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US20090306155 |
THIAZOLES, IMIDAZOLES, AND PYRAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES
The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of...
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US20090306166 |
Method of Controlling Phytopathogenic Diseases on Turfgrass
A method of controlling phytopathogenic diseases on turfgrass or on seeds thereof, which comprises applying to the turfgrass, the locus thereof or seeds thereof a composition, that, in addition to...
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US20090306159 |
Inhibition of Intermediate-Conductance Calcium Activated Potassium Channels in the Treatment and/or Prevention of Atherosclerosis
Methods for treating or preventing atherosclerosis in human or non-human animal subjects by inhibiting or blocking intermediate-conductance calcium activated potassium channels associated with...
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US20090306129 |
SUBSTITUTED PYRAZOLO [3,4-B] PYRIDINES AS PHOSPHODIESTERASE INHIBITORS
The present invention relates to phosphodiesterase (PDE) type IV selective inhibitors. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed...
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US20090306055 |
PHENYLAZOLE COMPOUNDS, PRODUCTION PROCESS AND ANTIOXIDANTS
The present invention is directed to compounds represented by the formula (1): B-D-Z (1), wherein B represent the following formula (B-1),
A represents an optionally substituted imidazole or...
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US20090306131 |
CELL LINES WITH LATENT IMMUNODEFICIENCY VIRUS AND METHODS OF USE THEREOF
The present invention provides isolated cells that comprise, integrated into the genome of the cell, a transcription-competent immunodeficiency virus or a transcription-competent immunodeficiency...
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US20090298797 |
COMBINATION THERAPY FOR THE TREATMENT OF INFLUENZA
Compositions and methods for treating one or more symptoms of influenza, preferably influenza due to infection with influenza A (H5N1) are provided. It has been discovered that administration of a...
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US20090291919 |
Compositions and Methods for Treating or Preventing Ophthalmic Light Toxicity
Methods are disclosed for treating ophthalmic conditions related to the production of toxic visual cycle products that accumulate in the eye, and are associated with reactions of the visual cycle...
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US20090286681 |
Synergistic Fungicidal Active Compounde Combinations Containing a Carboxamide, an Azole, a Second Azole or a Strobilurin
The present invention relates to novel active compound combinations comprising a known carboxamide, a known azole and additionally a second known azole or alternatively a known strobilurin, which...
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US20090285786 |
METHOD TO MODULATE HEMATOPOIETIC STEM CELL GROWTH
The present invention provides for compositions and methods for modulating hematopoietic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease...
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US20090286840 |
Thiophene-carboxamides useful as inhibitors of protein kinases
The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of...
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US20090286760 |
Novel Compositions and Methods for Treating Hyperproliferative Diseases
The invention relates to a composition that includes a first agent selected including an agent that possesses anti-inflammatory activity or acetaminophen, phenacetin, tramadol and the like; a...
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US20090286791 |
Amide Compounds
The present invention provides compounds represented by the formula (Ia):
the formula (Ib):
the formula (Ic):
and the formula (Id):
wherein each symbol is as defined in the specification....
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US20090281093 |
ANTI-INFLAMMATORY COMPOUNDS
The present invention relates to novel non steroidal anti-inflammatory compounds (NSAIDs) that release hydrogen sulfide (H 2 S). The present invention also provides methods for treating, preventing...
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US20090281131 |
DIEBENZOFURAN DERIVATIVES AS INHIBITORS OF PDE-4 AND PDE-10
The present invention relates to novel heterocyclic compounds that are useful as phosphodiesterase inhibitors (PDEs) in particular phosphodiesterase type 4 (PDE IV) inhibitors and phosphodiesterase...
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US20090274655 |
2-CARBOXY THIOPHENE DERIVATIVES AS ANTI VIRAL AGENTS
Anti-viral agents of compounds of Formula (I): wherein A, R 1 , R 2 and R 3 are as defined in the specification, processes for their preparation and their use in HCV treatment are provided.
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US20090275619 |
Amide Substituted Indazole and Benzotriazole Derivatives as Poly(ADP-Ribose)Polymerase (PARP) Inhibitors
The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly (ADP-ribose) polymerase (PARP) and thus useful for...
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US20090275617 |
Aryl-Substituted Nitrogen-Containing Heterocyclic Compounds
Disclosed is an aryl-substituted nitrogen-containing heterocyclic compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof. This compound serves as nociceptin...
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US20090275588 |
NOVEL SULFONAMIDE COMPOUNDS
The invention relates to novel sulfonamide compounds and their use as orexin receptor antagonists.
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US20090275598 |
Conformationally constrained 3-(4-hydroxy-phenyl)-substituted-propanoic acids useful for treating metabolic disorders
The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I:
where the definitions of the variables Q,...
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US20090275529 |
METHOD FOR IMPROVING CARDIOVASCULAR RISK PROFILE OF COX INHIBITORS
A method of reducing the increased risk of cardiovascular events attendant with the use of COX or selective COX-2 inhibitors including restoring disrupted cholesterol metabolic function engendered...
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US20090270359 |
SUBSTITUTED PYRAZOLE DERIVATIVES
The present invention provides a novel pyrazole derivative and an androgen receptor antagonist containing the derivative. The present invention provides a compound represented by the formula (I′)...
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US20090270370 |
FUSED HETEROCYCLIC COMPOUNDS
Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
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US20090270460 |
FXR AGONISTS
Compounds of formula wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.
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US20090270361 |
Substituted pyrazole derivatives and use thereof
The present invention aims to provide a novel pyrazole derivative and a pharmaceutical agent containing the same. The present invention provides a compound represented by the formula (I′)
...
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US20090263399 |
METHOD FOR ESTABLISHING THE SENSITIVITY OF TUMOURS TO CAPECITABIN AND TEST KIT
The invention relates to a method for establishing the sensitivity of tumors towards capecitabine, if applicable in combination with Docetaxel or Paclitaxel or the humanized antibody Herceptin, or...
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US20090264457 |
Combination of at least two 5HT6-Ligands
The present invention relates to a Combination of at least two 5HT6-Ligands of which one is a partial or agonist while the other is a full antagonist or an inverse agonist, a medicament comprising...
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US20090264289 |
Use of Arylcarboxylic Acid Biphenylamides for Seed Treatment
The invention relates to the use of arylcarbonic acid biphenylamides of formula (I)
wherein
X is halogen or methyl; n is zero, 1 or 2; Y is cyano, nitro, halogen, C 1 -C 4 -alkyl, C 1 -C 4...
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US20090264414 |
Amide Derivatives and Pharmaceutical Use Thereof
The use of substituted amides for modulating the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a...
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US20090264468 |
Methods for treating a disease in which Rho kinase is involved
A method for treating a disease in which Rho kinase is involved. The method is carried out by administering to a patient in need thereof a pharmaceutically effective amount of a compound of the...
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US20090263486 |
NANOPARTICLE-STABILIZED CAPSULE FORMULATION FOR TREATMENT OF INFLAMMATION
A formulation for the delivery of an anti-inflammatory agent to a subject is described. In one particular application of the invention, the formulation comprises oil-based or aqueous droplets...
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US20090263353 |
Novel Sulphonylpyrroles as Inhibitors of Hdac S Novel Sulphonylpyrroles
Compounds of a certain formula I,
in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, as well as salts thereof are novel effective HDAC inhibitors.
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US20090258892 |
FUSED PYRAZOLE DERIVATIVES AND METHODS OF TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF
The present invention relates to certain fused pyrazole derivatives of Formula (Ia), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as...
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US20090258912 |
N-(1-Alkyl-2-Phenylethyl)-Carboxamide Derivatives and Use Thereof as Fungicides
A compound of general formula (I):
A process for preparing this compound. A fungicidal composition comprising a compound of general formula (I). A method for treating plants by applying a...
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US20090253697 |
Novel Indole Derivatives, Preparation Thereof as Medicinal Products and Pharmaceutical Compositions, and Especially as KDR Inhibitors
The disclosure relates to compounds of formula (I):
wherein R1, R2, and R3 are as defined in the disclosure, compositions comprising said compounds, methods for their preparation, intermediates...
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US20090253699 |
Compounds for Nonsense Suppression, and Methods for Their Use
The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or...
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US20090253766 |
THIOPHENE DERIVATIVES AS FACTOR XIA INHIBITORS
The present invention provides compounds of Formula (I):
or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables A, L 1 , R 3 , and R...
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US20090253728 |
Methods and Compositions for Treating Nociceptive Pain
The present invention provides methods and compositions useful for the treatment and prevention of pain.
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US20090253673 |
Substituted Pyrazoles as Ghrelin Receptor Antagonists
Certain novel N-acylated spiropiperidine derivatives are ligands of the human ghrelin receptor(s) and, in particular, are antagonists/inverse agonists of the human ghrelin receptor. They are...
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US20090247504 |
Indazole Derivatives for Treatment of Alzheimer's Disease
Compounds of formula (IA) and (IB) are inhibitors of MARK, and hence are suitable for treatment of Alzheimer's disease.
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US20090247547 |
HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES B
The present teachings relate to compounds of Formula I:
and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R 1 , R 2 , R 3 , Y, Z, and are as defined...
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US20090247511 |
SYNERGISTIC INSECTICIDE AND FUNGICIDE MIXTURES
The present invention relates to novel active compound combinations comprising of at least two fungicidal components A and B and at least one insecticidal component C. A, B and C may be selected...
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US20090247586 |
CARBOXAMIDES FOR CONTROLLING MICRO-ORGANISMS IN PLANT AND MATERIAL PROTECTION
Novel carboxamides of the formula (I)
The present application is further directed toward a plurality of processes for preparing these compounds and their use for controlling unwanted...
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US20090239750 |
EMULSION COMPOSITION
There is provided an emulsion composition useful as a preparation containing an active agrochemical compound. The emulsion composition essentially consisting of 0.5 to 25% by weight of one or a...
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US20090239911 |
CYCLOHEXYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1
The present invention discloses novel compounds of Formula I: having 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention...
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US20090239923 |
CONCENTRATED AQUEOUS AND/OR ETHANOLIC SOLUTION OF 4-METHYLPYRAZOLE (FOMEPIZOLE)
A composition of matter comprising fomepizole and water wherein the content of water is about 3% to about 40% by weight, and methods of making fomepizole solutions effective to reduce the freezing...
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US20090239866 |
PEPTIDE DEFORMYLASE INHIBITORS
Novel PDF inhibitors and novel methods for their use are provided.
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US20090233953 |
ANTAGONISTS OF THE VANILLOID RECEPTOR SUBTYPE 1 (VR1) AND USES THEREOF
The present invention is directed to compounds of formula (I)
wherein variables X 1 , X 2 , Y, R 1a , R 1b , R 2a , R 2 , A 1 , A 2 , A 3 , and A 4 are as defined in the description, and...
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US20090233795 |
Fungicidal Mixtres Based On 3-Monosubstituted N-Bipenyl-Pyrazolecarboxamides
Fungicidal mixtures comprising, as active components,
1) at least one 3-mono disubstituted N-biphenylpyrazolecarboxamide of the formula I
in which X=oxygen or sulfur; R 1 =cyano, nitro,...
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US20090227647 |
Compounds, Compositions and Methods for the Treatment of Islet Amyloid Polypeptide (IAPP) Accumulation in Diabetes
Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of IAPP or amylin fibril diseases, and...
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