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US20120135918 METHODS OF INHIBITING THE GHRELIN/GROWTH HORMONE SECRETATOGUE RECEPTOR PATHWAY AND USES THEREOF  
The invention provides methods for treatment, prevention or management of obesity, obesity related disorders, diabetes mellitus, and metabolic syndrome in a subject by administering a ghrelin...
US20140128318 NOVEL OXYNTOMODULIN DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR TREATING OBESITY COMPRISING THE SAME  
The present invention relates to a novel peptide showing more excellent activities on a glucagon like peptide-1 receptor and a glucagon receptor than native oxyntomodulin, and a composition for...
US20090149387 Use of GLP-1 Peptides  
GLP-1(1-45) or a fragment or an analogue thereof can be used in the preparation of a medicament for peripheral administration in the suppression of appetite or induction of satiety.
US20060035827 Compositions and methods for the treatment or prevention of gallbladder disease  
Compositions and methods for the treatment or prevention of gallbladder disease are provided. In particular, pharmaceutical compositions containing an amount of serine proteinase inhibitor such as...
US20120302497 METHODS OF TREATING MEDICAL CONDITIONS USING CALCITONIN ANALOGS  
The present invention provides peptides and pharmaceutical compositions thereof for appetite suppression and weight control. Preferred peptides are calcitonin analogs, preferably with specific...
US20060246110 Sustained release pharmaceutical composition  
A sustained release delivery apparatus including a silicone support material formed from a methyl-vinyl siloxane polymer including a fumed silica as a reinforcing filler; a pharmaceutically active...
US20140038886 HYDROPHOBIC MODIFIED PEPTIDES AND THEIR USE FOR LIVER SPECIFIC TARGETING  
The present invention relates to hydrophobic modified peptides for the specific delivery of compounds to the liver, preferably to hepatocytes, in vitro as well as in vivo. The present invention...
US20110288010 UTILIZATION OF PEPTIDES AS ACTIVE INGREDIENTS FOR SLIMMING  
A method of using proteins of the SIRT family or of polypeptide or peptide fragments of SIRT proteins as an active ingredient for slimming, alone or in combination with at least one other active...
US20110288009 LEPTIN AND LEPTIN ANALOG CONJUGATES AND USES THEREOF  
The present invention features a compound having the formula A-X-B, where A is peptide vector capable of enhancing transport of the compound across the blood-brain barrier or into particular cell...
US20090227519 COMPOUNDS FOR CONTROL OF APPETITE  
This invention relates generally to neuropeptide Y (“NPY”) Y4 receptor agonists including pancreatic polypeptide (PP), analogs thereof, and peptide fragments of PP, e.g. PP(32-36), and analogs...
US20070071806 Tansmucosal drug delivery system  
Disclosed are preparations and formulations of high thermodynamic activity lipophilic associations (LA), in which there is pairing between an ionizable pharmaceutical agent and a lipophilic...
US20050222040 Vertebrate peptide modulators of lipid metabolism  
The invention provides vertebrate lipid mobilizing peptides, derivative compounds and compositions as well as methods of using such peptides, derivative compounds and compositions for modulating...
US20080014270 METHODS FOR IMPROVED LIPID METABOLISM AND BASAL METABOLIC RATE WITH LACTOFERRIN  
A pharmaceutical composition is provided having at least one kind to be selected from the group consisting of a lactoferrin group protein having lactoferrin and conalbumin, and an enzymatically...
US20100167992 Phenyl Ester Side Chains to Increase Polymer Resorptivity  
The present invention relates to polymers modified to increase their resorbability. In particular, the polymers of the invention have phenyl ester side chains which are good leaving groups and...
US20110028390 Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors  
The invention provides compounds of Formula (1) or a pharmaceutically acceptable salt of said compound, wherein R1, R2, and R3 are as described herein; pharmaceutical compositions thereof; and the...
US20060286035 Methods and compositions for modulating the interaction between adiponectin and its receptor  
The invention is directed to methods for identifying agents that mimic or modulate the interaction between adiponectin and its receptor. In particular, the invention is directed to methods for...
US20050032693 Novel polypeptides, their nucleic acids, and methods for their use in angiogenesis and vascularization  
The present invention is directed to novel polypeptides critical for angiogenesis and vascularization, and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors...
US20140296131 Truncated GLP-1 Derivatives and Their Therapeutical Use  
The invention relates to truncated GLP-1 analogues, in particular a GLP-1 analogue which is a modified GLP-1(7-35) (SEQ ID No 1) having: i) a total of 2, 3, 4, 5 6, 7, 8, or 9 amino acid...
US20100227809 COMBINATION TREATMENT FOR METABOLIC DISORDERS  
Various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis...
US20100009914 METHOD OF PROTECTING SENSITIVE MOLECULES FROM A PHOTO-POLYMERIZING ENVIRONMENT  
In one embodiment, the present invention is a substrate system of photo-polymerizable monomers and bioactive molecules admixed with the monomers and shielded from the monomers by an insoluble...
US20080020979 Peptides of Syndecan-1 For Inhibiting Angiogenesis  
The present invention provides a peptide derived from the extracellular domain of syndecan-1 that inhibits angiogenesis.
US20080268063 Coated Controlled Release Polymer Particles as Efficient Oral Delivery Vehicles for Biopharmaceuticals  
A composition for delivering an active agent to a patient. The composition includes a polymer core encapsulating the active agent and a mucoadhesive coating disposed about the core. The polymer...
US20100047292 METHODS OF PROCESSING MICROPARTICLES AND COMPOSITIONS PRODUCED THEREBY  
A method for processing multi-phasic dispersions is provided. The method comprises providing a multi-phasic dispersion including dispersed and continuous phases, positioning the multi-phasic...
US20080045461 N-TERMINALLY MODIFIED GLP-1 RECEPTOR MODULATORS  
The subject matter described herein provides novel human glucagon-like peptide-1 (GLP-1) receptor modulators that have biological activity similar or superior to native GLP-1 peptide and thus are...
US20130143793 PEPTIDE CONJUGATES OF GLP-1 RECEPTOR AGONISTS AND GASTRIN AND THEIR USE  
The present invention relates, inter alia, to certain peptide conjugates, and to the use of the conjugates in the treatment of a variety of diseases or disorders, including diabetes (type 1 and/or...
US20100286034 USES FOR AQUEOUS STREAMS CONTAINING PROTEINS  
The present invention relates to a protein hydrolysate comprising free amino acids and peptides whereby the weight ratio of free amino acids to peptides is about 1:1 and wherein at least about 50...
US20060228778 Novel vitamin D receptor related polypeptides, nucleic acid sequence encoding the same and uses thereof  
The present invention relates to novel vitamin D receptor related (VDRR) polypeptides, and formulations containing the same. Nucleic acid sequences encoding the VDRR polypeptides, expression...
US20140256620 METHODS FOR REDUCING CD36 EXPRESSION  
The invention provides a method for treating one or more complications of diabetes in a mammal. The method comprises administering to a mammal in need thereof an effective amount of an...
US20140249075 METHODS FOR REDUCING CD36 EXPRESSION  
The invention provides a method for treating one or more complications of diabetes in a mammal. The method comprises administering to a mammal in need thereof an effective amount of an...
US20120283170 Acylated Exendin-4 Compounds  
This invention provides new therapeutic peptides, i.e. new protracted Exendin-4 compounds, pharmaceutical compositions and the use of such.
US20100317571 METHODS FOR REDUCING CD36 EXPRESSION  
The invention provides a method for treating one or more complications of diabetes in a mammal. The method comprises administering to a mammal in need thereof an effective amount of an...
US20050159352 Use of monocarboxylate transporter protein for thyroid hormone transport  
The use of a monocarboxylate transporter protein or a functional part, derivative and/or analogue thereof for altering transport of a thyroid hormone or a functional part, derivative and/or...
US20070054364 Polypeptide variants  
The invention relates to the provision of oligomeric polypeptides (dimers, trimers etc) comprising the ligand binding domains of cytokines which are linked via flexible polypeptide linker...
US20120045394 HUMAN AND MOUSE TARGETING PEPTIDES IDENTIFIED BY PHAGE DISPLAY  
The present invention concerns methods and compositions for in vivo and in vitro targeting. A large number of targeting peptides directed towards human organs, tissues or cell types are disclosed....
US20140271586 Nutritional Composition Containing a Peptide Component with Adiponectin Simulating Properties and Uses Thereof  
The present disclosure relates to nutritional compositions including a protein equivalent source that includes a peptide component comprising selected peptides. The protein equivalent source may...
US20060094679 Method of preventing or treating liver disease  
An object of the present invention is to provide a method of preventing or treating liver disease, particularly non-alcoholic fatty liver disease, hepatic fibrosis, cirrhosis, or liver cancer. The...
US20150152150 Selective PYY compounds and uses thereof  
The invention relates to PYY compounds having the amino acid in the position corresponding to position 30 of hPYY(1-36) substituted with tryptophan and derivatives thereof with a modifying group...
US20100034801 Non-Polymeric Compositions for Controlled Drug Delivery  
The present invention provides a novel liquid composition suitable for in-situ formation of a depot system to deliver a bioactive substance in a controlled manner. The composition of the present...
US20050096269 Protein Cluster II  
The present invention relates to the identification of a human gene family expressed in metabolically relevant tissues. The genes encode a group polypeptides referred to as “Protein Cluster II”...
US20130244931 Novel GLP-1 Derivatives  
Novel polypeptide derivatives having protracted profile of action.
US20100062050 MEANS AND METHODS OF ENHANCING DELIVERY TO BIOLOGICAL SYSTEMS  
This invention relates to a peptide or polypeptide (a) which is esterified or thio-esterified (i) at the carboxylate of the C-terminus with a guanidinium alkanol, a guanidinium alkanethiol, a PEG...
US20090202620 POLYMER-STABILIZED LIPOSOMAL COMPOSITIONS AND METHODS OF USE  
The invention provides liposomal particle compositions, which incorporate a lipophilic biodegradable polymer, such as amino acid-containing polyester amide (PEA), polyester urethane (PEUR), and...
US20100137204 GLP-1 PHARMACEUTICAL COMPOSITIONS  
The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to...
US20050113297 Compositions and methods for enhancing phagocytosis or phagocyte activity  
The present invention provides a system for enhancing clearance or destruction of undesirable cells or noncellular molecular entities by tagging such cells or noncellular molecular entities with a...
US20120252722 METAL-BINDING THERAPEUTIC PEPTIDES  
The present invention is related methods of delivering MBD peptide-linked agents into live cells. The methods described herein comprise contacting MBD peptide-linked agents to live cells under a...
US20110280876 MUTATED NETRIN - 4, FRAGMENTS THEREOF AND THEIR USE AS MEDICINES  
A peptide fragment of the netrin-4 protein and nucleic acids coding for the peptide are described. The peptide can inhibit endothelial cell proliferation and cell migration, as well as activate...
US20100215614 Enterostatin as Inhibitor of Angiogenesis  
It has been discovered that enterostatin inhibits angiogenesis in an in vitro adipose tissue angiogenesis model. In concentrations from about 10−6 to about 10−9 M, enterostatin effectively blocked...
US20090253621 ARABINOGALACTAN PROTEIN HAVING THE PROPERTY OF ABSORBING FATS AND METHOD FOR OBTAINING THIS ARABINOGALACTAN PROTEIN  
The invention relates, firstly, to a method for eliminating ingested dietary fats before they are assimilated by the body, using an AGP extracted from cactus mucilage. Said AGP can be in any...
US20070275872 Peptides with Anti-Obesity Activity and Other Related Uses  
Novel peptides and uses thereof, including polypeptides and related molecules with uses, for example, in weight loss and for the treatment of obesity and related conditions associated with, for...
US20070270350 Methods and Compositions for the Prevention and Treatment of Inflammatory Diseases or Conditions  
The present invention relates to methods and compositions of treating or preventing inflammatory diseases or conditions in a patient comprising administering to the patient a therapeutically...