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US20090270469 |
SUBSTITUTED OXAZOLIDINONES
The present invention relates to new oxazolidinone modulators of skeletal muscle function and tone, pharmaceutical compositions thereof, and methods of use thereof.
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US20090264487 |
HEMIASTERLIN ANALOGS
This invention provides analogs of hemiasterlin, methods of synthesis of the analogs and use of the analogs as a cytotoxic anti-mitotic agents.
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US20090264340 |
COMPOSITIONS AND METHODS FOR INCREASING THE ORAL ABSORPTION OF ANTIMICROBIALS
The present invention provides compositions and methods for increasing absorption of antibacterial agents, particularly third generation cephalosporin antibacterial agents, in oral dosage solid...
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US20090247527 |
SUBSTITUTED GAMMA LACTAMS AS THERAPEUTIC AGENTS
A compound having the formula
or a pharmaceutically acceptable salt or a prodrug thereof is disclosed herein. Y, A, U, and B are as described herein. Methods, compositions, and medicaments...
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US20090239907 |
METHODS AND COMPOSITIONS FOR TREATING FISH DISEASES
Therapeutic and prophylactic treatments of aquatic species and aquatic diseases through the controlled introduction of a heterocyclic N-halamine into an aquatic habitat.
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US20090233974 |
SUBSTITUTED GAMMA LACTAMS AS THERAPEUTIC AGENTS
A compound having the formula
or a pharmaceutically acceptable salt or a prodrug thereof is disclosed herein. Y, A, and B are as described herein. Methods, compositions, and medicaments related...
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US20090221655 |
ANTIBACTERIAL AGENTS
The present invention provides a compound of Formula (I) Or a pharmaceutically acceptable salt thereof wherein: W is CH 2 NHC(═Z)R 1 , C(═Z)NHR 2 , or CH 2 het; X is H, C 1-6 alkyl, or C 2-6...
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US20090215775 |
Sulphonamido-Substituted Cyclohexyl Sulphones for Treatment of Cancer
Compounds of formula (I) are disclosed for treatment of cancer.
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US20090209590 |
Histone Deacetylase and Tubulin Deacetylase Inhibitors
In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel inhibitors of histone deacetylases, tubulin...
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US20090209511 |
Benzofuran Derivatives
The present invention provides a benzofuran derivative of the formula [1]:
wherein x is a group of the formula: —N═ or —CH═; Y is an optionally substituted amino group, an optionally...
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US20090209937 |
Apparatus and Methods for Treating Epilepsy Using Convection-Enhanced Delivery
Disclosed herein are apparatuses and methods for treating a neurological disorder associated with excessive neuronal excitability (e.g., epilepsy). Methods disclosed herein comprise administering...
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US20090186926 |
Self-Emulsifying Formulations of CETP Inhibitors
A liquid formulation for oral administration of the CETP inhibitor of formula (I) has improved bioavailability compared with conventional solid formulations. The formulation comprises the CETP...
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US20090186834 |
DIPHENYLHETEROCYCLE CHOLESTEROL ABSORPTION INHIBITORS
Various azetidinone, pyrrolidine, imidazolidine, and oxazolidine derivatives are described, as are pharmaceutical compositions containing these compounds and methods of treatment of diseases using...
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US20090176773 |
Non-Peptidic Inhibitors of AKAP/PKA Interaction
The invention relates to non-peptidic molecules which modulate, especially inhibit, the interaction of protein kinase A (PKA) and A kinase anchor proteins (AKAP) and to a host or target organism...
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US20090163561 |
AMORPHOUS METAXALONE AND AMORPHOUS DISPERSIONS THEREOF
The present invention provides various amorphous forms of the compound metaxalone (I), such as solid amorphous metaxalone and amorphous dispersions comprising metaxalone. The present invention...
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US20090163451 |
METHODS FOR TREATING VISCERAL PAIN
The invention features methods of treating visceral pain in humans by administering an effective amount of a 5HT 1B or 5HT 1D receptor agonist, (e.g., a triptan). These methods can be used, for...
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US20090156654 |
DERIVATIVE N-THIOLATED 2-OXAZOLIDINONE ANTIBIOTICS
This invention describes the discovery and synthesis of N-thiolated 2-oxazolidinones as a new class of anti bacterial agents. These compounds can be synthesized from 2-oxazolidinones by...
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US20090156653 |
Amino alcohol derivatives, salts thereof and immunosuppresive agents
An amino alcohol derivative represented by the following general formula (1) (for example, (±)-2-amino-5-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-2-
methylpentane- 1 -ol) exhibits strong...
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US20090149520 |
OXAZOLIDINONES CONTAINING OXINDOLES AS ANTIBACTERIAL AGENTS
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein X is C 1-4 alkyl; and Y is H or F. The compounds of the present invention are useful...
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US20090143450 |
METHOD FOR TREATING CENTRAL PAIN SYNDROM OR FOR INDUCING CENTRALLY GENERATED PAIN IN AN ANIMAL MODEL
The present invention provides a method for treating central pain syndrome in a mammal by administering an effective amount of a thalamic anticonvulsant compound. Also provided are methods for...
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US20090137548 |
1,3-Oxazolidin-2-One Derivatives Useful as Cetp Inhibitors
Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol,...
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US20090131462 |
Fungicidally Active Agent
The invention relates to a fungicidally active agent containing at least one other defined fungicide in addition to the fungicide...
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US20090118337 |
Methods and compositions for treating inflammation
A method of treating a subject with a cystic fibrosis related disorder includes administering a therapeutically effective amount of at least one PPARγ agonist or a derivative thereof.
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US20090111855 |
SUBSTITUTED PHENOXY THIAZOLIDINEDIONES AS ESTROGEN RELATED RECEPTOR-alpha MODULATORS
The present invention relates to compounds of Formula (I),
methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but...
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US20090082313 |
Multikinase Inhibitors for Use in the Treatment of Cancer
The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I):
...
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US20090076021 |
THERAPEUTIC COMBINATIONS AND METHODS FOR CARDIOVASCULAR IMPROVEMENT AND TREATING CARDIOVASCULAR DISEASE
A therapeutic combination, useful in a co-therapy method for improving cardiovascular performance and/or treating cardiovascular diseases, is provided comprising a first agent and a second agent,...
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US20090075979 |
CETP Inhibitors
Compounds having the structure of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing...
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US20090069313 |
Novel MAO-A inhibitors
The present invention provides a new medical use for the compounds of the formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically...
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US20090062297 |
Hydroxyalkylarylamide Derivatives
The present invention relates to a novel class of hydroxyalkylarylamide derivatives. The instant compounds can be used to treat cancer. The fluorinated arylamide derivatives can also inhibit...
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US20090054505 |
THERAPEUTIC OXAZOLIDINONES AND THIAZOLIDINONES
Disclosed herein is a compound represented by a formula
Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
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US20090048305 |
Antimicrobial ortho-Fluorophenyl Oxazolidinones For Treatment of Bacterial Infections
The present invention provides certain ortho-fluorophenyl oxazolidinones of the following formula I:
or pharmaceutically acceptable salts or prodrugs thereof that are antibacterial agents,...
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US20090036504 |
2-Aminoethoxyacetic Acid Derivatives and Their Use
The present application relates to novel 2-aminoethoxyacetic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their...
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US20090028802 |
ORGANOLEPTICALLY ACCEPTABLE INDOLE SEROTONIN RECEPTOR AGONIST ORAL DOSAGE FORMULATIONS AND METHODS OF USING THE SAME
Organoleptically acceptable oral dosage formulations of an indole receptor serotonin agonist, and methods of making and using the same, are provided. An aspect of the formulations is that they...
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US20090023708 |
Compounds Comprising a Lactam or a Lactam Derivative Moiety, Processes for Making Them, and Their Uses
The present invention relates to compounds of formula (I) comprising a lactam or a lactam derivative moiety, processes for preparing them, pharmaceutical compositions comprising said compounds and...
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US20090012089 |
Oxazolidinone Compounds and Their Use as Metabotropic Glutamate Receptor Potentiators
The present invention is directed to compounds of Formula I:
Wherein R 1 , R 2 , Y, m and n are further defined in the description. The invention also relates to processes for the preparation of...
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US20080312184 |
Composition for Preventing Plant Diseases and Method for Preventing the Diseases
The present invention is to provide a composition for preventing plant diseases which comprises at least Component I and Component II, is capable of obtaining a synergic effect that cannot be...
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US20080300288 |
Alkenyldiarylmethanes, Fused Analogs And Syntheses Thereof
Non-nucleoside inhibitors of HIV-1 reverse transcriptase are described. Such inhibitors may be used as part of a combination therapy to treat HIV infection. Compounds described herein exhibit...
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US20080292584 |
METAXALONE PRODUCTS, METHOD OF MANUFACTURE, AND METHOD OF USE
Disclosed herein are methods of using metaxalone. In one embodiment, the method comprises determining that a patient in need metaxalone therapy is taking a substance that is a n inhibitor or an...
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US20080287456 |
Oral Therapeutic Compound Delivery System
The present invention relates generally to therapeutic formulations. More particularly, this present invention provides an oral delivery system for a therapeutic compound that is a base, a salt of...
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US20080262056 |
Oxindole Oxazolidinones as Antibacterial Agents
The present invention relates to novel oxazolidinones derivatives of oxindoles of formula I or a pharmaceutically acceptable salt thereof wherein: Y 1 is CH or CF; R 1 is —C 1-4 alkyl,...
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US20080249148 |
Synthesis and characterization of polymorph form III 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-yl)thiazol-4-yl)benzonitrile
A polymorph Form III of 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-yl)thiazol-4-yl)benzoni
trile and methods of preparing Form III are described. Also provided are methods of contraception, treating or...
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US20080242711 |
INHIBITORS OF CHOLESTEROL ESTER TRANSFER PROTEIN
The invention relates to novel oxazolidinones their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This invention also provides compositions comprising a compound...
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US20080234337 |
Preventive and/or Remedy for Hyperkalemia Containing Ep4 Agonist
The present invention relates to a preventive and/or therapeutic agent for hyperkalemia, and a potassium excretion promoter containing EP 4 agonist. Since EP 4 agonist promotes potassium...
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US20080234340 |
Synthesis and characterization of polymorph form II of 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-YL)thiazol-4-YL)benzonitrile
A polymorph Form II of 4-(2-(4,4-dimethyl-2-oxooxazolidin-3-yl)thiazol-4-yl)benzoni
trile and methods of preparing Form II are described. Also provided are methods of contraception, treating or...
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US20080221182 |
ANTI-CANCER AND ANTI-MICROBIAL OXAZOLIDINONES
Disclosed herein are various novel oxazolidinone, imidazolidinone, and thiazolidinone analogs and methods of treating cancer and/or microbial infection using these analogs. Particular...
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US20080220079 |
SUSTAINED RELEASE COMPOSITIONS USING WAX-LIKE MATERIALS
Sustained release spherical or non-spherical pellets comprising (a) an active ingredient (b) a wax-like agent, and (c) a spheronizing agent are provided. Oral dosage forms comprising said pellets...
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US20080221183 |
ANTI-CANCER AND ANTI-MICROBIAL OXAZOLIDINONES
Disclosed herein are various novel oxazolidinone, imidazolidinone, and thiazolidinone analogs and methods of treating cancer and/or microbial infection using these analogs. Particular...
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US20080221181 |
COMPOUNDS FOR TREATING TUMORS
The invention provides compounds of formula (I):
wherein E, A, B′, R 6 , R 7 , R 8 , and R 9 are defined in the specification which compounds exhibit anticancer activity and are useful for...
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US20080207589 |
CYCLIZED DERIVATIVES AS EG-5 INHIBITORS
The present invention relates to new substituted imidazole compounds have the following Formula (I) and to the pharmaceutically acceptable salts, esters, or prodrugs thereof, to compositions of the...
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US20080146458 |
PROCESS FOR THE PREPARATION OF OXAZOLIDINONES AND METHOD OF USE THEREOF
Substituted oxazolidinone of the formula:
wherein R 2 is alkyl selected from the group consisting of methyl, ethyl, and isopropyl moieties, are described. The compounds are antibacterial.
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