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US20150196533 METHOD FOR CONCURRENT TREATMENT OF PAIN AND DEPRESSION  
Provided herein are methods for the concurrent treatment of pain and depression in a patient based, at least in part, on the discovery that the comorbid interaction between pain and depression can...
US20130216560 Lipidomic Biomarkers for Identification of High-Risk Coronary Artery Disease Patients  
The present invention inter alia provides a method, and use thereof, of predicting severe CVD complications such as AMI or CVD death by detecting the lipid concentrations or lipid ratios of a...
US20110263601 METHODS OF TREATING ULCERATIVE COLITIS  
Methods are disclosed for treating ulcerative colitis and related diseases and disorders, which comprise inhibiting tryptophan hydroxylase (TPH) in patients in need thereof.
US20110070272 Materials and Methods for Modulating Metabolism  
The subject invention provides materials and methods for modulating a variety of biological factors to treat biological conditions associated with the factors. In one embodiment of the invention,...
US20140073611 METHODS FOR DRUG SCREEN USING ZEBRAFISH MODEL AND THE COMPOUNDS SCREENED THEREFROM  
The disclosure relates to a platform of using zebrafish in screening candidates for treating and/or preventing myopia and keratoconus disease. The disclosure is mainly based on that Lumican, one...
US20110020436 TOPICAL APPLICATION OF MELATONIN DIRECTLY OR IN LIPOSOMES FOR THE AMELIORATION OF ITCHING AND HISTAMINE AND NON-HISTAMINE RELATED INFLAMMATORY SKIN CHANGES  
The invention is a topical therapeutically effective amount of melatonin encapsulated in a liposome applied topically to an area of skin affected by immunologic response, radiation treatment...
US20110245316 PREVENTION OR DELAY OF ONSET OF ORAL MUCOSITIS  
The present invention provides a method for preventing or delaying the onset of oral mucositis, including the onset of ulcerative or severe OM, in a patient receiving cancer therapy. The method...
US20140030307 NEW COMBINATION COMPRISING N-ACETYL-L-CYSTEINE AND ITS USE  
A combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin, and a medical product or pharmaceutical composition comprising such combination, useful for the...
US20130165398 CONCENTRATION-ENHANCING DRINK  
A concentration-enhancing drink contains, in each case independently of one another, per liter: 1 mg to 10 g, preferably 1 to 1000 mg, still more preferably 10 to 500 mg, in particular 50 to 300...
US20110166114 METHOD FOR TREATING SNORING AND SLEEP APNEA WITH LEUKOTRIENE ANTAGONISTS  
A method of treating snoring and/or sleep apnea comprising administering to a patient in need of such treatment a therapeutically effective amount of a leukotriene receptor antagonist.
US20120157420 TREATMENT AND PREVENTION OF SECONDARY INJURY AFTER TRAUMA OR DAMAGE TO THE CENTRAL NERVOUS SYSTEM  
A method of administering one or multiple medications to human patients with CNS injury through oral or parenteral (including transdermal, intravenous, subcutaneous, intramuscular) routes....
US20110300227 MALIGNANT NEOPLASM TREATMENT PROTOCOL  
Methods, compositions, and strategies for the treatment of malignant neoplasms are presented herein. The treatment modalities are directed towards exploiting characteristics of cancer cells as...
US20110098303 Method of promoting nail growth using thyromimetic compounds  
The present invention provides methods and compositions for increasing the rate of nail growth in mammals, especially humans, using thyromimetic compounds.
US20140179723 LOCAL COCHLEAR APPLICATION OF STATINS FOR STIMULATING NEURITE REGROWTH IN THE COCHLEA  
Statin compositions are disclosed for stimulating neurite growth from spiral ganglion neurons in the inner ear and methods for preventing damage to or treating damage of auditory neurons and/or...
US20120029001 METHOD OF TREATMENT OF NEPHROGENIC DIABETES INSIPIDUS  
Nephrogenic diabetes insipidus is treated with statins.
US20120053196 Combination Treatment of Breast Cancer  
The present disclosure provides products including an endocrine treatment product and a statin as a combined preparation for simultaneous, separate or sequential use in therapy. Further, there is...
US20100311803 METHOD FOR REDUCING INFLAMMATORY RESPONSES AND INFLAMMATION  
The present invention relates a method of preventing and/or reducing an inflammatory response and/or inflammation in one or more tissues. The method includes delivering to the one or more tissues...
US20120156255 DRUG ELUTING PATCH FOR THE TREATMENT OF LOCALIZED TISSUE DISEASE OR DEFECT  
A polymeric matrix for delivery of an HMG CoA reductase inhibitor such as a statin to tissue such as cardiac tissue in need thereof for the treatment or prevention of a disease or defect such as...
US20150147320 Ophthalmic Drug Delivery System Containing Phospholipid and Cholesterol  
An ophthalmic drug delivery system that contains phospholipid and cholesterol for prolonging drug lifetime in the eyes.
US20110245283 Methods for predicting the response to statins  
The invention provides methods for optimizing therapeutic efficacy for treating hypercholesterolemia in a subject having a cardiovascular disease (CVD), comprising (a) determining subject...
US20140296223 METHOD FOR REGULATING SKIN PIGMENTATION  
This invention relates to a method for regulating skin pigmentation of a subject, comprising the step of administering the agent for inhibiting the expression or activation of Microphthalmia...
US20120009142 METHODS FOR TREATING HEPATITIS C  
In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one...
US20110195962 USE OF MULTI-PHARMACOPHORE COMPOUNDS TO TREAT NASAL DISORDERS  
Compositions and methods for treating nasal disorders associated with nasal inflammation using a multipharmacophoric agent (MPA) that can prevent the production and/or release of at least one or...
US20110104282 New Therapy of Treatment of the Irritable Bowel Syndrome  
The invention provides for new methods for treatment and diagnosis of irritable bowel syndrome (IBS). In particular, there is disclosed the use of a Chlamydia activating agent and one or several...
US20150224082 FORMULATION AND METHOD TO INDUCE A DEEP STATE OF RELAXATION  
A relaxation formulation structured to induce a deep state of relaxation in a person comprises amounts of tryptophan, melatonin, vitamin B3, and vitamin B6. Another relaxation formulation also...
US20110301186 USE OF HAPTOGLOBIN GENOTYPING IN DIAGNOSIS AND TREATMENT OF CARDIOVASCULAR DISEASE  
This invention is directed to methods and compositions for the treatment of cardiovascular disorders. Specifically, the invention is directed to compositions comprising vitamin E, statins and/or...
US20110117211 Method of Treating or Preventing Tissue Deterioration, Injury or Damage Due to Disease of Mucosa  
An immunomodulatory compound is utilized to treat mucosa disease.
US20150152049 Materials And Methods Useful To Induce Vacuolization, Cell Death, Or A Combination Thereof  
The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death...
US20140213615 Materials and Methods Useful to Induce Vacuolization, Cell Death, or a Combination Thereof  
The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death...
US20110311648 Novel Methods for the Treatment of Cancer  
Compositions and methods for the treatment of malignancy and chronic viral infection are disclosed.
US20110159017 TRYTOPHAN CATABOLISM IN CANCER TREATMENT AND DIAGNOSIS  
The unexpected expression of tryptophan 2,3-dioxygenase (TDO2) in cancer cells and tumors has been established. Methods for diagnosing cancer based on the expression of TDO2 are provided, as are...
US20090017136 Formulation to prevent and treat fibromyalgia, depression and other muscle and nervous system disorders  
The formulation provides for the treatment and prevention of fibromyalgia, depression and other muscle and nervous system disorders. The formulation combines Coenzyme Q10, vitamin B1,...
US20110251196 Modulators of G Protein-Coupled Receptor 88  
The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled...
US20110091421 Methods of Novel Therapeutic Candidate Identification Through Gene Expression Analysis in Vascular-Related Diseases  
The present invention discloses multiple treatment regimens for vascular-related diseases and disorders. The present invention provides for methods of treating vascular-related disorders based on...
US20140235605 GENETIC POLYMORPHISMS ASSOCIATED WITH STATIN RESPONSE AND CARDIOVASCULAR DISEASES, METHODS OF DETECTION AND USES THEREOF  
The present invention provides compositions and methods based on genetic polymorphisms that are associated with response to statin treatment, particularly for reducing the risk of cardiovascular...
US20110269735 GENETIC POLYMORPHISMS ASSOCIATED WITH STATIN RESPONSE AND CARDIOVASCULAR DISEASES, METHODS OF DETECTION AND USES THEREOF  
The present invention provides compositions and methods based on genetic polymorphisms that are associated with response to statin treatment, particularly for reducing the risk of cardiovascular...
US20140079680 MELATONIN-BASED TREATMENT AND DIAGNOSIS OF BILE DUCT DISEASE  
Methods and composition for a melatonin signaling modulator-based diagnosis and therapy are described. For example, in certain aspects methods for administering an anti-tumor therapy using a...
US20140187600 USE OF METABOTROPIC GLUTAMATE RECEPTORS  
The invention concerns the use an mGluR modulator, e.g. an mGluR5 modulator, for the treatment, prevention or delay of progression of cognitive dysfunction.
US20140378522 UNIFYING MECHANISM AND METHODS TO PREVENT CANCER AND NEURODEGENERATIVE DISEASES  
The present invention relates to methods for preventing the development of cancer or neurodegenerative diseases by administering N-Acetylcysteine (NAC), melatonin, or a combination thereof. The...
US20140303228 Biomarkers for Amyotrophic Lateral Sclerosis and Methods Using the Same  
The disclosure provides biomarkers of amyotrophic lateral sclerosis (ALS). The disclosure also provides various methods of using the biomarkers, including methods for diagnosis of ALS, methods of...
US20070065463 Topical therapy for the treatment of migranes, muscle sprains, muscle spasms, spasticity and related conditions  
The invention is directed to topical formulations and methods of treating a migraines and/or cluster headaches, muscle sprains, muscle spasms, spasticity, tension headaches, tension related...
US20110065757 METHODS FOR TREATMENT OF KALLIKREIN-RELATED DISORDERS  
We have identified classes of kallikrein inhibitors as compounds that are useful in the reduction of vascular permeability (e.g., retinal vascular permeability and cerebral vascular permeability)...
US20150030583 Methods of Treating Serosal Cancer  
The discovery of clonally pure populations of serosal cancer stem cells (CSCs) as well as methods of producing CSCs, culturing the CSCs and using them in screening assays, has lead to the...
US20120322769 METHODS OF REDUCING VIRULENCE IN BACTERIA  
A method of reducing virulence in a bacterium comprising at least one of a GacS/GacA-type system, a HrpX/HrpY-type system, a T3SS-type system, and a Rsm-type system, the method comprising...
US20130303558 GENETIC POLYMORPHISMS ASSOCIATED WITH STROKE, METHODS OF DETECTION AND USES THEREOF  
The present invention provides compositions and methods based on genetic polymorphisms that are associated with vascular diseases such as stroke. In particular, the present invention relates to...
US20150133370 Dietary Compositions and Methods for Protection Against Chemotherapy, Radiotherapy, Oxidative Stress, and Aging  
The present invention relates to dietary compositions comprising reduced level of methionine, tryptophan, all amino acids, or protein, dietary compositions comprising glycerol as a substitute for...
US20100305183 METHOD AND COMPOSITION FOR REDUCING REPERFUSION INJURY  
The present invention relates to a method of preventing and/or reducing reperfusion injury to a tissue, organ, or organ system in a subject. The method includes administering to the subject an...
US20140302170 COMPOSITIONS AND METHODS FOR PROMOTING SLEEP  
Described herein are food formulations and methods, which promote sleep.
US20120003158 Biomarkers for Inflammatory Bowel Disease and Methods Using the Same  
The present invention provides various biomarkers of inflammatory bowel disease, including biomarkers for Crohn's disease and biomarkers for Ulcerative colitis. The present invention also provides...
US20140113949 METHODS FOR REDUCING NEURODEGENERATION  
The invention provides methods for reducing neurodegeneration in animals by administering a neurodegeneration reducing amount of melatonin to the animal. Generally, the melatonin is administered...