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US20090281137 |
INDOL-2-ONE DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS DISORDERS, GASTROINTESTINAL DISORDERS AND CARDIOVASCULAR DISORDERS
The present invention is related to new 3,3-disubstituted indol-2-one derivatives of the general Formula (I)
The new compounds are useful for the treatment or prophylaxis of the central nervous...
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US20090275578 |
Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
The present invention is directed to compounds of formula I:
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and n are as defined for formula I in the description. The invention...
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US20090264494 |
USE OF NEUROPROTECTIVE 3-SUBSTITUTED INDOLONE COMPOSITIONS
The present invention include providing a therapeutically effective amount of a 3-substituted indolin-2-one compositions to protect against neurodegeneration including diseases such as Alzheimer's...
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US20090221527 |
TUMOR NECROSIS FACTOR INHIBITORS
The present invention is directed to compounds that are allosteric inhibitors of tumor necrosis factor receptor I, compositions comprising such compounds, and methods of using such compounds and...
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US20090220554 |
Transglutaminase Inhibitors and Methods of Use Thereof
Transglutaminase inhibitors and methods of use thereof are provided.
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US20090208557 |
Kinase inhibitors
The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate,...
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US20090197876 |
INDOLINONE DERIVATIVES SUBSTITUTED IN THE 6 POSITION, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
The present invention relates to indolinone derivatives, substituted in the 6-position, of the formula
in which
R 1 to R 6 and X are as defined in Claim 1 , to their tautomers, enantiomers,...
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US20090182029 |
2-INDOLINONE DERIVATIVES AS SELECTIVE HISTONE DEACETYLASE INHIBITORS
Provided herein are isolated compounds of formula 1:
processes for their preparation and isolation, as well as pharmaceutical compositions which comprise these therapeutic agents, and methods of...
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US20090181896 |
Use of Natriuretic Peptide Receptor Antagonists to Treat Ocular, Otic and Nasal Edemetous Conditions
Methods and compositions to treat edematous ocular, otic and nasal conditions are described.
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US20090176840 |
USE OF GALR3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF DEPRESSION AND/OR ANXIETY AND COMPOUNDS USEFUL IN SUCH METHODS
This invention is directed to indolone derivatives which are antagonists or the GALR3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of...
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US20090163518 |
Novel Compounds
The present invention relates to substituted indoles useful as pharmaceutical compounds for treating respiratory disorders.
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US20090163494 |
PROTEIN KINASE INHIBITORS
This invention relates to selenophene compounds of formula (I) shown below:
Each variable in formula (I) is defined in the specification. These compounds can be used to treat cancer.
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US20090143449 |
Bi-Aryl or Aryl-Heteroaryl Substituted Indoles
The present invention relates to substituted indoles of Formula (I) useful as pharmaceutical compounds for treating respiratory disorders.
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US20090137641 |
Potassium Channel Activators for the Prevention and Treatment of Dystonia and Dystonia-Like Symptoms
The present invention is directed to the prevention, reversal and medical treatment of dystonia and dyskinesia as well as other diseases related to movement disorders, both in human beings and...
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US20090131506 |
Oxindoles as Kinase Inhibitors
The present invention relates to oxindoles of the formula I, their use as protein kinase activators or inhibitors, a method for their manufacture, their use for the preparation of a medicament for...
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US20090131494 |
Non-Nucleoside Reverse Transcriptase Inhibitors
Certain 1H-indole-2-carboxylates and -2-carboxamides are HIV reverse transcriptase inhibitors. These indole compounds and their pharmaceutically acceptable salts are useful in the inhibition of HIV...
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US20090131398 |
OXINDOLE DERIVATIVE AS FEEDING CONTROL AGENT
Disclosed is a compound represented by the formula (1) below, a prodrug thereof or a pharmaceutically acceptable salt of either, which is useful as a therapeutic, preventive or ameliorating agent...
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US20090130229 |
Antitumor uses of compound
The use of an arylidene 2-indolinone derivative for treating tumors involving Met, PDGF-R, FGF-RI, FGF-R3 or Kit tyrosine kinases, or a Ret oncoprotein which includes a MEN2-associated mutation is...
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US20090130165 |
MIF Inhibitors
The present invention relates to the use of specific benzimidazolone analogues and derivatives to inhibit the cytokine or biological activity of macrophage migration inhibitory factor (MIF), and...
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US20090111830 |
SUBSTITUTED ISOINDOLONES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS
The present invention is directed to compounds of formula I:
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and n are as defined for formula I in the description. The invention...
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US20090105216 |
3- (AMINOMETHYLIDEN) 2-INDOLINONE DERIVATES AND THEIR USE AS CELL PROLIFERATION INHIBITORS
The present invention encompasses compounds of general formula (1) wherein R 1 , R 2 , R 3 and X are defined as in claim 1 , which are suitable for the treatment of diseases characterised by...
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US20090082340 |
3-SUBSTITUTED-5- AND 6-AMINOALKYL INDOLE-2-CARBOXYLIC ACID AMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I
The present invention discloses and claims methods for the treatment of a patient suffering from a disease or disorder ameliorated by inhibition of casein kinase Iε activity comprising the...
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US20090076124 |
DEUTERIUM-ENRICHED ROPINIROLE
The present application describes deuterium-enriched ropinirole, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
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US20090076005 |
Kinase inhibitor compounds
The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein...
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US20090069313 |
Novel MAO-A inhibitors
The present invention provides a new medical use for the compounds of the formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically...
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US20090053310 |
NOVEL SUSTAINED RELEASE DOSAGE FORM
The novel sustained release dosage form comprising an active agent and a combination of a non-swelling pH dependent release retardant and a non swelling pH independent release retardant polymer...
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US20090036513 |
Antiviral Drugs for Treatment of Arenavirus Infection
Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel compounds in therapeutically effective amounts are disclosed. Methods for preparing...
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US20090028796 |
PESTICIDAL COMPOSITION COMPRISING INDOLE DERIVATES
The present invention is directed to pesticidal compositions comprising indole derivatives. These indole derivatives are especially active against phytopathogenic fungi. Furthermore, the invention...
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US20090012147 |
Indolone Derivatives, Processes For Preparing Them And Their Uses
The present invention relates to indolone derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
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US20090012061 |
A Method of Treating Cancer
The present invention relates to a method of treating cellular proliferative diseases, in particular cancer, which comprises administering a modulator of the activity of the mitotic kinesin KSP,...
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US20080319031 |
Novel Tyrosine Derivatives
The present invention relates to novel tyrosine derivatives of formula (I), their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present...
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US20080306019 |
Dopamine Receptor Agonists in the Treatment and Prevention of Hiv-Induced Dementia
Provided herein is a method of protecting a neuron from dysfunction induced by an HIV neurotoxin, comprising contacting the cell with a therapeutically effective dose of a dopamine D1 receptor...
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US20080299197 |
Triple Combination Release Multi-Layered Tablet
This invention pertains to a multi-layered tablet for a triple combination release of active agents to an environment of use. More particularly, the invention pertains to a multi-layered tablet ( 1...
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US20080293693 |
Treatment or Prevention of Ovarian Hyperstimulation Syndrome (Ohss) Using a Dopamine Agonist
Disclosed herein is a method for preventing ovarian hyperstimulation syndrome in a subject by administering an effective amount of a dopamine agonist in a pharmaceutically acceptable carrier. Also...
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US20080287504 |
CB1 MODULATOR COMPOUNDS
Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases...
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US20080275041 |
3-Heterocyclyl-Indole Derivatives as Inhibitors of Glycogen Synthase Kinase-3 (Gsk-3)
Compounds of formula Ia or Ib
wherein P; R 1 ; R 2 ; m; and n are as defined in the application, salts thereof, processed for their preparation, new intermediates used therein, pharmaceutical...
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US20080269311 |
Combination of Dpp-Iv Inhibitors and Compounds Modulating 5-Ht3 and/or 5-Ht4 Receptors
The present invention relates to a combination, such as a combined preparation or pharmaceutical composition, respectively, comprising of a DPP IV inhibitor or a pharmaceutically acceptable salt...
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US20080261873 |
Growth-Hormone Secretagogues
Disclosed are methods of treating a disorder of the stomach, intestine or duodenum in a human subject. The method includes administering to the subject, a pharmaceutical composition comprising a...
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US20080233179 |
TRANSDERMAL COMPOSITION HAVING ENHANCED COLOR STABILITY
A pharmaceutical composition for transdermal or transmucosal delivery of a pharmaceutical agent effective to treat a neurological disorder such as Parkinson's disease is disclosed. The composition...
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US20080227794 |
Metabotropic Glutamate-Receptor-Potentiating Isoindolones
Compounds of formula I:
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and n are as defined in the description, processes for the preparing the compounds, new intermediates...
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US20080221132 |
Multi-Functional Small Molecules as Anti-Proliferative Agents
The present invention relates to the compositions, methods, and applications of a novel approach to selective inhibition of several cellular or molecular targets with a single small molecule. More...
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US20080214645 |
USES OF 2-(1H-INDOLYLSULFANYL)-BENZYL AMINE DERIVATIVES AS SSRIS
The present invention relates to uses of 2-(1H-indolylsulfanyl)-benzyl amine derivatives of general formula (I):
in the treatment of affective disorders.
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US20080214644 |
2-(1H-INDOLYLSULFANYL)-BENZYL AMINE DERIVATIVES AS SSRI
The present invention relates to 2-(1H-indolylsulfanyl)-benzyl amine derivatives of general formula (I):
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US20080214606 |
Methods for the Identification and Use of Compounds Suitable for the Treatment of Drug Resistant Cancer Cells
The present invention relates to novel methods for the identification of compounds useful for the treatment of drug resistance, and to novel treatment methods using the identified compounds.
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US20080207722 |
Glepp-1 Inhibitors in the Treatment of Autoimmune and/or Inflammatory Disorders
The present invention is related to the use of a Glepp-1 inhibitor for the manufacture of a medicament for the treatment of an autoimmune and/or an inflammatory disorder.
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US20080188532 |
Indole Compound and Use Thereof
The present invention relates to a compound represented by the formula (I),
wherein all symbols are as defined in the description,
a salt thereof, a solvate thereof, or a prodrug...
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US20080176922 |
USES OF 2-(1H-INDOLYLSULFANYL)-BENZYL AMINE DERIVATIVES AS SSRIS
The present invention relates to uses of 2-(1H-indolylsulfanyl)-benzyl amine derivatives of general formula (I):
in the treatment of affective disorders.
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US20080176309 |
Inhibition of Shp2/PTPN11 Protein Tyrosine Phosphatase by NSC-87877, NSC-117199 and Their Analogs
Compounds and associated methods for inhibiting a protein tyrosine phosphatase. By a combination of experimental and virtual screenings of the NCI Diversity Set chemical library, NSC-87877 and...
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US20080167366 |
Use of 2-oxo-1-pyrrolidine derivatives for the preparation of a drug
The present invention relates to pharmaceutical compositions containing 2-oxo-1-pyrrolidine derivatives and methods for treating Parkinson's Disease in a chronic dopamine replacement therapy using...
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US20080152693 |
Implants for the treatment of dopamine associated states
Biodegradable implants comprising dopamine modulating compounds are described.
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