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US20140121103 COMPOSITIONS COMPRISING FUNGICIDAL SUBSTITUTED DITHIINES AND FURTHER ACTIVES  
The present invention relates to synergistic mixtures comprising at least one compound I and at least one active compound II as defined herein and to the use of these mixtures for combating...
US20070281011 Nanoparticulate posaconazole formulations  
The invention is directed to compositions comprising a nanoparticulate posaconazole, or a salt or derivative thereof, having improved bioavailability. The nanoparticulate posaconazole particles of...
US20120015993 Novel Pharmaceutical Forms, and Methods of Making and Using the Same  
Crystalline salts, polymorphs, solvates, and hydrates of bicalutamide, 5-fluorouracil, donepezil, anastrozole, nelfinavir, mirtazapine, lansoprazole, and tamsulosin, or derivatives thereof are...
US20110028486 INDOLES AS MODULATORS OF NICOTICIC ACETYLCHOLINE RECEPTOR SUBTYPE ALPHA-7  
The present invention relates to modulation of the α7 nicotinic acetylcholine receptor (nAChR) by a compound of List A or a salt thereof, which may be represented, but is not limited to the...
US20110152310 TRICYCLIC TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY  
The present invention relates to substituted tricyclic triazole compounds and compositions comprising substituted tricyclic triazole compounds. The invention further relates to methods of...
US20130196994 PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS  
Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological...
US20150094347 BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE  
Benzoxepin compounds of Formula I, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, wherein: Z1 is CR1 or N; Z2 is...
US20140135308 BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE  
Benzoxepin compounds of Formula I, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, wherein: Z1 is CR1 or N; Z2 is...
US20100048396 METHOD, USE AND AGENT FOR PROTECTING A PLANT AGAINST PYTHIUM AND RHIZOCTONIA  
The present invention relates to a method for protecting a plant against a phytopathogen selected from the genera Pythium and Rhizoctonia, wherein the seed of the plantis treated with (a)...
US20130237423 Low Toxicity, Low Odor, Low Volatility Solvent for Agricultural Chemical Formulations  
An agricultural chemical composition comprises a solvent having the general formula CO(ORa)(Rb), wherein Ra is a linear or branched alkyl group of one to eight carbon atoms and Rb is an aromatic...
US20100093638 TREAMENT FOR CHEMICAL SUBSTANCE ADDICTION  
The present invention provides a method for the treatment of chemical substance abuse by selectively inhibiting ghrelin activity in humans comprising administering to a human in need thereof a...
US20130059845 BICYCLIC AGONISTS OF GPR131 AND USES THEREOF  
The present disclosure relates to compounds that act as agonists of, or otherwise modulate the activity of, GPR131 and to their use in the treatment of various diseases. In particular embodiments,...
US20130012555 Compounds, Compositions and Methods for the Treatment of Islet Amyloid Polypeptide (IAPP) Accumulation in Diabetes  
Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of IAPP or amylin fibril diseases, and...
US20090048319 Method of Using a Micronutrient as Safener for a Triazole for Controlling Harmful Fungi  
A method of using a micronutrient selected from the group consisting of salts and adducts of Mg, Ca, B, Mn, Fe, Co and Zn and Mo as a safener for a triazole, selected from the group consisting of...
US20090291994 Use of Pyraclostrobin as Safener for Triticonazole for Controlling Harmful Fungi  
(1) Use of pyraclostrobin of the formula I as safener for(2) triticonazole of the formula II or salts or adducts thereof for controlling harmful fungi. The use of the compounds I and II in a...
US20050004186 MEK inhibiting compounds  
This invention provides substituted Phenyl-(2-[1,3,4]thiadiazol-2-yl-phenyl)-amine and (2-[1,3,4]Oxadiazol-2-yl-phenyl)phenyl-amine compounds which act as inhibitors of MAPK/ERK Kinase (“MEK”)...
US20080206303 Prolonged Release Formulations Comprising Anastrozole  
The present invention relates to slow release anastrozole formulations, more particularly to in situ gelling formulations comprising a polylactide polymer or poly(lactide-co-glycolide) co-polymer,...
US20110217359 PHARMACEUTICAL COMPOSITION FOR THE PROPHYLACTIC OR THERAPEUTIC TREATMENT OF DECUBITI AND FIRST DEGREE BURNS AND TREATMENT METHOD  
This invention relates to a pharmaceutical composition and method for preventing and treating decubitus by topical administration of a therapeutic dosage of a composition containing an antioxidant...
US20110059974 NOVEL RETINAMIDE RETINOIC ACID METABOLISM BLOCKING AGENTS  
Retinoic acid metabolism blocking agents (RAMBAs). The RAMBAs may be used for treatment of cancer, including breast and prostate cancers. Methods for preparing novel retinamide RAMBAs. The methods...
US20130203826 Pure Intermediate  
The present invention relates to an improved process for the preparation of Letrozole (I) and its synthetic intermediate 4-[(1-(1,2,4-triazoly)methyl]benzonitrile (III). In particular, it relates...
US20140235684 METAL-SALEN COMPLEX COMPOUND RESPONSIVE DRUG AND INTRA-CORPOREAL BEHAVIOR CONTROL SYSTEM FOR METAL-SALEN COMPLEX COMPOUND  
A metal-salen complex compound responsive drug, which has an antidotal property capable of neutralizing cytotoxicity of a metal-salen complex compound, and an intra-corporeal behavior control...
US20120108522 HDAC INHIBITORS AND HORMONE TARGETED DRUGS FOR THE TREATMENT OF CANCER  
The present invention relates to the methods of treating endocrine-regulated cancers, including hormone resistant cancers, for example. More specifically, the present invention relates to a method...
US20060135486 Use of sulfonamide-including compounds in combination with angiogenesis inhibitors  
The present invention relates to pharmaceutical compositions comprising a sulfonamide-including compound in combination with an angiogenesis inhibitor.
US20050058670 Oral itraconazole composition which is not affected by ingested food and process for preparing same  
A viscous and glassy composition for oral administration comprising itraconazole, an acidifing agent, an amphiphilic additive, a surfactant and an oil provides a high in vivo bioavailability of...
US20070054804 Use of fungicides for disinfecting cereal seed  
The use of active compound combinations comprising prothioconazole and tebuconazole for dressing seed against attack by phytopathogenic fungi.
US20140107070 PARAFFINIC OIL-IN-WATER EMULSIONS FOR CONTROLLING INFECTION OF CROP PLANTS BY FUNGAL PATHOGENS  
This disclosure features fungicidal combinations that include a paraffinic oil and an emulsifier. The combinations can further include one or more of the following: pigments, silicone surfactants,...
US20100330069 HETEROCYCLIC COMPOUNDS AND METHODS OF USE  
Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.
US20090163564 Translational Dysfunction Based Therapeutics  
Provided are methods and compositions for inhibiting eukaryotic translation initiation factor eIF4E. Such methods and compositions may be used alone or in conjunction with other therapies, such as...
US20110091534 COMPOSITIONS COMPRISING POLYMERIC MICELLES FOR DRUG DELIVERY  
The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same.
US20110070197 HEPATITIS C VIRUS INHIBITORS  
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus...
US20110070196 HEPATITIS C VIRUS INHIBITORS  
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus...
US20140336154 BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE  
Benzopyran and benzoxepin compounds of Formulas I and II, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful...
US20110130363 BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE  
Benzopyran and benzoxepin compounds of Formulas I and II, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful...
US20130053387 DESAZADESFERROTHIOCIN AND DESAZADESFERROTHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS  
Disclosed herein are new compounds of desazadesferrothiocin polyether (DADFT-PE) analogues, as well as pharmaceutical compositions comprising them and their application as metal chelation agents...
US20140308243 HEPATITIS C VIRUS INHIBITORS  
The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, esters, or prodrugs thereof: Q-G-A-L-B—Z—W (I), which inhibit RNA-containing virus, particularly...
US20120076755 Hepatitis C Virus Inhibitors  
The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, esters, or prodrugs thereof: Q-G-A-L-B-W (I), which inhibit RNA-containing virus, particularly the...
US20110189129 HEPATITIS C VIRUS INHIBITORS  
The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, esters, or prodrugs thereof: Q-G-A-L-B—W (I), which inhibit RNA-containing virus, particularly the...
US20100316607 HEPATITIS C VIRUS INHIBITORS  
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus...
US20110028500 PLANT PATHOGEN INHIBITOR COMBINATIONS AND METHODS OF USE  
Combinations, compositions and methods of use for modulating plant pathogen infection using plant extracts containing anthraquinone derivatives which induce resistance to plant phytopathogens and...
US20050222169 Compositions and methods of treating infections  
This invention relates to methods, compositions and treatment regimens for applying cooling active ingredients to the perineum of a woman to treat the symptoms of a vaginal or vulvar infection or...
US20080279962 Method of Scintigraphy  
The invention relates to combination comprising a pharmaceutically acceptable preparation of a compound of formula (I), or a pharmaceutically acceptable salt thereof, and a gallium and its use in...
US20130123284 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION  
Provided herein are compounds useful for kinase inhibition.
US20060069038 Irreversible caspase-3 inhibitors as active site probes  
The present invention encompasses a compound of Formula (I) useful as caspase active site probes. These probes can be used to determine whether a caspase has been activated, in cells or in tissues...
US20120258986 OLEFIN CONTAINING NUCLEAR TRANSPORT MODULATORS AND USES THEREOF  
The invention generally relates to the field of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to new substituted-heterocyclic azole compounds, the synthesis and use of...
US20130046000 COMPOUNDS FOR SUPPRESSING A PERIPHERAL NERVE DISORDER INDUCED BY AN ANTI-CANCER AGENT  
The present invention provides a medicament that suppresses (or mitigates) various neurological symptoms caused by a peripheral nerve disorder induced by an anti-cancer agent.
US20140107085 Bifunctional AKR1C3 Inhibitors/Androgen Receptor Modulators and Methods of Use Thereof  
The invention includes compositions comprising selective AKR1C3 inhibitors. The invention also includes compositions comprising bifunctional AKR1C3 inhibitors and selective androgen receptor...
US20090186928 Novel crystalline forms of an inhibitor of 11-beta-hydroxysteroid dehydrogenase type 1  
Novel crystalline salts of 3-[1-(4-chlorophenyl)-trans-3-fluorocyclobutyl]-4,5-dicyclop ropyl-r-4H-1,2,4-triazole are potent inhibitors of 11β-hydroxysteroid dehydrogenase Type 1 and are useful...
US20110257211 Small-Molecule Choline Kinase Inhibitors as Anti-Cancer Therapeutics  
Small molecule choline kinase inhibitors having the following formula: are provided herein. Also provided herein are pharmaceutical compositions containing Formula I compounds, together with...
US20120115903 Substituted Heteroaromatic Carboxamide and Urea Compounds as Vanilloid Receptor Ligands  
Substituted heteroaromatic carboxamide and urea compounds corresponding to formula (i) processes for the preparation thereof, pharmaceutical compositions containing these compounds and also a...
US20070066669 Fungicidal active combinations spiroxamine, prothioconazole and tebuconazole  
The present invention relates to a novel active compound combination that is highly suitable for controlling phytopathogenic fungi which contains the known...