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US20100196524 NOVEL PEPTIDES AND METHODS FOR PRODUCING THEM  
The present invention relates to the fields of life sciences and food, feed or pharmaceutical industry. Specifically, the invention relates to novel peptides, pilus structures, polynucleotides as...
US20080274952 Amylin Family Peptides And Methods For Making And Using Them  
The present invention relates to obesity related polypeptides (ORPs), related nucleic acids, expression constructs, host cells, and processes production of the obesity related polypeptides. The...
US20080233198 Method for delivering a peptide to a subject at a modulated rate via microcapsules of lactic-co-glycolic copolymer containing said peptide  
Micro-capsules for the slow release of drugs, consisting of a lactic-co-glycolic copolymer to which a plasticiser has been incorporated and which contain a drug of pharmaceutical interested within...
US20150087585 DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS  
Derivatives of purine, 3H-imidazo[4,5-b]pyrimidine and 1H-imidazo[4,5-d]pyrazine of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the...
US20130310311 NOVEL SELECTIVE INHIBITORS OF PROLYLCARBOXYPEPTIDASE  
The present invention relates to compounds of the formulae: in which C5-C16 alkyl, R1 is and isosteres and salts thereof.
US20110224135 USE OF CONKUNITZIN-S1 FOR THE MODULATION OF GLUCOSE-INDUCED INSULIN SECRETION  
The present invention relates to a (poly)peptide or a peptidomimetic thereof having the biological activity of Conkunitzin-S1, wherein said (poly)peptide is selected from (a) a polypeptide...
US20100331245 PEPTIDE YY ANALOGS  
The invention provides analogs of PYY. The invention also provides compositions and methods useful for controlling biological activities such as cell proliferation, nutrient transport, lipolysis,...
US20080113896 Blood Pressure Lowering Peptides in a Single Enzymatic Step  
A process to produce IPP and VPP from a protein source that comprises the -I-P-P- and -V-P-P- sequence in its protein sequence and whereby at least 40% of -I-P-P- sequence present in the protein...
US20060154871 Peptides  
The amino acid sequence of several peptides present in Colostrinin is disclosed. These peptides are useful, inter alia, in the treatment of disorders of the immune system and the central nervous...
US20060105938 Method of treating or preventing obeisity and lipid metabolism disorders and compositions for use therein  
The present invention provides a method of preventing or treating human obesity, said method comprising ingesting a composition containing, calculated on dry matter: 10-100 wt. % protein...
US20050222037 Compounds and methods for modulating VE-cadherin-mediated function  
Compositions and methods for modulating VE-cadherin-mediated functions are provided. The compositions and methods employ VE-cadherin modulating agents which generally comprise one or more of: (a)...
US20130303441 GLYCOGEN SYNTHASE KINASE-3 INHIBITORS  
Novel peptide inhibitors of GSK-3, compositions containing same and uses thereof are disclosed. The novel peptide inhibitors are substrate-competitive inhibitors and have an amino acid sequence...
US20120141416 MULTIMERIC PEPTIDE CONJUGATES AND USES THEREOF  
The present invention relates to multimeric (e.g., dimeric, trimeric) forms of peptide vectors that are capable of crossing the blood-brain barrier (BBB) or efficiently entering particular cell...
US20100222268 ANTIBIOTIC PEPTIDES  
This invention concerns novel antibiotic peptide and peptide derivates, especially for use in medicine. Further, the invention relates to compositions and methods for killing microbes, like...
US20140148382 PEPTIDE COMPOSITIONS AND METHODS FOR TREATING PATIENTS  
The present invention is directed to peptide compositions and methods of using the peptide compositions to treat prediabetes, diabetes, obesity, high blood pressure and metabolic syndrome.
US20140011732 Peptides Derivatized with A-B-C-D- and their Therapeutical Use  
The invention relates to protracted peptide derivatives such as Glucagon-Like Peptide-1 (GLP-1), exendin-4, and analogues thereof, as well as therapeutic uses thereof. The peptide derivative of...
US20120208748 PEPTIDE COMPOSITIONS AND METHODS FOR TREATING PATIENTS  
The present invention is directed to peptide compositions and methods of using the peptide compositions to treat prediabetes, diabetes, obesity, high blood pressure and metabolic syndrome.
US20120172293 PEPTIDE AND USE THEREOF  
The present invention aims to provide a peptide having a superior Y2 receptor agonist action and useful as an agent for the prophylaxis or treatment of obesity and the like. A peptide represented...
US20100261637 PEPTIDES DERIVATIZED WITH A-B-C-D- AND THEIR THERAPEUTICAL USE  
The invention relates to protracted peptide derivatives such as Glucagon-Like Peptide-1 (GLP-1), exendin-4, and analogues thereof, as well as therapeutic uses thereof. The peptide derivative of...
US20100256055 CONJUGATES OF NEUROTENSIN OR NEUROTENSIN ANALOGS AND USES THEREOF  
The present invention features a compound having the formula A-X—B, where A is peptide vector capable of enhancing transport of the compound across the blood-brain barrier or into particular cell...
US20100210536 USE OF LEPTIN (22-56 ) AS A THERAPEUTIC AGENT  
The present invention is directed to the use of the peptide compound Val-Pro-Ile-Gln-Lys-Val-Gln-Asp-Asp-Thr-Lys-Thr-Leu-Ile-Lys- Thr-Ile-Val-Thr-Arg-Ile-Asn-Asp-Ile-Ser-His-Thr-Gln-Ser-Val- Ser-Se...
US20100204117 CGRP AS A THERAPEUTIC AGENT  
The present invention is directed to the use of the peptide compound Ala-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu- Leu-Ser-Arg-Ser-Gly-Gly-Met-Val-Lys-Ser-Asn-Phe-Val-Pro-Thr- Asn-Va...
US20100144594 2-HETEROARYL-PYRROLO[3,4-C]PYRROLE DERIVATIVES AND THEIR USE AS SCD INHIBITORS  
The invention relates to heterocyclic derivatives of formula I wherein R, R1, A, B, D, M, L and n are as defined herein, or their physiologically compatible salts, their pharmaceutical...
US20100120669 THIADIAZOLE DERIVATIVES, INHIBITORS OF STEAROYL-COA DESATURASE  
The present invention relates to substituted thiadiazole compounds of the formula (I): and pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing them and their use...
US20100113363 Use of GLP-1 Peptides  
GLP-1(1-45) or a fragment or an analogue thereof can be used in the preparation of a medicament for peripheral administration in the suppression of appetite or induction of satiety.
US20060111286 Method of modulating endothelial cell activity  
The present invention relates generally to a method of modulating endothelial cell activity and to agents useful for same. More particularly, the present invention relates to a method of...
US20170166614 ESCULENTIN-2CHA PEPTIDE AND ANALOGUES THEREOF  
The present invention relates to an esculentin-2CHa peptide and analogues thereof, and the use each thereof in the treatment of diabetes, for example type 2 diabetes; insulin resistance; obesity,...
US20170137470 Kv1.3 Potassium Channel Antagonists  
The present invention relates to compounds which are capable of selectively binding to and inhibiting the activity of the potassium channel Kv1.3. The invention also relates to pharmaceutical...
US20170096462 CHIMERIC FGF21 PROTEINS WITH ENHANCED BINDING AFFINITY FOR BETA-KLOTHO FOR THE TREATMENT OF TYPE II DIABETES, OBESITY, AND RELATED METABOLIC DISORDERS  
The present invention relates to chimeric proteins that include an N-terminus coupled to a C-terminus, where the N-terminus includes an N-terminal portion of fibroblast growth factor 21 (“FGF21”)...
US20170096454 CYCLOHEPTAPEPTIDE AGENTS FOR TREATMENT OF CANCER AND OBESITY DISEASES  
New anticancer and anti-obesity agents based on cyclic peptide compounds are isolated from the stem barks of Maytenus variabilis (Loes.) C. Y. Cheng (Celastraceae). The invention also includes its...
US20170096449 Compositions and Methods Relating to Ionic Salts of Peptides  
The present invention relates to compounds of Formula I, compositions containing same, and methods of use.
US20170095530 Treatment of Obesity and Obesity-Related Disorders by Pharmalogical Targeting of Kv 1.3 Potassium Channels  
Activation of brown adipose tissue, treatment of obesity and/or treatment of obesity-related disorders in human or non-human animal subjects by administering to the subject a potassium channel...
US20170088602 FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND TO MYOSTATIN  
The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat...
US20170088594 GLYCOPROTEINS HAVING LIPID MOBILIZING PROPERTIES AND THERAPEUTIC USES THEREOF  
The invention provides formulations and methods for ameliorating symptoms associated with metabolic disorders, such as cachexia, hypoglycemia, obesity, diabetes, and the like by administering...
US20170079309 METHOD OF USE OF ACTIVATED FUNCTIONAL PROTEINS TO IMPROVE ANIMAL HEALTH  
It was found that feeding a composition including activated growth factor(s) increases feed to gain ratio, increases overall weight gain, reduces necessary antibiotic or electrolyte therapy and...
US20170056470 Peptides Of Syndecan-1 For Inhibiting Angiogenesis  
The present invention provides a peptide derived from the extracellular domain of syndecan-1 that inhibits angiogenesis.
US20170049853 MITOCHONDRIAL-DERIVED PEPTIDE MOTS3 REGULATES METABOLISM AND CELL SURVIVAL  
MOTS3 is a novel polypeptide. Methods of treating diseases such as diabetes, obesity, fatty liver, and cancer using MOTS3 and pharmaceutical compositions thereof are disclosed herein.
US20170049849 METHODS OF INHIBITING THE GHRELIN/GROWTH HORMONE SECRETATOGUE RECEPTOR PATHWAY AND USES THEREOF  
The invention provides methods for treatment, prevention or management of obesity, obesity related disorders, diabetes mellitus, and metabolic syndrome in a subject by administering a ghrelin...
US20170042969 PEPTIDES DERIVED FROM RS1 WHICH DOWN-REGULATE GLUCOSE ABSORPTION AFTER A GLUCOSE RICH MEAL AND INCREASE INSULIN SENSITIVITY  
The present invention relates to a pharmaceutical composition comprising a (poly)peptide which comprises or consists of QEP or a QEP derivative thereof a nucleic acid molecule encoding said...
US20170028014 METAP2 INHIBITORS AND METHODS OF TREATING OBESITY  
The present invention relates to modified or polymer conjugated MetAP2 inhibitors. The present invention also relates to methods of preventing, inducing, causing or increasing weight loss,...
US20170020163 METHODS AND COMPOSITIONS USING FRESH OR FROZEN MEAT TO IMPROVE FOOD EFFICIENCY IN ANIMALS SUCH AS DOGS  
Methods and compositions improve amino and fatty acids availability, for example by achieving better blood enrichment in limiting amino acids, such as arginine and lysine, and essential fatty...
US20170014476 SorCS1 for the Treatment of Obesity  
The present invention relates to SorCS1-like agents, including SorCS1, nucleic acid molecule encoding expression of SorCS1 and fragments thereof, as well as vectors containing said nucleic acid...
US20170008928 NOVEL PEPTIDES AND PEPTIDE DERIVATIVES AND USES THEREOF  
The invention relates to cholecystokinin (CCK) derivatives of the general formula I: P-L-X1-X2-X3-Gly-Trp-X6-DMeAsp-X8-NH2, wherein P is Chem. 1: HOOC—(CH2)x—CO—*, wherein x is an integer in the...
US20170007664 CYCLIC DEPSIPEPTIDE COMPOUNDS AND THEIR USES  
The present invention relates to novel cycloundecadepsipeptide compounds and their analogues which bind and inhibit cyclophilins, have reduced immunosuppressive activity and improved...
US20160354440 METHODS FOR TREATING METABOLIC DISORDERS USING FGF  
The method provides methods and compositions for treating metabolic disorders such as impaired glucose tolerance, elevated blood glucose, insulin resistance, dyslipidemia, obesity, and fatty liver.
US20160354429 Use of Melanocortins to Treat Insulin Sensitivity  
The present invention relates to peptide ligands of the melanocortin receptors, in particular the melancortin-4 receptor, and as such, are useful in the treatment of disorders responsive to the...
US20160346351 TARGETED OESOPHAGEAL ADMINISTRATION OF ZN-ALPHA2-GLYCOPROTEINS (ZAG), METHODS AND FORMULATIONS THEREOF  
The invention provides formulations and methods for ameliorating symptoms associated with metabolic disorders, such as hypoglycemia, obesity, diabetes, and the like by targeted administration to...
US20160346244 METAP2 INHIBITORS AND METHODS OF TREATING OBESITY  
The present invention relates to modified or polymer conjugated MetAP2 inhibitors. The present invention also relates to methods of preventing, inducing, causing or increasing weight loss,...
US20160324818 DIET FOOD COMPOSITION INCLUDING DHA TO REDUCE SHORT-TERM AND LONG-TERM LOW-GRADE INFLAMMATION  
Ready-to-use diet food composition to reduce low-grade inflammation and stabilize weight loss in the long term in an obese or overweight patient comprising, as a proportion of the total weight of...
US20160296593 NOVEL FAT ACCUMULATION INHIBITORY PEPTIDE AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OBESITY CONTAINING THE SAME  
The present invention relates to a fat accumulation inhibitory peptide which essentially comprises an amino acid sequence represented by SEQ ID NO: 1, a pharmaceutical composition for preventing...