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US20090306154 |
SYNERGISTIC ANTI-MICROBIAL MIXTURES OF TROPOLONE (DERIVATIVES) AND SELECTED COMPOUNDS
The present invention relates to the antimicrobial mixture comprising or consisting of:
(a) one, two or more tropolone derivatives of the formula (1)
wherein the...
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US20090298785 |
Method for Treating Ocular Cancer
It has now been found that the p53 pathway is inactivated in ocular cancers such as retinoblastoma. As such, the present invention is a method for inducing ocular cancer cell death using a p53...
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US20090285797 |
USE OF INHIBITORS OF CYP2A6 FOR REGULATING NICOTINE METABOLISM
The invention relates to methods and compositions for regulating nicotine metabolism. Also provided are methods for screening and assessing substances for regulating nicotine metabolism. Methods...
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US20090281156 |
ENHANCING PHOTOSTABILIZATION OF OXYMETAZOLINE
The photostability of oxymetazoline in a topical decongestant composition is enhanced by lowering the pH of the composition using a buffer solution.
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US20090275608 |
Methods of diagnosing and treating parp-mediated diseases
Disclosed are methods of identifying a disease treatable with modulators of differentially expressed genes in a disease, including at least PARP modulators, by identifying the level of expression...
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US20090275587 |
METHODS OF TREATING ISCHEMIC RELATED CONDITIONS
The present invention relates to methods of treating ischemia-related conditions by administering to a patient in need of such methods certain thiosemicarbazone compounds. Preferred embodiments of...
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US20090270474 |
Therapeutic Agent for Keratoconjunctival Disorder
An object of the present invention is to discover a new use of eprosartan or a salt thereof. Eprosartan or a salt thereof exhibits an excellent improving effect in a corneal disorder model, and...
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US20090269394 |
METHODS AND COMPOSITIONS FOR TREATING ONCHOMYCOSIS
The present invention relates to methods for treating and completely curing fungal, yeast and/or mold infections in human subjects comprising topically administering to a human subject in need...
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US20090264470 |
CB1 Antagonists and Inverse Agonists
The present invention relates to methods of treating obesity, anorexia nervosa, or bulimia nervosa comprising administering a compound of the invention. The present invention further relates to the...
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US20090233929 |
Imidazole Derivatives for the Treatment of Anxiety and Related Diseases
This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the...
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US20090226460 |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE
The present invention relates to pharmaceutical compositions for the treatment and/or prophylaxis of disease associated with fibrosis in a vertebrate, said composition comprising at least one...
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US20090221498 |
Use of Mas-G-Protein-Coupled Receptor Agonists in the Treatment of the Metabolic Syndrome, Its Components and its Complications
The present invention is characterized by the use of Mas-G-protein-coupled receptor agonists for the control, prevention and treatment of the body levels of triglycerides, cholesterol and glucose,...
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US20090208558 |
Use of Combination Preparations Comprising Antifungal Agents
The invention relates to the use of an antimycotic agent and an epithelial cell or endothelial cell adhesion inhibitor for producing a combination drug for the topical treatment of Candida ...
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US20090186929 |
Method and agent for inducing apoptosis/cell death in leukemia cells
A method for inducing apoptosis or cell death in leukemia cells includes inhibiting the production of nitric oxide (NO) by using a nitric oxide synthase (NOS) inhibitor. The NOS inhibitor includes...
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US20090186810 |
POTASSIUM CHANNEL MODULATORS AND PLATELET PROCOAGULANT ACTIVITY
Methods of modulating platelet procoagulant response are taught herein. Inhibition of platelet procoagulant response with agents that inhibit the Ca 2 +-sensitive K + channels, or Gardos channels,...
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US20090176843 |
SUBSTITUTED-ARYL-2-PHENYLETHYL-1H-IMIDAZOLE COMPOUNDS AS SUBTYPE SELECTIVE MODULATORS OF ALPHA 2B AND/OR ALPHA 2C ADRENERGIC RECEPTORS
A compound having selective modulating activity at the alpha 2B and/or alpha 2C adrenergic receptor subtypes is represented by the general Formula 1:
wherein n=1-4; X is C or N; R 1 —R 6...
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US20090163566 |
Imidazole Derivatives and their use for Modulating the Gabaa Receptor Complex
This invention relates to novel imidazole derivatives of the general formula (I): pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the...
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US20090163500 |
COMPOSITIONS AND METHODS FOR TREATING LYSOSOMAL DISORDERS
The present invention provides compositions and methods for treating lysosomal disorders using a class of substituted imidazole derivatives or compounds.
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US20090136598 |
Compositions for the Treatment and Prevention of Eyelid Swelling
The invention features topical formulations comprising an osmotically active agent and/or a vasoconstrictor and/or an astringent agent for the treatment and prevention of eyelid swelling, and...
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US20090130027 |
COMPOSITIONS AND METHODS FOR TREATING PURPURA
Embodiments of the present invention are directed to compositions and methods for the treatment of purpura. Preferred compositions comprise an α adrenergic receptor agonist selected from selective...
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US20090118343 |
TREATMENT OF SEVERE DISTAL COLITIS
This invention relates to methods and materials involved in the treatment of diseases with severe distal colitis component, and more specifically non-fungal and/or non-microbial induced mucositis...
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US20090118264 |
Medicament having neovascularization promoting action
Methods of use of medicaments having neovascularization promoting action, which medicaments comprise a retinoid antagonist such as...
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US20090099202 |
External Preparation for Athlete's Foot Treatment
External preparations for athlete's foot treatment capable of enhancing patient's compliance and capable of reducing the symptom of rubefaction, comprising an anti-trichophyton drug mixed with at...
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US20090098213 |
PAIN RELIEF AND SOOTHING CREAM AND METHOD FOR MAKING SAME
emollient and methyl salicylate, where said methyl salicylate comprises between 10 and 30 percent by weight of said cream; a skin stimulant comprising menthol crystals and two or more reactants...
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US20090075932 |
METHOD OF SELECTIVELY INHIBITING PKCiota
PKCiota inhibitor 1H-imidazole-4-carboxamide, 5-amino-1-[2,3-dihydroxy-4-[(phosphonooxy)methyl]cyclopentyl
]-,[1R-(1α,2β,3β,4α)], (ICA-1), targets a unique sequence (amino acid residues...
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US20090062244 |
PHARMACEUTICAL COMPOSITION
Topical composition for enhanced local and systemic delivery of poorly soluble biologically active compounds, comprises of non-volatile solvent or mixture of solvents to dissolve active component,...
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US20090060905 |
Use of 15-Lipoxygenase Inhibitors for Treating Obesity
The invention concerns the treatment of obesity, in particular abdominal visceral obesity. More specifically, the invention concerns the use of selective 15-lipoxygenase (LO) inhibitors for...
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US20090017015 |
Dpp-iv inhibitors for treating neurodegeneration and cognitive disorders
The invention relates to the use of a Dipeptidyl peptidase IV inhibitor (DPP-IV inhibitor) or a pharmaceutically acceptable salt thereof for the prevention, delay of progression or the treatment of...
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US20090011045 |
Pharmaceutical for Hygienic Administration in the Ear
The invention relates to a system for hygienically administering, particularly in animals, an ear medicament which can be dosed reproducibly even in the case of low volumes and which is not flung...
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US20090005763 |
Implantable Devices and Methods for Delivering Drugs and Other Substances to Treat Sinusitis and Other Disorders
Implantable devices and methods for delivering drugs and other substances to locations within the body of a human or animal subject to treat or diagnose sinusitis and a variety of other disorders....
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US20090005362 |
Compositions Comprising Antihistamines or Mast Cell Stabilizers, and Methods of Making and Using Same
Compositions comprise: (a) a material selected from the group consisting of antihistamines, stabilizers, salts thereof, and combinations thereof; and (b) a vasoconstrictor, decongestant, or a salt...
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US20080317737 |
Drug combination for the treatment of skin disorders
A topical treatment for skin disorders and diseases comprising a combination of at least one antifungal agent and at least one hydroxy acid agent formulated into shampoos, creams, lotions, gels,...
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US20080317690 |
Film-Forming Resins as a Carrier for Topical Application of Pharmacologically Active Agents
The invention provides a biological dressing for treatment of a dermatological disease comprised of one or more resins or other film-forming agents, a topically acceptable volatile solvent, and a...
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US20080275016 |
FULVENE AND FULVALENE ANALOGS AND THEIR USE IN TREATING CANCERS
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are fulvene and/or fulvalene analogs. The compounds and...
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US20080274184 |
Ecm-Based Graft Material
This invention is directed to graft materials comprising an extracellular matrix (ECM) and therapeutic agents. This invention is also directed to methods of using the graft materials for healing of...
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US20080268071 |
SUBSTITUTED CYCLOHEXANONES
Disclosed herein are substituted cyclohexanone-based NMDA receptor modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
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US20080268050 |
SPRAYABLE TOPICAL SKIN BARRIERS
Sprayable topical skin barriers for protecting and promoting healing of skin, and for providing comfort to a patient, comprise (i) a semi-solid hydrocarbon in a range by weight from about 25.0% to...
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US20080267867 |
Metal Complexes of N-Heterocyclic Carbenes as Radiopharmaceuticals and Antibiotics
A method for inhibiting microbial growth comprises administering an effective amount of a silver complex of a N-heterocyclic amine. A method for treating cancer cells or a method for imaging one or...
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US20080262015 |
Aryl imidazoles and their use as anti-cancer agents
Therapeutically effective 2,4,5-trisubstituted imidazole compounds are provided. Also provided are methods -of preparing the compounds and pharmaceutical compositions comprising the compounds alone...
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US20080255169 |
Sulphonamide Derivatives
The invention relates to sulphonamide derivatives of formula (I),
where
R C is optionally substituted 4-6-membered heterocyclic ring containing one or more N atoms, or R C forms together with...
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US20080249088 |
Topical Delivery of Antifungal Drugs
A topical formula for treatment of antifungal infections of the skin and nails comprises: (a) a therapeutically effective amount of a benzylamine or morpholine antifungal compound; (b) an aliphatic...
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US20080248123 |
Nanoparticulate anticonvulsant and immunosuppressive compositions
Described are controlled release nanoparticulate formulations comprising a nanoparticulate agent to be administered and a rate-controlling polymer which functions to prolong the release of the...
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US20080234342 |
Skin Conditioning Compositions Containing Compounds for Mimicking the Effect on Skin of Retinoic Acid
A skin care product comprising from about 0.001% to about 10% of a retinoid, in combination with 0.0001% to a bout 50% of a combination of retinoid boosters.
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US20080227757 |
Formulation for dermal application
The present invention relates to formulations on an aqueous basis with polyetherpolyol, dimethyl isosorbide, lipid and alcohol content suitable for penetration reinforcement of pharmaceutical...
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US20080207719 |
Treatment of Epilepsy
The disclosure relates to a method for the inhibition of the development of epilepsy with an alpha2-adrenoceptor antagonist or a pharmaceutically acceptable salt or ester thereof.
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US20080207686 |
Peptide Deformylase (Pdf) Inhibitors 4
The present invention relates to compounds of formula (I).
These compounds are a novel type of peptide deformylase (PDF) inhibitors, and are therefore of great interest especially as new...
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US20080207530 |
Treatment of COPD, gastro-esophageal reflux disease (GERD), food allergies and other gastrointestinal conditions and disorders ameliorated by proper histamine management using a combination of histidine decarboxylase inhibitors, LRA drugs, anti-H1 and/or anti-H2 drugs
The invention provides a method for the treatment of COPD and/or gastrointestinal disease conditions ameliorated by histamine management in a subject, comprising administering to the subject an...
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US20080153874 |
ALPHA-2B RECEPTOR AGONIST AND ANTICONVULSANT COMPOSITIONS FOR TREATING CHRONIC PAIN
Disclosed herein is a pharmaceutical composition comprising a pain-relieving anticonvulsant and an alpha-2B receptor agonist. The composition is effective for treating chronic pain, and methods of...
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US20080153832 |
PAN-ALPHA-2 RECEPTOR AGONIST AND RELAXANT COMPOSITIONS FOR TREATING GASTROINTESTINAL MOTILITY DISORDERS
Disclosed herein is a pharmaceutical composition comprising a relaxant and a pan-alpha-2 receptor agonist. The composition is effective for treating gastrointestinal motility disorders, and methods...
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US20080153829 |
PAN-ALPHA-2 RECEPTOR AGONIST AND 5HT4 SEROTONIN RECEPTOR COMPOSITIONS FOR TREATING GASTROINTESTINAL MOTILITY DISORDERS
Disclosed herein is a pharmaceutical composition comprising a 5-HT4 serotonin receptor agonist and a pan-alpha-2 receptor agonist. The composition is effective for treating gastrointestinal...
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