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US20160296585 |
INFANT NUTRITION FOR IMPROVEMENT IN INSULIN SENSITIVITY LATER IN LIFE
The present invention relates to a nutritional composition for use in treatment, prevention and/or reducing the risk of a metabolic syndrome disorder appearing later in life, wherein the... |
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US20160279201 |
METHODS OF TREATING METABOLIC DISORDERS
Methods of treating metabolic and/or lipid disorders are provided comprising administering to a patient in need thereof a therapeutically effective amount of Nrg4, an Nrg4 variant, or a... |
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US20160272683 |
Novel Amylin And Calcitonin Receptor Agonist
The present invention relates to peptides comprising an amino acid sequence SEQ ID NO: 1 (EASELSTAALGRLSAELHELATLPRTETGPESP), analogues and derivatives thereof and pharmaceutical compositions... |
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US20160263181 |
Therapeutic Process For The Treatment Of The Metabolic Syndrome And Associated Metabolic Disorders
The present invention is directed to a method of treating a patient suffering from the metabolic syndrome and/or related disorders including obesity, Type 2 diabetes, pre-diabetes, hypertension,... |
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US20160257728 |
BIOACTIVE RECOMBINANT BMP-9 PROTEIN, MB109, EXPRESSED AND ISOLATED FROM BACTERIA
The disclosure provides for the expression and purification of bioactive recombinant bone morphogenetic protein (BMP)-9 from bacteria (MB109) and the use of the MB109 to treat various diseases and... |
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US20160252497 |
CANCER MODELS AND ASSOCIATED METHODS
Models useful in determining whether fibroblast growth factor 19 variant polypeptides having glucose-lowering activity and/or anti-obesity activity also exhibit favorable oncology-related... |
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US20160250281 |
Peptide for Suppressing and Treating Obesity
The present invention relates to a composition for preventing, alleviating or treating obesity comprising a partial fragment of HIV-1 (Human Immunodeficiency Virus-1) Tat (Trans activator of... |
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US20160244497 |
FGF21 MUTANTS AND USES THEREOF
The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for... |
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US20160228503 |
Compositions and Formulations for Prevention and Treatment of Diabetes and Obesity, and Methods of Production and Use Thereof in Glucose and Caloric Control
Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides,... |
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US20160220635 |
GLYCOPROTEINS HAVING LIPID MOBILIZING PROPERTIES AND THERAPEUTIC USES THEREOF
The invention provides compositions and methods for ameliorating symptoms associated with hyperglycemia by administering a Zn-α2-glycoprotein or a functional fragment thereof, methods of... |
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US20160213743 |
SYNTHETIC APELIN FATTY ACID CONJUGATES WITH IMPROVED HALF-LIFE
The invention provides a conjugate, or a pharmaceutically acceptable salt thereof, comprising a synthetic polypeptide of Formula I: Q-R-P-R-L-C*-H-K-G-P-(Nle)-C*-F (I) or a amide or ester thereof;... |
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US20160206695 |
CHIMERIC FIBROBLAST GROWTH FACTOR (FGF) 2/FGF1 PEPTIDES AND METHODS OF USE
The present disclosure provides chimeric proteins having an N-terminus coupled to a C-terminus, wherein the N-terminus comprises an N-terminal portion of fibroblast growth factor (FGF) 2 and the... |
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US20160200788 |
COMPOSITIONS, USES AND METHODS FOR TREATMENT OF METABOLIC DISORDERS AND DISEASES
The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of fibroblast growth factor 19 (FGF19)... |
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US20160200787 |
COMPOSITIONS AND METHODS OF USE FOR TREATING METABOLIC DISORDERS
Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided. |
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US20160199435 |
METHODS FOR PREVENTING OR TREATING METABOLIC SYNDROME
The invention provides methods of preventing or treating metabolic syndrome in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic... |
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US20160193287 |
USES OF BT LIPOPEPTIDES AS THERAPEUTICS FOR OBESITY AND RELATED DISEASES
The invention provides compositions and uses for treating or preventing obesity and related diseases in patients. |
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US20160185818 |
BIDENTATE-BINDING MODULATORS OF LRRK2 AND JNK KINASES
Both JNK and LRRK2 are associated with Parkinson's disease (PD), myocardial infarction (MI), and other medical disorders. Here we report a reasonably selective and potent kinase inhibitors (e.g.,... |
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US20160176925 |
MELANOCORTIN RECEPTOR LIGANDS MODIFIED WITH HYDANTOIN
The present invention relates to peptide ligands of the melanocortin receptors, in particular the melancortin-4 receptor, and as such, are useful in the treatment of disorders responsive to the... |
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US20160176922 |
INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES
Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using... |
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US20160175411 |
INFANT NUTRITION WITH PROTEASE INHIBITOR
Provided is an infant nutrition comprising at least one protease inhibitor, a process for preparing such an infant nutrition and use of the infant nutrition for the treatment and/or prevention of... |
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US20160168223 |
FGF MUTANTS AND USES THEREOF
The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for... |
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US20160166634 |
BIOCONJUGATES OF SYNTHETIC APELIN POLYPEPTIDES
The invention provides a bioconjugates comprising a synthetic polypeptide of Formula I′ (SEQ ID NO: 1): or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10,... |
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US20160160219 |
COMPOSITION CONTAINING PPAR-gamma NEDDYLATION INHIBITOR FOR INHIBITING ADIPOCYTE DIFFERENTIATION AND USE THEREOF
Provided is a method for suppressing an adipose differentiation comprising administering to a subject in need thereof a PPAR-v neddylation inhibitor for inhibiting adipocyte differentiation and a... |
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US20160159871 |
CYCLIC APELIN DERIVATIVES FOR THE TREATMENT OF HEART FAILURE
The invention provides a synthetic polypeptide of Formula I′: X1-R-X3-R-L-X6-X7-K-X9-P-X11-X12-X13 or an amide, an ester, a salt thereof, or a bioconjugate thereof, wherein X1, X3, X6, X7, X9,... |
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US20160159861 |
APJ Receptor Compounds
The invention relates generally to compounds which are allosteric modulators (e.g., negative and positive allosteric modulators, allosteric agonists, and ago-allosteric modulators) of the G... |
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US20160145309 |
DISULFIDE CYCLIC POLYPEPTIDES FOR THE TREATMENT OF HEART FAILURE
The invention provides a synthetic polypeptide of Formula I′: X1-R-P-R-X5-X6-X7-K-X9-P-X11-X12-X13 or an amide, an ester, a salt or a bioconjugate thereof, wherein X1, X5, X6, X7, X9 and X11 to... |
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US20160144006 |
Maspin, Maspin Derivatives, and Maspin Mimetics for Reducing ROS, Inflammation, and Skin Aging
The present invention provides compositions, methods, and systems for treating inflammatory conditions (e.g., by inhibiting reactive oxygen species) in or on a subject with maspin, maspin... |
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US20160129083 |
MIC-1 FUSION PROTEINS AND USES THEREOF
The invention relates to MIC-1 fusion proteins. More specifically it relates to compounds comprising fusion proteins comprising a MIC-1 protein or an analogue thereof at the C-terminus of the... |
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US20160129082 |
COMPOSITIONS AND METHODS OF USE FOR TREATING METABOLIC DISORDERS
Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided. |
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US20160115213 |
Modified FGF-21 Polypeptides and Uses Thereof
Modified FGF-21 polypeptides and uses thereof are provided, for example, for the treatment of diseases associated with fibrosis. Modified FGF-21 polypeptides are disclosed that contain an internal... |
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US20160114002 |
COMPOSITIONS COMPRISING PLANT PROTEINS AND METHODS FOR PREVENTION OF METABOLIC AND CARDIOVASCULAR PATHOLOGIES IN PATIENT WITH CARDIOMETABOLIC RISK, INCLUDING HYPERGLYCEMIA
A composition for oral administration in humans comprising at least one plant protein chosen from pea proteins, rice proteins or a mixture thereof, and: at least one protein of animal origin... |
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US20160108091 |
CYCLIC POLYPEPTIDES FOR THE TREATMENT OF HEART FAILURE
The invention provides a cyclic polypeptide of Formula I (SEQ ID NO: 1): X1-R-X3-X4-L-S-X7-X8-X9-X10-X11-X12-X13 I or an amide, an ester or a salt thereof, or a bioconjugate thereof, wherein X1,... |
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US20160108087 |
THERAPEUTICS FOR THE INDUCTION OF ENDOGENOUS STEROIDOGENESIS AND METHODS ASSOCIATED WITH THEIR IDENTIFICATION
The present disclosure provides agents capable of promoting endogenous steroid production (such as endogenous testosterone production) without altering the endogenous luteinizing hormone. The... |
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US20160082118 |
GLP-1 RECEPTOR AGONIST PEPTIDE GASTRIN CONJUGATES
The present invention relates, inter alia, to certain peptide conjugates, and to the use of the conjugates in the treatment of a variety of diseases or disorders, including diabetes (type 1 and/or... |
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US20160077113 |
Methods of Identifying Candidate Compounds of the Human G Protein-Coupled Receptor, GPR50, as Modulators of Body Mass or Adiposity
The present invention relates to methods of using a G protein-coupled receptor (GPCR) to screen one or more candidate compounds as a modulator of body mass or of adiposity or of percentage body... |
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US20160075739 |
PEPTIDE FOR INDUCING MAST CELL-SPECIFIC APOPTOSIS AND USE THEREOF
A peptide according to the present invention can perform a function identical or similar to the function of natural CTLA-4 and has an excellent degree of skin penetration due to a small size. The... |
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US20160074477 |
METHODS AND COMPOSITIONS FOR REJUVENATING SKELETAL MUSCLE STEM CELLS
Methods and compositions for rejuvenating skeletal muscle stem cells are disclosed. |
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US20160058874 |
CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY
Provided are methods relating to the use of CDP-therapeutic agent conjugates for the treatment of a disease or disorder, e.g., autoimmune disease, inflammatory disease, central nervous system... |
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US20160051620 |
Methods for regulating transcription of multiple genes and expression of multiple targets
This invention discloses methods for regulating multiple organs, multiple genes and multiple targets by using a polypeptide, wherein the polypeptide comprising the amino acid sequence of SEQ ID... |
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US20160046704 |
GLYCOPROTEINS HAVING LIPID MOBILISING PROPERTIES AND THERAPEUTIC APPLICATIONS THEREOF
A biologically active lipid mobilising agent for use in therapy is disclosed which has the properties and characteristics of a Zn-α2-glycoprotein, or of a fragment thereof having an apparent... |
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US20160046684 |
Methods and compositions for treatment of PTP1B-related diseases
Cancer, obesity, and diabetes are examples of PTP1B-related diseases. The invention herein provides embodiments of therapeutic methods and compositions for treating PTP1B related diseases by... |
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US20160046681 |
ARTIFICIAL TRANSCRIPTION FACTORS REGULATING NUCLEAR RECEPTORS AND THEIR THERAPEUTIC USE
The invention relates to an artificial transcription factor comprising a polydactyl zinc finger protein targeting specifically a promoter region of a nuclear receptor genefused to an inhibitory or... |
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US20160039897 |
COMPOUNDS AND METHODS FOR TREATING OBESITY AND CONTROLLING WEIGHT
The present invention provides peptides and peptide compositions and methods of their controlling body weight and treating obesity. |
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US20160039879 |
NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF
The present invention relates to a compound of the Formula (I)): or pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition... |
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US20160038565 |
Methods of Mitigating Side Effects of Radiation Exposure and Chemotherapy
Compositions and methods for treating toxicity associated with exposure to radiation and side effects of treatments for hyperproliferative disorders are provided. Typically the compositions are... |
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US20160038487 |
NOVEL GLP-1 RECEPTOR MODULATORS
Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds... |
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US20160031960 |
COMPOSITIONS AND METHODS OF USE FOR TREATING METABOLIC DISORDERS
Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided. |
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US20160031955 |
Methods for Treating Mitochondrial Disorders and Neurodegenerative Disorders
The present invention relates to a recombinant inner mitochondrial membrane polypeptide, and its use in methods for treating mitochondrial disorders. |
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US20160030585 |
NOVEL FATTY ACIDS AND THEIR USE IN CONJUGATION TO BIOMOLECULES
The invention provides a conjugate comprising a biomolecule linked to a fatty acid via a linker wherein the fatty acid has the following Formulae A1, A2 or A3: wherein R1, R2, R3, R4, Ak, n, m and... |
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US20160024149 |
BIOACTIVE MOLECULES PRODUCED BY PROBIOTIC BACTERIA AND METHODS FOR ISOLATING AND USING THE SAME
The present invention is a method for isolating bioactive molecules secreted by probiotic bacteria such as Lactobacillus rhamnosus, and methods for using such bioactive molecules to activate NOD2,... |