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US20090318481 |
Potentiators Of Glutamate Receptors
This application relates to a substituted hydroxyphenyl ketone compound of formula I, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof and its use in treating...
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US20090312352 |
COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASE CAUSED BY YERSINIA SPP INFECTION
The invention generally relates to compositions and methods for treatment of disease caused by Yersinia spp. infection. More specifically, the invention relates to protein tyrosine phosphatase...
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US20090311325 |
ENHANCING SOLUBILITY AND DISSOLUTION RATE OF POORLY SOLUBLE DRUGS
The present invention relates generally to use of a polyvinyl alcohol-polyethylene glycol graft copolymer (PVA-PEG graft co-polymer), such as Kollicoat IR, in the formulation of solid dispersions...
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US20090312303 |
Antidiabetic Bicyclic Compounds
Bicyclic compounds containing a phenyl or pyridyl ring fused to a cycloalkyl or heterocyclic ring, to which is attached a 5-membered heterocyclic ring, including pharmaceutically acceptable salts...
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US20090312376 |
5-(4-METHANESULFONYL-PHENYL)-THIAZOLE DERIVATIVES FOR THE TREATMENT OF ACUTE AND CHRONIC INFLAMMATORY DISEASES
The invention relates to a compound of formula (I):
or a pharmaceutically acceptable salt, prodrug and/or solvate thereof, and to a method for the treatment an acute or chronic inflammatory...
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US20090306069 |
AZOLIDINONE-VINYL FUSED-BENZENE DERIVATIVES
The present invention is related to azolidinedione-vinyl fused-benzene derivatives of formula (I) for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases,...
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US20090304760 |
Biocidal Film-Forming Composition and Method for Coating Surfaces With It
A biocidal film-forming composition comprising, a nitrogen-containing biocide, a sulphur-containing biocide, an oleophilic carrier, and a film-forming agent. The invention also includes a method of...
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US20090298745 |
Treatment of Diabetes with Glycogen Phosphorylase Inhibitors
The invention provides a method of treatment of diabetes, particularly type II diabetes, or a diabetes related condition, comprising night time dosing of an inhibitor of glycogen phosphorylase,...
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US20090291986 |
COMPOSITION AND METHOD OF TREATING FACIAL SKIN DEFECT
This invention relates to a subcutaneous deliverable composition containing an agonist of the peroxisome proliferator-activated receptor-gamma, and a method for treating facial skin defects in a...
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US20090291066 |
COMPOSITION AND METHOD OF TREATING FACIAL SKIN DEFECT
This invention relates to a subcutaneous deliverable composition containing an agonist of the peroxisome proliferator-activated receptor-gamma, and a method for treating facial skin defects in a...
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US20090291992 |
ANDROGEN RECEPTOR-ABLATIVE AGENTS
Compounds of the thiazolidinedione family are provided and shown to be effective androgen receptor ablative agents that can be used in methods of treating or preventing cancer or precancer,...
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US20090275625 |
NOVEL THIAZOLIDIN 4-ONE DERIVATIVES
The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the...
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US20090264483 |
METHODS OF USING PPAR-gamma AGONISTS AND CASPASE-DEPENDENT CHEMOTHERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER
This invention relates to compositions and methods utilizing a caspase-dependent chemotherapeutic drug and a PPARy-agonist, such as VP-16 or Taxol as the chemotherapeutic drug and troglitazone or...
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US20090258914 |
Inhibitor of Anti-Apoptotic Proteins
A compound having the structure A is described as well as the use of such compounds to inhibit at least one BCL-2 protein family member.
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US20090253752 |
COMBINATION OF DPP-IV INHIBITOR, PPAR ANTIDIABETIC AND METMORFIN
The invention relates to a combination, such as a combined preparation or pharmaceutical composition, respectively, which comprises;
1) a dipeptidylpeptidase-IV (DPP-IV) inhibitor, 2) one...
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US20090247587 |
1,3-DIHYDROISOBENZOFURAN DERIVATIVES
The object is to provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia;...
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US20090246232 |
Pharmaceutical composition
Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent...
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US20090239830 |
Treatment of viral infections by modulation of host cell metabolic pathways
Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets for...
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US20090233974 |
SUBSTITUTED GAMMA LACTAMS AS THERAPEUTIC AGENTS
A compound having the formula
or a pharmaceutically acceptable salt or a prodrug thereof is disclosed herein. Y, A, and B are as described herein. Methods, compositions, and medicaments related...
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US20090233968 |
INHIBITORS OF THE ALPHA2BETA1/GPIa-IIA INTEGRIN
Novel compounds inhibiting the integrin α2β1/GPIa-IIa receptor are disclosed. Also disclosed are pharmaceutical compositions containing the compounds, as well as methods of their therapeutic use....
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US20090227493 |
COMBINED DRUG FOR TREATING DIABETES
The present invention provides a pharmaceutical composition (preferably a drug for therapeutic and/or prophylactic treatment of diabetes) comprising a GLP-1 receptor agonist and the insulin...
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US20090227644 |
AGENT FOR REGENERATION AND/OR PROTECTION OF NERVES
An EP2 agonist which may have an EP3 agonistic effect has an effect of regenerating and/or protecting nerves, and is therefore useful as a therapeutic agent for a disease of the peripheral nervous...
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US20090221617 |
LEAD COMPOUND OF ANTI-HYPERTENSIVE DRUG AND METHOD FOR SCREENING THE SAME
A system for screening a small molecule library with 250,000 molecules to find out a compound of an anti-hypertensive drug aiming at human Angiotensin II type IA receptor is provided. The system...
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US20090215758 |
Use of 2,5-Disubstituted Thiazol-4-One Derivatives in Drugs
The invention relates to 2,5-disubstituted thiazol-4-one derivatives and to their use in the production of drugs, to methods for producing them and to drugs containing said compounds.
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US20090209590 |
Histone Deacetylase and Tubulin Deacetylase Inhibitors
In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel inhibitors of histone deacetylases, tubulin...
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US20090203754 |
ANTI-BACTERIAL DRUG TARGETING OF GENOME MAINTENANCE INTERFACES
Methods for the design and identification of novel antimicrobial compounds are provided, as well as antimicrobial compounds identified using these methods. Pharmaceutical compositions that include...
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US20090197870 |
Pharmaceutical Compositions
Compounds for use in compositions and methods for modulating the activity of nuclear receptors are provided. In particular, compounds for use in compositions and methods for modulating the estrogen...
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US20090186834 |
DIPHENYLHETEROCYCLE CHOLESTEROL ABSORPTION INHIBITORS
Various azetidinone, pyrrolidine, imidazolidine, and oxazolidine derivatives are described, as are pharmaceutical compositions containing these compounds and methods of treatment of diseases using...
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US20090176837 |
COMPOUNDS WITH ACTIVITY AT RETINOIC ACID RECEPTORS
Disclosed herein are novel compounds with activity at RARβ 2 receptors. Further disclosed are the use of such compounds for treatment of or to alleviate symptoms of cancer, neurological disorders...
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US20090170840 |
NS1 protein inhibitors
The present invention generally relates to compounds to treat viral infections and methods of their use. In particular, compounds of the present invention inhibit the activity of NS1 protein,...
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US20090170908 |
SPIRO COMPOUNDS AND PHARMACEUTICAL USE THEREOF
The Spiro compound represented by the following general formula [Ia], its pharmaceutically acceptable salt or a solvate thereof
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US20090170814 |
7,8-BICYCLOAKYL-CHROMAN DERIVATIVES
7,8-Bicyclic-chroman derivatives of Formula I:
wherein the substituents are defined as in the specification or the pharmaceutically acceptable salts thereof, are disclosed. They are useful for...
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US20090163445 |
Synergistic microbicidal compositions
This invention relates to synergistic combinations of selected microbicides in combination with a second microbicide or formulation ingredient or raw material. The combinations have greater...
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US20090155176 |
Compositions and methods for treatment of diabetic retinopathy
The present invention provides compounds and methods for the treatment of diabetic retinopathy. In particular, LFA-1 antagonists are described herein to be used in the treatment of diabetic...
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US20090156644 |
Use of thiazole derivatives and analogues in the treatment of cancer
There is provided a use of a compound of formula (I), wherein X, Y, T, W, A 1 , A 2 R 1 , R 5 and R 6 have meanings given in the description for the manufacture of a medicament for the treatment...
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US20090136472 |
Use of thiazole derivatives and analogues in disorders caused by free fatty acids
There is provided a use of a compound of formula I,
wherein X, T, Y, W, A 1 , A 2 , R 1 , R 5 and R 6 have meanings given in the description, for the manufacture of a medicament for the...
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US20090124626 |
Pharmaceutical agent comprising insulin resistance improving agent
To provide a method for treating diabetes which has an excellent hypoglycemic action and causes minimal adverse drug reactions, there is provided a medicine comprising a DPP-IV inhibitor and an...
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US20090124676 |
SUBSTITUTED CYCLOPENTANES HAVING PROSTAGLANDIN ACTIVITY
Disclosed herein are compounds having a formula:
Therapeutic methods, medicaments, and compositions related thereto are also disclosed.
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US20090124675 |
INHIBITORS OF ANTI-APOPTOTIC PROTEINS
Various compounds comprising a thiazolidine ring are described as well as the use of such compounds to inhibit at least one BCL-2 protein family member. One of the compounds described has the...
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US20090118335 |
Acid Secretion Inhibitor
The present invention provides a compound having a superior acid secretion inhibitory action, an antiulcer activity and the like. A proton pump inhibitor containing a compound represented by the...
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US20090118306 |
Novel use of liver X receptor agonists
The present invention generally relates to a novel therapeutical use of liver X receptor (LXR) agonsits. More specifically, the present invention relates to the use of LXR agonist for the...
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US20090118337 |
Methods and compositions for treating inflammation
A method of treating a subject with a cystic fibrosis related disorder includes administering a therapeutically effective amount of at least one PPARγ agonist or a derivative thereof.
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US20090111782 |
COMPOSITION AND METHODS RELATING TO GLUCOCORTICOID RECEPTOR-ALPHA AND PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS
Methods of treating a glucocorticoid-responsive condition in a subject are provided according to embodiments of the present invention which include administering, in combination, a glucocorticoid...
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US20090111855 |
SUBSTITUTED PHENOXY THIAZOLIDINEDIONES AS ESTROGEN RELATED RECEPTOR-alpha MODULATORS
The present invention relates to compounds of Formula (I),
methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but...
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US20090105254 |
VHR PROTEIN TYROSINE PHOSPHATASE INHIBITORS, COMPOSITIONS AND METHODS OF USE
Disclosed herein are Vaccinia H1-related (VHR) protein tyrosine phosphatase (PTP) inhibitors that provide a method for treating cancer.
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US20090105257 |
AMINOPHENYLCYCLOPROPYL CARBOXYLIC ACIDS AND DERIVATIVES AS AGONISTS TO GPR40
The present invention relates generally to novel therapeutic compounds and more particularly to novel compounds, their use as GPR40 agonists, processes for their manufacture, and intermediates...
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US20090099238 |
USE OF A PPAR-ALPHA AGONIST TO TREAT PATIENTS SUFFERING FROM WEIGHT GAIN ASSOCIATED WITH A PPAR-GAMMA AGONIST TREATMENT
The present invention relates to the use of a pparα agonist to treat patients suffering from weight gain associated with a pparγ agonist treatment.
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US20090093507 |
CDK INHIBITORS CONTAINING A ZINC BINDING MOIETY
The present invention relates to CDK inhibitors and their use in the treatment of cell proliferative diseases such as cancer. The compounds of the invention may further act as HDAC inhibitors.
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US20090088462 |
Pharmaceutical Composition for Enhancing Adiponectin Production
Method for treatment of a human patient having hypoadiponectinemia. 5-[4-(6-methoxy-1-methyl-1H-benzimidazol-2-ylmethoxy)benzyl]
thiazolidine-2,4-dione or a pharmacologically salt thereof is...
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US20090082406 |
Cancer Therapy
This invention relates to a method of regulating the cell cycle and treating cancer with a peroxisome proliferator-activated receptor γ agonist and a mevalonate pathway inhibitor or a mevalonate...
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