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US20150111893 Nuclear Transport Modulators and Uses Thereof  
The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula I, and methods of using said...
US20130317031 Nuclear Transport Modulators And Uses Thereof  
The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula I, and methods of using said...
US20110003795 Substituted Aromatic Carboxamide and Urea Derivatives as Vanilloid Receptor Ligands  
The invention relates to substituted aromatic carboxamide and urea derivatives, to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the...
US20080009504 Antifungal agents  
The present invention relates to novel enfumafungin derivatives of formula I and pharmaceutically acceptable salts thereof, their synthesis, and their use as inhibitors of (1,3)-β-D-glucan...
US20140341850 HALOALKYL HETEROARYL BENZAMIDE COMPOUNDS  
A new class of haloalkyl heteroaryl benzamides is described. These compounds show strong activity against hepatitis viruses.
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The biodegradable drug delivery systems described here are formulated for implantation into the nail unit and its surrounding tissues for the treatment of various nail unit conditions. The systems...
US20070238733 Compositions useful as inhibitors of voltage-gated sodium channels  
The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of...
US20070154516 DRUG DELIVERY SYSTEM  
A pharmaceutical composition comprises a first active (e.g., antibacterial) agent and a second (e.g., antifungal) active agent, and comprises a component that is adapted for bioadhesion to a...
US20090253691 TRISUBSTITUTED 1,2,4-TRIAZOLES  
The present invention relates to 3-aniline-5-aryl triazole derivatives and analogues or pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions...
US20100168088 PYRROLIDINE DERIVATIVES AS NK-3 RECEPTOR ANTAGONISTS  
The present invention relates to a compound of formula I wherein Ar1, Ar2, R1, R2, R3, n, o, and p are as described herein or to a pharmaceutically active salt, to all stereoisomeric forms,...
US20100215775 USE OF C10-C14-ALKANEDIOLS IN THE PREPARATION OF A COMPOSITION FOR THE PROPHYLAXIS AND/OR TREATMENT OF MALASSEZIA-INDUCED DANDRUFF FORMATION  
The invention relates to the use of C10-C14-alkane-1,2-diols, in particular 1,2-decanediol, 1,2-dodecanediol and/or 1,2-tetradecanediol, in the preparation of a composition for the prophylaxis...
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The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds, processes for...
US20130253009 Compositions for Drug Administration  
The present invention provides compositions and methods and for increasing the bioavailability of therapeutic agents in a subject, as well as compositions and methods for providing migraine pain...
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This invention relates to CXCR4 inhibitors and their use in treating and/or preventing a variety of angiogenic, microvascular and ocular disorders including primary indications for diabetic...
US20100168070 COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE  
The invention relates to substituted 1,2-ethylenediamines of general formula (I), wherein the radicals R1-R13, A, B, L and i are as defined in the description and in the claims. The invention also...
US20120083494 NOVEL TRIAZOLE DERIVATIVES WITH IMPROVED RECEPTOR ACTIVITY AND BIOAVAILABILITY PROPERTIES AS GHRELIN ANTAGONISTS OF GROWTH HORMONE SECRETAGOGUE RECEPTORS  
The present invention provides novel triazole derivatives with improved receptor activity and bioavailability properties as ghrelin analogue ligands of growth hormone secretagogue receptors...
US20140141977 Suspension Concentrates  
The invention relates to suspension concentrates comprising a) one or more pesticides that are solid at room temperature, b) one or more specific copolymers, c) one or more additional auxiliary...
US20150210675 LONG CHAIN BASE SPHINGOSINE KINASE INHIBITORS  
The invention relates to inhibitors of Sphingosine Kinase enzymatic activity, and methods of treating diseases and disorders by administering inhibitors of Sphingosine Kinase enzymatic activity.
US20140113823 FORMULATION COMPONENT  
This invention relates to the use of aromatic esters as adjuvants in compositions, particularly for agrochemical use, as well to compositions comprising such an aromatic ester, in combination with...
US20140302988 1,2,4-Triazolyl-Substituted Ketoenols  
The invention relates to novel compounds of the formula (I) in which X, Y and CKE have the meanings given above, to a plurality of processes and intermediates for their preparation, and to their...
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Compound of a compound of formula (1) or a salt, N-oxide, hydrate or solvate thereof, in the preparation of a composition for inhibition of HSP90 activity: wherein ring A is an aromatic or...
US20130324560 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS  
The present invention relates to new insecticides of the formula (I) in which R1, R2, R3, R4, R5, R6, A, Q and n can have the definitions stated in the description, to a number of processes for...
US20120094830 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS  
The present invention relates to new insecticides of the formula (I) in which R1, R2, R3, R4, R5, R6, A, Q and n can have the definitions stated in the description, to a number of processes for...
US20090069288 Novel therapeutic compounds  
Disclosed herein are novel compounds of Formula (I), wherein the variables are defined as herein. The compounds of Formula (I) are useful as kinase inhibitors and as such would be useful in...
US20080193448 Combinations and Methods of Using an Indolinone Compound  
The invention provides methods of treating cancer using a compound of formula (1) or a pharmaceutically acceptable salt thereof, particularly a malate salt, in combination with various additional...
US20090318291 Fungicidal mixtures of 1-methylpyrazol-4-ylcarboxanilides and azolopyrimidinylamines  
Fungicidal mixtures of 1-methylpyrazol-4-ylcarboxanilides and azolopyrimidinylamines Fungicidal mixtures comprising as active components: 1) at least one 1-methylpyrazol-4-ylcarboxanilide of the...
US20080269263 Synergistic Fungidical Active Substance Combinations  
The present invention relates to novel active substance combinations which contain spiroxamine, which is known, a known azole and a known carboxamide and which are very suitable for controlling...
US20100069340 PHARMACEUTICAL COMPOSITIONS OF AN SRC KINASE INHIBITOR AND AN AROMATASE INHIBITOR  
This invention is directed to a pharmaceutical composition comprising an Src kinase inhibitor and an aromatase inhibitor, and to the use of a combination of an Src kinase inhibitor and an...
US20100034813 SUBSTITUTED PYRAZOLE AND TRIAZOLE COMPOUNDS AS KSP INHIBITORS  
Disclosed are new substituted pyrazole and triazole compounds of Formula (I) and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the derivatives together with...
US20100048655 Comb Polymers and Use Thereof for the Production of Active or Effective Ingredient Formulations  
The present invention relates to novel comb polymers, to a process for their manufacture and to the use thereof in the stabilization in an aqueous phase of active or effect substances which are...
US20070249546 OPHTHALMIC AND RELATED AQUEOUS SOLUTIONS CONTAINING ANTIFUNGAL AGENTS, USES THEREFOR AND METHODS FOR PREPARING THEM  
The invention relates generally to concentrates and aqueous solutions for topical application comprising antifungal additives or agents as well as to preparation and use of such concentrates and...
US20090197896 Methods and compositions for increasing solubility of azole drug compounds that are poorly soluble in water  
The combination of any two of a polyol, a polyol ether, and a low carbon organic alcohol provides a synergistic effect on the solubility of azole compounds, such as metronidazole, in aqueous fluid.
US20110053936 SUBSTITUTED SPIRO[CYCLOALKYL-1,3'-INDOL]-2'(1'H)-ONE DERIVATIVES AND THEIR USE AS P38 MITOGEN-ACTIVATED KINASE INHIBITORS  
The present disclosure is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I), processes for preparation thereof, pharmaceutical compositions...
US20100179204 CO-CRYSTALS OF PROPICONAZOLE  
The present invention relates to co-crystals of propiconazole and a co-crystal forming compound.
US20100048649 COMBINATIONS COMPRISING BICYCLIC S1P LYASE INHIBITORS  
Methods and compositions for treating immunological and inflammatory diseases and disorders are disclosed. Particular methods and compositions comprise the administration of an agent that inhibits...
US20090105286 Low-molecular inhibitors of cytohesin-family guanine nucleotide exchange factors  
The invention relates to drugs and the use thereof, wherein said drugs contain compounds selected from a group comprising general formulas (1), (2), (3) and (4) and/or enantiomers, diastereomers...
US20140121236 Compositions and Methods for Treating Myotonic Dystrophy Type 1  
Disclosed is a compound for treatment of Myotonic Dystrophy type 1 having the formula: Wherein X is selected from the group consisting of O, N, C, or S, Y is a homo- or heteroatomic 5-membered...
US20140051709 Compositions and Methods for Treating Myotonic Dystrophy Type 1  
Disclosed is a compound for treatment of Myotonic Dystrophy type 1 having the formula: Wherein X is selected from the group consisting of O, N, C, or S, Y is a homo- or heteroatomic 5-membered...
US20120165339 CYCLOPROPANE DERIVATIVES  
A cyclopropane derivative represented by the following formula (I) or a pharmaceutically acceptable salt thereof has orexin receptor inhibitory action, and thus, is extremely useful as an agent...
US20100173781 METHOD FOR MODULATING THE RELEASE RATE OF MICROENCAPSULATED ACTIVE INGREDIENTS  
A method for modulating the release rate of microencapsulated active ingredients comprising the following steps: I) preparation of an aqueous suspension A) comprising microcapsules of at least one...
US20100125040 PESTICIDAL COMBINATIONS  
A method of controlling growth and/or controlling or preventing pathogenic damage or pest damage in a plant propagation material, a plant, parts of a plant and/or plant organs that grow at a later...
US20050282878 Process for the purification of fluconazole  
The present invention relates to processes for the purification of crude fluconazole including at least a first leaching, a second leaching, and an acid/base treatment and to highly purified...
US20100113530 S1P LYASE INHIBITORS FOR THE TREATMENT OF CEREBRAL MALARIA  
Methods and compositions for treating, managing, and/or preventing cerebral malaria are disclosed.
US20100113423 Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof  
The present disclosure provides compounds that function as modulators of aldehyde dehydrogenase (ALDH) enzymatic activity, as well as compositions and formulations comprising the compounds. The...
US20140288136 METHODS AND USES OF CYTOCHROME P450 INHIBITORS  
Methods are provided for treating or preventing chronic obstructive pulmonary diseases such as emphysema, and fibrotic diseases including heart, liver, kidney and vascular diseases, by...
US20120190716 METHODS AND USES OF CYTOCHROME P450 INHIBITORS  
Methods are provided for treating or preventing chronic obstructive pulmonary diseases such as emphysema, and fibrotic diseases including heart, liver, kidney and vascular diseases, by...
US20060089316 Method for reducing a susceptibility to tumor formation induced by 3-deoxyglucosone and precursors thereof  
Disclosed are methods of using various compounds, which are known to bind to 3-deoxyglucosone (3DG) or precursors thereof, in order to reduce a susceptibility to tumor formation and/or to prevent...
US20120015910 Synergistic fungicidal active substance combinations  
Novel active compound combinations comprising a carboxamide of the general formula (I) (group 1) in which A, R1, R2 and R3 are as defined in the description, and the active compound groups (2) to...
US20120083463 Insecticidal and Fungicidal Active Compound Combinations  
The present invention relates to active compound combinations consisting, firstly, of a known halogen-substituted derivative (component A) and, secondly, of further known pesticidally active...
US20110224206 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY  
The present invention relates to substituted pyrrole compounds of formula I and compositions comprising substituted tri-substituted triazole compounds. The invention further relates to methods of...