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US20090297472 |
Hepatitis C Virus Inhibitors
Hepatitis C virus inhibitors having the general formula
are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
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US20090291997 |
CARVEDILOL DIHYDROGEN PHOSPHATE MONOHYDRATE
Disclosed herein is crystalline carvedilol dihydrogen phosphate monohydrate having high aqueous solubility and the process for preparation thereof. The invention further discloses methods for...
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US20090286845 |
Carvedilol phosphate
The invention encompasses novel amorphous and crystalline forms of carvedilol phosphate, carvedilol hydrogen phosphate, and carvedilol dihydrogen phosphate as well as methods of making the novel...
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US20090286844 |
Carvedilol phosphate
The invention encompasses novel amorphous and crystalline forms of carvedilol phosphate, carvedilol hydrogen phosphate, and carvedilol dihydrogen phosphate as well as methods of making the novel...
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US20090286843 |
MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION
The embodiments provide compounds of the general formulas I-XIX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide...
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US20090286825 |
Indole derivatives as crth2 receptor antagonists
Compounds according to formula (I) wherein the radicals R 1 , R 2 and R 3 are as herein defined, and wherein Ar represents an aryl group or heteroaryl group, preferably phenyl, n is 1 or 2, and...
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US20090285766 |
Photosensitising Composition and Uses Thereof
The present invention provides a photosensitising composition comprising a mixture of: at least one surfactant; at least one alcohol; and/or water, with the proviso that when the at least one...
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US20090281158 |
PRODRUGS OF CC-1065 ANALOGS
Prodrugs of analogs of the anti-tumor antibiotic CC-1065 having a cleavable protective group such as a piperazino carbamate, a 4-piperidino-piperidino carbamate or a phosphate, in which the...
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US20090281093 |
ANTI-INFLAMMATORY COMPOUNDS
The present invention relates to novel non steroidal anti-inflammatory compounds (NSAIDs) that release hydrogen sulfide (H 2 S). The present invention also provides methods for treating, preventing...
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US20090275630 |
COSMETIC COMPOSITION COMPRISING AN IMIDOPERCARBOXYLIC ACID DERIVATIVE AND A N-ACYLATED AMINO ACID ESTER
Composition containing, in a physiologically acceptable medium, at least one imidopercarboxylic acid compound and at least one N-acylated amino acid ester of formula (A) as described herein.
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US20090270476 |
PHARMACEUTICAL COMPOSITION FOR TREATMENT OR PREVENTION OF NEPHRITIS AND MANUFACTURING METHOD THEREOF
A pharmaceutical composition for treatment of nephritis of the present invention comprises a triprenylphenol compound as an active substance, preferably the triprenylphenol compound represented by...
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US20090270414 |
2,3,4,9- TETRAHYDRO-1H-CARBAZOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS
The invention relates to novel tetrahydro-1H-carbazole derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects...
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US20090269305 |
NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION
The embodiments provide compounds of the general Formulae I, II, III, IV, V, VI, VII, and X, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The...
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US20090263478 |
CARVEDILOL FORMS, COMPOSITIONS, AND METHODS OF PREPARATION THEREOF
Disclosed are amorphous carvedilol salt forms, controlled-release carvedilol compositions, and methods of preparing the forms and compositions.
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US20090263341 |
SOFT ANTICHOLINERGIC ESTERS
Soft anticholinergic esters of the formulas:
wherein R 1 and R 2 are both phenyl or one of R 1 and R 2 is phenyl and the other is cyclopentyl; R is C 1 -C 8 alkyl, straight or branched...
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US20090263327 |
MINIMALLY INVASIVE PHYSIOLOGICAL FUNCTION MONITORING AGENTS
Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function...
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US20090258892 |
FUSED PYRAZOLE DERIVATIVES AND METHODS OF TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF
The present invention relates to certain fused pyrazole derivatives of Formula (Ia), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as...
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US20090258858 |
MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS
Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.
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US20090239925 |
TRICYCLIC INDENO-PYRROLE DERIVATIVES AS SEROTONIN RECEPTOR MODULATORS
The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More...
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US20090233977 |
Method of Treating Atherosclerosis, dyslipidemias and related conditions
A method of treating atherosclerosis is disclosed wherein nicotinic acid or another nicotinic acid receptor agonist is administered to the patient in combination with a DP receptor antagonist. The...
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US20090233970 |
COMBINED NSAID AND ACID BLOCKER FORMULATION AND METHOD
The present invention is directed to co-administration of a non-steroidal anti-inflammatory agent (NSAID) and acid blocking agent for the treatment of pain and inflammation with reduced...
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US20090232898 |
Pharmaceutical Compositions Useful in the Treatment of Migraine
There is provided pharmaceutical compositions for the treatment of migraine comprising a pharmacologically-effective amount of a triptan or an ergot, or a pharmaceutically-acceptable salt thereof;...
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US20090221569 |
USE OF LHRH ANTAGONISTS FOR INTERMITTENT TREATMENTS
The invention relates to methods of treatment or prophylaxis of physiological and/or pathological conditions with at least one LHRH antagonist, in particular at least one peptidomimetic LHRH...
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US20090215852 |
COMPOSITIONS AND METHODS FOR AMELIORATING CACHEXIA
The invention provides preparations, formulations, kits and other products of manufacture (e.g., blister packs) comprising combinations of beneficial ingredients that are serviceable as therapies...
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US20090215736 |
CASPASE INHIBITORS AND USES THEREOF
This invention provides caspase inhibitors of formula I:
wherein Z is oxygen or sulfur; R 1 is hydrogen, —CHN 2 , R, CH 2 OR, CH 2 SR, or —CH 2 Y; between R 3 and R 4 represents a...
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US20090209459 |
Method of Treating Myasthenia Gravis
The invention relates to the use of agents that bind the complement protein C5 in the treatment of diseases associated with inappropriate complement activation and in particular in the treatment of...
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US20090203632 |
COMPOSITIONS AND METHODS FOR TREATING CONTRACTURE
A method for treating contracture is provided that includes administering to a patient in need thereof a composition that includes a therapeutic agent effective in treating contracture....
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US20090197821 |
COMPOSITIONS AND METHODS FOR THE DELIVERY OF POORLY WATER SOLUBLE DRUGS AND METHODS OF TREATMENT
The present embodiment of the invention is generally directed to compositions comprising suspensions of poorly water-soluble compounds recrystallized in nanoparticulate sizes ranging from 0.1 to 5...
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US20090192128 |
GENETIC RISK ASSESSMENT IN HEART FAILURE: IMPACT OF GENETIC VARIATION OF BETA 1 ADRENERGIC RECEPTOR GLY389ARG POLYMORPHISM
The invention provides methods for (a) reducing mortality associated with heart failure; (b) improving oxygen consumption; (c) treating heart failure; (d) treating hypertension; (e) improving the...
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US20090191152 |
INTRALYMPHATIC CHEMOTHERAPY DRUG CARRIERS
A chemotherapeutic composition can be configured for subcutaneous administration for preferential intralymphatic accumulation while also providing a therapeutic systemic concentration that is not...
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US20090186883 |
Stable Aqueous Suspension
An aqueous pharmaceutical suspension comprising: (i) at least one non-steroidal anti-inflammatory drug; (ii) an aqueous buffer system; (iii) xanthan gum; (iv) polyvinyl pyrrolidone; and (v)...
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US20090170923 |
HCV INHIBITORS
The present invention relates to compounds that are useful in the treatment of viruses belonging to Flaviviridae, including flaviviruses, pestiviruses, and hepaciviruses. The invention includes...
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US20090170882 |
Methods and compositions
Compounds, compositions and methods relating to kinesin inhibition are described herein.
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US20090163481 |
PPAR-DELTA LIGANDS AND METHODS OF THEIR USE
The disclosure provides compounds, compositions, and methods for modulating PPARδ receptor. In one embodiment, the compounds of the disclosure comprise a tri-substituted thiazole group. The...
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US20090163451 |
METHODS FOR TREATING VISCERAL PAIN
The invention features methods of treating visceral pain in humans by administering an effective amount of a 5HT 1B or 5HT 1D receptor agonist, (e.g., a triptan). These methods can be used, for...
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US20090162440 |
SODIUM ALGINATE MICROSPHERE VASCULAR EMBOLUS CONTAINING WATER-SOLUBLE DRUG AND PREPARATION AND APPLICATION THEREOF
The present disclosure relates to a kind of sodium alginate microsphere vascular embolus that contains water-soluble drug and preparation and application thereof. The embolus preparation falls into...
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US20090156656 |
USE OF LIGHT-ACTIVE INDOCYANINE GREEN FOR TREATING INFLAMMATORY DISORDERS IN THE ORAL CAVITY
In a process for treating disorders, especially inflammatory disorders, in the oral cavity, by introducing a substance activable by a light source, the substance comprises the active ingredient...
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US20090143279 |
Methods and compositions for treating metabolic disorders
The present invention provides methods of treating of disorders characterized by defective mitochondrial activity. In particular compounds of the present invention can be used in the treatment...
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US20090131501 |
Agents Useful for Reducing Amyloid Precursor Protein and Treating Dementia and Methods of Use Thereof
The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention...
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US20090130228 |
PHARMACEUTICAL COMBINATION FOR THE TREATMENT AND OR CHEMOSENSIBILIZATION OF REFRACTORY TUMORS TO ANTICANCER DRUGS
This invention is related to a pharmaceutical combination that contains a Casein kinase 2 (CK2) peptide inhibitor (termed P15) along with the standard chemotherapeutic drugs used in cancer...
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US20090124651 |
CATECHOLAMINE DERIVATIVES AND PRODRUGS THEREOF
The present invention relates to novel catecholamine derivatives of Formula I, to processes for their preparation, pharmaceutical compositions containing them and to their use in therapy.
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US20090118349 |
BIS-ALKYLATING AGENTS AND THEIR USE IN CANCER THERAPY
The present invention relates to (i) conjugates comprising two DNA alkylating subunits linked by a moiety fitting to the minor groove of the DNA, (ii) to their preparation and (iii) to their use in...
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US20090118348 |
DRUG-INTRODUCED PHOTO-CROSSLINKED HYALURONIC ACID DERIVED GEL
A drug-introduced photo-crosslinked hyaluronic acid derived gel which is a photo-crosslinked hyaluronic acid gel into which a drug is introduced through a covalent bond, and has characteristics...
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US20090118347 |
Method of Treating Down Syndrome
A method of, or the use of compounds of the invention for, treating the cognitive impairments associated with Down syndrome, the method or use comprising treating or administering to a person with...
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US20090117197 |
COMPOSITIONS AND METHODS FOR AMELIORATING CACHEXIA
The invention provides preparations, formulations, kits and other products of manufacture (e.g., blister packs) comprising combinations of beneficial ingredients that are serviceable as therapies...
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US20090117125 |
SYNTHESIS OF 8H-3A-AZA-CYCLOPENTA[A]INDENES AND 5,10-DIHYDROPYRROLO[1,2-B]ISOQUINOLINES DERIVATIVES AND THEIR USE AS ANTITUMOR THERAPEUTIC AGENTS
The present disclosure relates to a series of bis(hydroxymethyl) and its bis(carbamate) of 8H-3a-azacyclopenta[a]indene-1-yl and 5,10-dihydropyrrolo-[1,2-b]isoquinolines derivatives (Formula...
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US20090110755 |
Compositions and Methods for Preventing Migraines
The present invention relates to compositions and methods for preventing migraines. The migraine prophylaxis composition is a single dosage form comprising at least one form of elemental magnesium...
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US20090105223 |
Compound Having Activity Of Blocking NMDA Receptor Channel, and Pharmaceutical Agent Using The Same
To provide a novel compound having NMDA receptor channel blocking activity, and also a pharmaceutical agent comprising the compound. A pharmaceutical agent for the treatment or prevention of a...
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US20090104297 |
HERBAL COMPOSITION FOR TREATMENT OF INFECTIONS CAUSED BY DERMATOPHYTES
The present invention relates to a novel herbal composition comprising extract of roots of the plant Murraya koenigii for the treatment of infections caused by dermatophytes, particularly tinea ...
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US20090104119 |
Dendrimer Based Compositions And Methods Of Using The Same
The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer based multifunctional compositions and systems for use in...
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