|
Match
|
Document |
Document Title |
|
|
US20090298818 |
PHARMACEUTICAL COMPOUNDS
The invention provides the use of a compound for the manufacture of a medicament for the treatment of pain, wherein the compound is a compound of the formula (VI):
or a salt, solvate, tautomer...
|
|
|
US20090291983 |
3-Oxoisoindoline-1-Carboxamide Derivatives as Analgesic Agents
Compounds of formula I
wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as described in the specification, pharmaceutically acceptable salts, methods of making, pharmaceutical compositions...
|
|
|
US20090286775 |
Bicyclic Derivatives as P38 Kinase Inhibitors
New bicyclic derivatives of formula (I), wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as p38 kinase inhibitors.
|
|
|
US20090275630 |
COSMETIC COMPOSITION COMPRISING AN IMIDOPERCARBOXYLIC ACID DERIVATIVE AND A N-ACYLATED AMINO ACID ESTER
Composition containing, in a physiologically acceptable medium, at least one imidopercarboxylic acid compound and at least one N-acylated amino acid ester of formula (A) as described herein.
|
|
|
US20090238870 |
Dividable galenical form allowing modified release of the active ingredient
Dividable galenical form for the modified release of active ingredient, wherein the non-subdivided galenical form and a portion of said form obtained by subdivision have identical dissolution...
|
|
|
US20090239926 |
METHODS FOR THE TREATMENT OF PSORIASIS OR PSORIATIC ARTHRITIS USING CYCLOPROPYL-N-CARBOXAMIDE
Methods of treating, managing or preventing psoriasis or psoriatic arthritis are disclosed. Specific methods encompass the administration of...
|
|
|
US20090221575 |
Sulfonamide derivatives and use thereof for the modulation of metalloproteinases
The present invention is related to sulfonamide derivatives of Formula (Ia)
where the groups are as defined in the description, and use thereof in particular for the treatment and/or prophylaxis...
|
|
|
US20090215730 |
Antineoplastic compounds and pharmaceutical compositions thereof
Chemical compounds derived by in silico molecular modelling, having a well defined structure suitable for the blocking of the phosphorylation event, through the specific interaction of the chemical...
|
|
|
US20090215772 |
Hydroxybenzamide derivatives and their use as inhibitors of HSP90
The invention provides compounds of the formula (I):
or salts, tautomers, solvates and N-oxides thereof; wherein R 1 is hydroxy or hydrogen; R 2 is hydroxy; methoxy or hydrogen; provided that...
|
|
|
US20090215742 |
AMIDE RESORCINOL COMPOUNDS
The present invention is directed to compounds of formula (I),
and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as HSP-90 inhibitors.
|
|
|
US20090209532 |
PHARMACEUTICAL COMPOUNDS
Compounds of formula (I) exhibit COMT enzyme inhibiting activity and are thus useful as COMT inhibitors.
|
|
|
US20090203761 |
PROCESS FOR PREPARING (3-OXO-2,3-DIHYDRO-1H-ISOINDOL-1-YL) ACETYLGUANIDINE DERIVATIVES
The present invention relates to processes for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl)acetylguanidine derivatives of the formula I
via 3-hydroxy-2,3-dihydro-1H-isoindol-1-one derivatives...
|
|
|
US20090203665 |
HETEROCYCLIC-SUBSTITUTED PHENYL METHANONES
The present invention relates to compounds of formula I
wherein
R 1 ,
R 2 , and
are defined in the specification
and to pharmaceutically acceptable acid addition salts thereof.
|
|
|
US20090176858 |
HCV PROTEASE INHIBITORS AND USES THEREOF
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
|
|
|
US20090170835 |
ISOINDOLINE DERIVATIVES
Provided is a novel isoindoline compound of the formula (I):
The compound is useful for anesthesia by inducing sedation in a mammal.
|
|
|
US20090170842 |
BRCA1-BASED BREAST OR OVARIAN CANCER PREVENTION AGENTS AND METHODS OF USE
A pharmaceutical composition for use in treating, inhibiting, and/or preventing breast and/or ovarian cancer can include: a molecule having a structure of one of Compounds 1-38, pharmaceutically...
|
|
|
US20090149505 |
Metabotropic Glutamate Receptor-Potentiating Isoindolones
Compounds of Formula I:
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined in the description, processes for the preparing such compounds, new intermediates employed in their...
|
|
|
US20090118268 |
OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS
This invention relates to the use of a group of aryl ureas in treating p38 mediated diseases, and pharmaceutical compositions for use in such therapy.
|
|
|
US20090099186 |
INHIBITORS OF VIRAL REPLICATION
The embodiments provide compounds of the general Formulas I-IV, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide...
|
|
|
US20090082368 |
METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY
Disclosed are compositions which modulate the interaction with nerve growth factor and precursors thereof with neurotrophic receptors. Also disclosed are methods of using the compositions of the...
|
|
|
US20090075978 |
SUBSTITUTED PROPIOLIC ACID AMIDES AND THEIR USE FOR PRODUCING DRUGS
The present invention relates to substituted propiolic acid amides, to methods for the production thereof, to medicaments containing these compounds and to the use thereof for producing medicaments.
|
|
|
US20090062284 |
Thio-Substituted Biarylmethanesulfinyl Derivatives
The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that...
|
|
|
US20090054462 |
Hydroisoindoline tachykinin receptor antagonists
The present invention is directed to certain hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The...
|
|
|
US20090031435 |
SMA Therapy and Cell Based Assay
This invention relates to therapies for diseases involving splicing defects, such as spinal muscular atrophy (SMA), and methods to identify compounds for treating this disease. The invention...
|
|
|
US20090030064 |
Sugar-coated preparation
A preparation wherein an active ingredient unstable to oxygen is stabilized by coating a portion containing the active ingredient unstable to oxygen with a sugar-coated layer containing (1) sugar...
|
|
|
US20090030063 |
Combined pharmaceutical preparation for treatment of type 2 diabetes
For controlling the condition of type 2 diabetes, a pharmaceutical including a combination of mitiglinide, a pharmacologically acceptable salt thereof or a hydrate thereof and an α-glucosidase...
|
|
|
US20090017003 |
THIOSULFONATE ANTI-INFLAMMATORY AGENTS
The present invention relates to novel thiosulfonates derivatives. The present invention also provides methods for preventing, treating and/or reducing inflammation-associated diseases in the...
|
|
|
US20090010886 |
Method for the Treatment of Myeloproliferative Diseases Using(+)-2-[1-(3-Ethoxy-4-Methoxyphenyl)-2- Methylsulfonylethyl]-4- Acetylaminoisoindoline-1,3- Dione
Methods of treating, preventing and/or managing a myeloproliferative disease are disclosed. Specific methods encompass the administration of a selective cytokine inhibitory drug, or a...
|
|
|
US20080267905 |
Methods and Compositions Using Selective Cytokine Inhibitory Drugs for Treatment and Management of Cancers and Other Diseases
Methods of treating, preventing and/or managing cancer as well as and diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass...
|
|
|
US20080255149 |
Carboxyamine Compounds and Methods of Use Thereof
The invention relates to the use of carboxyamine compounds and salts thereof in the treatment of HDAC dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of...
|
|
|
US20080234358 |
NAPHTHALENE DERIVATIVES
A compound of formula (I)
wherein
R 1 and R 3 are the same or different and represent ═O, hydrogen, C 1-6 alkyl, C 1-6 dialkyl, ═CHC 1 -C 5 alkyl, ═S, or a 5- or 6-membered aryl; R 4 ...
|
|
|
US20080221196 |
PHARMACEUTICALLY ACTIVE ISOINDOLINE DERIVATIVES
Isoindolin-1-one and Isoindoline-1,3-dione substituted in the 2-position with an α-(3,4-disubstituted phenyl)alkyl group and in the 4- and/or 5-position with a nitrogen-containing group are...
|
|
|
US20080213213 |
Method For the Treatment of Myelodysplastic Syndromes Using (+)-2-[1-(3-Ethoxy-4-Methoxyphenyl)-2-Methylsulfonylethyl]-4-Acetylaminoisoindoline-1,3-Dione
Methods of treating, preventing and/or managing a myelodysplastic syndrome are disclosed. Specific methods encompass the administration of a selective cytokine inhibitory drug, or a...
|
|
|
US20080207689 |
Formamide Derivatives For The Treatment of Diseases
The invention relates to compounds of formula (1)
and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives....
|
|
|
US20080200531 |
CDKI pathway inhibitors as inhibitors of tumor cell growth
The invention provides new methods for inhibiting the CDKI pathway and specifically inhibiting tumor cell growth. The invention further provides new and specific inhibitors of tumor cell growth, as...
|
|
|
US20080199538 |
Compound to enhance lucid erotic dreams
A compound that contains herbal supplements to increase the frequency and lucidity of a person's erotic or sexual dreams. The compound can be used by anyone wishing to enhance their lucid erotic...
|
|
|
US20080194565 |
5-Phenyl-Pentanoic Acid Derivatives as Matrix Metalloproteinase Inhibitors for the Treatment of Asthma and Other Diseases
The present invention relates to C ompounds having the structure of Formula I: wherein n is an integer from 1 to 5; R 1 is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl,...
|
|
|
US20080176868 |
Preparation and use of compounds as protease inhibitors
Disclosed are compounds of the formula I
or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein
Q is a bond or —N(R 5 )—; T is a bond, —O—,...
|
|
|
US20080176920 |
Neuronal Pain Pathway Modulators
The present invention relates to compounds that may be used to inhibit activation of protein kinase G (“PKG”). It is based, at least in part, on the discovery of the tertiary structure of PKG...
|
|
|
US20080171771 |
New Compounds 391
This invention relates to novel compounds having the structural formula I below:
and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a...
|
|
|
US20080171781 |
HEMODYNAMICS IMPROVING AGENT
Agents which contains a serotonin derivative as an active ingredient are effective for improving hemodynamics and for preventing or improving deterioration of hemodynamics associated with aging and...
|
|
|
US20080153758 |
Compounds Which Inhibits Protein Prenylation E.G. Geranylgeransferse or Farnesyltransferase Inhibitors for Treating Parkinson's Disease
The invention relates to compounds and their uses, particularly in the pharmaceutical industry. The invention more specifically relates to new uses of compounds that inhibit the prenylation of...
|
|
|
US20080149097 |
Beta-agonist compounds comprising nitric oxide donor groups and reactive oxygen species scavenger groups and their use in the treatment of respiratory disordersB
The present invention relates to multifunctional β-agonist compounds comprising a reactive oxygen species scavenger group and a nitric oxide donor, and to methods of treating chronic obstructive...
|
|
|
US20080145336 |
Isoindoline compounds and methods of their use
Novel isoindoline compounds are disclosed. Methods of treating, preventing and/or managing cancer, diseases and disorders associated with, or characterized by, undesired angiogenesis, and diseases...
|
|
|
US20080138295 |
Bechet's disease using cyclopropyl-N-carboxamide
Methods of treating, preventing and/or managing cancer as well as and diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass...
|
|
|
US20080108659 |
POLY(ADP-RIBOSE)POLYMERASE INHIBITORS
Compounds which inhibit the activity of poly(ADP-ribose)polymerase, compositions containing the compounds and methods of treating diseases using the compounds is disclosed.
|
|
|
US20080085893 |
MATRIX METALLOPROTEASE INHIBITORS
The present invention relates to compounds of Formula I,
wherein R1, R2, R3, R4, R5, R6, and R7 are defined in the specification. In addition, the present invention relates to methods treating...
|
|
|
US20080032979 |
Omega-Carboxyaryl Substituted Diphenyl Ureas As Raf Kinease Inhibitors
This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
|
|
|
US20080015237 |
NEW COMPOUNDS I/418
There is provided compounds of formula I,
wherein R 1 to R 7 have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular...
|
|
|
US20080004613 |
Methods and devices for treatment of migraines
Methods for treating a migraine by cooling a patient's nasopharyngeal cavity are described. In one method, a cooling assembly is inserted into a nasal cavity through a patient's nostril. The...
|