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US20090286840 Thiophene-carboxamides useful as inhibitors of protein kinases  
The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of...
US20090275629 THERAPY FOR THE TREATMENT OF DISEASE  
Disclosed herein are pharmaceutical compositions comprising various combinations of an antimuscarinic or an anticholinergic agent, a compound that causes stimulation of salivary glands, and a...
US20090275591 1-HETEROCYCLYLSULFONYL, 2-AMINOMETHYL, 5- (HETERO-) ARYL SUBSTITUTED 1-H-PYRROLE DERIVATIVES AS ACID SECRETION INHIBITOR  
The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by...
US20090274655 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI VIRAL AGENTS  
Anti-viral agents of compounds of Formula (I): wherein A, R 1 , R 2 and R 3 are as defined in the specification, processes for their preparation and their use in HCV treatment are provided.
US20090270475 INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE-PHENYL DERIVATIVES  
Disclosure is provided for imidazole-phenyl derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these...
US20090270473 DUAL-ACTING ANTIHYPERTENSIVE AGENTS  
The invention relates to compounds having the formula: wherein: Q, W, Y, Z, r, and Ar are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT...
US20090270357 Method and use of nanoparticles to bind biocides in paints  
This invention relates to the use of a combination of selected substances in paint to prevent the settlement and growth of different biofouling organisms with a reduced negative effect on the...
US20090269394 METHODS AND COMPOSITIONS FOR TREATING ONCHOMYCOSIS  
The present invention relates to methods for treating and completely curing fungal, yeast and/or mold infections in human subjects comprising topically administering to a human subject in need...
US20090269301 Novel Inhibitors of Glutaminyl Cyclase  
The present invention relates to compounds of formula (I), combinations and uses thereof for disease therapy, R 1 represents heteroaryl, -carbocyclyl-heteroaryl, -alkenylheteroaryl or...
US20090263467 COMBINATION DRUG THERAPY USING ORALLY DISSOLVING FILM OR ORALLY DISINTEGRATING TABLET DOSAGE FORMS TO TREAT DRY MOUTH AILMENTS  
A combination drug therapy can be administered to patients to treat xerostomia or dry mouth or Sjogren's syndrome in the form of orally dissolving film or orally disintegrating tablets. Some of the...
US20090263438 INHIBITION AND DISPERSION OF BACTERIAL BIOFILMS WITH IMIDAZOLE-TRIAZOLE DERIVATIVES  
Disclosure is provided for imidazole-triazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these...
US20090263398 PHARMACEUTICAL COMBINATIONS  
The invention provides a combination comprising an ancillary compound and a compound having the formula (0): or salts or tautomers or N-oxides or solvates thereof; wherein X is a group R 1 -A-NR 4...
US20090258016 Substituted imidazole derivatives  
The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with...
US20090253764 USE OF AMPK-ACTIVATING IMIDAZOLE DERIVATIVES, PREPARATION PROCESS THEREFOR AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM  
The invention relates to the use of imidazole derivatives of the formula (1): in which A, R′ 1 , R′ 2 and R′ 3 are as defined in the description, as AMPK activators. The invention also...
US20090253673 Substituted Pyrazoles as Ghrelin Receptor Antagonists  
Certain novel N-acylated spiropiperidine derivatives are ligands of the human ghrelin receptor(s) and, in particular, are antagonists/inverse agonists of the human ghrelin receptor. They are...
US20090239866 PEPTIDE DEFORMYLASE INHIBITORS  
Novel PDF inhibitors and novel methods for their use are provided.
US20090239841 Diaryl Ureas as CB1 Antagonists  
Compounds of Formula I are provided. In which the variables are as described herein. Such compounds may be used to modulate CB1 activity in vivo or in vitro, and are particularly useful in the...
US20090233941 Co-Crystals of Calixarenes and Biologically Active Molecules  
This invention relates to co-crystals of at least one molecule of calyx[n]arene or at least one of its derivatives, and at least one biologically active molecule, compositions and medicines...
US20090233901 VLA-4 INHIBITORY DRUG  
There is provided a VLA-4 inhibitory drug having good oral absorbability and exhibiting sufficient anti-inflammatory effects when administered orally. A compound represented by the following...
US20090232898 Pharmaceutical Compositions Useful in the Treatment of Migraine  
There is provided pharmaceutical compositions for the treatment of migraine comprising a pharmacologically-effective amount of a triptan or an ergot, or a pharmaceutically-acceptable salt thereof;...
US20090232885 Drug Delivery Systems Comprising Weakly Basic Drugs and Organic Acids  
The present invention is directed to pharmaceutical compositions, and methods of making such compositions, wherein the compositions comprise a plurality of TPR and RR particles, wherein: the TPR...
US20090227634 Pyrazole Derivatives as 5-LO-Inhibitors  
The invention relates to compounds of formula (I) processes for their preparation, their use as 5-lipoxygenase inhibitors and pharmaceutical compositions containing the same.
US20090221658 Pharmacological Treatment for Sleep Apnea  
The present invention relates generally to pharmacological methods for the prevention or amelioration of sleep-related breathing disorders via administration of agents or combinations of agents...
US20090221589 Use of aminoalcohol derivatives for the treatment of overactive bladder  
The present invention relates to the use of new beta-agonists of general formula (Ia) or (Ib) wherein the groups R 1 to R 12 and R 1 to R 7 , respectively, have the meanings given in the claims...
US20090221488 Certain Compositions and Methods of Treatment  
Disclosed inter alia is the use of certain chromenone derivatives, which are modulators of a mitotic kinesin such as KSP, in the treatment of cellular proliferative diseases. The chromenones...
US20090215795 CYCLIC AMIDINE DERIVATIVES  
A cyclic amidine derivative represented by the formula: [wherein R 1 , R 2 and R 3 represent hydrogen, C 1-6 alkyl, aryl-C 1-6 alkyl, etc.; R 4 , R 5 and R 7 represent hydrogen, C 1-6 ...
US20090215753 Topical Compositions for Paediatric Use  
The present invention provides pharmaceutical compositions for treating a paediatric mammal, the compositions comprising a therapeutic agent and a pharmaceutically acceptable carrier, the...
US20090209480 CENTRAL ADMINISTRATION OF STABLE FORMULATIONS OF THERAPEUTIC AGENTS FOR CNS CONDITIONS  
The present invention concerns compositions, methods and/or apparatus of central administration of various CNS-active agents. In particular embodiments, intrathecal administration is advantageous...
US20090203653 Compositions and Methods Using Apocynin Compounds and Nitric Oxide Donors  
The invention describes novel compositions comprising at least one apocynin compound or a pharmaceutically acceptable salt thereof, and at least one nitric oxide donor, and, optionally, at least...
US20090202518 Treatment of sepsis and inflammation with alpha2A Adrenergic antagonists  
Provided are methods for treating a mammal undergoing sepsis, or at risk for sepsis. Also provided are methods of preventing or treating a physiological effect of sepsis in a mammal. Additionally...
US20090198145 COMPOSITIONS, METHODS, AND SYSTEMS FOR RAPID INDUCTION AND MAINTENANCE OF CONTINUOUS REM SLEEP  
Compositions, kits, methods, and systems to induce, maintain, monitor, and interpret a continuous, un-fragmented REM sleep state in humans, generate dreams, recover sleep, create brain neuronal...
US20090197796 Methods for treating and preventing cancers that express the hypothalamic-pituitary-gonadal axis of hormones and receptors  
Methods are provided for treating HPG axis-positive cancers, preventing or slowing proliferation of cells of HPG axis-positive cancer origin, preventing HPG axis-positive cancers in a patient at...
US20090182007 ORGANIC COMPOUNDS  
The present invention provides a compound of formula (I): said compound is inhibitor of aldosterone synthase, and thus can be employed for the treatment of a disorder or disease mediated by...
US20090181949 1H-IMIDAZOLE DERIVATIVE HAVING CB1, AGONISTIC, CB1 PARTIAL AGONISTIC OR CB1 ANTAGNISTIC ACTIVITY  
The present invention relates to a group of novel 1H-imidazole derivatives, to methods for the preparation of these compounds, and to pharmaceutical compositions containing one or more of these...
US20090181945 TWO CYCLIC CINNAMIDE COMPOUND  
The present invention relates to a novel two cyclic cinnamide compound and a pharmaceutical agent comprising the compound as an active ingredient. The two cyclic cinnamide compound represented by...
US20090176831 Compounds and Methods for Treating Cancer and Diseases of the Central Nervous System  
Disclosed are compounds of the general formula (I): compositions comprising an effective amount of said compounds either alone or in combination with other chemotherapeutic agents, and methods...
US20090170872 Compounds and Their Pharmaceutical Use  
The present invention relates to novel compounds of the general formula (I), their analogs, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable...
US20090163518 Novel Compounds  
The present invention relates to substituted indoles useful as pharmaceutical compounds for treating respiratory disorders.
US20090163500 COMPOSITIONS AND METHODS FOR TREATING LYSOSOMAL DISORDERS  
The present invention provides compositions and methods for treating lysosomal disorders using a class of substituted imidazole derivatives or compounds.
US20090163494 PROTEIN KINASE INHIBITORS  
This invention relates to selenophene compounds of formula (I) shown below: Each variable in formula (I) is defined in the specification. These compounds can be used to treat cancer.
US20090163451 METHODS FOR TREATING VISCERAL PAIN  
The invention features methods of treating visceral pain in humans by administering an effective amount of a 5HT 1B or 5HT 1D receptor agonist, (e.g., a triptan). These methods can be used, for...
US20090162297 BUCCAL, POLAR AND NON-POLAR SPRAY CONTAINING ONDANSETRON  
Buccal aerosol sprays or capsules using polar and non-polar solvents have now been developed which provide ondansetron for rapid absorption through the oral mucosa, resulting in fast onset of...
US20090156619 Heterocycle Substituted Amide and Sulfur Amide Derivatives as Histone Deacetylase (HDAC) Inhibitors  
The present invention related to compounds of formula (I): or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof. Compounds of the present invention are inhibitors of histone...
US20090156606 OPTICAL CORRECTION  
The present disclosure describes compositions which improve visual acuity and to methods for their use.
US20090156585 ORGANIC COMPOUNDS  
A specific combination, linked pro-drug or a compound of an angiotensin receptor antagonist and a NEPi are used in the treatment of hypertension.
US20090149474 GABA-B RECEPTOR MODULATORS  
The present invention relates to novel imidazole derivatives having a positive allosteric GABA B receptor (GBR) modulator effect, methods for the preparation of said compounds and to their use,...
US20090149471 Monocyclic Heterocyclic Compounds  
This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
US20090137652 METHODS FOR NEUROPROTECTION  
This invention is directed to methods for providing neuroprotection comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group...
US20090137651 PHARMACEUTICAL COMPOSITION FOR EXTERNAL USE  
A pharmaceutical composition for external use, including: i) luliconazole represented by the following structural formula (1) and/or a salt thereof; and ii) one or two or more selected from...
US20090137650 New Compounds  
The present invention relates to new compounds of formula I, where R 1 and R 2 are independently halo or C 1-3 haloalkyl, X is ethenyl or ethynyl, or a salt thereof.
Matches 1 - 50 out of 175 1 2 3 4 >