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US20090298901 |
(E)-1-(4-((1R,2S,3R)-1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL)ETHANONE OXIME DIHYDRATE AND METHODS OF ITS USE
(E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-
2-yl)-ethanone oxime dihydrate, compositions comprising it, and methods of its use are disclosed.
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US20090286842 |
NAPHTHYLMETHYLIMIDIZOLES AS THERAPEUTIC AGENTS
Disclosed herein is a method of treating stress urinary incontinence comprising administering a compound to a mammal in need thereof, wherein said compound has the formula
Compositions and...
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US20090286799 |
METHODS FOR THE TREATMENT OF BRAIN EDEMA
The present invention is based on the discoveries that PAN-811 (1) reduces infarct volume, suppresses brain edema and decreases mortality associated with ischemia; (2) blocks veratridine-induced...
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US20090281156 |
ENHANCING PHOTOSTABILIZATION OF OXYMETAZOLINE
The photostability of oxymetazoline in a topical decongestant composition is enhanced by lowering the pH of the composition using a buffer solution.
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US20090275617 |
Aryl-Substituted Nitrogen-Containing Heterocyclic Compounds
Disclosed is an aryl-substituted nitrogen-containing heterocyclic compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof. This compound serves as nociceptin...
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US20090270473 |
DUAL-ACTING ANTIHYPERTENSIVE AGENTS
The invention relates to compounds having the formula:
wherein: Q, W, Y, Z, r, and Ar are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT...
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US20090264375 |
INTRAOCULAR IRRIGATING SOLUTIONS AND METHODS FOR TREATING CORNEAL EDEMA
One aspect of the present invention relates to methods of treating corneal edema comprising contacting a cornea with an ophthalmic irrigating composition comprising histidine. In certain...
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US20090258016 |
Substituted imidazole derivatives
The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with...
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US20090253764 |
USE OF AMPK-ACTIVATING IMIDAZOLE DERIVATIVES, PREPARATION PROCESS THEREFOR AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
The invention relates to the use of imidazole derivatives of the formula (1):
in which A, R′ 1 , R′ 2 and R′ 3 are as defined in the description, as AMPK activators. The invention also...
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US20090247601 |
PEPTIDE DERIVATIVES WITH THERAPEUTIC ACTIVITY
Dipeptide compounds containing a histidine residue proved to have interesting blocking activity on secondary products from lipid oxidative stress, in particular on unsaturated aldehydes such as...
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US20090239922 |
Kinesin inhibitors as cancer therapeutics
The invention provides novel compounds having a substituted imidazole ring, and methods of using such compounds for the treatment of certain disorders such as hematological cancers and solid...
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US20090233970 |
COMBINED NSAID AND ACID BLOCKER FORMULATION AND METHOD
The present invention is directed to co-administration of a non-steroidal anti-inflammatory agent (NSAID) and acid blocking agent for the treatment of pain and inflammation with reduced...
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US20090227647 |
Compounds, Compositions and Methods for the Treatment of Islet Amyloid Polypeptide (IAPP) Accumulation in Diabetes
Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of IAPP or amylin fibril diseases, and...
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US20090221547 |
Immunosuppressant Compounds and Compositions
The present invention relates to immunosuppressants, processes for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds...
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US20090209597 |
IMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABA ALPHA RECEPTOR COMPLEX
This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the...
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US20090202659 |
Modulation of Peripheral Clocks in Adipose Tissue
Genes encoding the transcription factors controlling the core circadian oscillator (BMAL, Clock, NPAS, Per) and their regulatory targets (Rev-erbα, Rev-erb) have been found in adipose tissue. The...
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US20090198145 |
COMPOSITIONS, METHODS, AND SYSTEMS FOR RAPID INDUCTION AND MAINTENANCE OF CONTINUOUS REM SLEEP
Compositions, kits, methods, and systems to induce, maintain, monitor, and interpret a continuous, un-fragmented REM sleep state in humans, generate dreams, recover sleep, create brain neuronal...
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US20090186930 |
NOVEL IMIDAZOLE DERIVATIVES, PREPARATION AND USER THEREOF AS MEDICINE
The invention concerns novel imidazole derivatives of general formula (I), wherein Z′ and Z represent different variable groups. Said products have an antitumoral activity. The invention also...
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US20090186014 |
METHOD FOR TREATMENT OF PANCREATITIS
A method for treating acute or chronic pancreatitis in a subject comprises administering to the subject a therapeutically effective amount of an ACE2 inhibitor.
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US20090176837 |
COMPOUNDS WITH ACTIVITY AT RETINOIC ACID RECEPTORS
Disclosed herein are novel compounds with activity at RARβ 2 receptors. Further disclosed are the use of such compounds for treatment of or to alleviate symptoms of cancer, neurological disorders...
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US20090156619 |
Heterocycle Substituted Amide and Sulfur Amide Derivatives as Histone Deacetylase (HDAC) Inhibitors
The present invention related to compounds of formula (I): or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof. Compounds of the present invention are inhibitors of histone...
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US20090156562 |
NOVEL COLORED SOLUTIONS OF INJECTABLE DRUGS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS
The invention is directed to pharmaceutical compositions comprising colored solutions, colored emulsions, or colored powders of injectable pharmaceuticals wherein said pharmaceuticals are selected...
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US20090137654 |
METHODS OF MODULATING BINDING OF SON OF SEVENLESS TO PHOSPHATIDIC ACID AND IDENTIFYING COMPOUNDS THAT MODULATE SUCH BINDING
The present invention relates to methods of modulating binding of Son of sevenless to phosphatidic acid and identifying compounds that modulate such binding. In particular, the present invention...
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US20090137591 |
COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of...
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US20090136598 |
Compositions for the Treatment and Prevention of Eyelid Swelling
The invention features topical formulations comprising an osmotically active agent and/or a vasoconstrictor and/or an astringent agent for the treatment and prevention of eyelid swelling, and...
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US20090130027 |
COMPOSITIONS AND METHODS FOR TREATING PURPURA
Embodiments of the present invention are directed to compositions and methods for the treatment of purpura. Preferred compositions comprise an α adrenergic receptor agonist selected from selective...
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US20090118269 |
Methods for Treating Spinal Muscular Atrophy Using Tetracycline Compounds
Methods for using tetracycline compounds for the treatment of spinal muscular atrophy are described.
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US20090111863 |
Compounds, Compositions and Methods for the Treatment of Beta-Amyloid Diseases and Synucleinopathies
Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of β-amyloid diseases, such as observed...
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US20090105324 |
IMIDAZOLE DERIVATIVES FOR USE AS EDG-1 ANTAGONISTS
The invention relates to chemical compounds of formula (I): or pharmaceutically acceptable salts thereof, which possess Edg-1 antagonistic activity and are accordingly useful for their anti cancer...
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US20090093487 |
Compositions for topical application having androgenic actions
A composition comprising at least one physiologically tolerated film-forming agent, at least one physiologically tolerated solvent, at least one plasticizer and a compound of the formula I
or a...
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US20090087425 |
Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease
There is provided a pharmaceutical composition for treating respiratory disease comprising an NO-donating steroid and at least one bronchodilator. Also provided is a method for treating respiratory...
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US20090082411 |
Pharmaceutical for prevention or treatment of bone metabolic disease
A method for treating a bone metabolic disease by administering to a human a pharmacologically effective amount of an angiotensin II receptor antagonist which is a compound of the following formula...
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US20090076111 |
Methods for improving glycemic control in humans
The present invention is directed to methods for improving glycemic control in humans and animals comprising the step of administering a composition comprising an amino acid content including...
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US20090068180 |
COMPOSITIONS AND METHODS FOR TREATING IMMUNOLOGICAL AND INFLAMMATORY DISEASES AND DISORDERS
Methods and compositions for treating immunological and inflammatory diseases and disorders are disclosed. Particular methods and compositions comprise the administration of an agent that inhibits...
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US20090060852 |
Compounds, Formulations and Methods for Reducing Skin Wrinkles, Creasing and Sagging
Methods, compounds, and topical formulations for reduction of skin sagging, creasing and/or wrinkling are disclosed. The methods comprise topically applying a composition comprising an α2...
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US20090053290 |
TRANSDERMAL DRUG DELIVERY COMPOSITIONS AND TOPICAL COMPOSITIONS FOR APPLICATION ON THE SKIN
Transdermal delivery compositions and topical compositions for application to the skin are provided. The transdermal delivery composition includes at least two penetrants working synergistically...
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US20090041667 |
Treatment of Depressive Disorders
The invention provides for the use of carbonic anhydrase activators; protein kinase C activators and FGF-18 to treat depressive disorders. The invention also relates to improved animal models and...
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US20090035302 |
Rage Antagonists As Agents To Reverse Amyloidosis And Diseases Associated Therewith
Disclosed are RAGE antagonist compounds that have the ability to reverse pre-existing amyloidosis. Treatment with the RAGE antagonist compounds described herein may be used to reduce plaque size...
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US20090030046 |
NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME
Compounds are provided which are activators of the enzyme glucokinase and thus are useful in treating diabetes and related diseases, which compounds have the structure
where Q is
and R 1 , R 2...
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US20090023794 |
Use of Sumoylation Inhibitors for the Treatment of Neurodegenerative Disease
The invention generally provides screening methods for the identification of therapeutic compounds useful for the treatment of a neurodegenerative disease, and related prophylactic and therapeutic...
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US20090023228 |
Dual-acting Imidazole antihypertensive agents
The invention is directed to compounds having the formula:
wherein: Ar, r, R 2-3 , X, and R 5.7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These...
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US20090018179 |
NOVEL CRYSTALS AND PROCESS OF MAKING 5-(-METHYL)-2-METHOXY-BENZOIC ACID
The present invention relates to a novel crystals of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-
[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-metho
xy-benzoic acid and...
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US20090012142 |
Compositions and Methods for Increasing Lean Muscle Mass and/or Reducing Fat Gain
Compositions and methods for increasing lean muscle mass and/or reducing fat gain in growing animals by feeding the animals a composition having a total lysine to metabolizable energy ratio of from...
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US20090012141 |
Composition and Method for Making Oligo-Benzamide Compounds
The present invention includes compound compositions and methods of making compounds that include an oligo-benzamide compound having at least two optionally substituted benzamides.
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US20090005410 |
N-(2-(HETARYL)ARYL) ARYLSULFONAMIDES AND N-(2-(HETARYL) HETARYL ARYLSULFONAMIDES
Compounds are provided that act as potent antagonists of the CCR9 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR9. The...
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US20090005361 |
Combination of Organic Compounds
The present invention relates to a combination, such as a combined preparation or pharmaceutical composition, respectively, comprising a therapeutic agent acting on the renin-angiotensin system...
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US20080319040 |
N-Acylic Aminoacid Derivatives, Method For The Production Thereof, Pharmacological Composition And The Use In The Form Anti-Allergic, Anti-Inflammatory And Hypolipidemic Agents
The present invention relates to N-acyl derivatives of amino acids and pharmaceutically acceptable salts thereof
wherein n is 2 or 3; and R 1 represents
or...
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US20080306115 |
Midazole-4-Carboxamide Derivatives For Use As Cb1 Modulators
The present invention relates to substituted 1,2-diphenylimidazol-4-carboxamide compounds of formula I
to processes for preparing such compounds, their use in the treatment of obesity,...
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US20080305110 |
Novel Ligand of G Protein Coupled Receptor Protein and Use Thereof
The present invention provides a method of screening an agonist or antagonist to a G protein-coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino...
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US20080293735 |
Therapeutic treatment for metabolic syndrome, type 2 diabetes, obesity, or prediabetes
The present invention is directed to a method for treating a patient suffering from the metabolic syndrome, Type 2 diabetes, obesity, or prediabetes, comprising the step of increasing the ratio of...
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