for treating, preventing or ameliorating neoplasia in a subject. This method includes administering to the subject an amount of actein or an amount of an extract of black...
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US20090263453 |
Methods and Compositions for Treating Pain Comprising a Statin
Methods and compositions are provided for reducing, treating or preventing pain and/or inflammation in a patient in need of such treatment, the methods and compositions comprising administering a...
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US20090258912 |
N-(1-Alkyl-2-Phenylethyl)-Carboxamide Derivatives and Use Thereof as Fungicides
A compound of general formula (I):
A process for preparing this compound. A fungicidal composition comprising a compound of general formula (I). A method for treating plants by applying a...
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US20090253662 |
GENETIC RISK ASSESSMENT IN HEART FAILURE: IMPACT OF GENETIC VARIATION OF ALDOSTERONE SYNTHASE PROMOTER POLYMORPHISM
The invention provides methods for (a) reducing mortality associated with heart failure; (b) improving oxygen consumption; (c) treating heart failure; (d) treating hypertension; (e) improving the...
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US20090247603 |
Stabilized pharmaceutical compositions comprising an HMG-CoA reductase inhibitor
The present invention is a new stable drug composition particularly suitable for use as an antihypercholesterolaemic or antihyperlipidaemic agent. The present invention is specifically a drug...
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US20090247547 |
HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES B
The present teachings relate to compounds of Formula I:
and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R 1 , R 2 , R 3 , Y, Z, and are as defined...
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US20090239927 |
Statin and Omega-3 Fatty Acids For Lipid Therapy
A method of lipid therapy, comprising providing a subject group having a baseline triglyceride level of 200 to 499 mg/dl and being at or near its low-density lipoprotein cholesterol (LDL-C) level...
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US20090239919 |
Glutamate receptor modulators and therapeutic agents
The present invention discloses methods of modulating the activity of Group I mGluRs using a defined class of benzamide compounds. In one embodiment, methods of modulating the activity of mGluR1...
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US20090239866 |
PEPTIDE DEFORMYLASE INHIBITORS
Novel PDF inhibitors and novel methods for their use are provided.
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US20090239829 |
THIOARYL SUBSTITUTED INHIBITORS OF ZINC PROTEASES AND THEIR USE
There are described compounds having the general formula (I) below and their pharmaceutically acceptable salts thereof, wherein E, X, m, q, R 1 , R 2 , n and ZBG have the meanings reported in the...
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US20090233972 |
SUBSTITUTED HETEROCYCLES AS ANTI-INFECTIVES
The present invention discloses compounds of Formulae (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof:
which inhibit RNA-containing viruses, particularly the hepatitis C...
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US20090233970 |
COMBINED NSAID AND ACID BLOCKER FORMULATION AND METHOD
The present invention is directed to co-administration of a non-steroidal anti-inflammatory agent (NSAID) and acid blocking agent for the treatment of pain and inflammation with reduced...
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US20090233968 |
INHIBITORS OF THE ALPHA2BETA1/GPIa-IIA INTEGRIN
Novel compounds inhibiting the integrin α2β1/GPIa-IIa receptor are disclosed. Also disclosed are pharmaceutical compositions containing the compounds, as well as methods of their therapeutic use....
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US20090232886 |
ORAL DOSAGE COMBINATION PHARMACEUTICAL PACKAGING
Pharmaceutical fixed dose combination products are formed by merging a fixed dose of a first pharmaceutical formulation from primary module, with a fixed dose of a second pharmaceutical formulation...
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US20090227610 |
NOVEL TRIGLYCERIDE REDUCING AGENT
The present invention relates to hypotriglyceridemic agent containing HMG-CoA reductase inhibitor and cAMP protease inhibitor.
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US20090226515 |
STATIN COMPOSITIONS
The present invention relates to an improved statin or salt thereof composition, especially an atorvastatin composition, which exhibits enhanced dissolution properties in acidic media. It comprises...
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US20090226510 |
PHARMACEUTICAL COMPOSITIONS OF ATORVASTATIN
A unit dosage form comprising atorvastatin or a pharmaceutically acceptable salt thereof, prepared without a granulation step, wherein the measured atorvastatin potency of said dosage form shows a...
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US20090221667 |
Process for Annealing Amorphous Atorvastatin
Processes for annealing amorphous atorvastatin is described. Pharmaceutical compositions and formulations containing annealed amorphous atorvastatin are also described.
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US20090221620 |
GENTIC POLYMORPHISMS ASSOCIATED WITH STROKE, METHODS OF DETECTION AND USES THEREOF
The present invention provides compositions and methods based on genetic polymorphisms that are associated with vascular diseases such as stroke. In particular, the present invention relates to...
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US20090221546 |
INHIBITORS OF FACTOR XA AND OTHER SERINE PROTEASES INVOLVED IN THE COAGULATION CASCADE
Compounds useful as intermediates for synthesis of compounds of Formula (1):
wherein A, B, C, G, and W 1 have any of the values defined in the specification.
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US20090215856 |
Methods for monitoring IL-18
This invention relates to methods for monitoring IL-18.
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US20090215855 |
New Crystalline Atorvastatin Hemicalcium Salt Polymorph Form
The present invention relates to a new crystalline polymorph B-52 form of atorvastatin hemicalcium salt [A[(3R,5R)-7-[3-phenyl-4-[(phenyl...
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US20090215854 |
ANTIMICROBIAL COMPOSITIONS, PRODUCTS AND METHODS EMPLOYING SAME
Antimicrobial compositions that provide enhanced immediate and residual anti-viral and antibacterial efficacy against rhinovirus, rotavirus, coronovirus, respiratory syricytial virus, Gram-positive...
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US20090215844 |
Compositions Comprising Nebivolol
Nebivolol has been shown to be beneficial in the treatment of cardiovascular diseases such hypertension, congestive heart failure, arterial stiffness and endothelial dysfunction. The present...
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US20090214466 |
Methods of Alleviating Disorders and Their Associated Pain
The invention relates generally to the field of treatment of headache, post-laminectomy syndrome, and other disorders associated with localized pain. The compositions and methods described herein...
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US20090209614 |
GLUTAMINE-CONTAINING COMPOSITIONS AND A METHOD FOR INCREASING BLOOD FLOW USING SAME
The present invention provides a glutamine-containing composition which functions to increase blood flow. Glutamine is present in the composition in an amount of 25 mg/kg body weight to 150 mg/kg...
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US20090209613 |
Use of allymercaptocaptopril for treating or preventing obesity and obesity related diseases
Use of allylmercaptocaptopril for treating or preventing obesity and/or an obesity related disease or disorder is disclosed.
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US20090209612 |
PROCESS FOR THE PREPARATION OF ATORVASTATIN
The invention relates to processes for the preparation of atorvastatin. Atorvastatin is known by the chemical name...
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US20090209585 |
CYCLOALKENE DERIVATIVES, PROCESS FOR PRODUCTION OF THE DERIVATIVES, AND USE OF THE SAME
The present invention relates to a cycloalkene derivative represented by the formula (I):
wherein each symbol is as defined in the specification, a pharmaceutical agent containing the...
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US20090208539 |
STABLE ATORVASTATIN FORMULATIONS
A simple yet efficient formulation for providing excellent bioefficacy, wherein the formulation includes atorvastatin or a salt thereof, in crystalline or amorphous form, with at least one...
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US20090203653 |
Compositions and Methods Using Apocynin Compounds and Nitric Oxide Donors
The invention describes novel compositions comprising at least one apocynin compound or a pharmaceutically acceptable salt thereof, and at least one nitric oxide donor, and, optionally, at least...
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US20090202524 |
PAI-1 EXPRESSION AND ACTIVITY INHIBITORS FOR THE TREATMENT OF OCULAR DISORDERS
The invention concerns in one embodiment a method for treating glaucoma or elevated IOP in a patient comprising administering to the patient an effective amount of a composition comprising an agent...
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US20090202463 |
ANTIMICROBIAL COMPOSITIONS, PRODUCTS AND METHODS EMPLOYING SAME
Antimicrobial compositions that provide enhanced immediate and residual anti-viral and antibacterial efficacy against rhinovirus, rotavirus, coronovirus, respiratory syncytial virus, Gram-positive...
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US20090197858 |
HYPERCHOLESTROLEMIA AND TENDINOUS INJURIES
This invention provides compositions and methods of inhibiting, suppressing, or treating a tendinous or musculoskeletal soft tissue injury. The invention further provides a method of ameliorating...
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US20090197845 |
Method for treating olfactory disorder
Disclosed is a method for treating olfactory disorders, which comprises administering to a patient a therapeutically effective amount of 3-β-hydroxymethylglutarate CoA (HMG-CoA) reductase, which...
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US20090197843 |
Treatment of Prevention of Unscheduled Bleeding in Women on Progestogen Containing Medication
The present invention relates to a method of treating or preventing unscheduled bleeding in women, the unscheduled bleeding being the result of repeated administration of a hormonal composition...
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US20090196932 |
PHARMACEUTICAL COMPOSITIONS OF ATORVASTATIN
A dry-granulated pharmaceutical composition comprising atorvastatin or a pharmaceutically acceptable salt thereof, as well as a dry-granulated pharmaceutical composition comprising atorvastatin or...
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US20090196922 |
BILAYER TABLET FOR PREVENTING CARDIOVASCULAR EVENTS
The present invention relates to a bilayer tablet which comprises a compartment containing a pharmaceutically acceptable simvastatin compound as its active ingredient; and at the same time a...
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US20090192172 |
2-Alkyl-Cycloalk(en)yl-Carboxamides
Novel 2-alkylcycloalk(en)ylcarboxamides of the formula (I)
in which
X, s, R 1 , L, R 2 and A are as defined in the description,
a plurality of processes for preparing these compounds...
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US20090192128 |
GENETIC RISK ASSESSMENT IN HEART FAILURE: IMPACT OF GENETIC VARIATION OF BETA 1 ADRENERGIC RECEPTOR GLY389ARG POLYMORPHISM
The invention provides methods for (a) reducing mortality associated with heart failure; (b) improving oxygen consumption; (c) treating heart failure; (d) treating hypertension; (e) improving the...
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US20090192119 |
Inhibition of the Renin-Angiotensin System for the Treatment of Renal, Vascular and Cartilage Pathology
A method of treating a disease or condition in which up-regulating GAGs is therapeutically beneficial is disclosed. The method comprises locally administering to a subject a therapeutically...
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US20090186920 |
SULFONAMIDES AS OREXIN ANTAGONISTS
The present invention is concerned with novel sulfonamides of formula
wherein R 1 , R 2 , R 3 and n are as described in the description and claims. The compounds are orexin receptor...
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US20090182031 |
Reduction of Hair Growth
Mammalian hair growth is reduced by topically applying a composition including a heat shock protein inhibitor.
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US20090182030 |
PROCESS FOR THE PREPARATION OF AMORPHOUS CALCIUM SALT OF ATORVASTATIN
A process for the preparation of amorphous atorvastatin calcium. The process includes providing a reaction mixture having a pH between 6.5 and 8.0 containing a sodium salt of atorvastatin and...
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US20090181850 |
LOW ODOR, LOW VOLATILITY SOLVENT FOR AGRICULTURAL CHEMICALS
A composition includes an agricultural component in an amount of at least about 27% by weight and a solvent composition in an amount not greater than about 55% by weight. The solvent composition...
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US20090176860 |
ZOFENOPRIL CALCIUM
The present invention relates to zofenopril calcium form A substantially free of other forms of zofenopril calcium and to zofenopril calcium having a chemical purity of more than 98.5%. The present...
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