|
Match
|
Document |
Document Title |
|
|
US20090275603 |
NF- kB Inhibitors And Uses Thereof
A new class of imidazolines as 4-position esters with very potent anti-inflammatory as well as antimicrobial activity is described. The synthesis of these imidazolines includes a multicomponent...
|
|
|
US20090264491 |
METHODS AND COMPOSITIONS FOR TREATING POST-OPERATIVE PAIN COMPRISING CLONIDINE
The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot...
|
|
|
US20090264490 |
CLONIDINE FORMULATIONS IN A BIODEGRADABLE POLYMER CARRIER
Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine at or near a target site, one can relieve pain caused by...
|
|
|
US20090264489 |
Method for Treating Acute Pain with a Formulated Drug Depot in Combination with a Liquid Formulation
Effective methods for treating pain are provided. Through the injection of liquid formulation comprising an active ingredient followed by the administration of drug depot comprising an active...
|
|
|
US20090263451 |
Anti-Inflammatory and/or Analgesic Agents for Treatment of Myofascial Pain
Effective treatments of myofascial pain and/or inflammation are provided. Through the administration of an effective amount of at least one anti-inflammatory agent and/or analgesic at or near a...
|
|
|
US20090263450 |
ALPHA ADRENERGIC RECEPTOR AGONISTS FOR TREATMENT OF INFLAMMATORY DISEASES
Effective treatments of pain and/or inflammation from tendonitis, carpal tunnel syndrome, tarsal tunnel syndrome, osteoarthritis, bursitis and/or an oral-facial disease are provided. Through the...
|
|
|
US20090263443 |
METHODS FOR TREATING POST-OPERATIVE EFFECTS SUCH AS SPASTICITY AND SHIVERING WITH CLONDINE
Effective treatments of spasticity and shivering that accompanies surgeries are provided. Through the administration of an effective amount of clonidine at or near a target site, one can relax...
|
|
|
US20090263441 |
DRUG DEPOTS HAVING DIFFREENT RELEASE PROFILES FOR REDUCING, PREVENTING OR TREATING PAIN AND INFLAMMATION
Effective treatments of pain and/or inflammation are provided. Through the administration of an effective amount of at least analgesic and/or at least one anti-inflammatory agent at or near a...
|
|
|
US20090246256 |
Compositions and Methods for Transmucosal Delivery of Lofexidine
The present invention provides for compositions and methods for accelerating the rate of delivery of lofexidine to the systemic circulation by transmucosal administration through the nasal,...
|
|
|
US20090239918 |
SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF
The invention provides methods for treating pain in mammals. In particular, the invention provides well-defined aminoimidazolines, aminothiazolines, and aminooxazolines and pharmaceutical...
|
|
|
US20090233943 |
NEW COMPOUNDS 835
This invention relates to novel compounds having the structural formula I below:
and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a...
|
|
|
US20090232886 |
ORAL DOSAGE COMBINATION PHARMACEUTICAL PACKAGING
Pharmaceutical fixed dose combination products are formed by merging a fixed dose of a first pharmaceutical formulation from primary module, with a fixed dose of a second pharmaceutical formulation...
|
|
|
US20090214504 |
Methods and Compositions for Topical Treatment of Medical Conditions Including Wounds and Inflammation
A method for treating a patient suffering from a wound, ulcer, or inflammation includes providing a topical formulation comprising a carrier and a combination of active ingredients that includes at...
|
|
|
US20090209422 |
Insecticidal Substituted Aminoalkyl Heterocyclic and Heteroaryl Derivatives
Certain substituted aminoalkyl heteroaryl and heterocyclyl derivatives have provided unexpected insecticidal and acaricidal activity. These compounds are represented by formula I: wherein R, R 1 ,...
|
|
|
US20090197934 |
IMIDAZOLINYLMETHYL ARYL SULFONAMIDE
This invention relates to an alpha-1A receptor partial agonist, which is represented by Formula I:
and pharmaceutically acceptable salts or solvates thereof. The invention further relates to...
|
|
|
US20090197931 |
IMIDAZOLINYLMETHY ARYL SULFONAMIDE
This invention relates to an alpha-1 A receptor partial agonist, which is represented by Formula I:
and pharmaceutically acceptable salts or solvates thereof. The invention further relates to...
|
|
|
US20090143364 |
CHIRAL CIS-IMIDAZOLINES
and the pharmaceutically acceptable salts and esters thereof, wherein X 1 , X 2 , X 3 , Y 1 , Y 2 and R are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and...
|
|
|
US20090130178 |
FORMULATION FOR DECREASING TOBACCO, ALCOHOL, DRUG OR FOOD CONSUMPTION
Formulations have been developed which assist individuals having an addiction such as smoking to reduce or quit engaging in the addictive behavior. Representative behaviors include smoking,...
|
|
|
US20090105222 |
PREVENTION AND TREATMENT OF FUNCTIONAL SOMATIC DISORDERS, INCLUDING STRESS-RELATED DISORDERS
Methods for the prevention or treatment of stress-related disorders by administering a therapeutically effective amount of a dual serotonin/norepinephrine reuptake inhibitor to an individual under...
|
|
|
US20090087490 |
EXTENDED RELEASE FORMULATION AND METHOD OF TREATING ADRENERGIC DYSREGULATION
A composition and method of treating adrenergic dysregulation by administering the composition is disclosed, wherein the composition comprises a α 2 -adrenergic receptor agonist; a...
|
|
|
US20090048323 |
SUBSTITUTED IMIDAZOLINE COMPOUNDS
Substituted imidazoline derivatives corresponding to Formula I:
a method for producing them from substituted aldehyde compounds of Formula B:
and the use of such imidazoline derivatives and...
|
|
|
US20090023639 |
Methods of Treatment
A method of treating weight loss due to underlying disease in a patient, the method comprising administering to the patient an effective amount of an agent which reduces sympathetic nervous system...
|
|
|
US20090018180 |
2-IMIDAZOLINES
The present invention relates to compounds of formula I
wherein
X—Y, R 1 , and n are as defined herein
and to their pharmaceutically active salts. Compounds of formula I have a good...
|
|
|
US20080319041 |
Lofexidine enantiomers for use as a treatment for CNS disease and pathologies and its chiral synthesis
The invention relates to methods for treatment of CNS disease and pathologies using non-racemic mixtures of lofexidine enantiomers. The invention also relates to processes for the manufacture of...
|
|
|
US20080287460 |
NEW COMPOUNDS 835
This invention relates to novel compounds having the structural formula I below:
and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a...
|
|
|
US20080261873 |
Growth-Hormone Secretagogues
Disclosed are methods of treating a disorder of the stomach, intestine or duodenum in a human subject. The method includes administering to the subject, a pharmaceutical composition comprising a...
|
|
|
US20080200335 |
1-(Imidazolin-2-Yl)Amino-1,2-Diphenylethane Compounds For Combating Animal Pests
The present invention relates to 1-(imidazolin-2-yl)amino-1,2-diphenylethane compounds of the formula I and their agriculturally acceptable salts, wherein A is a radical of the formula A 1 or A 2...
|
|
|
US20080193428 |
Composition and Method for Modulating and Maintaining Vaginal Bacterial Flora and Vaginal Acidity
The present invention relates to the use of benzoic acid and/or its sodium salt in combination with saccharide(s) as active components in the manufacture of a vaginal composition for modulating...
|
|
|
US20080153832 |
PAN-ALPHA-2 RECEPTOR AGONIST AND RELAXANT COMPOSITIONS FOR TREATING GASTROINTESTINAL MOTILITY DISORDERS
Disclosed herein is a pharmaceutical composition comprising a relaxant and a pan-alpha-2 receptor agonist. The composition is effective for treating gastrointestinal motility disorders, and methods...
|
|
|
US20080153830 |
ALPHA AND/OR BETA-ADRENERGIC ANTAGONISTS AND AGONISTS TO TREAT PAIN
The present disclosure provides for improved methods for treating pain, including pain associated with chronic inflammatory diseases, neuropathic pain and cancer by using α-adrenergic antagonists...
|
|
|
US20080153808 |
ALPHA-2 RECEPTOR PAN AGONIST AND SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITOR COMPOSITIONS FOR TREATING CHRONIC PAIN
Disclosed herein is a pharmaceutical composition comprising a serotonin-norepinephrine reuptake inhibitor and a pan-alpha-2 receptor agonist. The composition is effective for treating chronic pain,...
|
|
|
US20080146549 |
Accelerated opiate dependence detoxification process
The present invention provides accelerated detoxification methods for the treatment of a substance abuse-related condition in a subject. A method of the present invention may comprise administering...
|
|
|
US20080140450 |
Treatment of metabolic syndrome with norfluoxetine
The invention relates to methods of treating metabolic syndrome, or the specific disorders associated with metabolic syndrome, comprising the administration of norfluoxetine enriched for the (R) or...
|
|
|
US20080132550 |
HETEROCYCLIC COMPOUNDS AS P2X7 ION CHANNEL BLOCKERS
The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II:
wherein R, R 1 , R 2 , R 3 , R 4 , R 5 , X and Y are as defined...
|
|
|
US20080114015 |
NF-kB inhibitors and uses thereof
A diastereomers of imidazolines as 4-position acids are described. The imidazoline diastereomers potentiate the activity of antitumor drugs and are potent inhibitors of the transcription factor...
|
|
|
US20080108685 |
Novel Use for Alpha Sympathomimetics Having a 2-Imidazoline Structure
The invention relates to the use of α-sympathomimetics having a 2 -imidazoline structure for the preparation of a medicament for the prophylaxis and/or treatment of viral diseases.
|
|
|
US20080058318 |
MILNACIPRAN FOR THE TREATMENT OF COGNITIVE DYSFUNCTION ASSOCIATED WITH FIBROMYALGIA
Methods for treating cognitive dysfunction associated with fibromyalgia by administering high-dose milnacipran to a patient suffering from such cognitive dysfunction are provided. Also provided are...
|
|
|
US20080058317 |
MILNACIPRAN FOR THE TREATMENT OF FATIGUE ASSOCIATED WITH FIBROMYALGIA SYNDROME
Methods for treating fatigue associated with fibromyalgia by administering high-dose milnacipran to a patient suffering from such fatigue are provided. Also provided are methods for the long-term...
|
|
|
US20080027052 |
METHODS FOR TREATING CYSTIC KIDNEY DISEASE
The present invention relates to methods for treating or preventing cystic kidney diseases or disorders using calcimimetics and pharmaceutically acceptable salts of these compounds. Various aspects...
|
|
|
US20080019975 |
Novel Regimens for Treating Diseases and Disorders
Methods and materials are provided for induction-maintenance regimens of targeted anti-inflammatory therapies (TATs) for treatment of a variety of diseases and disorders. Preferred embodiments...
|
|
|
US20080019970 |
METHODS FOR PREVENTING, POSTPONING OR IMPROVING THE OUTCOME OF SPINAL DEVICE AND FUSION PROCEDURES
Methods for identifying subjects who could benefit therapeutically from administration of a high specificity cytokine inhibitor are provided. Subjects that are identified include those that are...
|
|
|
US20080019927 |
Compositions and methods for dermally treating neuropathy with minoxidil
The present invention is drawn to adhesive solidifying formulations containing minoxidil that can be used for treating neuropathies including diabetic neuropathy. The formulation can include an...
|
|
|
US20080004310 |
LYOPHILIZED PHARMACEUTICAL COMPOSITION
A stable pharmaceutical composition with increased solubility that includes at least one lyophilized compound that is papaverine, phentolamine or alprostadil.
|