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US20060148002 Methods and compositions for the treatment and diagnosis of body weight disorders  
The invention relates to methods and compositions for the treatment and diagnosis of body weight disorders, including, but not limited to, obesity, overweight, anorexia, cachexia, insulin...
US20060069161 Methods and reagents for the treatment of metabolic disorders  
The invention features compositions, methods, and kits for the treatment of metabolic disorders such as diabetes and obesity.
US20070274992 Secreted Protein Family  
This invention relates to a new family of secreted proteins, termed the SECFAM3 family, its family members including the novel human proteins INSP123, INSP124, and INSP125, herein identified as...
US20100098762 Thermosensitive Pluronic Derivative Hydrogels With High Biodegradability And Biocompatibility For Tissue Regeneration And Preparation Method Thereof  
The present invention relates to a thermosensitive pluronic derivative hydrogel for tissue regeneration in which a biodegradable polymer is introduced at one end or both ends of a pluronic...
US20070275900 Prodrugs Cleavable by Cd26  
The present invention provides a new prodrug technology and new prodrugs in order to increase the solubility, to modulate plasma protein binding or to enhance the biovailability of a drug. In the...
US20120322725 GLUCAGON ANTAGONIST-GIP AGONIST CONJUGATES AND COMPOSITIONS FOR THE TREATMENT OF METABOLIC DISORDERS AND OBESITY  
Provided herein are peptide combinations comprising a GIP agonist peptide and a glucagon antagonist peptide. In some embodiments, the peptide combination is provided as a composition, e.g., a...
US20110171178 COMPOSITIONS AND METHODS OF USING PROISLET PEPTIDES AND ANALOGS THEREOF  
Embodiments relate to proislet peptides, preferably HIP, that exhibit increased stability and efficacy, and methods of using the same to treating a pathology associated with impaired pancreatic...
US20090291130 Physiologically Active Polypeptide- or Protein-Encapsulating Polymer Micelles, and Method for Production of the Same  
The invention provides a physiologically active polypeptide- or protein-encapsulating polymer micelle composition derived from a block copolymer comprising hydrophilic segments and hydrophobic...
US20070041970 NS4 NUCLEIC ACIDS AND POLYPEPTIDES AND METHODS OF USE FOR THE TREATMENT OF BODY WEIGHT DISORDERS  
The present invention is directed to novel polypeptides NS4 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
US20120270771 APOLIPOPROTEIN A-1 MIMIC PEPTIDES, AND THERAPEUTIC AGENT FOR TREATING HYPERLIPIDEMIA AND DISEASES RELATED TO HYPERLIPIDEMIA COMPRISING SAME  
The present invention relates to apolipoprotein A-1 mimic peptides, and therapeutic agent for treating hyperlipidemia and diseases related to hyperlipidemia comprising the same. More specifically,...
US20140107018 ANTICANCER AND ANTI-OBESITY CYCLIC PEPTIDE AGENTS  
A compound having formula (I) or formula (II): for use in anticancer or anti-obesity.
US20100129459 BIODEGRADABLE MICROSPHERE COMPOSITION SUITABLE FOR THE CONTROLLED RELEASE OF GLUCOSE CONTROLLING PEPTIDE AND FORMULATION THEREOF  
Disclosed are biodegradable microspheres, capable of releasing a glucose-regulating peptide in a controlled manner, comprising a biodegradable polymer carrier with the glucose-regulating peptide...
US20140249076 AMYLIN-CALCITONIN CHIMERIC PEPTIDES CONJUGATED TO DURATION ENHANCING MOIETIES  
Provided herein are amylin-calcitonin peptide conjugates having enhanced duration of biological activity, and methods of use thereof. The amylin-calcitonin peptide conjugates include duration...
US20080124335 Novel Polypeptide and the Use Thereof  
The present invention provides a variety of useful polypeptides. In particular, a polypeptide comprising the same or substantially the same amino acid sequence as the amino acid sequence...
US20100210552 HUMAN GLUCAGON-LIKE PEPTIDE-1 MIMICS AND THEIR USE IN THE TREATMENT OF DIABETES AND RELATED CONDITIONS  
The present invention provides novel human glucagon-like peptide-1 (GLP-1) peptide mimics that mimic the biological activity of the native GLP-1 peptide and thus are useful for the treatment or...
US20050065087 Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin D derivatives and a bone morphogenetic protein  
The present invention relates to pharmaceutical compositions and methods of treatment comprising administering to a patient in need thereof a combination of a 2-alkylidene-19-nor-vitamin D...
US20100234285 Benzofuranyl Derivatives  
The present invention provides compounds of Formula (I) that act as glucokinase activators; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated...
US20100203119 PHARMACEUTICAL TREATMENT PROCESS USING CHITOSAN OR DERIVATIVE THEREOF  
The present invention provides a solid composition for oral administration comprising: (i) a drug compound;(ii) chitosan or a derivative thereof or a salt of chitosan or salt of a derivative of...
US20100143341 THIENOPYRIMIDINES FOR PHARMACEUTICAL COMPOSITIONS  
The present invention relates to novel pharmaceutical compositions of general formula (I) comprising thienopyrimidine compounds. Moreover, the present invention relates to the use of the...
US20140221271 SHK-BASED PHARMACEUTICAL COMPOSITIONS AND METHODS OF MANUFACTURING AND USING THE SAME  
Disclosed herein are pharmaceutical compositions having the sequence Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe- Gln-Cys-Lys-His-Ser-Xaa-Lys-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys- Thr-Cy...
US20130237476 ADIPOSE TISSUE TARGETED PEPTIDES  
The application provides synthetic peptide conjugates capable of targeting and causing ablation of adipose tissue in mammal comprising at least one targeting peptide and at least one therapeutic...
US20130336893 Exedin-4 Peptide Analogues  
The present invention relates to exendin-4 peptide analogues and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as...
US20080311214 Polymerized solid lipid nanoparticles for oral or mucosal delivery of therapeutic proteins and peptides  
The present invention encompasses lipid nano/micro particles, which have been modified, preferably on their surface, to contain a molecule or ligand, which targets the nano/micro particles to a...
US20050261185 Therapeutic proteins  
The present invention relates to a method for the treatment of a medical condition associated with obesity and/or insulin resistance, comprising administering to a subject in need thereof an...
US20140073561 METHODS OF TREATING MEDICAL CONDITIONS USING PEPTIDES  
The present invention provides peptides and pharmaceutical compositions thereof for appetite suppression and weight control. Preferred peptides are calcitonin analogs, preferably with specific...
US20060035835 Novel protein, production and use thereof  
The present invention relates to a novel SSD (sterol-sensing domain)-containing protein derived from human liver, human testis and human brain, or a salt thereof, and a DNA encoding the same....
US20100047248 METHODS OF PROCESSING COMPOSITIONS CONTAINING MICROPARTICLES  
A method for processing multi-phasic dispersions is provided. The method comprises providing a multi-phasic dispersion including dispersed and continuous phases, providing one or more non-solvents...
US20090239797 PRODUCTION OF HIGH LEVELS OF TRANSGENIC FACTOR IX WITHOUT GENE RESCUE, AND ITS THERAPEUTIC USES  
A non-human trangenic mammalian animal, as described above, contains an exogenous double stranded DNA sequence stably integrated into the genome of the animal, which comprises cis-acting...
US20050186608 Method for the production of transgenic proteins useful in the treatment of obesity and diabetes  
Transgenic proteins therapeutically useful in the treatment of obesity and related conditions can be produced in and purified from the milk of transgenic animals. The peptides are made as...
US20100029558 Alpha1 proteinase inhibitor peptides methods and use  
The invention is directed to the use of peptides that can bind and block the interaction of α1 proteinase inhibitor (α1PI) and one or more molecules, for example antibodies to HIV-1 envelope...
US20140221278 DISEASE TREATMENT VIA ANTIMICROBIAL PEPTIDES OR THEIR INHIBITORS  
Provided are methods for the treatment of disease and promotion of healing that include providing a therapeutically effective amount of a mammalian antimicrobial peptide (AMP) or analog thereof,...
US20100143243 Frozen compositions and methods for piercing a substrate  
Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at...
US20100111855 Frozen compositions and methods for piercing a substrate  
Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at...
US20090005299 Method For Producing Carboxy-Terminal-Amidified Peptides  
The invention relates to the production of carboxy-terminal (C-terminal) amidified peptides with C-terminal amidified lysin, in particular with the biological activity of GLP-1, the chemical...
US20080161227 Blood Pressure Lowering Peptides From Glycomacropeptide  
A process to produce IPP from a protein source whereby the protein source comprises a protein having the -I-P-P- sequence and having in the protein amino acid sequence at least 6 times more...
US20140086981 PGC-1ALPHA-MODULATING PEPTIDES  
Peptides of general formula (I): R1—Wn—Xm-AA1-AA2-AA3-AA4-AA5-AA6-Yp—Zq—R2 their stereoisomers, mixtures thereof and/or their cosmetically or pharmaceutically acceptable salts, a preparation...
US20100235935 PLASMA ANTI-DIABETIC NUCB2 PEPTIDE (PLADIN) AND USES THEREOF  
The present invention provides pladin (plasma anti-diabetic nucb2 peptide) polypeptide and functional equivalent thereof that are useful for treating diabetes. The present invention provides a...
US20100234307 PREPARATION AND USE OF BIPHENYL AMINO ACID DERIVATIVES FOR THE TREATMENT OF OBESITY  
This invention relates to certain biphenyl amino acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
US20090011995 PRODUCTION OF A SOLUBLE NATIVE FORM OF RECOMBINANT PROTEIN BY THE SIGNAL SEQUENCE AND SECRETIONAL ENHANCER  
The present invention is drawn to a method for enhancing secretional efficiency of a heterologous protein using a secretional enhancer consisting of a modified signal sequence which comprises the...
US20140328782 PEPTIDE INHIBITING MATRIX METALLOPROTEANASES ACTIVITY AND USE THEREOF  
The present invention relates to a peptide inhibiting a matrix metalloproteanases activity and use thereof. The peptide inhibiting a matrix metalloproteanases activity exhibits an excellent...
US20140066367 SUBCUTANEOUS DELIVERY OF A LONG-ACTING NATRIURETIC PEPTIDE  
This document provides methods and material related to natriuretic polypeptides. For example, substantially pure polypeptides having a natriuretic peptide activity, nucleic acids encoding...
US20100173824 Azepinoindole Derivatives As Pharmaceutical Agents  
Compounds, compositions and methods for modulating the activity of receptors are provided. In particular, compounds and compositions are provided for modulating the activity of receptors and for...
US20100167989 ISOPROPOXYPHENYLMETHYL INHIBITORS OF SGLT2  
The present invention relates to new isopropoxyphenylmethyl inhibitors of SGLT2, pharmaceutical compositions thereof, and methods of use thereof.
US20090136472 Use of thiazole derivatives and analogues in disorders caused by free fatty acids  
There is provided a use of a compound of formula I, whereinX, T, Y, W, A1, A2, R1, R5 and R6 have meanings given in the description, for the manufacture of a medicament for the treatment of a...
US20090018066 PHARMACEUTICAL COMPOSITIONS FOR MODULATING THE ACTIVITY OF A NOVEL TRIGLYCERIDE HYDROLASE  
Use of an inhibitor or activator of the triglyceride hydrolyse activity of a protein comprising a polypeptide strand encoded by the DNA sequence according to SEQ No. 1 for the preparation of a...
US20080064630 Osteogenic Growth Peptide Fusion Proteins  
Fusion protein comprising a protein to be fused, e.g. a therapeutic protein fused to the C-terminal of osteogenic growth peptide (OGP). The fusion proteins have a prolonged circulation time.
US20070060526 Methods of facilitating neural cell survival using non-peptide and peptide BDNF neurotrophin mimetics  
Methods and compounds for treating neurological and other disorders are provided. Included is the administering to a subject in need thereof an effective amount of a compound having binding and/or...
US20120263665 PEPTIDE  
The present invention relates to novel peptides and to topical and food compositions comprising them. The novel peptides have applications in skin lightening and immunomodulation when applied...
US20110065633 ESTER-BASED PEPTIDE PRODRUGS  
Prodrug formulations of bioactive polypeptides are provided wherein the bioactive polypeptide has been modified by the linkage of a dipeptide to the bioactive polypeptide through an ester linkage....
US20110046046 PROPHYLACTIC OR THERAPEUTIC COMPOSITION FOR DIABETES OR OBESITY  
Disclosed is a safe and non-toxic prophylactic or therapeutic composition for diabetes or obesity. The prophylactic or therapeutic composition for diabetes or obesity comprises as an active...