|
Match
|
Document |
Document Title |
|
|
US20100004271 |
HETEROCYCLIC COMPOUNDS AS AGANIST FOR THE THYROID RECEPTOR
The invention provides Compounds of formula (I) or pharmaceutically acceptable esters, amides, solvates or salts thereof, including salts of such esters or amides, and solvates of such esters,...
|
|
|
US20100004247 |
COMBINATION COMPRISING A MEK INHIBITOR AND AN AURORA KINASE INHIBITOR 188
The present invention relates to a therapeutic combination comprising a MEK inhibitor and an Aurora kinase inhibitor, and to methods for the production of an anti-cancer effect in a patient, which...
|
|
|
US20090325949 |
5 HT RECEPTOR MEDIATED NEUROGENESIS
The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes...
|
|
|
US20090326029 |
NON-CYCLIC SUBSTITUTED BENZIMIDAZOLE THIOPHENE BENZYL ETHER COMPOUNDS
The present invention provides benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
|
|
|
US20090318445 |
PDF INHIBITORS
The invention relates to novel compounds that are inhibitors of peptidyl deformylase (PDF). The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display...
|
|
|
US20090318514 |
Novel Pharmaceutical Compositions
The invention provides the use of compounds of formula (I) or pharmaceutically acceptable esters, amides, solvates or salts thereof, including salts of such esters or amides, and solvates of such...
|
|
|
US20090318521 |
Synthesis of 4-Bromomethyl-2'-Formylbiphenyl and 4-Bromomethyl-2'-Hydroxymethylbiphenyl and Its Use in Preparation of Giotensin II Antagonists
4-bromomethyl-2′-formylbiphenyl and 4-bromomethyl-2′-hydroxymethylbiphenyl are useful starting material for the preparation various angiotenzin II antagonists, which are prepared from...
|
|
|
US20090312383 |
Fused Heterocyclic Compounds
There is provided a CRF receptor antagonist comprising a compound of the formula (I):
wherein R 1 is an optionally substituted hydrocarbyl, an optionally substituted C-linked heterocyclic...
|
|
|
US20090312384 |
Benzimidazole As Cooling Compounds
A method of providing a cooling sensation to the skin or mucous membranes of the mouth by applying thereto a quantity of at least one chemical compound sufficient to cause a desirable degree of...
|
|
|
US20090304714 |
IKKi Inhibitor Therapies and Screening Methods, and Related IKKi Diagnostics
The present invention provides diagnostics, screening methods, and treatment methods related to obesity, insulin resistance, diabetes, weight loss, and related disorders. In particular, the present...
|
|
|
US20090291968 |
SUBSTITUTED INDAZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS
Objects of the present invention are the compounds of formula I
their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the...
|
|
|
US20090286838 |
TREATMENT FOR CANCER
The present invention provides methods for the treatment of tumors, comprising administration of an effective amount of at least one taxoid and an effective amount of at least one benzimidazol...
|
|
|
US20090286791 |
Amide Compounds
The present invention provides compounds represented by the formula (Ia):
the formula (Ib):
the formula (Ic):
and the formula (Id):
wherein each symbol is as defined in the specification....
|
|
|
US20090286772 |
2-(Phenyl or Heterocyclic)-1H-Phenanthro[9,10-D]Imidazoles
The invention encompasses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme...
|
|
|
US20090281098 |
BENZOIMIDAZOLE COMPOUND CAPABLE OF INHIBITING PROSTAGLANDIN D SYNTHETASE
The present invention provides a benzimidazole compound represented by Formula (I)
wherein X 1 is oxygen or carbonyl, and R 1 is a furan ring having 1 to 3 substituents or a pyrrole ring that...
|
|
|
US20090281120 |
BICYCLIC HETEROCYCLIC COMPOUND
A compound represented by the formula (I), a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof:
wherein X, Y, and W each independently represent a carbon atom or a...
|
|
|
US20090270366 |
Benzoimidazole compounds
Benzoimidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H 4 receptor, and in treating conditions such as inflammation, H 4 ...
|
|
|
US20090264488 |
NOVEL SOLID FORMS OF BENDAMUSTINE HYDROCHLORIDE
Novel solid forms of bendamustine hydrochloride are described, as well as methods of their preparation and use.
|
|
|
US20090264414 |
Amide Derivatives and Pharmaceutical Use Thereof
The use of substituted amides for modulating the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a...
|
|
|
US20090258909 |
Novel Benzimidazole Derivatives Useful as Selective Androgen Receptor Modulators (SARMS)
The present invention is directed to novel benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the...
|
|
|
US20090253707 |
HETEROANNELATED ANTHRAQUINONE DERIVATIVES AND THE SYNTHESIS METHOD THEREOF
A heteroannelated anthraquinone derivative compound is provided. The heteroannelated anthraquinone derivative compound is represented by a formula (I):
wherein R 1 is a substituent being one...
|
|
|
US20090252787 |
GRANULAR PHARMACEUTICAL COMPOSITIONS
Pharmaceutical compositions comprising a plurality of formulated particles containing at least one active ingredient and at least one pharmaceutically acceptable excipient, granulated with a...
|
|
|
US20090253656 |
BCRP/ABCG2 INHIBITOR
The present invention is directed to a breast cancer resistance protein (BCRP/ABCG2) inhibitor. The BCRP inhibitor contains, as an active ingredient, an acrylonitrile derivative represented by...
|
|
|
US20090246274 |
PHARMACEUTICAL COMPOSITION 271
The invention concerns pharmaceutical compositions containing a hydrogen sulphate salt of 6-(4-bromo-2-chloro-phenylamino)-7-fluoro-3-methyl-3H-benzoi
midazole-5-carboxylic acid...
|
|
|
US20090247508 |
Benzoimidazole Compounds
Benzoimidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H 4 receptor, and in treating conditions such as inflammation, H 4 ...
|
|
|
US20090247520 |
INHIBITORS OF ANTIGEN RECEPTOR-INDUCED NF-kappa B ACTIVATION
A method to identify selective inhibitors of antigen receptor-mediated NF-κB activation is provided, as well as compositions having one or more of those inhibitors and methods of using those...
|
|
|
US20090239915 |
Substituted 2-phenyl-benzimidazoles and their use as pharmaceuticals
The present invention relates to derivatives of 2-phenyl-benzimidazoles of the formula I,
in which X, R, R1 to R3 and n have the meanings indicated in the claims, which modulate the...
|
|
|
US20090221569 |
USE OF LHRH ANTAGONISTS FOR INTERMITTENT TREATMENTS
The invention relates to methods of treatment or prophylaxis of physiological and/or pathological conditions with at least one LHRH antagonist, in particular at least one peptidomimetic LHRH...
|
|
|
US20090221657 |
Compounds, Compositions Containing Them, Preparation Thereof and Uses Thereof I
Compounds of Formula I, or pharmaceutically acceptable salts thereof:
wherein R 1 , R 2 , R 3 , R 4 , R 5 , and G are as defined in the specification as well as salts and pharmaceutical...
|
|
|
US20090220610 |
Suspension Comprising Benzimidazole Carbamate and a Polysorbate
This invention is directed to a pharmaceutical composition for drinking water administration comprising benzimidazole carbamate particles having an effective average particle size of less than 450...
|
|
|
US20090221589 |
Use of aminoalcohol derivatives for the treatment of overactive bladder
The present invention relates to the use of new beta-agonists of general formula (Ia) or (Ib) wherein the groups R 1 to R 12 and R 1 to R 7 , respectively, have the meanings given in the claims...
|
|
|
US20090209606 |
Cancer Treatments
Methods and compositions for treating cancers characterized by death-resistant cancer cells are described. In general, such methods involve administration of a therapeutically effective amount of a...
|
|
|
US20090209571 |
Phenanthrene derivatives as MPGES-1 inhibitors
The invention encompasses novel compounds of Formula or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and...
|
|
|
US20090203696 |
Aryl- and Heteroaryl-Ethyl-Acylguanidine Derivatives, Their Preparation and Their Application in Therapeutics
Disclosed are compounds according to formula (I):
wherein A, Q, X, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are as defined herein. The disclosure also relates to pharmaceutical...
|
|
|
US20090202478 |
Hepatitis C Virus Inhibitors
The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such...
|
|
|
US20090203743 |
SMALL MOLECULE ENTRY INHIBITORS
The present invention concerns the compounds having the formula
N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R 1 and R 8 each are...
|
|
|
US20090197889 |
SYNTHESIS AND ANTI-PROLIFERATIVE EFFECT OF BENZIMIDAZOLE DERIVATIVES
This invention provides for compounds, compositions, and methods that involve anti-proliferative and anti-neoplastic activity in cancer cells. In particular, a series of benzimidazole, purine,...
|
|
|
US20090192146 |
SUBSTITUTED ORGANOSULFUR COMPOUNDS AND METHODS OF USING THEREOF
The present invention provides substituted di-, tri-, tetra- and penta-sulfide compounds and compositions, and methods of using the same for the treatment and/or prevention of a cell proliferative...
|
|
|
US20090192169 |
Bicyclic Benzimidazole Compounds and Their Use as Metabotropic Glutamate Receptor Potentiators
Compounds of Formula I:
wherein A, B, D, L, R 1 , R 2 , R 3 , R 4 , m, and n are as defined for Formula I in the description. The invention also relates to processes for the preparation of the...
|
|
|
US20090192158 |
Methods for Treating or Preventing Neoplasias
The present invention is directed to a method for treating or preventing a neoplasia in a human patient in need of such treatment comprising administering to the patient a compound that inhibits...
|
|
|
US20090181943 |
Inhibitors of Histone Deacetylase
This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula compounds of the Formula (I)
and N-oxides,...
|
|
|
US20090181964 |
Propane-1,3-Dione Derivative or Salt Thereof
It is intended to provide a compound useful as a GnRH receptor antagonist. The inventors further investigated propane-1,3-dione derivatives. As a result, they confirmed that a compound having a...
|
|
|
US20090176849 |
Process for the preparation of 2-alkyl-1-((2'-substituted-biphenyl-4-yl) Methyl)-imidazole, dihydroimidazole or benzimidazloe derivatives
The invention relates to a new process for the preparation of sartans 2-butyl-3-[[2′-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1â
€²-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one is...
|
|
|
US20090176848 |
FORTIFIER
An agent for enhancing therapeutic or prophylactic effect of a renin-angiotensin system inhibitor on renal diseases is disclosed, including a specific prostaglandin I derivative such as beraprost...
|
|
|
US20090170812 |
Transcription factor modulating compounds and methods of use thereof
Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole...
|
|
|
US20090170921 |
Benzimidazole derivatives
A compound of formula (I) or a pharmaceutically acceptable salt or prodrug ester thereof:
wherein R1-R7 are as disclosed in the specification.
|
|
|
US20090170922 |
Benzimidazole derivatives and their use as a medicament
A subject of the present application is new benzimidazole derivatives of formula
in which A, Y, R 1 , R 2 , R 3 and R 4 represent different variable groups. These products have an antagonist...
|
|
|
US20090170859 |
Viral Polymerase Inhibitors
An enantiomer, diastereoisomer or tautomer of a compound, represented by formula I:
wherein A, B, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 are as defined herein, or a salt...
|
|
|
US20090170842 |
BRCA1-BASED BREAST OR OVARIAN CANCER PREVENTION AGENTS AND METHODS OF USE
A pharmaceutical composition for use in treating, inhibiting, and/or preventing breast and/or ovarian cancer can include: a molecule having a structure of one of Compounds 1-38, pharmaceutically...
|
|
|
US20090163497 |
Compounds Useful as Antagonists of CCR2
The present invention provides compounds of general formula (I) or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R 1 are defined generally and in subsets herein. Compounds of...
|